Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism

Gene Therapy

Volumn 8, Issue 1, 2001, Pages 49-57

  Leissner, P ^a   Legrand, V ^a   Schlesinger, Y ^a   Hadji, D A ^a   Van Raaij, M ^b   Cusack, S ^b   Pavirani, A ^a   Mehtali, M ^a,c  

^a TRANSGENE S A   (France)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^c CRUCELL HOLLAND BV   (Netherlands)

Author keywords

Adenovirus targeting; CAR binding site; Fiber; In vivo tropism

Indexed keywords

ALANINE; ASPARTIC ACID; CELL RECEPTOR; GLUTAMIC ACID; LIGAND; SERINE; TYROSINE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL SPECIFICITY; CELL TYPE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; VIROGENESIS; VIRUS CAPSID; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS MUTATION; VIRUS PARTICLE;

ADENOVIRUSES, HUMAN; ANIMALS; ANTIGENS, VIRAL; CAPSID; CAPSID PROTEINS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GENOME, VIRAL; HUMANS; LIGANDS; MICE; MICE, INBRED C57BL; MUTATION; POLYMERASE CHAIN REACTION; TROPISM; VIRUS ASSEMBLY;

ADENOVIRIDAE; ANIMALIA; DNA VIRUSES; MIRIDAE;

EID: 0035137320     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301343     Document Type: Article

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