Redefining peripheral tolerance in the BALB/c to CBA mouse cardiac allograft model: Vascular and cytokine analysis after transient CD4 T cell depletion

Transplantation

Volumn 66, Issue 11, 1998, Pages 1510-1518

  Mottram, Patricia L ^a   Raisanen Sokolowski, Anne ^a   Glysing Jensen, Troels ^a   Stein Oakley, Alicia N ^b   Russell, Mary E ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL INFILTRATION; CYTOKINE RELEASE; GRAFT SURVIVAL; HEART GRAFT; IMMUNOLOGICAL TOLERANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; HEART TRANSPLANTATION; IMMUNE TOLERANCE; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 0032535745     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199812150-00015     Document Type: Article

References (56)

1. Charlton B, Auchincloss H Jr, Fathman CG. Mechanisms of transplantation tolerance. Annu Rev Immunol 1994; 12: 707.
2. Starzl TE, Demitris AJ, Trucco M, et al. Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation 1993; 55: 1272.
3. Cobbold SP, Adams E, Marshall SE, Davies JD, Waldmann H. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol Rev 1996; 149: 5.
4. Dallman MJ, Shiho O, Page TH, Wood KJ, Morris PJ. Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 1991; 173: 79,
5. Mottram PL, Wheelahan J, Mirisklavos A, Clunie GJ, McKenzie IF. Prolongation of murine cardiac allografts following treatment of graft recipients with monoclonal anti-L3T4 and Ly-2 antibodies. Transplant Proc 1987; 19: 582.
6. Cobbold SP, Qin S, Leong LYW, Martin G, Waldmann H. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol Rev. 1992; 129: 164.
7. Pearson TC, Darby CR, Bushell AR, West LJ, Morris PJ, Wood KJ. The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model. Transplantation 1993; 55: 361.
8. Qin S, Cobbold SP, Pope H, et al. Infectious transplantation tolerance. Science 1993; 259: 974.
9. Dallman MJ, Wood KJ, Hamano K, et al. Cytokines and peripheral tolerance to alloantigen. Immunol Rev 1993; 133: 5.
10. Takeuchi T, Lowry R, Konieczny B. Heart allografts in murine systems: the differential activation of TH2-like effector cells in peripheral tolerance. Transplantation 1992; 53: 1281.
11. Mottram PL, Han W-R, Purcell LJ, McKenzie IFC, Hancock WW. IL-4 and IL-10 but not IL-2 or IFN-γ cytokine expression in long-surviving mouse heart allografts after brief CD4 mAb therapy. Transplantation 1995; 59: 559.
12. Nickerson P, Steiger J, Zheng XX, et al. Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation 1997; 63: 489.
13. Mottram P, Räisänen-Sokolowski A, Glysing-Jensen T, Stein-Oakley A, Russell M. Cardiac allografts from interleukin 4 (IL-4) knockout recipients: assessment of transplant arteriosclerosis and peripheral tolerance. J Immunol 1998; 161: 602.
14. Räisänen-Sokolowski A, Mottram P, Glysing-Jensen T, Satoskar A, Russell M. Heart transplants in interferon-gamma, interleukin 4 and interleukin 10 knockout mice: recipient environment alters graft rejection. J Clin Invest 1997; 100: 2449.
15. Orloff MS, DeMara EM, Coppage ML, et al. Prevention of chronic rejection and graft arteriosclerosis by tolerance induction. Transplantation 1995; 59: 282.
16. Shin Y, Adams D, Wyner L, Akalin E, Sayegh M, Karnovsky M. Intrathymic tolerance in the Lewis-to-F344 chronic cardiac allograft rejection model. Transplantation 1995; 59: 1647.
17. Wood P, Roberts I, Yang C, Cossens I, Bell E. Prevention of chronic rejection by donor-specific blood transfusion in a new model of chronic cardiac allograft rejection. Transplantation 1996; 61: 1440.
18. Madsen J, Yamada K, Allan J, et al. Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine. Transplantation 1998; 65: 304.
19. Räisänen-Sokolowski A, Glysing-Jensen T, Mottram P, Russell M. Sustained anti-CD4/CD8 blocks inflammatory activation and intimal thickening in mouse heart allografts. Arterioscl Thromb Vase Biol 1997; 17: 2115.
20. Mottram PL, Smith JA, Mason A, Mirisklavos A, Dumble LJ, Clunie GJ. Electrocardiographic monitoring of cardiac transplants in mice. Cardiovasc Res 1988; 22: 315.
21. Mottram PL, Purcell LJ, Pietersz GA, McKenzie IF. Tolerance induction with anti-CD8 monoclonal antibodies in the mouse heart transplant model. Transplant Proc 1993; 25: 2935.
22. Chen Z, Cobbold SP, Metcalfe S, Waldmann H. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts and to rat xenografts, using monoclonal antibodies to CD4 and CD8. Eur J Immunol 1992; 22: 805.
23. Davies JD, Martin G, Phillips J, Marshall SD, Cobbold SP, Waldmann H. T cell regulation in adult transplantation tolerance. J Immunol 1996; 157: 529.
24. Davies JD, Cobbold SP, Waldmann H. Strain variation in susceptibility to monoclonal antibody-induced transplantation tolerance. Transplantation 1997; 63: 1570.
25. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973; 16: 343.
26. Billingham R, Medewar P. Technique of free skin grafting in mammals. J Exp Biol. 1951; 28: 385.
27. Mottram PL, Pietersz GA, Smyth MJ, Purcell LJ, Clunie GJ, McKenzie IF. Evidence that an anthracycline-anti-CD8 immunoconjugate, idarubicin-anti-Ly-2.1, prolongs heart allograft survival in mice. Transplantation 1993; 55: 484.
28. Russell ME, Hancock WW, Akalin E, et al. Chronic cardiac rejection in the Lewis to F344 rat model: blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis. J Clin Invest 1996; 97: 833.
29. Armstrong A, Strauch A, Starling R, Sedmak D, Orosz C. Morphometric analysis of neointimal formation in murine cardiac allografts. Transplantation 1997; 63: 941.
30. Adams DH, Wyner LR, Karnovsky MJ. Experimental graft arteriosclerosis. II. Immunocytochemical analysis of lesion development. Transplantation 1993; 56: 794.
31. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986; 103: 2787.
32. Sander B, Hoiden I, Anderssen U, Moller E, Abrams JS. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. J Immunol Methods 1996; 166: 201.
33. Mottram P, Purcell L, Han W, Maguire J, Stein-Oakley A. Interleukin 4, the cytokine that isn't there: reactivity of IL-4 antibodies with cells in IL-4 -/-mice. Transplantation 1997; 63: 911.
34. Brown M, Engelman L, Frans J, Hill M, Jennich R, Toporek J. BMDP statistical software: 1983 printing with additions. Berkeley: University of California Press, 1983.
35. Russell ME, Wallace AF, Wyner LR, Newell JB, Karnovsky MJ. Upregulation and modulation of inducible nitric oxide synthesis in rat cardiac allografts with chronic rejection and transplant arteriosclerosis. Circulation 1995; 92: 457.
36. Dallman MJ, Wood KJ, Morris PJ. Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats. J Exp Med 1987; 165: 566.
37. Bishop DK, Shelby J, Eichwald EJ. Mobilisation of T lymphocytes following cardiac transplantation. Transplantation 1992; 53: 849.
38. Bugeon I, Cuturi M-C, Hallet M-M, Paineau J, Chabannes D, Soulillou J-P. Peripheral tolerance of an allograft in adult rats characterised by low interleukin-2 and IFN-γ mRNA levels and by strong accumulation of major histocompatibility complex transcripts in the graft. Transplantation 1991; 54: 219.
39. Scully R, Qin S, Cobbold S, Waldmann H. Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994; 24.
40. Mottram PL, Mirisklavos A, Dumble LJ, Clunie GJ. T suppressor cells induced by transfusions and cyclosporine: studies in the murine cardiac allograft model. Transplantation 1990; 50: 1033.
41. Hall BM. Cells mediating allograft rejection. Transplantation 1991; 51: 1141.
42. Chen Z, Cobbold S, Waldmann H, Metcalfe S. Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation 1996; 62: 1200.
43. Mannon RB, Ruiz P, Bustos M, Griffiths R, Platt JL, Coffman TM. Chronic rejection (CR) of mouse kidney allografts: role of direct allorecognition: 16th Annual Meeting of the American Society of Transplant Physicians. Chicago: SNP Interactive, 1997.
44. Chitilian HV, Auchincloss HJ. Studies of transplantation immunology with major histocompatibility complex knockout mice. J Heart Lung Transplant. 1997; 16: 153.
45. Davies JD, Leong YW, Mellor A, Cobbold SP, Waldmann H. T cell suppression in transplantation tolerance through linked recognition. J Immunol 1996; 156: 3602.
46. Wong W, Morris P, Wood K. Pretransplant administration of a single donor class 1 major histocompatibility complex molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts. Transplantation 1997; 63: 1490.
47. Bennett S, Carbone F, Karamalis F, Miller J, Heath W. Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J Exp Med 1997; 186: 65.
48. Hornick P, Mason P, Yacoub M, Rose M, Bachelor R, Lechler R. Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. Circulation 1997; 97: 1257.
49. Glysing-Jensen T, Räisänen-Sokolowski A, Sayegh M, Russell M. Chronic blockade of CD28-B7-mediated T-cell costimulation by CTLA4Ig reduces intimal thickening in MHC class I and II incompatible mouse heart allografts. Transplantation 1997; 64: 1641.
50. Lee J, Laks H, Drinkwater DC, et al. Cardiac gene transfer by intracoronary infusion of adenovirus vector-mediated reporter gene in the transplanted mouse heart. J Thorac Cardiovasc Surg 1996; 111: 246.
51. Josien R, Pannetier C, Douillard P, et al. Graft-infiltrating T helper cells, CD45RC phenotype and TH1/TH2-related cytokines in donor-specific transfusion-induced tolerance in adult rats. Transplantation 1995; 60: 1131.
52. Russell ME, Wallace AF, Hancock WW, et al. Upregulation of cytokines associated with macrophage activation in the Lewis to F344 rat chronic cardiac rejection model. Transplantation 1995; 59: 572.
53. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. J Immunol 1994; 152: 5135.
54. Russell P, Chase C, Colvin R. Coronary atherosclerosis in transplanted mouse hearts. IV. Effects of treatment with monoclonal antibodies to intercellular adhesion molecule-1 and leukocyte function-associated antigen-1. Transplantation 1995; 60: 724.
55. Isobe M, J-I S, Satoshi Y, Horie S, Okubo Y, Sekiguchi M. Assessment of tolerance induction to cardiac allograft by anti-ICAM-1 and anti-LFA-1 monoclonal antibodies. J Heart Lung Transplant 1997; 16: 1149.
56. Larsen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996; 61: 4.