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Volumn 65, Issue 3, 2003, Pages 267-274

Forced expression of cytidine deaminase confers sensitivity to capecitabine

Author keywords

Capecitabine; Cytidine deaminase; Gemcitabine; Sensitivity; Transfection

Indexed keywords

5' DEOXY 5 FLUOROCYTIDINE; CAPECITABINE; COMPLEMENTARY DNA; CYTIDINE DEAMINASE; CYTIDINE DERIVATIVE; DIHYDROPYRIMIDINE DEHYDROGENASE; ENZYME INHIBITOR; FLUOROURACIL; GEMCITABINE; LIPOFECTIN; TETRAHYDROURIDINE; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

EID: 0344305589     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074480     Document Type: Article
Times cited : (24)

References (41)
  • 1
    • 0032127244 scopus 로고    scopus 로고
    • Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
    • Miwa M, Ura M, Nishida M, Sawada N, Ishikawa T, Mori K, Shimma N, Umeda I, Ishitsuka H: Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur J Cancer 1998;34:1274-1281.
    • (1998) Eur J Cancer , vol.34 , pp. 1274-1281
    • Miwa, M.1    Ura, M.2    Nishida, M.3    Sawada, N.4    Ishikawa, T.5    Mori, K.6    Shimma, N.7    Umeda, I.8    Ishitsuka, H.9
  • 7
    • 0028022127 scopus 로고
    • Gemcitabine: Current status of phase I and II trials
    • Kaye SB: Gemcitabine: Current status of phase I and II trials. J Clin Oncol 1994;12:1527-1531.
    • (1994) J Clin Oncol , vol.12 , pp. 1527-1531
    • Kaye, S.B.1
  • 9
    • 0031824267 scopus 로고    scopus 로고
    • The role of gemcitabine in the treatment of other tumours
    • Carmichael J: The role of gemcitabine in the treatment of other tumours. Br J Cancer 1998;78:21-25.
    • (1998) Br J Cancer , vol.78 , pp. 21-25
    • Carmichael, J.1
  • 13
    • 0026571795 scopus 로고
    • Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation
    • Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W: Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation. Cancer Res 1992;52:533-539.
    • (1992) Cancer Res , vol.52 , pp. 533-539
    • Heinemann, V.1    Xu, Y.Z.2    Chubb, S.3    Sen, A.4    Hertel, L.W.5    Grindey, G.B.6    Plunkett, W.7
  • 14
    • 0027197028 scopus 로고
    • Kinetic studies on 2′,2′-difluorodeoxycytidine (gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase
    • Bouffard DY, Laliberte J, Momparler RL: Kinetic studies on 2′,2′-difluorodeoxycytidine (gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase. Biochem Pharmacol 1993;45:1857-1861.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1857-1861
    • Bouffard, D.Y.1    Laliberte, J.2    Momparler, R.L.3
  • 15
    • 0029967966 scopus 로고    scopus 로고
    • Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine
    • Neff T, Blau CA: Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine. Exp Hematol 1996;24:1340-1346.
    • (1996) Exp Hematol , vol.24 , pp. 1340-1346
    • Neff, T.1    Blau, C.A.2
  • 16
    • 0032520918 scopus 로고    scopus 로고
    • The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase
    • Eda H, Ura M, F-Ouchi K, Tanaka Y, Miwa M, Ishitsuka H: The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase. Cancer Res 1998;8:1165-1169.
    • (1998) Cancer Res , vol.8 , pp. 1165-1169
    • Eda, H.1    Ura, M.2    F-Ouchi, K.3    Tanaka, Y.4    Miwa, M.5    Ishitsuka, H.6
  • 17
    • 0031913998 scopus 로고    scopus 로고
    • High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2′-deoxycytidine anti-metabolite, 2′-deoxy-2′-methylidenecytidine
    • Miwa M, Eda H, Ura M, Ouchi KF, Keith DD, Foley LH, Ishitsuka H: High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2′-deoxycytidine anti-metabolite, 2′-deoxy-2′- methylidenecytidine. Clin Cancer Res 1998;4:493-497.
    • (1998) Clin Cancer Res , vol.4 , pp. 493-497
    • Miwa, M.1    Eda, H.2    Ura, M.3    Ouchi, K.F.4    Keith, D.D.5    Foley, L.H.6    Ishitsuka, H.7
  • 18
    • 0032520168 scopus 로고    scopus 로고
    • Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts
    • Ishikawa T, Sekiguchi F, Fukase Y, Sawada N, Ishitsuka H: Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res 1998;58:685-690.
    • (1998) Cancer Res , vol.58 , pp. 685-690
    • Ishikawa, T.1    Sekiguchi, F.2    Fukase, Y.3    Sawada, N.4    Ishitsuka, H.5
  • 19
    • 0031961050 scopus 로고    scopus 로고
    • Recombinant gene products of two natural variants of the human cytidine deaminase gene confer different deamination rates of cytarabine in vitro
    • Kirch HC, Schröder J, Hoppe H, Esche H, Seeber S, Schutte J: Recombinant gene products of two natural variants of the human cytidine deaminase gene confer different deamination rates of cytarabine in vitro. Exp Hematol 1998;26:421-425.
    • (1998) Exp Hematol , vol.26 , pp. 421-425
    • Kirch, H.C.1    Schröder, J.2    Hoppe, H.3    Esche, H.4    Seeber, S.5    Schutte, J.6
  • 21
    • 0345628622 scopus 로고    scopus 로고
    • Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia
    • Schröder JK, Kirch C, Seeber S, Schutte J: Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia. Br J Haematol 1998;103:1096-1103.
    • (1998) Br J Haematol , vol.103 , pp. 1096-1103
    • Schröder, J.K.1    Kirch, C.2    Seeber, S.3    Schutte, J.4
  • 23
    • 0034126666 scopus 로고    scopus 로고
    • Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: Regulation by methylation and involvement in growth regulation
    • Lau KM, LaSpina M, Long J, Ho SM: Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: Regulation by methylation and involvement in growth regulation. Cancer Res 2000;60:3175-3182.
    • (2000) Cancer Res , vol.60 , pp. 3175-3182
    • Lau, K.M.1    LaSpina, M.2    Long, J.3    Ho, S.M.4
  • 24
    • 0029806438 scopus 로고    scopus 로고
    • Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues
    • Nishida M, Hino A, Mori K, Matsumoto T, Yoshikubo T, Ishitsuka H: Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues. Biol Pharm Bull 1996;19:1407-1411.
    • (1996) Biol Pharm Bull , vol.19 , pp. 1407-1411
    • Nishida, M.1    Hino, A.2    Mori, K.3    Matsumoto, T.4    Yoshikubo, T.5    Ishitsuka, H.6
  • 26
    • 0020056302 scopus 로고
    • In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas
    • Spears CP, Shahinian AH, Moran RG, Heidelberger C, Corbett TH: In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. Cancer Res 1982;42:450-456.
    • (1982) Cancer Res , vol.42 , pp. 450-456
    • Spears, C.P.1    Shahinian, A.H.2    Moran, R.G.3    Heidelberger, C.4    Corbett, T.H.5
  • 27
    • 9344248389 scopus 로고    scopus 로고
    • Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats
    • Shirasaka T, Nakano K, Takechi T, Satake H, Uchida J, Fujioka A, Saito H, Okabe H, Oyama K, Takeda S, Unemi N, Fukushima M: Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats. Cancer Res 1996;56:2602-2606.
    • (1996) Cancer Res , vol.56 , pp. 2602-2606
    • Shirasaka, T.1    Nakano, K.2    Takechi, T.3    Satake, H.4    Uchida, J.5    Fujioka, A.6    Saito, H.7    Okabe, H.8    Oyama, K.9    Takeda, S.10    Unemi, N.11    Fukushima, M.12
  • 28
    • 0019271884 scopus 로고
    • High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur
    • Marunaka T, Umeno Y, Yoshida K, Nagamachi M, Minami Y, Fujii S: High-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur. J Pharm Sci 1980;69:1296-1300.
    • (1980) J Pharm Sci , vol.69 , pp. 1296-1300
    • Marunaka, T.1    Umeno, Y.2    Yoshida, K.3    Nagamachi, M.4    Minami, Y.5    Fujii, S.6
  • 30
    • 0033030892 scopus 로고    scopus 로고
    • Biomodulation of 5-fluorouracil by interferon α in human renal carcinoma cells: Relation to the expression of thymidine phosphorylase
    • Morita T, Tokue A: Biomodulation of 5-fluorouracil by interferon α in human renal carcinoma cells: Relation to the expression of thymidine phosphorylase. Cancer Chem Pharm 1999;44:91-96.
    • (1999) Cancer Chem Pharm , vol.44 , pp. 91-96
    • Morita, T.1    Tokue, A.2
  • 32
    • 0032520168 scopus 로고    scopus 로고
    • Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts
    • Ishikawa T, Sekiguchi F, Fukase Y, Sawada N, Ishitsuka H: Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res 1998;58:685-690.
    • (1998) Cancer Res , vol.58 , pp. 685-690
    • Ishikawa, T.1    Sekiguchi, F.2    Fukase, Y.3    Sawada, N.4    Ishitsuka, H.5
  • 35
    • 0034844358 scopus 로고    scopus 로고
    • Role of thymidine phosphorylase in biomodulation of fluoropyrimidines
    • Morita T, Matsuzaki A, Suzuki K, Tokue A: Role of thymidine phosphorylase in biomodulation of fluoropyrimidines. Curr Pharm Biotechnol 2001;2:257-267.
    • (2001) Curr Pharm Biotechnol , vol.2 , pp. 257-267
    • Morita, T.1    Matsuzaki, A.2    Suzuki, K.3    Tokue, A.4
  • 36
    • 0035342546 scopus 로고    scopus 로고
    • Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA
    • Morita T, Matsuzaki A, Tokue A: Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA. Int J Cancer 2001;92:451-456.
    • (2001) Int J Cancer , vol.92 , pp. 451-456
    • Morita, T.1    Matsuzaki, A.2    Tokue, A.3
  • 38
    • 0034046892 scopus 로고    scopus 로고
    • Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil in patients with metastatic renal cell cancer
    • Rini BI, Vogelzang NJ, Dumas MC, Wade JL 3rd, Taber DA, Stadler WM: Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil in patients with metastatic renal cell cancer. J Clin Oncol 2000;18:2419-2426.
    • (2000) J Clin Oncol , vol.18 , pp. 2419-2426
    • Rini, B.I.1    Vogelzang, N.J.2    Dumas, M.C.3    Wade III, J.L.4    Taber, D.A.5    Stadler, W.M.6
  • 39
    • 0035883565 scopus 로고    scopus 로고
    • Phase I study to evaluate multiple regimens of intravenous 5-fluorouracil administered in combination with weekly gemcitabine in patients with advanced solid tumors: A potential broadly active regimen for advanced solid tumor malignancies
    • Mani S, Vogelzang NJ, Bertucci D, Stadler WM, Schilsky RL, Ratain MJ: Phase I study to evaluate multiple regimens of intravenous 5-fluorouracil administered in combination with weekly gemcitabine in patients with advanced solid tumors: A potential broadly active regimen for advanced solid tumor malignancies. Cancer 2001;92:1567-1576.
    • (2001) Cancer , vol.92 , pp. 1567-1576
    • Mani, S.1    Vogelzang, N.J.2    Bertucci, D.3    Stadler, W.M.4    Schilsky, R.L.5    Ratain, M.J.6
  • 41
    • 0037080146 scopus 로고    scopus 로고
    • Dose-escalating study of capecitabine plus gemcitabine combination therapy in patients with advanced cancer
    • Schilsky RL, Bertucci D, Vogelzang NJ, Kindler HL, Ratain MJ: Dose-escalating study of capecitabine plus gemcitabine combination therapy in patients with advanced cancer. J Clin Oncol 2002;20:582-587.
    • (2002) J Clin Oncol , vol.20 , pp. 582-587
    • Schilsky, R.L.1    Bertucci, D.2    Vogelzang, N.J.3    Kindler, H.L.4    Ratain, M.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.