Saccharomyces cerevisiae as a genetic model in anticancer therapy

Current Pharmacogenomics

Volumn 3, Issue 1, 2005, Pages 1-7

  Kurtz, J Emmanuel ^a,b   Dufour, P ^b   Bergerat, J P ^b   Exinger, Francoise ^a  

^a IRCAD   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Cancer; Chemotherapy; Pyrimidine metabolism; Saccharomyces cerevisiae

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; ANTINEOPLASTIC ANTIMETABOLITE; CAPECITABINE; CYCLOPHOSPHAMIDE; CYTARABINE; CYTIDINE DERIVATIVE; CYTOSINE DEAMINASE; DEOXYURIDINE PHOSPHATE; DIHYDROPYRIMIDINE DEHYDROGENASE; DNA; DOXIFLURIDINE; FLUCYTOSINE; FLUOROPYRIMIDINE; FLUOROURACIL; GEMCITABINE; HYDROXYUREA; MESYLIC ACID METHYL ESTER; METHOTREXATE; PHOSPHOTRANSFERASE; PYRIMIDINE DERIVATIVE; PYRIMIDINE NUCLEOTIDE; RNA; THYMIDINE DERIVATIVE; THYMIDINE KINASE; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; UNINDEXED DRUG; URACIL; URIDINE KINASE; URIDINE PHOSPHORYLASE;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RESEARCH; CELL FUNCTION; COLON CANCER; COLORECTAL CANCER; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG TARGETING; GENE MUTATION; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC MODEL; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PROGNOSIS; PYRIMIDINE METABOLISM; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; STOMACH CANCER;

SACCHAROMYCES CEREVISIAE;

EID: 14844343597     PISSN: 15701603     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570160053175045     Document Type: Review

References (55)

1. Ahmed, N. K. (1984) Enzymes of the de novo and salvage pathways for pyrimidine biosynthesis in normal colon, colon carcinoma, and xenografts. Cancer 54(7), 1370-1373.
2. Beausejour, C. M.; Eliopoulos, N.; Momparler, L.; Le, N. L. and Momparler, R. L. (2001) Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene. Cancer Gene Ther. 8(9), 669-676.
3. Burger, H.; Cappello, A.; Schenk, P. W.; Stoter, G.; Brouwer, J. and Nooter, K. (2000) A genome-wide screening in Saccharomyces cerevisiae for genes that confer resistance to the anticancer agent cisplatin. Biochem. Biophys. Res. Commun. 269(3), 767-774.
4. Cardenas, M. E.; Cruz, M. C.; Del Poeta, M.; Chung, N.; Perfect, J. R. and Heitman, J. (1999) Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clin. Microbiol. Rev. 12(4), 583-611.
5. Chang, M.; Bellaoui, M.; Boone, C. and Brown, G. W. (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc. Natl. Acad. Sci. USA 99(26), 16934-16939.
6. Chevallier, M. R.; Jund, R. and Lacroute, F. (1975) Characterization of cytosine permeation in Saccharomyces cerevisiae. J. Bacteriol. 122(2), 629-641.
7. Drews, J. and Reyser, S. (1997) The role of innovation in drug development. Nat. Biotechnol. 15(13), 1318-1319.
8. Drews, J. (1996) Genomic sciences and the medicine of tomorrow. Nat. Biotechnol. 14(11), 1516-1518.
9. Edler, D.; Glimelius, B.; Hallstrom, M.; Jacobsen, A.; Johnston, P. G.; Magnusson, I.; Ragnhammar, P. and Blomgren, H. (2002) Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J. Clin. Oncol. 20(7), 1721-1728.
10. Erbs, P.; Regulier, E.; Leroy, P.; Poitevin, Y.; Exinger, F.; Jund, R. and Mehtali, M. (2000) In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene. Cancer Res. 60(14), 3813-3822.
11. Erbs, P.; Exinger, F. and Jund, J. (1997) Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. Curr. Genet. 31, 1-6.
12. Exinger, D.; Exinger, F.; Mennecier, B.; Limacher, J. M.; Dufour, P. and Kurtz, J. E. (2003) Multitargeted antifolate (pemetrexed) : a comprehensive review of its mechanisms of action, recent results and future prospects. Cancer Ther. 1, 313-319.
13. Foury, F. (1997) Human genetic diseases: A cross-talk between man and yeast. Gene 195, 1-10.
14. Fox, S. B.; Engels, K.; Comley, M.; Whitehouse, R. M.; Turley, H.; Gatter, K. C. and Harris, A. L. (1997) Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF. Ann. Oncol. 8(3), 271-275.
15. Greenhalf, W.; Lee, J. and Chaudhuri, B. (1999) A selection system for human apoptosis inhibitors using yeast. Yeast 15 13), 1307-1321.
16. Ichikawa, W.; Uetake, H.; Shirota, Y.; Yamada, H.; Nishi, N.; Nihei, Z.; Sugihara, K. and Hirayama, R. (2003) Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin. Cancer Res. 9(2), 786-791.
17. Henning, K. A.; Li, L.; Iyer, N.; McDaniel, L. D.; Reagan, M. S. Legerski, R.; Schultz, R. A.; Stefanini, M., Lehmann, A. R.; Mayne, L. V. and Friedberg, E. C. (1995) The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell 82(4), 555-564.
18. Ichikawa, W.; Uetake, H.; Shirota, Y.; Yamada, H.; Nishi, N.; Nihei, Z.; Sugihara, K. and Hirayama, R. (2003) Combinations of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin. Cancer Res. 9(2), 786-791.
19. Ishikawa, Y.; Kubota, T.; Otani, Y.; Watanabe, M.; Teramoto, T.; Kumai, K.; Takechi, T.; Fukushima, M. and Kitajima, M. (1999) Thymiylate synthase and dihydropyrimidine dehydrogenase levels in gastric cancer. Anticancer Res. 19(6C), 5635-5640.
20. Jelinski, S. A. and Samson, L. D. (1999) Global response of Saccharomyces cerevisiae to an alkylating agent. Proc. Natl. Acad. Sci. USA 96, 1486-1591.
21. Jund, R. and Lacroute, F. (1972) Regulation of orotidylic acid pyrophosphorylase in Saccharomyces cerevisiae. J. Bacteriol. 109(1), 196-202.
22. Jund, R.; Weber, E. and Chevallier, M. R. (1988) Primary structure of the uracil transport protein of Saccharomyces cerevisiae. Eur. J. Biochem. 171, 417-424.
23. Kanzaki, A.; Takebayashi, Y.; Bando, H.; Eliason, J. F.; Watanabe, S.; Miyashita, H.; Fukumoto, M.; Toi, M. and Uchida, T. (2002) Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. Int. J. Cancer 97, 631-635.
24. Kern, L.; De Montigny, J.; Lacroute, F. and Jund, R. (1991) Regulation of the pyrimidine salvage pathway by the FUR1 gene product of Saccharomyces cerevisiae. Curr. Genet. 19, 333-337.
25. Kornmann, M.; Link, K. H.; Galuba, I.; Ott, K.; Schwabe, W.; Häusler, P.; Scholz, P.; Sträter, J.; Polat, S.; Leibl, B.; Kettner, E.; Schlichting, C.; Baumann, W.; Schramm, H.; Hecker, U.; Ridwelski, K.; Vogt, J. H.; Zerbian, K. -U.; Schütze, F.; Kreuser, E. D.; Behnke, D. and Beger, H. G. (2002) Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer. J. Gastrointest. Surg. 6, 331-337
26. Kornmann, M.; Schwabe, W.; Sander, S.; Kron, M.; Sträter, J.; Polat, S.; Kettner, E.; Weiser, H. F.; Baumann, W.; Schramm, H.; Häusler, P.; Ott, K.; Behnke, D.; Staib, L.; Beger, H. G. and Link, K. H. (2003) Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels predictors for survival in colorectal cancer patients receiving adjuvant 5-Fluorouracil. Clin. Cancer Res. 9, 4116-4124.
27. Kralovansky, J.; Koves, I.; Orosz, Z.; Katona, C.; Toth, K.; Rahoty, P.; Czegledi, K.; Kovacs, T.; Budai, B.; Hullan, L. and Jeney, A. (2002) Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors. Oncology 62(2), 167-174.
28. Kurtz, J. E; Exinger, F.; Erbs, P. and Jund, R. (1999) New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Curr. Genet. 36(3), 130-136.
29. Kurtz, J. E; Exinger, F.; Erbs, P. and Jund, R. (2002) The URHI uridine ribohydrolase of Saccharomyces cerevisiae. Curr. Genet. 41(3), 132-141
30. Kurtz, J. E.; Andres, E.; Natarajan-Amé, S.; Noël, E. and Dufour, P. (2003) Oral chemotherapy in colorectal cancer treatment: review of the literature. Eur. J. Int. Med. 14, 18-25.
31. Liljelund, P. and Lacroute, F. (1986) Genetic characterization and isolation of the Saccharomyces cerevisiae gene coding for uridine monophosphokinase. Mol. Gen. Genet. 205 1), 74-81.
32. Liu, M.; Cao, D.; Russell, R.; Hanschumacher, R. E. and Pizzorno, G. (1998) Expression, characterization and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. Cancer Res. 58 23), 5418-5423.
33. Mackiewicz, P.; Kowalczuk, M.; Mackiewicz, D.; Nowicka, A.; Dukiewicz, M.; Laszkiewicz, A.; Dudek, M. R. and Cebrat, S. (2002) How many protein-coding genes are there in the Saccharomyces cerevisiae genome? Yeast 19(7), 619-629.
34. Maxwell, P. J.; Longley, D. B.; Latif, T.; Boyer, J.; Allen, W.; Lynch, M.; McDermott, U.; Harkin, D. P.; Allegra, C. J. and Johnston, P. G. (2003) Identification of 5-fluorouracil-inducible target genes using c-DNA micro-array profiling. Cancer Res. 63(1), 4602-4606.
35. Miyashita, H.; Takebayashi, Y.; Eliason, J. F.; Fujimori, F.; Nitta, Y.; Sato, A.; Morikawa, H.; Ohashi, A.; Katutoshi, M.; Fukumoto, M.; Mori, S. and Uchida, T. (2002) Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma. Cancer 94, 2959-2966.
36. Morita, T.; Matsuzaki, A.; Kurokawa, S. and Tokue, A. (2003) Forced expression of cytidine deaminase confers sensitivity to capecitabine. Oncology 65(3), 267-274.
37. Munder, T. and Hinnen, A. (1999) Yeast cells as tools for target-oriented screening. Appl. Microbiol. Biotechnol. 52 3), 311-320.
38. Peters, G. J.; van Groeningen, C. J.; Laurensse, E. J. and Pinedo, H. M. (1991) A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer 68(9), 1903-1909.
39. Ramotar, D. and Wang, H. (2003) Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae. Curr. Genet. 43(4), 213-224.
40. Russo, G.; Zegar, C. and Giordano, A. (2003) Advantages and limitations of microarray technology in human cancer. Oncogene 22, 6497-6507.
41. Salonga, D.; Danenberg, K. D.; Johnson, M.; Metzger, R.; Groshen, S.; Tsao-Wei, D. D.; Lenz, H. J.; Leichman, C. G.; Leichman, L.; Diasio, R. B. and Danenberg, P. V. (2000) Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin. Cancer Res. 6(4), 1322-1327.
42. Takahashi, H.; Maeda, Y.; Watanabe, K.; Taguchi, K.; Sasaki, F. and Todo, S. (2000) Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma ongoing adjuvant doxifluridine treatment. Int. J. Oncol. 17 6), 1205-1211.
43. Takenoue, T.; Kitayama, J.; Takei, T.; Umetani, N.; Matsude, K.; Nita, M. E.; Hatano, K.; Tsuruo, T. and Muto, T. (2000) Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immunohistochemical method. Ann. Surg. Oncol. 7(3), 193-198.
44. Takiguchi, N.; Ishii, R.; Koda, K.; Oda, K. and Miyazaki, M. (2003) Thymidine phosphorylase expression correlates with malignant potential and anti-tumor effect of doxifluridine on gastric cancer: multivariate analysis for adjuvant chemotherapy doxifluridine vs 5-fluorouracil. Oncol. Rep. 10(5), 1105-1111.
45. Terashima, M.; Fujiwara, H.; Takagane, A.; Abe, K.; Irinoda, T.; Nakaya, T.; Yonezawa, H.; Oyama, K.; Saito, K.; Kanzaki, N.; Ohtani, S.; Nemoto, T.; Hoshino, Y.; Kogure, M. and Gotoh, M. (2003) Prediction of sensitivity to fluoropyrimidines by metabolic and target enzyme activities in gastric cancer. Gastric Cancer 6 (Suppl. 1), 71-81.
46. Terashima, M.; Irinoda, T.; Fujiwara, H.; Nakaya, T.; Takagane, A.; Abe, K.; Yonezawa, H.; Oyama, K.; Inaba, T.; Saito, K.; Takechi, T. and Fukushima, M. (2002) Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer. Anticancer Res. 22 2A), 761-768.
47. Tominaga, T.; Toi, M.; Ohashi, Y. and Ane, O. (2002) Prognostic and predictive value of thymidine phosphorylase activity in early-stage breast cancer patients. Clin. Breast Cancer 3(1), 55-64.
48. Tsujitani, S.; Konishi, I.; Suzuki, K.; Oka, S.; Gomyo, Y.; Matsumoto, S.; Hirooka, Y. and Kaibara, N. (2000) Expression of thymidylate synthase in relation to survival and chemosensitivity in gastric cancer patients. J. Exp. Clin. Cancer Res. 19(2), 189-195.
49. Tugendreich, S.; Perkins, E.; Couto, J.; Barthmaier, P.; Sun, D.; Tang, S.; Tulac, S.; Nguyen, A.; Yeh, E.; Mays, A.; Wallace, E.; Lila, T.; Shivak, D.; Prichard, M.; Andrejka, M.; Kim, L. and Melese, T. (2001) A streamlined process to phenotypically profile heterologous cDNAs in parallel using yeast cell-based assays. Genome Res. 11 11), 1899-1912.
50. Van Hille, B. and Hill, B. T. (1998) Yeast cells expressing differential levels of human or yeast DNA topoisomerase II: a potent tool for identification and characterization of topoisomerase II-targeting antitumour agents. Cancer Chemother. Pharmacol. 42(5), 345-356.
51. Wang, W.; Marsh, S.; Cassidy, J. and McLeod, H. L. (2001) Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors. Cancer Res. 61, 5505-5510.
52. Xu, Q. and Reed, J. C. (1998) Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol. Cell. 1(3), 337-346.
53. Yang, Q.; Barbareschi, M.; Mori, M.; Mauri, F.; Muscarà, M.; Nakamura, M.; Nakamura, Y.; Yoshimura, G.; Sakurai, T.; Caffo, O.; Galligioni, E.; Dalla Palma, P. and Kakudo, K. (2002) Prognostic value of thymidine phosphorylase expression in breast carcinoma. Int. J. Cancer 97, 512-517.
54. Zhang, L.; Zhang, Y.; Zhou, Y.; Zhao, Y.; Zhou, Y. and Cheng, J. (2002) Expression profile of the response of Saccharomyces cerevisiae to 5-fluorocytosine using a DNA microarray. Int. J. Antimicrob. Agents 20, 444-450.
55. Zhang, N.; Osborn, M.; Gitsham, P.; Yen, K.; Miller, J. R. and Oliver, S. G. (2003) Using yeast to place human genes in functional categories. Gene 303(9), 121-129.