Effect of varying types of anti-arthritic drugs on TH1 and TH2 immune responses in mice

International Journal of Immunopathology and Pharmacology

Volumn 18, Issue 1, 2005, Pages 133-144

  Yamaki, K ^a   Uchida, H ^a   Li, X ^a   Yanagisawa, R ^b   Takano, H ^b   Hayashi, H ^c   Mori, Y ^c   Yoshino, Shin ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^c HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

Anti arthritic drug; Antibody; Arthritis; Cytokines; Ovalbumin; Th1 Th2 immune response

Indexed keywords

ANTIRHEUMATIC AGENT; AURANOFIN; DEXAMETHASONE; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INDOMETACIN; INTERLEUKIN 10; METHOTREXATE; OVALBUMIN; PENICILLAMINE;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG STRUCTURE; FEMALE; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STATISTICAL ANALYSIS; TH1 CELL; TH2 CELL;

EID: 14844331697     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200501800114     Document Type: Article

References (40)

1. Feldmann M., S. Dower and F.M. Brennan. 1996. The role of cytokines in normal and pathological situations. In Cytokines in autoimmunity. F.M. Brennan, M. Feldmann, ed. R.G. Landes Co. Austin, p. 1.
2. Yocum D.E. 1999. T cells: pathogenic cells and therapeutic targets in rheumatoid arthritis. Semin. Arth. Rheum. 29:27.
3. Mossmann T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
4. Mossmann T.R. and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
5. Dickensheets H.L., C. Venkataraman, U. Schindler and R.P. Donnelly. 1999. Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc. Natl. Acad. Sci. USA 96:10800.
6. van Roon J.A., J.L. van Roy, A. Duits, F.F. Lafeber and J.W. Bijilsma. 1995. Proinflammatory cytokine production and cartilage damage due to rheumatoid synovial T helper-1 activation is inhibited by interleukin-4. Ann. Rheum. Dis. 54:836.
7. Yin Z., J. Braun, L. Neure, P. Wu, L. Liu, U. Eggens and J. Sieper. 1997. Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum. 40:1788.
8. Liblau R.S., S.M. Singer and H.O. McDevitt. 1995. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16:34.
9. Sigidin Y.A., G.V. Loukina, B. Skurkovich and S. Skurkovich. 2001. Randomized, double-blind trial of anti-interferon-γ antibodies in rheumatoid arthritis. Scand. J. Rheumatol. 30:203.
10. Olivenstein R., R. Taha, E.M. Minshall and Q.A. Hamid. 1999. IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash. J. Allergy Clin. Immunol. 103:238.
11. Corry D.B., H.G. Folkesson, M.L. Warnock, D.J. Erle, M.A. Matthay, J.P. Wiener-Kronish and R.M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hypersensitivity. J. Exp. Med. 183:109.
12. Yoshino S. 1995. Antigen-induced arthritis in rats is suppressed by the inducing antigen administered orally before, but not after immunization. Cell. Immunol. 163:55.
13. Yoshino S., E. Sasatomi, Y. Mori and M. Sagai. 1999. Oral administration of lipopolysaccharide exacerbates collagen-induced arthritis in mice. J. Immunol. 163:3417.
14. Yoshino S., Y. Murata and M. Ohsawa. 1998. Successful induction of adjuvant arthritis in mice by treatment with a monoclonal antibody against IL-4. J. Immunol. 161:6904.
15. Reder A.T., M. Thapar, A.M. Sapugay and M.A. Jensen. 1995. Eicosanoids modify experimental allergic encephalomyelitis. Am. J. Ther. 2:711.
16. Oh-hashi K., S. Watanabe, T. Kobayashi and H. Okuyama. 1997. Reevaluation of the effect of high alpha-linolenate and high linoleate diet on antigen-induced antibody and anaphylactic responses in mice. Biol. Pharm. Bull. 20:217.
17. De Freitas L.A., L.M. Mbow, M. Estay, J.A. Bleyenberg and R.G. Titus. 1999. Indomethacin treatment slows disease progression and enhanced a Th1 response in susceptible BALB/c mice infected with Leishmania major. Parasite Immunol. 21:273.
18. Ramierz F., D.J. Fowell, M. Puklavec, S. Simmonds and D. Mason. 1996. Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J. Immunol. 156:2406.
19. Constantin A., P. Loubet-Lescoulie, N. Lambert, B. Yassine-Diab, M. Abbal, B. Mazieres, C. de Preval and A. Cantagrel. 1998. Antiinflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis: evidence of increased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain reaction. Arthritis Rheum. 41:57.
20. Baus E., F. Van Laethem, F. Andris, S. Rolin, J. Urbain and O. Leo. 2001. Dexamethasone increases intracellular cyclic AMP concentration in murine T lymphocyte cell lines. Steroids 66:39.
21. Cronstein B.N., D. Naime and E. Ostad. 1993. The antiinflammatory mechanism of methotrexate. J. Clin. Invest. 92:2675.
22. Huang S., S. Apasov, M. Koshiba and M. Sitkovsky. 1997. Role of A2a extracellular adenosine receptor-mediated inhibition of T-cell activation and expansion. Blood 90:1600.
23. Munoz E., A.M. Zubiaga, M. Merrow, N.P. Sauter and B.T. Huber. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:95.
24. Heo Y., W.T. Lee and D.A. Lawrence. 1998. Differential effects of lead and cAMP on development and activities of Th1- and Th2-lymphocytes. Toxicol. Sci. 43:172.
25. Winther K., P. Oxholm and H. Sengelov. 1998. Effect of auranofin on human platelet aggregation, release of serotonin, and cyclic-AMP formation. Inflammation 12:107.
26. Scheinberg M.A., L.M. Santos and A.E. Finkelstein. 1982. The effect of auranofin and sodium aurothiomalate on peripheral blood monocytes. J. Rheumatol. 9:366.
27. Trinchieri G. and F. Gerosa. 1996. Immunoregulation by interleukin-12. J. Leukoc. Biol. 59:505.
28. Blotta M.H., R.H. DeKruyff and D.T. Umetsu. 1997. Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. J. Immunol. 158:5589.
29. 2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsi veness. J. Immunol. 161:2723.
30. Franchimont D., J. Galon, M. Gadina, R. Visconti, Y. Zhou, M. Aringer, D.M. Frucht, G.P. Chrousos and J.J. O'Shea. 2000. Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes. J. Immunol. 164:1768.
31. Kim T.S., B.Y. Kang, M.H. Lee, Y.K. Choe and S.Y. Hwang. 2001. Inhibition of interleukin-12 production by auranofin, an anti-rheumatic gold compound, deviates CD4(+) T cells from the Th1 to Th2 pathway. Br. J. Pharmacol. 134:571.
32. Jeon K.I., J.Y. Jeong and D.M. Jue. 2000. Thiol-reactive metal compounds inhibit NF-κB activation by blocking IκB kinase. J. Immunol. 164:5981.
33. Du C. and S. Sriram. 2000. Induction of interleukin-12/p40 by superantigens in macrophages is mediated by activation of nuclear factor-κB. Cell. Immunol. 199:50.
34. Gruol D.J. and S. Bourgeois. 1994. Expression of the mdr1 P-glycoprotein gene: a mechanism of escape from glucocorticoid-induced apoptosis. Biochem. Cell. Biol. 72:561.
35. Norris M.D., D. de Graaf,M. Haber, M. Kavallaris, J. Madafiglio, J. Gilbert, E. Kwan, B.W. Stewart, E.B. Mechetner, A.V. Gudkov and I.B. Roninson. 1996. Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate. Int. J. Cancer 65:613.
36. de Graaf D., R.C. Sharma, E.B. Mechetner, R.T. Schimke and I.B. Roninson. 1996. P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc. Natl. Acad. Sci. USA 93:1238.
37. Lohoff M., S. Prechtl, F. Sommer, M. Roellinghoff, E. Schmitt, G. Gradehandt, P. Rohwer, B.D. Stride, S.P. Cole and R.G. Deeley. 1998. A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th2), but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 after antigenic stimulation in vivo. J. Clin. Invest. 101:703.
38. McIntyre K.W., D.J. Shuster, K.M. Gillooly, R.R. Warrier, S.E. Connaughton, L.B. Hall, L.H. Arp, M.K. Gately and J. Magram. 1996. Reduced incidence and severity of collagen-induced arthritis-in interleukin-12-deficient mice. Eur. J. Immunol. 26:2933.
39. Scola M.P., S.D. Thompson, H.I. Brunner, M.K. Tsoras, D. Witte, M.A. van Dijk, A.A. Grom, M.H. Passo and D.N. Glass. 2002. Interferon-γ:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue. J. Rheumatol. 29:369.
40. Morinobu A., Z. Wang and S. Kumagai. 2000. Bucillamine suppresses human Th1 cell development by a hydrogen peroxide-independent mechanism. J. Rheumatol. 27:851.