Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate

Experimental Neurology

Volumn 192, Issue 2, 2005, Pages 420-436

  Folbergrová, Jaroslava ^a   Druga, Rastislav ^a   Otáhal, Jakub ^a   Haugvicová, Renata ^a   Mareš, Pavel ^a   Kubová, Hana ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

2R,4R APDC; DL homocysteic acid induced seizures; EEG recordings; Energy metabolites; Fluoro Jade B staining; Immature rats; Metabotropic glutamate receptors; Neuronal degeneration; Protection

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 4 AMINOPYRROLIDINE 2,4 DICARBOXYLATE; ANTICONVULSIVE AGENT; CARBOXYLIC ACID DERIVATIVE; DYE; GLUCOSE; GLYCOGEN; HOMOCYSTEIC ACID; LACTIC ACID; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; BRAIN INJURY; BRAIN METABOLISM; BRAIN REGION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG EFFICACY; ELECTROENCEPHALOGRAM; ENERGY; EXPERIMENTAL MODEL; GLUCOSE BRAIN LEVEL; GLYCOGEN ANALYSIS; IMMATURITY; LOW DRUG DOSE; MALE; NERVE CELL DEGENERATION; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL; TONIC CLONIC SEIZURE; TREATMENT OUTCOME;

EID: 14844297453     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2004.12.019     Document Type: Article

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