Antitrypanosomal activities of proteasome inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 6, 2002, Pages 2038-2040

  Nkemgu Njinkeng, Joseph ^a   Rosenkranz, Vera ^a   Wink, Michael ^a   Steverding, Dietmar ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITRYPANOSOMAL AGENT; N ACETYLLEUCYLLEUCYLMETHIONAL; N ACETYLLEUCYLLEUCYLNORLEUCINAL; N BENZYLOXYCARBONYLISOLEUCYL GAMMA TERT BUTYL GLUTAMYLALANYLLEUCINAL; N BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; N BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCYL BORONIC ACID; N BENZYLOXYCARBONYLLEUCYLLEUCYLPHENYLALANAL; N BENZYLOXYCARBONYLLEUCYLLEUCYLTYROSYL ALPHA KETO ALDEHYDE; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ANIMALS; APOPTOSIS; CYSTEINE ENDOPEPTIDASES; HL-60 CELLS; HUMANS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS;

EID: 0036095746     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.6.2038-2040.2002     Document Type: Article

References (21)

1. Novel inhibitors of the proteasome and their therapeutic use in inflammation
2. Proteasome inhibitors: A novel class of potent and effective antitumor agents
3. Anti-sleeping sickness drugs and cancer chemotherapy
4. Structure and functions of the 20S and 26S proteasomes
5. The current status of antiparasite chemotherapy
6. Activation of the cell death program by inhibition of proteasome function
7. Purification and characterization of proteasomes from Trypanosoma brucei
8. Proteasome inhibitors: From research tools to drug candidates
9. Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl α-keto aldehydes (glyoxals)
10. Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: Development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin β-lactone
11. In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense
12. Proteasome inhibitors as anti-cancer agents
13. Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes
14. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
15. Proteasome inhibitors: From in vitro uses to clinical trials
16. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
17. Ubiquitin proteasome pathway: Implications and advances in cancer therapy
18. Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro
19. Prohibitin and RACK homologues are up-regulated in trypanosomes induced to undergo apoptosis and in naturally occurring terminally differentiated forms
20. Programmed cell death in procyclic form Trypanosoma brucei rhodesiense-identification of differentially expressed genes during Con A induced death
21. African trypanosomiasis or sleeping sickness