Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains

Hypertension

Volumn 32, Issue 4, 1998, Pages 639-646

  Frantz, Simon A ^a   Kaiser, Michael ^a   Gardiner, Sheila M ^e   Gauguier, Dominique ^b   Vincent, Madeleine ^c   Thompson, John R ^a   Bennett, Terence ^e   Samani, Nilesh J ^d  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITÉ LYON 1   (France)

^d GLENFIELD HOSPITAL   (United Kingdom)

^e Glenfield General Hospital ^*

Author keywords

Congenic strains; Genes; Hypertension, genetic; Quantitative trait locus; Rats, inbred SHR

Indexed keywords

MESSENGER RNA;

ANIMAL MODEL; ARTICLE; CHROMOSOME 1; CHROMOSOME MAP; CONTROLLED STUDY; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RAT; RNA ANALYSIS; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0031751636     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.32.4.639     Document Type: Article

References (46)

1. Hilbert P, Lindpaintner K, Beckmann JS, Serikawa T, Soubrier F, Dubay C, Cartwright P, De Gouyon B, Julier C, Takahasi S, Vincent M, Ganten D, Georges M, Lathrop GM. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature. 1991;353:521-529.
2. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, Lander ES. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 1991;67:213-224.
3. Deng Y, Dene H, Pravenec M, Rapp JP. Genetic mapping of two new blood pressure quantitative loci in the rat by genotyping endothelin system genes. J Clin Invest. 1994;93:2701-2709.
4. Deng AY, Dene H, Rapp JP. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest. 1994;94:431-436.
5. Pravenec M, Gauguier D, Schott J-J, Buard J, Kren V, Bila C, Szpirer C, Szpirer J, Wang J-M, Huang H, St Lezin E, Spence AM, Flodman P, Printz M, Lathrop GM, Vergnaud G, Kurtz TW. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Clin Invest. 1995;96:1973-1978.
6. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet. 1996;12:44-51.
7. Gu L, Dene H, Deng AY, Hoebee B, Bihoreau M-T, James M, Rapp JP. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J Clin Invest. 1996;97:777-788.
8. Yagil C, Sapojnikov M, Kreutz R, Katni G, Lindpaintner K, Ganten D, Yagil Y. Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension. Hypertension. 1998;31:119-124.
9. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, Brosnan MJ, Devlin AM, Kelman AW, Lindpaintner K, Dominiczak AF. Quantitative trait loci in genetically hypertensive rats: possible sex specificity. Hypertension. 1996;28:898-906.
10. Samani NJ, Gauguier D, Vincent M, Kaiser MA, Bihoreau MT, Lodwick D, Wallis R, Parent V, Kimber P, Rattray F, Thompson JR, Sassard J, Lathrop M. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13: age-related differences in effect. Hypertension. 1996;28:1118-1122.
11. Rapp JP, Deng AY. Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension. Hypertension. 1995;25:1121-1128.
12. Samani NJ, Lodwick D, Vincent M, Dubay C, Kaiser MA, Kelly MP, Lo M, Harris J, Sassard J, Lathrop M, Swales JD. A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure. J Clin Invest. 1993;92:1099-1103.
13. Iwai N, Inagami T. Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats. J Hypertens. 1992;10:1155-1157.
14. A gene: co-segregation with hypertension and mapping to rat chromosome 1. J Hypertens. 1993;11:83-88.
15. A gene as a candidate gene contributing to the hypertension in spontaneously hypertensive rat. Biochem Biophys Res Commun. 1992;188:64-69.
16. A gene and blood pressure co-segregation using Dahl-salt sensitive rats. Am J Hypertens. 1993;6:330-334.
17. Nara Y, Nabika T, Ikeda K, Sawamura M, Mano M, Endo J, Yamori Y. Basal high blood pressure co-segregates with the loci in chromosome 1 in the F2 generation from crosses between normotensive Wistar Kyoto rats and stroke-prone spontaneously hypertensive rats. Biochem Biophys Res Commun. 1993;194:1344-1351.
18. Iwai N, Inagami T. Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension. 1991;17:161-169.
19. Huang H, Pravenec M, Wang J, Kren V, St Lezin EM, Szpirer C, Szpirer J, Kurtz TW. Mapping and sequence analysis of the gene encoding the beta subunit of the epithelial sodium channel in experimental models of hypertension. J Hypertens. 1995;13:1247-1251.
20. Kreutz R, Sturk B, Rubattu S, Hubner N, Szpirer C, Ganten D, Lindpaintner K. Role of the alpha-, beta-, and gamma-subunits of the epithelial sodium channel in a model of polygenic hypertension. Hypertension. 1997;29:131-136.
21. Shimkets RA, Wamock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW, Canessa CM, Rossier BC, Lifton RP. Liddle's syndrome: heritable human hypertension caused by mutations in the beta-subunit of the epithelial sodium channel. Cell. 1994;79:407-414.
22. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP. Hypertension caused by a truncated epithelial sodium channel gamma-subunit: genetic heterogeneity of Liddle syndrome. Nat Genet. 1995;11:76-82.
23. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz TW, Lemmark A, Levan G, Mao Y-P, Pettersson A, Pravenec M, Simon JS, Szpirer C, Szpirer J, Trollet MR, Winer ES, Lander ES. A genetic linkage map of the laboratory rat. Nat Genet. 1995;9:63-69.
24. Bihoreau MT, Gauguier D, Kato N, Hyne G, Lindpaintner K, Rapp JP, James MR, Lathrop GM. A linkage map of the rat genome derived from three F2 crosses. Genome Res. 1997;7:434-440.
25. Nabika T, Ito T, Kitada K, Serikawa T, Mashimo T, Soubrier F, Julier C, Ohno Y, Saruta T, Tanase H, Masuda J, Yamori Y, Nara Y. Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1. Mamm Genome. 1997;8:215-217.
26. Gardiner SM, Bennett T. Baroreflex sensitivity in conscious rats: the influence of recording. Cardiovasc Res. 1986;20:379-383.
27. Samani NJ, Swales JD, Brammar WJ. Expression of the renin gene in extra-renal tissues of the rat. Biochem J. 1988;253:907-910.
28. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
29. Hilton DA, Sarend V, Pringle JH. Demonstration of coxsackie virus RNA in formalin-fixed tissue sections from childhood myocarditis cases by in situ hybridization and the polymerase chain reaction. J Pathol. 1993;170:45-51.
30. Feinberg AP, Vogelstein B. A technique for labelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983;132:6-13.
31. Lander E, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newburg L. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics. 1987;1:174-181.
32. Lander E, Bostein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989;12:185-199.
33. A gene shows genotype-dependent tissue-specific expression. Clin Sci 1994;87:1-4.
34. Kunes J, Kren V, Klir P, Zicha J, Pravenec M. Genetic determination of heart and kidney weights studied using a set of recombinant inbred strains: the relationship to blood pressure. J Hypertens. 1990;8:1091-1095.
35. Ely DL, Danneshvar H, Turner ME, Johnson ML, Salisbury RL. The hypertensive Y chromosome elevates blood pressure in F11 normotensive rats. Hypertension. 1993;21:1071-1075.
36. St Lezin EM, Pravenec M, Wong AL, Liu WH, Wang N, Lu SH, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TW. Effects of renin gene transfer on blood pressure and renin gene expression in congenic strains of Dahl salt-resistant rats. J Clin Invest. 1996;97:522-527.
37. Kren V, Pravenec M, Lu SH, Krenova D, Wang JM, Wang N, Merriouns T, Wong A, St Lezin E, Lau D, Szpirer C, Szpirer J, Kurtz TW. Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. J Clin Invest. 1997;99:577-581.
38. Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension. 1997;29:619-627.
39. Zhang QY, Dene H, Deng AY, Garrett MR, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mamm Genome. 1997;8:636-641.
40. St Lezin E, Liu WZ, Wang JM, Wang N, Kren V, Krenova D, Musilova A, Zdobinska M, Zidek V, Lau D, Pravenec M. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. Hypertension. 1997;30:854-858.
41. Cicila GT, Dukhanina OI, Kurtz TW, Walder R, Garrett MR, Dene H, Rapp JP. Blood pressure and survival of a rat chromosome 7 congenic strain bred from Dahl rats. Mamm Genome. 1997;8:896-902.
42. St Lezin E, Liu WZ, Wang N, Wang JM, Kren V, Zidek V, Zdobinska M, Krenova D, Bottger A, van Zutphen BFM, Pravenec M. Effect of renin gene transfer on blood pressure in the spontaneously hypertensive rat. Hypertension. 1998;31:373-377.
43. Ishinaga Y, Nabika T, Shimada T, Hiraoka J, Nara Y, Yamori Y. Re-evaluation of the SA gene in spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Pharmacol Physiol. 1997;24:18-22.
44. 1 genes in the Milan hypertensive rat. J Hypertens. 1998;16:139-144.
45. Iwai N, Ohmici N, Hanai K, Nakamura Y, Kinoshita M. Human SA gene locus as a candidate locus for essential hypertension. Hypertension. 1994;23:375-380.
46. Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F. Evaluation of the SA locus in human hypertension. Hypertension. 1995;25:6-13.