CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

Gene Therapy

Volumn 8, Issue 17, 2001, Pages 1347-1353

  Alemany, R ^a   Curiel, D T ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Adenovirus; Biodistribution; CAR; Vector

Indexed keywords

AMINO ACID; VIRUS PROTEIN; VIRUS RECEPTOR; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS; LIVER CELL; LIVER DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; TARGET CELL; VIRUS INFECTIVITY;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; GENE EXPRESSION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; INJECTIONS, INTRAVENOUS; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; PROTEIN BINDING; RECEPTORS, VIRUS; TISSUE DISTRIBUTION;

ADENOVIRIDAE; ANIMALIA; COXSACKIEVIRUS;

EID: 0034830243     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301515     Document Type: Article

References (24)

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4. Targeting adenovirus
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13. Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions
14. Evaluation of the biodistribution, persistence, toxicity, and potential of germ line transmission of a replication-competent human adenovirus following intraprostatic administration in the mouse
15. Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products
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17. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants
18. Biodistribution of an adenoviral vector carrying the luciferase reporter gene following intravesical or intravenous administration to a mouse
19. Rapid and sensitive detection of enhanced green fluorescent protein expression in paraffin sections by confocal laser scanning microscopy
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24. Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells