Coxsackie and adenovirus receptor binding ablation reduces adenovirus liver tropism and toxicity

Human Gene Therapy

Volumn 16, Issue 2, 2005, Pages 248-261

  Yun, Chae Ok ^a   Yoon, A Rum ^a   Yoo, Ji Young ^a   Kim, Hoguen ^a   Kim, Minjung ^a   Ha, Taeyong ^a   Kim, Gwi Eon ^a   Kim, Hyunhee ^a   Kim, Joo Hang ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; DL K420A Z; DL LACZ; UNCLASSIFIED DRUG; VIRUS VECTOR; YKL K420A; YLL K420A;

ADENOVIRUS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BETA SHEET; CELL DEGENERATION; COMPLEX FORMATION; CONTROLLED STUDY; COXSACKIE VIRUS B; DRUG EFFICACY; ENZYME ASSAY; GENE MUTATION; GENE TRANSFER; GENETIC TRANSDUCTION; HISTOPATHOLOGY; HOST CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; LETHALITY; LIVER CELL; LIVER FUNCTION; LIVER NECROSIS; LIVER TOXICITY; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; TUMOR CELL; VIRAL GENE DELIVERY SYSTEM; VIROGENESIS; VIRUS INFECTION; VIRUS REPLICATION;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; HUMANS; LIVER; MICE; MICE, INBRED C57BL; NEOPLASMS; PROTEIN BINDING; RECEPTORS, VIRUS; TROPISM; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALIA; COXSACKIEVIRUS; HUMAN ADENOVIRUS; HUMAN ENTEROVIRUS B; NOTOLABRUS CELIDOTUS;

EID: 14844320793     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2005.16.248     Document Type: Article

References (20)

1. AKIYAMA, M., THORNE, S., KIRN, D., ROELVINK, P.W., EINFELD, D.A., KING, C.R., and WICKHAM, T.J. (2004). Ablating CAR and integrin binding in adenovirus vectors reduces nontarget organ transduction and permits sustained bloodstream persistence following intraperitoneal administration. Mol. Ther. 9, 218-230.
2. ALEMANY, R., and CURIEL, D.T. (2001). CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther. 8, 1347-1353.
3. BERGELSON, J.M., CUNNINGHAM, J.A., DROGUETT, G., KURT-JONES, E.A., KRITHIVAS, A., HONG, J.S., HORWITZ, M.S., CROWELL, R.L., and FINBERG, R.W. (1997). Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275, 1320-1323.
4. BERNT, K.M., NI, S., LI, Z.Y., SHAYAKHMETOV, D.M., and LIEBER, A. (2003). The effect of sequestration by nontarget tissues on anti-tumor efficacy of systemically applied, conditionally replicating adenovirus vectors. Mol. Ther. 8, 746-755.
5. EINFELD, D.A., SCHROEDER, R., ROELVINK, P.W., LIZONOVA, A., KING, C.R., KOVESDI, I., and WICKHAM, T.J. (2001). Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions. J. Virol. 75, 11284-11291.
6. JAKUBCZAK, J.L., ROLLENCE, M.L., STEWART, D.A., JAFARI, J.D., VON SEGGERN, D.J., NEMEROW, G.R., STEVENSON, S.C., and HALLENBECK, P.L. (2001). Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells. J. Virol. 75, 2972-2981.
7. KANERVA, A., MIKHEEVA, G.V., KRASNYKH, V., COOLIDGE, CJ., LAM, J.T., MAHASRESHTI, P.J., BARKER, S.D., STRAUGHN, M., BARNES, M.N., ALVAREZ, R.D., HEMMINKI, A., and CURIEL, D.T. (2002). Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells. Clin. Cancer Res. 8, 275-280.
8. LEISSNER, P., LEGRAND, V., SCHLESINGER, Y., HADJI, D.A., VAN RAAIJ, M., CUSACK, S., PAVIRANI, A., and MEHTALI, M. (2001). Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism. Gene Ther. 8, 49-57.
9. MARTIN, K., BRIE, A., SAULNIER, P., PERRICAUDET, M., YEH, P., and VIGNE, E. (2003). Simultaneous CAR- and alpha V integrin-binding ablation fails to reduce Ad5 liver tropism. Mol. Ther. 8, 485-494.
10. MIZUGUCHI, H., and HAYAKAWA, T. (2002). Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes. Gene 285, 69-77.
11. MJZUGUCHI, H., KOIZUMI, N., HOSONO, T., ISHII-WATABE, A., UCHIDA, E., UTOGUCHI, N., WATANABE, Y., and HAYAKAWA, T. (2002). CAR- or alphav integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice. Gene Ther. 9, 769-776.
12. MURUVE, D.A., BARNES, M.J., STILLMAN, I.E., and LIBERMANN, T.A. (1999). Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum. Gene Ther. 10, 965-976.
13. NEMEROW, G.R. (2000). Cell receptors involved in adenovirus entry. Virology 274, 1-4.
14. PAIELLI, D.L., WING, M.S., ROGULSKI, K.R., GILBERT, J.D., KOLOZSVARY, A., KIM, J.H., HUGHES, J., SCHNELL, M., THOMPSON, T., and FREYTAG, S.O. (2000). Evaluation of the biodistribution, persistence, toxicity, and potential of germ-line transmission of a replication-competent human adenovirus following intraprostatic administration in the mouse. Mol. Ther. 1, 263-274.
15. PERROTTE, P., WOOD, M., SLATON, J.W., WILSON, D.R., PAGLIARO, L., PRICE, R.E., and DINNEY, C.P. (2000). Biosafety of in vivo adenovirus-p53 intravesical administration in mice. Urology 56, 155-159.
16. ROELVINK, P.W., MI LEE, G., EINFELD, D.A., KOVESDI, I., and WICKHAM, T.J. (1999). Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae. Science 286, 1568-1571.
17. RUSSELL, W.C. (2000). Update on adenovirus and its vectors. J. Gen. Virol. 81, 2573-2604.
18. SCHOGGINS, J.W., GALL, J.G., and FALCK-PEDERSEN, E. (2003). Subgroup B and F fiber chimeras eliminate normal adenovirus type 5 vector transduction in vitro and in vivo. J. Virol. 77, 1039-1048.
19. WOOD, M., PERROTTE, P., ONISHI, E., HARPER, M.E., DINNEY, C., PAGLIARO, L., and WILSON, D.R. (1999). Biodistribution of an adenoviral vector carrying the luciferase reporter gene following intravesical or intravenous administration to a mouse. Cancer Gene Ther. 6, 367-372.
20. YANG, Y., ERTL, H.C., and WILSON, J.M. (1994). MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1, 433-442.