Evaluation of the Biodistribution, Persistence, Toxicity, and Potential of Germ-Line Transmission of a Replication-Competent Human Adenovirus Following Intraprostatic Administration in the Mouse

Molecular Therapy

Volumn 1, Issue 3, 2000, Pages 263-274

  Paielli, Dell L ^a   Wing, Mark S ^a   Rogulski, Kenneth R ^a   Gilbert, Jeff D ^a   Kolozsvary, Andy ^a   Kim, Jae Ho ^a   Hughes, Joe ^b   Schnell, Mike ^b   Thompson, Tim ^c   Freytag, Svend O ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Human gene therapy; adenovirus; toxicity; germ line transmission

Indexed keywords

RECOMBINANT DNA; VIRUS DNA;

ADENOVIRUS; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BLADDER; C57BL MOUSE; DISEASE TRANSMISSION; EMBRYO; FEMALE; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; INJECTION; LIVER; MALE; METABOLISM; MOUSE; POLYMERASE CHAIN REACTION; PROSTATE; SEMINAL VESICLE; SOUTHERN BLOTTING; TESTIS; VIROLOGY; VIRUS INFECTION; VIRUS REPLICATION;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANIMALS; BLOTTING, SOUTHERN; DISEASE TRANSMISSION, VERTICAL; DNA, RECOMBINANT; DNA, VIRAL; EMBRYO; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INJECTIONS; LIVER; MALE; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; PROSTATE; SEMINAL VESICLES; TESTIS; URINARY BLADDER; VIRUS REPLICATION;

EID: 0034150206     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0037     Document Type: Article

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