Prolonged suppression of brain nitric oxide synthase activity by 7-nitroindazole protects against cerebral hypoxic-ischemic injury in neonatal rat

Brain and Development

Volumn 23, Issue 5, 2001, Pages 349-354

  Ishida, Akira ^a,b   Trescher, William H ^a,b   Lange, Mary S ^b   Johnston, Michael V ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

Cerebral ischemia; N Methyl D aspartate; Newborn; Nitric oxide synthase

Indexed keywords

7 NITROINDAZOLE; BRAIN ENZYME; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY LIGATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME REPRESSION; NEWBORN; NONHUMAN; RAT;

AGING; ANIMALS; ANIMALS, NEWBORN; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTAMIC ACID; HYPOXIA-ISCHEMIA, BRAIN; INDAZOLES; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS;

EID: 0034896809     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0387-7604(01)00237-6     Document Type: Article

References (59)

1. Nitric oxide synthase in models of focal ischemia
2. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse
3. The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia
4. G-nitro-L-arginine in focal stroke in the 7-day old rat
5. Inhibitor of nitric oxide synthesis reduces hypoxic-ischemic brain damage in the neonatal rat
6. Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia
7. G-nitro-L-arginine enhances neuronal death following transient forebrain ischemia in gerbils
8. Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat
9. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo
10. The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels
11. Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat
12. The selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats
13. Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia
14. Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition
15. The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat
16. Reduction of the neurological deficit in mice with traumatic brain injury by nitric oxide synthase inhibitors
17. Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest
18. Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system
19. Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity
20. Effects of hypoxia and reoxygenation on nitric oxide production and cerebral blood flow in developing rat striatum
21. Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes
22. Increase in nitric oxide in the hypoxic-ischemic neonatal rat brain and suppression by 7-nitroindazole and aminoguanidine
23. Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles
24. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: Antinociceptive and cardiovascular effects
25. Potentiation of NMDA-mediated toxicity on nigrostriatal neurons by a low dose of 7-nitro indazole
26. Localization of nitric oxide synthase indicating a neural role for nitric oxide
27. Protein measurement with the folin phenol reagent
28. Quantitative assessment of neuroprotection against NMDA-induced brain injury
29. Evaluation of brain damage in a rat model of neonatal hypoxic-ischemia
30. Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: A light microscopic study
31. Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury
32. Selective sparing of NADPH-diaphorase neurons in neonatal hypoxia-ischemia
33. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
34. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues
35. Neuronal NADPH diaphorase is a nitric oxide synthase
36. Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury
37. Increased neurons containing neuronal nitric oxide synthase in the brain of a hypoxic-ischemic neonatal rat model
38. Delayed increase in neuronal nitric oxide synthase immunoreactivity in thalamus and other brain regions after hypoxic-ischemic injury in neonatal rats
39. Time course of inhibition of brain nitric oxide synthase by 7-nitro indazole
40. Protective effect of aminoguanidine on hypoxic-ischemic brain damage and temporal profile of brain nitric oxide in neonatal rat
41. Hypoxia-induced generation of nitric oxide free radicals in cerebral cortex of newborn guinea pigs
42. L-NAME reduces infarct volume in a filament model of transient middle cerebral artery occlusion in the rat pup
43. Transient changes in the presence of nitric oxide synthases and nitrotyrosine immunoreactivity after focal cortical lesions
44. Induction of neuronal nitric oxide after hypothermic circulatory arrest
45. Nitric oxide production during focal cerebral ischemia in rats
46. Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat
47. ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats
48. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
49. Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia
50. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion
51. Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase
52. Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury
53. Aminoguanidine prevented the impairment of learning behavior and hippocampal long-term potentiation following transient cerebral ischemia
54. A novel neuronal messenger molecule in brain: The free radical, nitric oxide
55. Neuroprotective efficacy of N omega-nitro-L-arginine after focal cerebral ischemia in the mouse and inhibition of cortical nitric oxide synthase
56. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine
57. Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo
58. Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity
59. Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: In vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid