메뉴 건너뛰기




Volumn 115, Issue 3, 2005, Pages 747-754

IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CD23 ANTIGEN; GLUTAMINE; HYDROCORTISONE; IMMUNOGLOBULIN E; INTERLEUKIN 13; STAT6 PROTEIN;

EID: 14644435711     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200522818     Document Type: Article
Times cited : (161)

References (69)
  • 1
    • 2542486456 scopus 로고    scopus 로고
    • Asthma: Mechanisms of disease persistence and progression
    • Cohn, L., Elias, J.A., and Chupp, G.L. 2004. Asthma: mechanisms of disease persistence and progression. Annu. Rev. Immunol. 22:789-815.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 789-815
    • Cohn, L.1    Elias, J.A.2    Chupp, G.L.3
  • 2
    • 0035888013 scopus 로고    scopus 로고
    • Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
    • Walter, D.M., et al. 2001. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 167:4668-4675.
    • (2001) J. Immunol. , vol.167 , pp. 4668-4675
    • Walter, D.M.1
  • 3
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: Central mediator of allergic asthma
    • Wills-Karp, M., et al. 1998. Interleukin-13: Central mediator of allergic asthma. Science. 282:2258-2261.
    • (1998) Science , vol.282 , pp. 2258-2261
    • Wills-Karp, M.1
  • 4
    • 0032545433 scopus 로고    scopus 로고
    • Requirement for IL-13 independently of IL-4 in experimental asthma
    • Grünig, G., et al. 1998. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 282:2261-2263.
    • (1998) Science , vol.282 , pp. 2261-2263
    • Grünig, G.1
  • 5
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu, Z., et al. 1999. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103:779-788.
    • (1999) J. Clin. Invest. , vol.103 , pp. 779-788
    • Zhu, Z.1
  • 6
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β-1
    • Lee, C., et al. 2001. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor β-1. J. Exp. Med. 194:809-821.
    • (2001) J. Exp. Med. , vol.194 , pp. 809-821
    • Lee, C.1
  • 7
    • 0036679426 scopus 로고    scopus 로고
    • Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling
    • doi:10.1172/JCI200214136
    • Lanone, S., et al. 2002. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J. Clin. Invest. 110:463-474. doi:10.1172/JCI200214136.
    • (2002) J. Clin. Invest. , vol.110 , pp. 463-474
    • Lanone, S.1
  • 8
    • 0034764068 scopus 로고    scopus 로고
    • Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types
    • Lee, J.H., et al. 2001. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am. J. Respir. Cell. Mol. Biol. 25:474-485.
    • (2001) Am. J. Respir. Cell. Mol. Biol. , vol.25 , pp. 474-485
    • Lee, J.H.1
  • 9
    • 2942668626 scopus 로고    scopus 로고
    • Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation
    • Zhu, Z., et al. 2004. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science. 304:1678-1682.
    • (2004) Science , vol.304 , pp. 1678-1682
    • Zhu, Z.1
  • 10
    • 0037013925 scopus 로고    scopus 로고
    • Intrinsic defect in T cell production of IL-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    • Mattes, J., et al. 2002. Intrinsic defect in T cell production of IL-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J. Exp. Med. 195:1433-1444.
    • (2002) J. Exp. Med. , vol.195 , pp. 1433-1444
    • Mattes, J.1
  • 11
    • 0037180805 scopus 로고    scopus 로고
    • Helper T cells regulate type-2 innate immunity in vivo
    • Shinkai, K., Mohrs, M., and Locksley, R.M. 2002. Helper T cells regulate type-2 innate immunity in vivo. Nature. 420:825-829.
    • (2002) Nature , vol.420 , pp. 825-829
    • Shinkai, K.1    Mohrs, M.2    Locksley, R.M.3
  • 12
    • 0242467200 scopus 로고    scopus 로고
    • Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity
    • Yang, M., et al. 2003. Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity. J. Allergy Clin. Immunol. 112:935-943.
    • (2003) J. Allergy Clin. Immunol. , vol.112 , pp. 935-943
    • Yang, M.1
  • 13
    • 1642362240 scopus 로고    scopus 로고
    • Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production
    • Voehringer, D., Shinkai, K., and Locksley, R.M. 2004. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity. 20:267-277.
    • (2004) Immunity , vol.20 , pp. 267-277
    • Voehringer, D.1    Shinkai, K.2    Locksley, R.M.3
  • 14
    • 0027522374 scopus 로고
    • Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
    • Punnonen, J., et al. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. U. S. A. 90:3730-3734.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 3730-3734
    • Punnonen, J.1
  • 15
    • 0029047583 scopus 로고
    • IL-13 downregulates CD14 expression and TNF-α secretion in human monocytes
    • Cosentino, G., et al. 1995. IL-13 downregulates CD14 expression and TNF-α secretion in human monocytes. J. Immunol. 155:3145-3151.
    • (1995) J. Immunol. , vol.155 , pp. 3145-3151
    • Cosentino, G.1
  • 16
    • 0038152342 scopus 로고    scopus 로고
    • The biology of IgE and the basis of allergic disease
    • Gould, H.J., et al. 2003. The biology of IgE and the basis of allergic disease. Annu. Rev. Immunol. 21:579-628.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 579-628
    • Gould, H.J.1
  • 17
    • 0007391938 scopus 로고    scopus 로고
    • Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms
    • Williams, T.J., Jones, C.A., Miles, E.A., Warner, J.O., and Warner, J.A. 2000. Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms. J. Allergy Clin. Immunol. 105:951-959.
    • (2000) J. Allergy Clin. Immunol. , vol.105 , pp. 951-959
    • Williams, T.J.1    Jones, C.A.2    Miles, E.A.3    Warner, J.O.4    Warner, J.A.5
  • 18
    • 0035185008 scopus 로고    scopus 로고
    • High IL-13 production by human neonatal T cells: Neonate immune system regulator?
    • Ribeiro-do-Couto, L.M., et al. 2001. High IL-13 production by human neonatal T cells: neonate immune system regulator? Eur. J. Immunol. 31:3394-3402.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3394-3402
    • Ribeiro-do-Couto, L.M.1
  • 19
    • 0141528826 scopus 로고    scopus 로고
    • Toward asthma prevention-does all chat really matters happen before we learn to read?
    • Martinez, F.D. 2003. Toward asthma prevention-does all chat really matters happen before we learn to read? N. Engl. J. Med. 349:1473-1475.
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1473-1475
    • Martinez, F.D.1
  • 20
    • 0033753747 scopus 로고    scopus 로고
    • Generics of asthma and allergic disease
    • Cookson, W.O., and Moffatt, M.F. 2000. Generics of asthma and allergic disease. Hum. Mol. Genet. 9:2359-2364.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2359-2364
    • Cookson, W.O.1    Moffatt, M.F.2
  • 21
    • 0242659391 scopus 로고    scopus 로고
    • Genetic polymorphism in allergy and asthma
    • Vercelli, D. 2003. Genetic polymorphism in allergy and asthma. Curr. Opin. Immunol. 15:609-613.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 609-613
    • Vercelli, D.1
  • 22
    • 0034102759 scopus 로고    scopus 로고
    • A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
    • Graves, P.E., et al. 2000. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J. Allergy Clin. Immunol. 105:506-513.
    • (2000) J. Allergy Clin. Immunol. , vol.105 , pp. 506-513
    • Graves, P.E.1
  • 23
    • 0033929090 scopus 로고    scopus 로고
    • An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90)
    • Liu, X., et al. 2000. An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). J. Allergy Clin. Immunol. 106:167-170.
    • (2000) J. Allergy Clin. Immunol. , vol.106 , pp. 167-170
    • Liu, X.1
  • 24
    • 0141989966 scopus 로고    scopus 로고
    • A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis
    • Wang, M., et al. 2003. A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. Hum. Genet. 113:387-390.
    • (2003) Hum. Genet. , vol.113 , pp. 387-390
    • Wang, M.1
  • 25
    • 0141956386 scopus 로고    scopus 로고
    • Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis
    • Heinzmann, A., et al. 2003. Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis. J. Allergy Clin. Immunol. 112:735-739.
    • (2003) J. Allergy Clin. Immunol. , vol.112 , pp. 735-739
    • Heinzmann, A.1
  • 26
    • 0034162827 scopus 로고    scopus 로고
    • Genetic variants of IL-13 signalling and human asthma and atopy
    • Heinzmann, A., et al. 2000. Genetic variants of IL-13 signalling and human asthma and atopy. Hum. Mol. Genet. 9:549-559.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 549-559
    • Heinzmann, A.1
  • 27
    • 0347420388 scopus 로고    scopus 로고
    • Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children
    • He, J.Q., et al. 2003. Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children. Genes Immun. 4:385-389.
    • (2003) Genes Immun. , vol.4 , pp. 385-389
    • He, J.Q.1
  • 28
    • 12244268667 scopus 로고    scopus 로고
    • Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients
    • Tsunemi, Y., et al. 2002. Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients. J. Dermatol. Sci. 30:100-107.
    • (2002) J. Dermatol. Sci. , vol.30 , pp. 100-107
    • Tsunemi, Y.1
  • 29
    • 0036857130 scopus 로고    scopus 로고
    • Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program
    • DeMeo, D., et al. 2002. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet. Epidemiol. 23:335-348.
    • (2002) Genet. Epidemiol. , vol.23 , pp. 335-348
    • DeMeo, D.1
  • 30
    • 0033188305 scopus 로고    scopus 로고
    • An IL-13 promoter polymorphism associated with increased risk of allergic asthma
    • van der Pouw Kraan, T.C., et al. 1999. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun. 1:61-65.
    • (1999) Genes Immun. , vol.1 , pp. 61-65
    • Van Der Pouw Kraan, T.C.1
  • 31
    • 0034808223 scopus 로고    scopus 로고
    • Identification and association of polymorphisms in the Interleukin-13 gene with asthma and atopy in a Dutch population
    • Howard, T.D., et al. 2001. Identification and association of polymorphisms in the Interleukin-13 gene with asthma and atopy in a Dutch population. Am. J. Respir. Cell. Mol. Biol. 25:377-384.
    • (2001) Am. J. Respir. Cell. Mol. Biol. , vol.25 , pp. 377-384
    • Howard, T.D.1
  • 32
    • 0042029642 scopus 로고    scopus 로고
    • Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: The German Multicenter Atopy Study
    • Liu, X., et al. 2003. Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J. Allergy Clin. Immunol. 112:382-388.
    • (2003) J. Allergy Clin. Immunol. , vol.112 , pp. 382-388
    • Liu, X.1
  • 33
    • 0242362647 scopus 로고    scopus 로고
    • Association between an interleukin-13 promoter polymorphism and atopy
    • Hummelshoj, T., et al. 2003. Association between an interleukin-13 promoter polymorphism and atopy. Eur. J. Immunogenet. 30:355-359.
    • (2003) Eur. J. Immunogenet. , vol.30 , pp. 355-359
    • Hummelshoj, T.1
  • 34
    • 0036138963 scopus 로고    scopus 로고
    • Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    • Howard, T.D., et al. 2002. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J. Hum. Genet. 70:230-236.
    • (2002) Am J. Hum. Genet. , vol.70 , pp. 230-236
    • Howard, T.D.1
  • 35
    • 1942494043 scopus 로고    scopus 로고
    • Association studies for asthma and atopic diseases: A comprehensive review of the literature
    • Hoffjan, S., Nicolae, D., and Ober, C. 2003. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir. Res. [serial online]. 4:14. http://respiratory-research.com.
    • (2003) Respir. Res. [Serial Online] , vol.4 , pp. 14
    • Hoffjan, S.1    Nicolae, D.2    Ober, C.3
  • 37
    • 0036279758 scopus 로고    scopus 로고
    • Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma
    • Arima, K., et al. 2002. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J. Allergy Clin. Immunol. 109:980-987.
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 980-987
    • Arima, K.1
  • 38
    • 4444318528 scopus 로고    scopus 로고
    • Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants
    • Chen, W., Ericksen, M.B., Levin, L.S., and Khurana Hershey, G.K. 2004. Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants. J. Allergy Clin. Immunol. 114:553-560.
    • (2004) J. Allergy Clin. Immunol. , vol.114 , pp. 553-560
    • Chen, W.1    Ericksen, M.B.2    Levin, L.S.3    Khurana Hershey, G.K.4
  • 39
    • 0037044781 scopus 로고    scopus 로고
    • Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine
    • Madhankumar, A.B., Mintz, A., and Debinski, W. 2002. Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine. J. Biol. Chem. 277:43194-43205.
    • (2002) J. Biol. Chem. , vol.277 , pp. 43194-43205
    • Madhankumar, A.B.1    Mintz, A.2    Debinski, W.3
  • 40
    • 0027464685 scopus 로고
    • Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses
    • Minty, A., et al. 1993. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature. 362:248-250.
    • (1993) Nature , vol.362 , pp. 248-250
    • Minty, A.1
  • 41
    • 0030587813 scopus 로고    scopus 로고
    • Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
    • Takeda, K., Kamanaka, M., Tanaka, T., Kishimoto, T., and Akira, S. 1996. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J. Immunol. 157:3220-3222.
    • (1996) J. Immunol. , vol.157 , pp. 3220-3222
    • Takeda, K.1    Kamanaka, M.2    Tanaka, T.3    Kishimoto, T.4    Akira, S.5
  • 42
    • 0004060480 scopus 로고    scopus 로고
    • John Wiley & Sons Ltd. Chichester, United Kingdom/New York, New York, USA
    • Brown, H., and Prescott, R. 1999. Applied mixed models in medicine. John Wiley & Sons Ltd. Chichester, United Kingdom/New York, New York, USA. 442 pp.
    • (1999) Applied Mixed Models in Medicine
    • Brown, H.1    Prescott, R.2
  • 43
    • 0023919271 scopus 로고
    • Human recombinant interleukin 4 induces FcεR2/CD23 on notmal human monocytes
    • Vercelli, D., et al. 1988. Human recombinant interleukin 4 induces FcεR2/CD23 on notmal human monocytes. J. Exp. Med. 167:1406-1416.
    • (1988) J. Exp. Med. , vol.167 , pp. 1406-1416
    • Vercelli, D.1
  • 44
    • 0027331547 scopus 로고
    • Allergy-associated Iε and Fcε receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element
    • Köhler, I., and Rieber, E.P. 1993. Allergy-associated Iε and Fcε receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element. Eur. J. Immunol. 23:3066-3071.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 3066-3071
    • Köhler, I.1    Rieber, E.P.2
  • 46
    • 0035138763 scopus 로고    scopus 로고
    • Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching
    • Jabara, H.H., Brodeur, S.R., and Geha, R.S. 2001. Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching. J. Clin. Invest. 107:371-378.
    • (2001) J. Clin. Invest. , vol.107 , pp. 371-378
    • Jabara, H.H.1    Brodeur, S.R.2    Geha, R.S.3
  • 47
    • 0037393323 scopus 로고    scopus 로고
    • IL-13 receptors and signaling pathways: An evolving web
    • Hershey, G.K. 2003. IL-13 receptors and signaling pathways: an evolving web [review]. J. Allergy Clin. Immunol. 111:677-690.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 677-690
    • Hershey, G.K.1
  • 48
    • 4344628556 scopus 로고    scopus 로고
    • Mechanism of action of interleukin-13 antagonist (IL-13E13K) in cells expressing various types of IL-4R
    • Kioi, M., Kawakami, K., and Puri, R.K. 2004. Mechanism of action of interleukin-13 antagonist (IL-13E13K) in cells expressing various types of IL-4R. Cell. Immunol. 229:41-51.
    • (2004) Cell. Immunol. , vol.229 , pp. 41-51
    • Kioi, M.1    Kawakami, K.2    Puri, R.K.3
  • 49
    • 0035967912 scopus 로고    scopus 로고
    • Solution structure of interleukin-13 and insights into receptor engagement
    • Eisenmesser, E.Z., Horita, D.A., Altieri, A.S., and Byrd, R.A. 2001. Solution structure of interleukin-13 and insights into receptor engagement. J. Mol. Biol. 310:231-241.
    • (2001) J. Mol. Biol. , vol.310 , pp. 231-241
    • Eisenmesser, E.Z.1    Horita, D.A.2    Altieri, A.S.3    Byrd, R.A.4
  • 50
    • 2642583283 scopus 로고    scopus 로고
    • Mapping complex disease loci in whole-genome association studies
    • Carlson, C.S., Eberle, M.A., Kruglyak, L., and Nickerson, D.A. 2004. Mapping complex disease loci in whole-genome association studies. Nature. 429:446-452.
    • (2004) Nature , vol.429 , pp. 446-452
    • Carlson, C.S.1    Eberle, M.A.2    Kruglyak, L.3    Nickerson, D.A.4
  • 51
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
    • Botstein, D., and Risch, N. 2003. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease [review]. Nat. Genet. 33(Suppl.):228-237.
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 228-237
    • Botstein, D.1    Risch, N.2
  • 52
    • 0032167603 scopus 로고    scopus 로고
    • The murine IL-13 receptor α2: Molecular cloning, characterization and comparison with murine IL-13 receptor α1
    • Donaldson, D.D., et al. 1998. The murine IL-13 receptor α2: Molecular cloning, characterization and comparison with murine IL-13 receptor α1. J. Immunol. 161:2317-2324.
    • (1998) J. Immunol. , vol.161 , pp. 2317-2324
    • Donaldson, D.D.1
  • 53
    • 0344091551 scopus 로고    scopus 로고
    • Enhanced Interleukin-13 responses in mice lacking IL-13 receptor α2
    • Wood, N., et al. 2003. Enhanced Interleukin-13 responses in mice lacking IL-13 receptor α2. J. Exp. Med. 197:703-709.
    • (2003) J. Exp. Med. , vol.197 , pp. 703-709
    • Wood, N.1
  • 54
    • 0037393502 scopus 로고    scopus 로고
    • Cytokine regulation of IL-13Rα2 and IL-13Rα1 in vivo and in vitro
    • Zheng, T., et al. 2003. Cytokine regulation of IL-13Rα2 and IL-13Rα1 in vivo and in vitro. J. Allergy Clin. Immunol. 111:720-728.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 720-728
    • Zheng, T.1
  • 55
    • 0034640298 scopus 로고    scopus 로고
    • Conversion of interleukin-13 into a high affinity agonise by a single amino acid substitution
    • Oshima, Y., Joshi, B.H., and Puri, R.K. 2000. Conversion of interleukin-13 into a high affinity agonise by a single amino acid substitution. J. Biol. Chem. 275:14375-14380.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14375-14380
    • Oshima, Y.1    Joshi, B.H.2    Puri, R.K.3
  • 56
    • 0035889904 scopus 로고    scopus 로고
    • A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity
    • LeVan, T.D., et al. 2001. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J. Immunol. 167:5838-5844.
    • (2001) J. Immunol. , vol.167 , pp. 5838-5844
    • LeVan, T.D.1
  • 57
    • 0035097791 scopus 로고    scopus 로고
    • Differences in proliferation of the hematopoietic cell line TF-1 and cytokine production by peripheral blood leukocytes induced by 2 naturally occurring forms of human IL-3
    • Schweiger, A., et al. 2001. Differences in proliferation of the hematopoietic cell line TF-1 and cytokine production by peripheral blood leukocytes induced by 2 naturally occurring forms of human IL-3. J. Allergy Clin. Immunol. 107:505-510.
    • (2001) J. Allergy Clin. Immunol. , vol.107 , pp. 505-510
    • Schweiger, A.1
  • 58
    • 0344364566 scopus 로고    scopus 로고
    • An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
    • Tokuhiro, S., et al. 2003. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat. Genet. 35:341-348.
    • (2003) Nat. Genet. , vol.35 , pp. 341-348
    • Tokuhiro, S.1
  • 59
    • 9144221958 scopus 로고    scopus 로고
    • Transforming growth factor-β1 promoter polymorphism C-509T is associated with asthma
    • Silverman, E.S., et al. 2004. Transforming growth factor-β1 promoter polymorphism C-509T is associated with asthma. Am. J. Respir. Crit. Care Med. 169:214-219.
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , pp. 214-219
    • Silverman, E.S.1
  • 60
    • 2342480580 scopus 로고    scopus 로고
    • Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro
    • Ozaki, K., et al. 2004. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro. Nature. 429:72-75.
    • (2004) Nature , vol.429 , pp. 72-75
    • Ozaki, K.1
  • 61
    • 1842483836 scopus 로고    scopus 로고
    • Allele-specific repression of lymphotoxin-α by activated B cell factor-1
    • Knight, J.C., Keating, B.J., and Kwiatkowski, D.P. 2004. Allele-specific repression of lymphotoxin-α by activated B cell factor-1. Nat. Genet. 36:394-399.
    • (2004) Nat. Genet. , vol.36 , pp. 394-399
    • Knight, J.C.1    Keating, B.J.2    Kwiatkowski, D.P.3
  • 62
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S., and Hirschhorn, J.N. 2003. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33:177-182.
    • (2003) Nat. Genet. , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 63
    • 0025083185 scopus 로고
    • IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice
    • Tepper, R.I., et al. 1990. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 62:457-467.
    • (1990) Cell. , vol.62 , pp. 457-467
    • Tepper, R.I.1
  • 64
    • 0025036906 scopus 로고
    • Eosinophilia in transgenic mice expressing interleukin 5
    • Dent, L.A., Strath, M., Mellor, A.L., and Sandetson, C.J. 1990. Eosinophilia in transgenic mice expressing interleukin 5. J. Exp. Med. 172:1425-1431.
    • (1990) J. Exp. Med. , vol.172 , pp. 1425-1431
    • Dent, L.A.1    Strath, M.2    Mellor, A.L.3    Sandetson, C.J.4
  • 65
    • 0025871907 scopus 로고
    • Hydrocortisone and IL-4 induce IgE isotype switching in human B cells
    • Jabara, H.H., Ahern, D.J., Vercelli, D., and Geha, R.S. 1991. Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. J. Immunol. 147:1557-1560.
    • (1991) J. Immunol. , vol.147 , pp. 1557-1560
    • Jabara, H.H.1    Ahern, D.J.2    Vercelli, D.3    Geha, R.S.4
  • 66
    • 0035967886 scopus 로고    scopus 로고
    • Solution structure of human IL-13 and implication for receptor binding
    • Moy, F.J., Diblasio, E., Wilhelm, J., and Powers, R. 2001. Solution structure of human IL-13 and implication for receptor binding. J. Mol. Biol. 310:219-230.
    • (2001) J. Mol. Biol. , vol.310 , pp. 219-230
    • Moy, F.J.1    Diblasio, E.2    Wilhelm, J.3    Powers, R.4
  • 67
    • 0036284915 scopus 로고    scopus 로고
    • Myb proteins repress human ε germline transcription by inhibiting STAT6-dependent promoter activation
    • Monticelli, S., Ghittoni, R., Kabesch, M., and Vercelli, D. 2002. Myb proteins repress human ε germline transcription by inhibiting STAT6-dependent promoter activation. Mol. Immunol. 38:1129-1138.
    • (2002) Mol. Immunol. , vol.38 , pp. 1129-1138
    • Monticelli, S.1    Ghittoni, R.2    Kabesch, M.3    Vercelli, D.4
  • 68
    • 0142245596 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: Expression as multiple forms in a dynamic, variably sized fraction of the clone
    • Albesiano, E., et al. 2003. Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone. Blood. 102:3333-3339.
    • (2003) Blood , vol.102 , pp. 3333-3339
    • Albesiano, E.1
  • 69
    • 0025650466 scopus 로고
    • CD40 and IgE: Synergism between anti-CD40 mAb and IL-4 in the induction of IgE synthesis by highly purified human B cells
    • Jabara, H.H., Fu, S.M., Geha, R.S., and Vercelli, D. 1990. CD40 and IgE: Synergism between anti-CD40 mAb and IL-4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172:1861-1864.
    • (1990) J. Exp. Med. , vol.172 , pp. 1861-1864
    • Jabara, H.H.1    Fu, S.M.2    Geha, R.S.3    Vercelli, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.