CAR-or αv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice

Gene Therapy

Volumn 9, Issue 12, 2002, Pages 769-776

  Mizuguchi, H ^a   Koizumi, N ^a,b   Hosono, T ^a   Ishii Watabe, A ^a   Uchida, E ^a   Utoguchi, N ^b   Watanabe, Y ^b   Hayakawa, T ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Adenovirus vector; Fiber; Gene therapy; Penton base; Retargeting

Indexed keywords

2,4,5 TRIHYDROXYVALERIC ACID; ADENOVIRUS VECTOR; ALPHA5 INTEGRIN; ARGINYLGLYCYLASPARTIC ACID; DNA BASE; VIRUS DNA; VIRUS RECEPTOR; ARGINYL-GLYCYL-ASPARTIC ACID; CAR RECEPTOR; OLIGOPEPTIDE; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL TYPE; CONTROLLED STUDY; COXSACKIE VIRUS; DNA BASE COMPOSITION; DNA MODIFICATION; GENE ACTIVITY; GENE CONSTRUCT; GENE MUTATION; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; RECEPTOR BINDING; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTION; VIRUS RECOMBINANT; ADENOVIRUS; ANIMAL; CELL LINE; COMPARATIVE STUDY; GENE DELETION; GENE THERAPY; GENE VECTOR; GENETIC ENGINEERING; GENETIC TRANSDUCTION; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; METHODOLOGY;

ADENOVIRIDAE; ANIMALIA; COXSACKIEVIRUS; DNA VIRUSES;

ADENOVIRIDAE; ANIMALS; CELL LINE; GENE DELETION; GENE THERAPY; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; INJECTIONS, INTRAVENOUS; LIVER; MICE; OLIGOPEPTIDES; RECEPTORS, VIRUS; RECEPTORS, VITRONECTIN; TRANSDUCTION, GENETIC;

EID: 0035998392     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301701     Document Type: Article

References (35)

1. Adenovirus vectors for gene delivery
2. Adenoviral vectors for gene transfer
3. Dvances in adenoviral vectors: From genetic engineering to their biology
4. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
5. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
6. HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
7. Integrin αvβ5 selectively promotes adenovirus mediated cell membrane permeabilization
8. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
9. Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells
10. Mutations in the DG Loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR
11. Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae
12. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR
13. Influence of adenoviral fiber mutationss on viral encapsidation, infectivity and in vivo tropism
14. CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors
15. Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions
16. Dependence of efficient adenoviral gene delivery in malignant glioma cells on the expression levels of the Coxsackievirus and adenovirus receptor
17. A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob
18. Efficient gene transfer by fiber-mutant adenoviral vectors containing RGD peptide
19. Phage libraries displaying cyclic peptides with different ring sizes: Ligand specificities of the RGD-directed integrins
20. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants
21. Biodistribution of an adenoviral vector carrying the luciferase reporter gene following intravesical or intravenous administration to a mouse
22. Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers
23. Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells
24. Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions
25. Heparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5
26. Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5)
27. Insertion of an RDG motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector
28. A system for the propagation of adenoviral vectors with genetically modified receptor specificities
29. SK HEP-1: A human cell line of endothelial origin
30. A simple method for constructing E1 and E1/E4 deleted recombinant adenovirus vector
31. Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs
32. Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method
33. The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12
34. Optimization of transcriptional regulatory elements for constructing plasmid vectors
35. Hemagglutination properties and nucleotide sequence analysis of the fiber gene of adenovirus genome typesp and 11a