Differential role of RB in response to UV and IR damage

Nucleic Acids Research

Volumn 33, Issue 5, 2005, Pages 1581-1592

  Bosco, Emily E ^a   Knudsen, Erik S ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DOUBLE STRANDED DNA; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL KINETICS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; FIBROBLAST CULTURE; GENE CONTROL; GENE LOSS; IONIZING RADIATION; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION EXPOSURE; RADIATION RESPONSE; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION; ANIMAL; CELL CULTURE; DOWN REGULATION; GENE EXPRESSION REGULATION; KINETICS; PHYSIOLOGY;

ANIMALS; CELL CYCLE; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DOWN-REGULATION; GENE EXPRESSION REGULATION; KINETICS; MICE; RADIATION, IONIZING; RETINOBLASTOMA PROTEIN; ULTRAVIOLET RAYS;

EID: 15044339763     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki283     Document Type: Article

References (62)

1. Hartwell,L. (1992) Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. [i#Cell#1i], [b#71#1b], 543-546.
2. Friedberg,E.C. (1995) Out of the shadows and into the light: The emergence of DNA repair. [i#Trends Biochem. Sci.#1i], [b#20#1b], 381.
3. Hoeijmakers,J.H. (2001) Genome maintenance mechanisms for preventing cancer. [i#Nature#1i], [b#411#1b], 366-374.
4. Hartwell,L.H. and Weinert,T.A. (1989) Checkpoints: Controls that ensure the order of cell cycle events. [i#Science#1i], [b#246#1b], 629-634.
5. Chellappan,S.P., Hiebert,S., Mudryj,M., Horowitz,J.M. and Nevins,J.R. (1991) The E2F transcription factor is a cellular target for the RB protein. [i#Cell#1i], [b#65#1b], 1053-1061.
6. Stevaux,O. and Dyson,N.J. (2002) A revised picture of the E2F transcriptional network and RB function. [i#Curr. Opin. Cell Biol.#1i], [b#14#1b], 684-691.
7. Sherr,C.J. (1996) Cancer cell cycles. [i#Science#1i], [b#274#1b], 1672-1677.
8. Harbour,J.W., Luo,R.X., Dei Santi,A., Postigo,A.A. and Dean,D.C. (1999) Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. [i#Cell#1i], [b#98#1b], 859-869.
9. Bartek,J., Bartkova,J. and Lukas,J. (1997) The retinoblastoma protein pathway in cell cycle control and cancer. [i#Exp. Cell Res.#1i], [b#237#1b] 1-6.
10. Harrington,E.A., Bruce,J.L., Harlow,E. and Dyson,N. (1998) pRB plays an essential role in cell cycle arrest induced by DNA damage. [i#Proc. Natl Acad. Sci. USA#1i], [b#95#1b], 11945-11950.
11. Knudsen,E.S., Buckmaster,C., Chen,T.T., Feramisco,J.R. and Wang,J.Y. (1998) Inhibition of DNA synthesis by RB: Effects on G1/S transition and S-phase progression. [i#Genes Dev.#1i], [b#12#1b], 2278-2292.
12. Herrera,R.E., Sah,V.P., Williams,B.O., Makela,T.P., Weinberg,R.A. and Jacks,T. (1996) Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. [i#Mol. Cell. Biol.#1i], [b#16#1b], 2402-2407.
13. Mayhew,C.N., Perkin,L.M., Zhang,X., Sage,J., Jacks,T. and Knudsen,E.S. (2004) Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents. [i#Oncogene#1i], [b#23#1b], 4107-4120.
14. Yamasaki,L. (2003) Role of the RB tumor suppressor in cancer. [i#Cancer Treat Res.#1i], [b#115#1b], 209-239.
15. Harbour,J.W., Lai,S.L., Whang-Peng,J., Gazdar,A.F., Minna,J.D. and Kaye,F.J. (1988) Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. [i#Science#1i], [b#241#1b], 353-357.
16. Lee,W.H., Bookstein,R. and Lee,E.Y. (1988) Studies on the human retinoblastoma susceptibility gene. [i#J. Cell. Biochem.#1i], [b#38#1b], 213-227.
17. Knudson,A.Jr. (1993) Genetics of tumors of the head and neck. [i#Arch. Otolaryngol. Head Neck Surg.#1i], [b#119#1b], 735-737.
18. Bookstein,R. (1994) Tumor suppressor genes in prostatic oncogenesis. [i#J. Cell. Biochem. Suppl.#1i], [b#19#1b], 217-223.
19. Lan,Z., Sever-Chroneos,Z., Strobeck,M.W., Park,C.H., Baskaran,R., Edelmann,W., Leone,G. and Knudsen,E.S. (2002) DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2. [i#J. Biol. Chem.#1i], [b#277#1b], 8372-8381.
20. Cam,H., Balciunaite,E., Blais,A., Spektor,A., Scarpulla,R.C., Young,R., Kluger,Y. and Dynlacht,B.D. (2004) A common set of gene regulatory networks links metabolism and growth inhibition. [i#Mol. Cell#1i], [b#16#1b] 399-411.
21. Ishida,S., Huang,E., Zuzan,H., Spang,R., Leone,G., West,M. and Nevins,J.R (2001) Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. [i#Mol. Cell. Biol.#1i], [b#21#1b], 4684-4699.
22. Polager,S., Kalma,Y., Berkovich,E. and Ginsberg,D. (2002) E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis. [i#Oncogene#1i], [b#21#1b], 437-446.
23. Markey,M.P., Angus,S.P., Strobeck,M.W., Williams,S.L., Gunawardena,R.W., Aronow,B.J. and Knudsen,E.S. (2002) Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action. [i#Cancer Res.#1i], [b#62#1b], 6587-6597.
24. Classon,M. and Harlow,E. (2002) The retinoblastoma tumour suppressor in development and cancer. [i#Nature Rev. Cancer#1i], [b#2#1b], 910-917.
25. Marino,S., Vooijs,M., van Der Gulden,H., Jonkers,J. and Berns,A. (2000) Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. [i#Genes Dev.#1i], [b#14#1b], 994-1004.
26. Knudsen,K.E., Booth,D., Naderi,S., Sever-Chroneos,Z., Fribourg,A.F., Hunton,I.C., Feramisco,J.R., Wang,J.Y. and Knudsen,E.S. (2000) RB-dependent S-phase response to DNA damage. [i#Mol. Cell. Biol.#1i], [b#20#1b], 7751-7763.
27. Sever-Chroneos,Z., Angus,S.P., Fribourg,A.F., Wan,H., Todorov,I., Knudsen,K.E. and Knudsen,E.S. (2001) Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase. [i#Mol. Cell. Biol.#1i], [b#21#1b], 4032-4045.
28. Paull,T.T., Rogakou,E.P., Yamazaki,V., Kirchgessner,C.U., Gellert,M. and Bonner,W.M. (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. [i#Curr. Biol.#1i], [b#10#1b], 886-895.
29. Wang,Q.E., Zhu,Q., Wani,M.A., Wani,G., Chen,J. and Wani,A.A. (2003) Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage. [i#DNA Repair (Amst.)#1i], [b#2#1b], 483-499.
30. Sage,J., Miller,A.L., Perez-Mancera,P.A., Wysocki,J.M. and Jacks,T. (2003) Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. [i#Nature#1i], [b#424#1b], 223-228.
31. Dyson,N. (1998) The regulation of E2F by pRB-family proteins. [i#Genes Dev.#1i], [b#12#1b], 2245-2262.
32. Siddik,Z.H. (2003) Cisplatin: Mode of cytotoxic action and molecular basis of resistance. [i#Oncogene#1i], [b#22#1b], 7265-7279.
33. Van Triest,B., Pinedo,H.M., Giaccone,G. and Peters,G.J. (2000) Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. [i#Ann. Oncol.#1i], [b#11#1b], 385-391.
34. Lawrence,T.S., Blackstock,A.W. and McGinn,C. (2003) The mechanism of action of radiosensitization of conventional chemotherapeutic agents. [i#Semin. Radiat. Oncol.#1i], [b#13#1b], 13-21.
35. Chao,C., Saito,S., Kang,J., Anderson,C.W., Appella,E. and Xu,Y. (2000) p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. [i#EMBO J.#1i], [b#19#1b], 4967-4975.
36. Bartek,J. and Lukas,J. (2001) Pathways governing G1/S transition and their response to DNA damage. [i#FEBS Lett.#1i], [b#490#1b], 117-122.
37. Hwang,B.J., Toering,S., Francke,U. and Chu,G. (1998) p48 activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity. [i#Mol. Cell. Biol.#1i], [b#18#1b] 4391-4399.
38. Bohr,V.A., Smith,C.A., Okumoto,D.S. and Hanawalt,P.C. (1985) DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. [i#Cell#1i], [b#40#1b], 359-369.
39. van der Horst,G.T., van Steeg,H., Berg,R.J., van Gool,A.J., de Wit,J., Weeda,G., Morreau,H., Beems,R.B., van Kreijl,C.F., de Gruijl,F.R. [i#et al.#1i] (1997) Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition. [i#Cell#1i] [b#89#1b], 425-435.
40. Schul,W., Jans,J., Rijksen,Y.M., Klemann,K.H., Eker,A.P., de Wit,J., Nikaido,O., Nakajima,S., Yasui,A., Hoeijmakers,J.H. [i#et al.#1i] (2002) Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice. [i#EMBO J.#1i], [b#21#1b], 4719-4729.
41. Mitchell,D.L. (1988) The relative cytotoxicity of (6-4) photoproducts and cyclobutane dimers in mammalian cells. [i#Photochem. Photobiol.#1i], [b#48#1b], 51-57.
42. Rieger,K.E. and Chu,G. (2004) Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells. [i#Nucleic Acids Res.#1i] [b#32#1b], 4786-4803.
43. Paunesku,T., Mittal,S., Protic,M., Oryhon,J., Korolev,S.V., Joachimiak,A. and Woloschak,G.E. (2001) Proliferating cell nuclear antigen (PCNA): Ringmaster of the genome. [i#Int. J. Radiat. Biol.#1i], [b#77#1b], 1007-1021.
44. Cleaver,J.E., Karplus,K., Kashani-Sabet,M. and Limoli,C.L. (2001) Nucleotide excision repair 'a legacy of creativity'. [i#Mutat. Res.#1i], [b#485#1b], 23-36.
45. Takemura,M., Kitagawa,T., Izuta,S., Wasa,J., Takai,A., Akiyama,T. and Yoshida,S. (1997) Phosphorylated retinoblastoma protein stimulates DNA polymerase alpha. [i#Oncogene#1i], [b#15#1b], 2483-2492.
46. Sterner,J.M., Dew-Knight,S., Musahl,C., Kornbluth,S. and Horowitz,J.M. (1998) Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. [i#Mol. Cell. Biol.#1i] [b#18#1b], 2748-2757.
47. Pennaneach,V., Salles-Passador,I., Munshi,A., Brickner,H., Regazzoni,K., Dick,F., Dyson,N., Chen,T.T., Wang,J.Y., Fotedar,R. [i#et al.#1i] (2001) The large subunit of replication factor C promotes cell survival after DNA damage in an LxCxE motif-and Rb-dependent manner. [i#Mol. Cell#1i], [b#7#1b], 715-727.
48. Gladden,A.B. and Diehl,J.A. (2003) The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding. [i#J. Biol. Chem.#1i], [b#278#1b], 9754-9760.
49. Kennedy,B.K., Barbie,D.A., Classon,M., Dyson,N. and Harlow,E. (2000) Nuclear organization of DNA replication in primary mammalian cells. [i#Genes Dev.#1i], [b#14#1b], 2855-2868.
50. Dimitrova,D.S. and Berezney,R. (2002) The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells. [i#J. Cell. Sci.#1i], [b#115#1b], 4037-4051.
51. Bosco,G., Du,W. and Orr-Weaver,T.L. (2001) DNA replication control through interaction of E2F-RB and the origin recognition complex. [i#Nature Cell Biol.#1i], [b#3#1b], 289-295.
52. Harbour,J.W. and Dean,D.C. (2000) The Rb/E2F pathway: Expanding roles and emerging paradigms. [i#Genes Dev.#1i], [b#14#1b], 2393-2409.
53. Bakkenist,C.J. and Kastan,M.B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. [i#Nature#1i], [b#421#1b], 499-506.
54. Khanna,K.K., Keating,K.E., Kozlov,S., Scott,S., Gatei,M., Hobson,K., Taya,Y., Gabrielli,B., Chan,D., Lees-Miller,S.P. [i#et al.#1i] (1998) ATM associates with and phosphorylates p53: Mapping the region of interaction. [i#Nature Genet.#1i], [b#20#1b], 398-400.
55. Siliciano,J.D., Canman,C.E., Taya,Y., Sakaguchi,K., Appella,E. and Kastan,M.B. (1997) DNA damage induces phosphorylation of the amino terminus of p53. [i#Genes Dev.#1i], [b#11#1b], 3471-3481.
56. Hirao,A., Kong,Y.Y., Matsuoka,S., Wakeham,A., Ruland,J., Yoshida,H., Liu,D., Elledge,S.J. and Mak,T.W. (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. [i#Science#1i], [b#287#1b], 1824-1827.
57. Stiff,T., O'Driscoll,M., Rief,N., Iwabuchi,K., Lobrich,M. and Jeggo,P.A. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. [i#Cancer Res.#1i], [b#64#1b], 2390-2396.
58. Motoyama,N. and Naka,K. (2004) DNA damage tumor suppressor genes and genome instability. [i#Curr. Opin. Genet. Dev.#1i], [b#14#1b], 11-16.
59. Nahle,Z., Polakoff,J., Davuluri,R.V., McCurrach,M.E., Jacobson,M.D., Narita,M., Zhang,M.Q., Lazebnik,Y., Bar-Sagi,D. and Lowe,S.W. (2002) Direct coupling of the cell cycle and cell death machinery by E2F. [i#Nature Cell. Biol.#1i], [b#4#1b], 859-864.
60. Samuelson,A.V. and Lowe,S.W. (1997) Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins. [i#Proc. Natl Acad. Sci. USA#1i], [b#94#1b], 12094-12099.
61. Moll,A.C., Imhof,S.M., Bouter,L.M. and Tan,K.E. (1997) Second primary tumors in patients with retinoblastoma. A review of the literature. [i#Ophthalmic Genet.#1i], [b#18#1b], 27-34.
62. Fletcher,O., Easton,D., Anderson,K., Gilham,C., Jay,M. and Peto,J. (2004) Lifetime risks of common cancers among retinoblastoma survivors. [i#J. Natl Cancer Inst.#1i], [b#96#1b], 357-363.