Transplantation tolerance in NF-κB-impaired Mice is not due to regulation but is prevented by transgenic expression of Bcl-xL

Journal of Immunology

Volumn 174, Issue 6, 2005, Pages 3447-3453

  Zhou, Ping ^a   Balin, Samuel J ^a   Mashayekhi, Mona ^a   Hwang, Kwang Woo ^a,b   Palucki, David A ^a   Alegre, Maria Luisa ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; LEUKOSIALIN; PROTEIN BCL XL;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; GRAFT REJECTION; HEART GRAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN GRAFT; SPLEEN CELL; T LYMPHOCYTE; TRANSGENE; TRANSPLANTATION TOLERANCE;

EID: 14844347541     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.6.3447     Document Type: Article

References (55)

1. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
2. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
3. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
4. Wange, R. L., and Y. Huang. 2004. T cell receptor signaling: beyond complex complexes. J. Biol. Chem. 14:14.
5. Noguchi, H., M. Matsushita, T. Okitsu, A. Moriwaki, K. Tomizawa, S. Kang, S. T. Li, N. Kobayashi, S. Matsumoto, K. Tanaka, et al. 2004. A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat. Med. 10:305.
6. Karin, M., and A. Lin. 2002. NF-κB at the crossroads of life and death. Nat. Immunol. 3:221.
7. Ruland, J., and T. W. Mak. 2003. From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-κB. Semin. Immunol. 15:177.
8. Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286.
9. Marx, J. 1995. How the glucocorticoids suppress immunity. Science 270:232.
10. Karin, M., Y. Yamamoto, and Q. M. Wang. 2004. The IKK NF-κB system: a treasure trove for drug development. Nat. Rev. Drug Discov. 3:17.
11. Smiley, S. T., V. Csizmadia, W. Gao, L. A. Turka, and W. W. Hancock. 2000. Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFκB: implications for tolerance induction. Transplantation 70:415.
12. Csizmadia, V., W. Gao, S. A. Hancock, J. B. Rottman, Z. Wu, L. A. Turka, U. Siebenlist, and W. W. Hancock. 2001. Differential NF-κB and IκB gene expression during development of cardiac allograft rejection versus CD154 monoclonal antibody-induced tolerance. Transplantation 71:835.
13. Boothby, M. R., A. L. Mora, D. C. Scherer, J. A. Brockman, and D. W. Ballard. 1997. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB. J. Exp. Med. 185:1897.
14. Finn, P. W., J. R. Stone, M. R. Boothby, and D. L. Perkins. 2001. Inhibition of NF-κB-dependent T cell activation abrogates acute allograft rejection. J. Immunol. 167:5994.
15. Zhou, P., K. W. Hwang, D. A. Palucki, Z. Guo, M. Boothby, K. A. Newell, and M. L. Alegre. 2003. Impaired NF-κB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts. Am. J. Transplant. 3:139.
16. Lechler, R. I., O. A. Garden, and L. A. Turka. 2003. The complementary roles of deletion and regulation in transplantation tolerance. Nat. Rev. Immunol. 3:147.
17. L and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182:821.
18. Corry, R. J., H. J. Winn, and P. S. Russell. 1973. Primarily vascularized allografts of hearts in mice: the role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 16:343.
19. Chen, Z. H. 1991. A technique of cervical heterotopic heart transplantation in mice. Transplantation 52:1099.
20. Graca, L., A. Le Moine, S. P. Cobbold, and H. Waldmann. 2003. Antibody-induced transplantation tolerance: the role of dominant regulation. Immunol. Res. 28:181.
21. Chiffoleau, E., P. T. Walsh, and L. Turka. 2003. Apoptosis and transplantation tolerance. Immunol. Rev. 193:124.
22. Wells, A, D., X. C. Li, Y. Li, M. C. Walsh, X. X. Zheng, Z. Wu, G. Nunez, A. Tang, M. Sayegh, W. W. Hancock, et al. 1999. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat. Med. 5:1303.
23. L. Cell Death Differ. 10:1032.
24. Pearson, T. C., D. Z. Alexander, K. J. Winn, P. S. Linsley, R. P. Lowry, and C. P. Larsen. 1994. Transplantation tolerance induced by CTLA4-Ig. Transplantation 57:1701.
25. Larsen, C. P., D. Z. Alexander, D. Hollenbaugh, E. T. Elwood, S. C. Ritchie, A. Aruffo, R. Hendrix, and T. C. Pearson. 1996. CD40-gp39 interactions play a critical role during allograft rejection: suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 61:4.
26. Chen, Z., S. Cobbold, S. Metcalfe, and H. Waldmann. 1992. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8. Eur. J. Immunol. 22:805.
27. Orosz, C. G., E. Wakely, S. D. Bergese, A. M. VanBuskirk, R. M. Ferguson, D. Mullet, G. Apseloff, and N. Gerber. 1996. Prevention of murine cardiac allograft rejection with gallium nitrate: comparison with anti-CD4 monoclonal antibody. Transplantation 61:783.
28. Bushell, A., P. J. Morris, and K. J. Wood. 1994. Induction of operational tolerance by random blood transfusion combined with anti-CD4 antibody therapy: a protocol with significant clinical potential. Transplantation 58:133.
29. Adams, A. B., M. M. Durham, L. Kean, N. Shirasugi, J. Ha, M. A. Williams, P. A. Rees, M. C. Cheung, S. Mittelstaedt, A. W. Bingaman, et al. 2001. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. J. Immunol. 167:1103.
30. Monk, N. J., R. E. Hargreaves, J. E. Marsh, C. A. Farrar, S. H. Sacks, M. Millrain, E. Simpson, J. Dyson, and S. Jurcevic. 2003. Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat. Med. 9:1275.
31. + T cell tolerance and linked suppression. J. Immunol. 163:4805.
32. Graca, L., K. Honey, E. Adams, S. P. Cobbold, and H. Waldmann. 2000. Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J. Immunol. 165:4783.
33. Qin, S., S. P. Cobbold, H. Pope, J. Elliott, D. Kioussis, J. Davies, and H. Waldmann. 1993. 'Infectious' transplantation tolerance. Science 259:974.
34. + regulatory T cells: a potential explanation for the blood-transfusion effect. Transplantation 76:449.
35. Schmidt-Supprian, M., G. Courtois, J. Tian, A. J. Coyle, A. Israel, K. Rajewsky, and M. Pasparakis. 2003. Mature T cells depend on signaling through the IKK complex. Immunity 19:377.
36. + T cells reveals an essential requirement for nuclear factor κB in regulating mature T cell survival and in vivo function. J. Exp. Med. 197:861.
37. Campos, L., A. Naji, B. C. Deli, J. H. Kern, J. I. Kim, C. F. Barker, and J. F. Markmann. 1995. Survival of MHC-deficient mouse heterotopic cardiac allografts. Transplantation 59:187.
38. + cells are essential for allorejection. J. Exp. Med. 184:2013.
39. Han, W. R., L. J. Murray-Segal, and P. L. Mottram. 1999. Assessment of peripheral tolerance in anti-CD4 treated C57BL/6 mouse heart transplants recipients. Transplant. Immunol. 7:37.
40. Mottram, P. L., A. Raisanen-Sokolowski, T. Glysing-Jensen, A. N. Stein-Oakley. and M. E. Russell. 1998. Redefining peripheral tolerance in the BALB/c to CBA mouse cardiac allograft model: vascular and cytokine analysis after transient CD4 T cell depletion. Transplantation 66:1510.
41. He, G., O. S. Kim, J. R. Thistlethwaite, J. Hart, C. T. Siegel, G. L. Szot, and K. A. Newell. 1999. Differential effect of an anti-CD8 monoclonal antibody on rejection of murine intestine and cardiac allografts. Transplant. Proc. 31:1239.
42. Szot, G. L., P. Zhou, I. Rulifson, J. Wang, Z. Guo, O. Kim, K. A. Newel, J. R. Thistlethwaite, J. A. Bluestone, and M. L. Alegre. 2001. Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice. Am. J. Transplant. 1:38.
43. + immunoregulatory cells. J. Immunol. 167:1137.
44. + T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. USA 100:10878.
45. + T cells via a CD30-dependent mechanism. J. Clin. Invest. 113:310.
46. + precursors in a thymus-independent process. J. Immunol. 172:923.
47. + regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172:6003.
48. Francois Bach, J. 2003. Regulatory T cells under scrutiny. Nat. Rev. Immunol. 3:189.
49. Sivakumar, V., K. J. Hammond, N. Howells, K. Pfeffer, and F. Weih. 2003. Differential requirement for Rel/nuclear factor κB family members in natural killer T cell development. J. Exp. Med. 197:1613.
50. Stanic, A. K., J. S. Bezbradica, J. J. Park, N. Matsuki, A. L. Mora, L. Van Kaer, M. R. Boothby, and S. Joyce. 2004. NF-κB controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J. Immunol. 172:2265.
51. Li, Y., X. C. Li, X. X. Zheng, A. D. Welis, L. A. Turka, and T. B. Strom. 1999. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat. Med. 5:1298.
52. He, C., S. Schenk, Q. Zhang, A. Valujskikh, J. Bayer, R. L. Fairchild, and P. S. Heeger. 2004. Effects of T cell frequency and graft size on transplant outcome in mice. J. Immunol. 172:240.
53. Zheng, X. X., A. Sanchez-Fueyo, M. Sho, C. Domenig, M. H. Sayegh, and T. B. Strom. 2003. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 19:503.
54. Wu, Z., S. J. Bensinger, J. Zhang, C. Chen, X. Yuan, X. Huang, J. F. Markmann, A. Kassaee, B. R. Rosengard, W. W. Hancock, et al. 2004. Homeostatic proliferation is a barrier to transplantation tolerance. Nat. Med. 10:87.
55. Sun, L., L. Deng, C. K. Ea, Z. P. Xia, and Z. J. Chen. 2004. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14:289.