메뉴 건너뛰기




Volumn 12, Issue 1, 2005, Pages 56-62

Glucagon-like peptide-1: Physiology therapeutic potential

Author keywords

Dipeptidyl peptidase IV; DPP IV; Exendin; Incretin hormones; Type 2 diabetes

Indexed keywords

ALBUGON; CJC 1131; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DP 728; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; LIRAGLUTIDE; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 14944371913     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.med.0000151395.52819.47     Document Type: Review
Times cited : (20)

References (78)
  • 1
    • 3242730474 scopus 로고    scopus 로고
    • Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
    • Holst JJ, Gromada J: Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 2004; 287:E199-E206. This review provides an overview the current status of incretin function in humans.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Holst, J.J.1    Gromada, J.2
  • 2
    • 12644253798 scopus 로고    scopus 로고
    • Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
    • Furuta M, Yano H, Zhou A, et al. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci U S A 1997; 94:6646-6651.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6646-6651
    • Furuta, M.1    Yano, H.2    Zhou, A.3
  • 3
    • 1442274636 scopus 로고    scopus 로고
    • Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1
    • Ugleholdt R, Zhu X, Deacon CF, et al. Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology 2004; 145:1349-1355.
    • (2004) Endocrinology , vol.145 , pp. 1349-1355
    • Ugleholdt, R.1    Zhu, X.2    Deacon, C.F.3
  • 4
    • 0037312818 scopus 로고    scopus 로고
    • Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis
    • Drucker DJ: Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 2003; 17:161-171.
    • (2003) Mol Endocrinol , vol.17 , pp. 161-171
    • Drucker, D.J.1
  • 5
    • 0033175006 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (Glucagon-like peptide-1): An intestinal hormone signalling nutritional abundance, with an unusual therapeutic potential
    • Holst JJ: Glucagon-like peptide 1 (Glucagon-like peptide-1): an intestinal hormone signalling nutritional abundance, with an unusual therapeutic potential. Trends Endocrinol Metab 1999; 10:229-234.
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 229-234
    • Holst, J.J.1
  • 6
    • 0035123108 scopus 로고    scopus 로고
    • Glucagon-like peptide 2 improves nutrient absorption and nutritional statue in short-bowel patients with no colon
    • Jeppesen PB, Hartmann B, Thulesen J, et al. Glucagon-like peptide 2 improves nutrient absorption and nutritional statue in short-bowel patients with no colon. Gastroenterology 2001; 120:806-815.
    • (2001) Gastroenterology , vol.120 , pp. 806-815
    • Jeppesen, P.B.1    Hartmann, B.2    Thulesen, J.3
  • 7
    • 10744224629 scopus 로고    scopus 로고
    • Role of gastrointestinal hormones in postprandial reduction of bone resorption
    • Henriksen DB, Alexandersen P, Bjarnason NH, et al. Role of gastrointestinal hormones in postprandial reduction of bone resorption. J Bone Miner Res 2003; 18:2180-2189.
    • (2003) J Bone Miner Res , vol.18 , pp. 2180-2189
    • Henriksen, D.B.1    Alexandersen, P.2    Bjarnason, N.H.3
  • 8
    • 2642519637 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes mellitus with agonists of the Glucagon-like peptide-1 receptor or DPP-IV inhibitors
    • Holst JJ: Treatment of type 2 diabetes mellitus with agonists of the Glucagon-like peptide-1 receptor or DPP-IV inhibitors. Expert Opin Emerg Drugs 2004; 9:155-166.
    • (2004) Expert Opin Emerg Drugs , vol.9 , pp. 155-166
    • Holst, J.J.1
  • 9
    • 0029043139 scopus 로고
    • Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide
    • Fehmann HC, Goke R, Goke B: Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr Rev 1995; 16:390-410.
    • (1995) Endocr Rev , vol.16 , pp. 390-410
    • Fehmann, H.C.1    Goke, R.2    Goke, B.3
  • 10
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, et al. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987; 2:1300-1304.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3
  • 11
    • 0028883257 scopus 로고
    • Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide
    • Kolligs F, Fehmann HC, Goke R, et al. Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide. Diabetes 1995; 44:16-19.
    • (1995) Diabetes , vol.44 , pp. 16-19
    • Kolligs, F.1    Fehmann, H.C.2    Goke, R.3
  • 12
    • 0028821658 scopus 로고
    • Glucagon-like peptide-1 is a physiological incretin in rat
    • see comments
    • Wang Z, Wang RM, Owji AA, et al. Glucagon-like peptide-1 is a physiological incretin in rat. J Clin Invest 1995; 95:417-421 [see comments].
    • (1995) J Clin Invest , vol.95 , pp. 417-421
    • Wang, Z.1    Wang, R.M.2    Owji, A.A.3
  • 13
    • 0032960834 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: Studies with the antagonist exendin 9-39
    • in-process citation
    • Edwards CM, Todd JF, Mahmoudi M, et al. Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39. Diabetes 1999; 48:86-93 [in-process citation].
    • (1999) Diabetes , vol.48 , pp. 86-93
    • Edwards, C.M.1    Todd, J.F.2    Mahmoudi, M.3
  • 14
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi LA, Brown TJ, MaClusky N, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 1996; 2:1254-1258.
    • (1996) Nat Med , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    MaClusky, N.3
  • 15
    • 0037373183 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXV. The Glucagon Receptor Family
    • Mayo KE, Miller LJ, Bataille D, et al. International Union of Pharmacology. XXXV. The Glucagon Receptor Family. Pharmacol Rev 2003; 55:167-194. This is a very comprehensive and useful review of the current knowledge regarding this family of receptors
    • (2003) Pharmacol Rev , vol.55 , pp. 167-194
    • Mayo, K.E.1    Miller, L.J.2    Bataille, D.3
  • 16
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
    • Fehmann HC, Habener JF: Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 1992; 130:159-166.
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 17
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
    • in-process citation
    • Buteau J, Roduit R, Susini S, et al. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 1999; 42:856-864 [in-process citation].
    • (1999) Diabetologia , vol.42 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3
  • 18
    • 0037357951 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells
    • Egan JM, Bulotta A, Hui H, et al. Glucagon-like peptide-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev 2003; 19:115-123.
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 115-123
    • Egan, J.M.1    Bulotta, A.2    Hui, H.3
  • 19
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, et al. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48:2270-2276.
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3
  • 20
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000; 49:741-748.
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 21
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, Wang X, Pineyro MA, et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 1999; 48:2358-2366.
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3
  • 22
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti R, Zhou J, Doyle ME, et al. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000; 141:4600-4605.
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3
  • 23
    • 2942568445 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
    • Buteau J, El-Assaad W, Rhodes CJ, et al. Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 2004; 47:806-815. This study demonstrates the ability of Glucagon-like peptide-1 to counteract apoptosis in human β cells, whether induced by lipotoxicity, glucotoxicity, or both.
    • (2004) Diabetologia , vol.47 , pp. 806-815
    • Buteau, J.1    El-Assaad, W.2    Rhodes, C.J.3
  • 24
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • Brubaker PL, Drucker DJ: Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004; 145:2653-2659. This is a useful review of the current status with respect to the intracellular mechanisms involved in the protective effects of Glucagon-like peptide-1
    • (2004) Endocrinology , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 25
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen MB, Damholt MB, Madsbad S, et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 2001; 86:3717-3723.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 26
    • 0027533758 scopus 로고
    • Truncated Glucagon-like peptide-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man
    • Wettergren A, Schjoldager B, Mortensen PE, et al. Truncated Glucagon-like peptide-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci 1993; 38:665-673.
    • (1993) Dig Dis Sci , vol.38 , pp. 665-673
    • Wettergren, A.1    Schjoldager, B.2    Mortensen, P.E.3
  • 27
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck MA, Niedereichholz U, Ettler R, et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997; 273:E981-E988.
    • (1997) Am J Physiol , vol.273
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 28
    • 0344433933 scopus 로고    scopus 로고
    • Inhibition of gastric emptying by physiological and pharmacological doses of exogenous glucagon-like peptide-1 (Glucagon-like peptide-1) outweighs insulinotropic effects in healthy normoglycemic volunteers
    • Nauck MA, Niedereichholz U, Ettler R, et al. Inhibition of gastric emptying by physiological and pharmacological doses of exogenous glucagon-like peptide-1 (Glucagon-like peptide-1) outweighs insulinotropic effects in healthy normoglycemic volunteers. Am J Physiol 1997.
    • (1997) Am J Physiol
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 29
    • 0029011447 scopus 로고
    • Ileal release of glucagon-like peptide-1 (Glucagon-like peptide-1). Association with inhibition of gastric acid secretion in humans
    • Layer P, Holst JJ, Grandt D, et al. Ileal release of glucagon-like peptide-1 (Glucagon-like peptide-1). Association with inhibition of gastric acid secretion in humans. Dig Dis Sci 1995; 40:1074-1082.
    • (1995) Dig Dis Sci , vol.40 , pp. 1074-1082
    • Layer, P.1    Holst, J.J.2    Grandt, D.3
  • 30
    • 14944377458 scopus 로고    scopus 로고
    • Regulation of antro-pyloro-duodenal and proximal gastric motility by Glucagon-like peptide-1: Involvement of a cholinergic pathway
    • Schirra J, Nicolaus M, Struckmeier C, et al. Regulation of antro-pyloro-duodenal and proximal gastric motility by Glucagon-like peptide-1: involvement of a cholinergic pathway. Regul Peptide 2004; 122:37. Although still in abstract form, this study is important because it demonstrates for the first time that Glucagon-like peptide-1 is a physiologic regulator of gastric motility.
    • (2004) Regul Peptide , vol.122 , pp. 37
    • Schirra, J.1    Nicolaus, M.2    Struckmeier, C.3
  • 31
    • 0028107226 scopus 로고
    • The role of the gut in regulation food intake in man
    • Read N, French S, Cunningham K: The role of the gut in regulation food intake in man. Nutr Rev 1994; 52:1-10.
    • (1994) Nutr Rev , vol.52 , pp. 1-10
    • Read, N.1    French, S.2    Cunningham, K.3
  • 32
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, et al. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 1998; 101:515-520.
    • (1998) J Clin Invest , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3
  • 33
    • 0002300343 scopus 로고    scopus 로고
    • Glucagon-like peptide-1: A potent regulator of food intake in humans
    • Gutzwiller JP, Ke B, Drewe J, et al. Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut 1999; 44:81-86.
    • (1999) Gut , vol.44 , pp. 81-86
    • Gutzwiller, J.P.1    Ke, B.2    Drewe, J.3
  • 34
    • 0033021677 scopus 로고    scopus 로고
    • Energy intake and appetite are suppressed by glucagon-like peptide-1 (Glucagon-like peptide-1) in obese men
    • Naslund E, Barkeling B, King N, et al. Energy intake and appetite are suppressed by glucagon-like peptide-1 (Glucagon-like peptide-1) in obese men. Int J Obes Relat Metab Disord 1999; 23:304-311.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 304-311
    • Naslund, E.1    Barkeling, B.2    King, N.3
  • 35
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • Gutzwiller JP, Drewe J, Goke B, et al. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol 1999; 276:R1541-R1544.
    • (1999) Am J Physiol , vol.276
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3
  • 36
    • 17944365214 scopus 로고    scopus 로고
    • A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans
    • Verdich C, Flint A, Gutzwiller JP, et al. A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans. J Clin Endocrinol Metab 2001; 86:4382-4389.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4382-4389
    • Verdich, C.1    Flint, A.2    Gutzwiller, J.P.3
  • 37
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • see comments
    • Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379:69-72 [see comments].
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 38
    • 0029859220 scopus 로고    scopus 로고
    • Central administration of Glucagon-like peptide-1-(7-36) amide inhibits food and water intake in rats
    • Tang-Christensen M, Larsen PJ, Goke R, et al. Central administration of Glucagon-like peptide-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol 1996; 271:R848-R856,
    • (1996) Am J Physiol , vol.271
    • Tang-Christensen, M.1    Larsen, P.J.2    Goke, R.3
  • 39
    • 0029007063 scopus 로고
    • Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary
    • Goke R, Larsen PJ, Mikkelsen JD, et al. Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary. Neuroendocrinology 1995; 62:130-134.
    • (1995) Neuroendocrinology , vol.62 , pp. 130-134
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3
  • 40
    • 0031924498 scopus 로고    scopus 로고
    • Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment
    • Tang-Christensen M, Vrang N, Larsen PJ: Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment. Diabetes 1998; 47:530-537.
    • (1998) Diabetes , vol.47 , pp. 530-537
    • Tang-Christensen, M.1    Vrang, N.2    Larsen, P.J.3
  • 41
    • 0031029936 scopus 로고    scopus 로고
    • Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
    • Larsen PJ, Tang-Christensen M, Holst JJ, et al. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem, Neuroscience 1997; 77:257-270.
    • (1997) Neuroscience , vol.77 , pp. 257-270
    • Larsen, P.J.1    Tang-Christensen, M.2    Holst, J.J.3
  • 42
    • 0032830989 scopus 로고    scopus 로고
    • Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus
    • Rinaman L: Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus. Am J Physiol 1999; 277:R582-R590.
    • (1999) Am J Physiol , vol.277
    • Rinaman, L.1
  • 43
    • 0032763050 scopus 로고    scopus 로고
    • A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia
    • Rinaman L: A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia. Am J Physiol 1999; 277:R1537-R1540.
    • (1999) Am J Physiol , vol.277
    • Rinaman, L.1
  • 44
    • 11144244302 scopus 로고    scopus 로고
    • The role of central Glucagon-like peptide-1 in mediating the effects of visceral illness: Differential effects in rats and mice
    • Lachey JL, D'Alessio DA, Rinaman L, et al. The role of central Glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology 2005; 146:458-462.
    • (2005) Endocrinology , vol.146 , pp. 458-462
    • Lachey, J.L.1    D'Alessio, D.A.2    Rinaman, L.3
  • 45
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • Bullock BP, Heller RS, Habener JF: Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996; 137:2968-2978.
    • (1996) Endocrinology , vol.137 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 46
    • 0038577144 scopus 로고    scopus 로고
    • Cardiac function in mice lacking the glucagon-like peptide-1 receptor
    • Gros R, You X, Baggio LL, et al. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology 2003; 144:2242-2252. This study demonstrates that mice without a Glucagon-like peptide-1 receptor have impaired cardiac function, suggesting that endogenous Glucagon-like peptide-1 has a physiologic role in cardiac function.
    • (2003) Endocrinology , vol.144 , pp. 2242-2252
    • Gros, R.1    You, X.2    Baggio, L.L.3
  • 47
    • 4544235815 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects schemic and reperfused myocardium via PI3Kinase and p42/p44 MARK signalling pathways
    • Bose AK, Mocanu MM, Mensah KN, et al. Glucagon-like peptide-1 protects schemic and reperfused myocardium via PI3Kinase and p42/p44 MARK signalling pathways [abstract]. Diabetes 2004; 53(suppl): A1.
    • (2004) Diabetes , vol.53 , Issue.SUPPL.
    • Bose, A.K.1    Mocanu, M.M.2    Mensah, K.N.3
  • 48
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004; 109:962-965. This study shows that Glucagon-like peptide-1 treatment may have beneficial effects on cardiac function, which is of great relevance for diabetes patients.
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3
  • 49
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Hentosz T, et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004; 110:955-961. This study shows that Glucagon-like peptide-1 treatment may have beneficial effects on cardiac function, which is of great relevance for diabetes patients.
    • (2004) Circulation , vol.110 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3
  • 50
    • 0036307872 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    • Yamamoto H, Lee CE, Marcus JN, et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest 2002; 110:43-52.
    • (2002) J Clin Invest , vol.110 , pp. 43-52
    • Yamamoto, H.1    Lee, C.E.2    Marcus, J.N.3
  • 51
    • 0345726358 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites
    • Yamamoto H, Kishi T, Lee CE, et al. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 2003; 23:2939-2946.
    • (2003) J Neurosci , vol.23 , pp. 2939-2946
    • Yamamoto, H.1    Kishi, T.2    Lee, C.E.3
  • 52
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, et al. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 2002; 359:824-830.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3
  • 53
    • 0036721026 scopus 로고    scopus 로고
    • Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
    • Perry T, Haughey NJ, Mattson MP, et al. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther 2002; 302:881-888.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 881-888
    • Perry, T.1    Haughey, N.J.2    Mattson, M.P.3
  • 54
    • 0141461415 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    • During MJ, Cao L, Zuzga DS, et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 2003; 9:1173-1179.
    • (2003) Nat Med , vol.9 , pp. 1173-1179
    • During, M.J.1    Cao, L.2    Zuzga, D.S.3
  • 55
    • 3442896818 scopus 로고    scopus 로고
    • A new Alzheimer's disease interventive strategy. Glucagon-like peptide-1
    • Perry TA, Greig NH: A new Alzheimer's disease interventive strategy. Glucagon-like peptide-1. Curr Drug Targets 2004; 5:565-571.
    • (2004) Curr Drug Targets , vol.5 , pp. 565-571
    • Perry, T.A.1    Greig, N.H.2
  • 56
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993; 36:741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3
  • 57
    • 0031033531 scopus 로고    scopus 로고
    • Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (Glucagon-like peptide-1) in subjects with NIDDM
    • Rachman J, Barrow BA, Levy JC, et al. Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (Glucagon-like peptide-1) in subjects with NIDDM. Diabetologia 1997; 40:205-211.
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1    Barrow, B.A.2    Levy, J.C.3
  • 58
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsboll T, Agerso H, Krarup T, et al. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 2003; 88:220-224.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 220-224
    • Vilsboll, T.1    Agerso, H.2    Krarup, T.3
  • 59
    • 0029797540 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
    • Deacon CF, Pridal L, Klarskov L, et al. Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am J Physiol 1996; 271:E458-E464.
    • (1996) Am J Physiol , vol.271
    • Deacon, C.F.1    Pridal, L.2    Klarskov, L.3
  • 60
    • 2642549434 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of recombinant Glucagon-like peptide-1 for 7 days dose-dependently improved glycemic controls in type 2 diabetes
    • Ehlers MRW, Roderick EH, Schneider RL, et al. Continuous subcutaneous infusion of recombinant Glucagon-like peptide-1 for 7 days dose-dependently improved glycemic controls in type 2 diabetes [abstract]. Diabetes 2002; 51(suppl 2):A579.
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Ehlers, M.R.W.1    Roderick, E.H.2    Schneider, R.L.3
  • 61
    • 0034814047 scopus 로고    scopus 로고
    • Exendin-4 reduces fasting and post-prandial glucose and decreases energy intake in healthy volunteers
    • Edwards CM, Stanley SA, Davis R, et al. Exendin-4 reduces fasting and post-prandial glucose and decreases energy intake in healthy volunteers. Am J Physiol Endocrinol Metab 2001; 281:E155-E161.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Edwards, C.M.1    Stanley, S.A.2    Davis, R.3
  • 62
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, et al. Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004; 27:2628-2635. This is the first published study on the long-term effects of type 2 diabetes with an exendin-based Glucagon-like peptide-1 receptor activator.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3
  • 63
    • 12244304380 scopus 로고    scopus 로고
    • Exenatide does not cause pancreatic tumours or malignancies in rats and mice following a 2-year period of exposure
    • Hiles R, Carpenter T, Serota D, et al. Exenatide does not cause pancreatic tumours or malignancies in rats and mice following a 2-year period of exposure [abstract]. Diabetes 2004; 53(suppl 2):A380.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Hiles, R.1    Carpenter, T.2    Serota, D.3
  • 64
    • 2342599057 scopus 로고    scopus 로고
    • One week's treatment with the long-acting glucagon-like peptide 1 derivative Liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes
    • Degn KB, Juhl CB, Sturis J, et al. One week's treatment with the long-acting glucagon-like peptide 1 derivative Liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes 2004; 53: 1187-1194.
    • (2004) Diabetes , vol.53 , pp. 1187-1194
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3
  • 65
    • 0034781256 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 derivatives as novel compounds for the treatment of type 2 diabetes
    • Knudsen LB, Agersø H, Bjenning C, et al. Glucagon-like peptide-1 derivatives as novel compounds for the treatment of type 2 diabetes. Drugs Future 2001; 26:677-685.
    • (2001) Drugs Future , vol.26 , pp. 677-685
    • Knudsen, L.B.1    Agersø, H.2    Bjenning, C.3
  • 66
    • 2542451393 scopus 로고    scopus 로고
    • Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog Liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial
    • Madsbad S, Schmitz O, Ranstam J, et al. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog Liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial. Diabetes Care 2004; 27:1335-1342. This is the first study of the long-term effects of diabetes treatment with an albumin bound Glucagon-like peptide-1 analog.
    • (2004) Diabetes Care , vol.27 , pp. 1335-1342
    • Madsbad, S.1    Schmitz, O.2    Ranstam, J.3
  • 67
    • 14944345673 scopus 로고    scopus 로고
    • Liraglutide as add-on to metformin in type 2 diabetes: Significant improvement in glycaemic control with a reduction in body weight compared with glimepiride
    • Nauck M, Hompesch M, Filipczak R, et al. Liraglutide as add-on to metformin in type 2 diabetes: significant improvement in glycaemic control with a reduction in body weight compared with glimepiride [abstract]. Diabetologia 2004; 47(suppl 1):A281.
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Nauck, M.1    Hompesch, M.2    Filipczak, R.3
  • 68
    • 0037339649 scopus 로고    scopus 로고
    • Development and characterization of a glucagon-like peptide 1 -albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo
    • Kim JG, Baggio LL, Bridon DP, et al. Development and characterization of a glucagon-like peptide 1 -albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo. Diabetes 2003; 52:751-759. This study shows how remarkably well Glucagon-like peptide-1 functions even when covalently bound to a molecule as large as albumin.
    • (2003) Diabetes , vol.52 , pp. 751-759
    • Kim, J.G.1    Baggio, L.L.2    Bridon, D.P.3
  • 69
    • 0242725075 scopus 로고    scopus 로고
    • CJC-II31, a long acting Glucagon-like peptide-1 derivative, exhibits an extended pharmacokinetic profile in healthy human volunteers
    • Lawrence B, Dreyfus J, Wen S, et al. CJC-II31, a long acting Glucagon-like peptide-1 derivative, exhibits an extended pharmacokinetic profile in healthy human volunteers [abstract]. Diabetes 2003; 52(suppl 1):A125.
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Lawrence, B.1    Dreyfus, J.2    Wen, S.3
  • 70
    • 4344667831 scopus 로고    scopus 로고
    • A recombinant human glucagon-like peptide (GLP)-1-albumin protein (Albugon) mimics peptidergic activation of Glucagon-like peptide-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
    • 2004
    • Baggio LL, Huang Q, Brown TJ, 2004. A recombinant human glucagon-like peptide (GLP)-1-albumin protein (Albugon) mimics peptidergic activation of Glucagon-like peptide-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis. Diabetes 2004; 53: 2492-2500. This study shows that even large-molecular weight analogs of Glucagon-like peptide-1 can activate the neural systems involved in Glucagon-like peptide-1 action on, for example, appetite and the gastrointestinal tract.
    • (2004) Diabetes , vol.53 , pp. 2492-2500
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3
  • 71
    • 2342499498 scopus 로고    scopus 로고
    • Albugon fusion protein: A long acting analogue of Glucagon-like peptide-1 that provides lasting antidiabetic effect in animals
    • Bloom M, Bock J, Duttaroy A, et al. Albugon fusion protein: a long acting analogue of Glucagon-like peptide-1 that provides lasting antidiabetic effect in animals [abstract]. Diabetes 2003; 52(suppl 1):A112.
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1
    • Bloom, M.1    Bock, J.2    Duttaroy, A.3
  • 72
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, et al. Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 1995; 44:1126-1131.
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3
  • 73
    • 0031690479 scopus 로고    scopus 로고
    • Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes
    • Holst JJ, Deacon CF: Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes. Diabetes 1998; 47:1663-1670.
    • (1998) Diabetes , vol.47 , pp. 1663-1670
    • Holst, J.J.1    Deacon, C.F.2
  • 74
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig
    • Deacon CF, Hughes TE, Holst JJ: Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. Diabetes 1998; 47:764-769.
    • (1998) Diabetes , vol.47 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 75
    • 20244385394 scopus 로고    scopus 로고
    • Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory action of DPP-IV inhibitors
    • in press
    • Hansotia T, Baggio L, Delmeire D, et al. Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory action of DPP-IV inhibitors. Diabetes 2004 (in press).
    • (2004) Diabetes
    • Hansotia, T.1    Baggio, L.2    Delmeire, D.3
  • 76
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • Ahren B, Simonsson E, Larsson H, et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 2002; 25:869-875.
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahren, B.1    Simonsson, E.2    Larsson, H.3
  • 77
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
    • Ahren B, Landin-Olsson M, Jansson PA, et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab 2004; 89:2078-2084. This is the first proof-of-concept study using the DPP-IV inhibitor LAF 237.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2078-2084
    • Ahren, B.1    Landin-Olsson, M.2    Jansson, P.A.3
  • 78
    • 4544286404 scopus 로고    scopus 로고
    • Prolonged efficacy of LAF237 in patients with type 2 diabetes (T2DM) inadequately treated with metformin
    • Ahren B, Gomis R, Standl E, et al. Prolonged efficacy of LAF237 in patients with type 2 diabetes (T2DM) inadequately treated with metformin. Diabetes 2004; 53:7-LB. Although still in abstract form, this important study shows the remarkable clinical effects of a DPP-IV inhibitor in a long-term study.
    • (2004) Diabetes , vol.53
    • Ahren, B.1    Gomis, R.2    Standl, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.