Effects of non-steroidal anti-inflammatory drugs on the pharmacokinetics and elimination of aciclovir in rats

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 3, 2005, Pages 393-398

  Gwak, Hye Sun ^a   Oh, Jung Hyun ^b   Han, Hyo Kyung ^b  

^a Ewha Womans University   (South Korea)

^b Chosun University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; KETOPROFEN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC CATION TRANSPORTER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG URINE LEVEL; MALE; NONHUMAN; RAT; URINARY EXCRETION;

ACYCLOVIR; ANIMALS; ANTI-HIV AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; DRUG SYNERGISM; HALF-LIFE; INJECTIONS, INTRAVENOUS; KETOPROFEN; MALE; METABOLIC CLEARANCE RATE; NAPROXEN; ORGANIC ANION TRANSPORT PROTEIN 1; RATS; RATS, SPRAGUE-DAWLEY;

EID: 14644433620     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357055533     Document Type: Article

References (44)

1. Angelin, B., Arvidsson, A., Dahlqvist, R., Hedman, A., Schenk-Gustafsson, K. (1987) Quinidine reduces biliary clearance of digoxin in man. Eur. J. Clin. Invest. 17: 262-265
2. Apiwattanakul, N., Sekine, T., Chairoungdua, A., Kanai, Y., Nakajima, N., Sophasan, S., Endou, H. (1999) Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol. Pharmacol. 55: 847-854
3. Ayrton, A., Morgan, P. (2001) Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31: 469-497
4. Becker, B. N., Fall, P., Hall, C., Milam, D., Leonard, J., Glick, A., Schulman, G. (1993) Rapidly progressive acute renal failure due to acyclovir: case report and review of the literature. Am. J. Kidney Dis. 22: 611-615
5. Berndt, W. O., Hayes, A. W. (1982) The effect of probenecid on citrinin-induced nephrotoxicity. Toxicol. Appl. Pharmacol. 64: 118-124
6. Brigden, D., Whiteman, P. (1983) The mechanism of action, pharmacokinetics and toxicity of acyclovir - a review. J. Infect. Dis. 6 (Suppl. 1): 3-9
7. Burckhardt, B. C., Burckhardt, G. (2003) Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev. Physiol. Biochem. Pharmacol. 146: 95-158
8. Cha, S. H., Sekine, T., Fukushima, J.-I., Kanai, Y., Kobayashi, Y., Goya, T., Endou, H. (2001) Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. 59: 1277-1286
9. Cihlar, T., Ho, E. S. (2000) Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1 (hOAT1). Anal. Biochem. 283: 49-55
10. Cihlar, T., Lin, D. C., Pritchard, J. B., Fuller, M. D., Mendel, D. B., Sweet, D. H. (1999) The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol. Pharmacol. 56: 570-580
11. de Miranda, P., Whitley, R. J., Blum, M. R., Keeney, R. E., Barton, N., Cocchetto, D. M., Good, S., Hemstreet, G. P., Kirk, L. E., Page, D. A., Elion, G. B. (1979) Acyclovir kinetics after intravenous infusion. Clin. Pharmacol. Ther. 26: 718-728
12. de Miranda, P., Krasny, H. C., Page, D. A., Elion, G. B. (1981a) The disposition of acyclovir in different species. J. Pharmacol. Exp. Ther. 219: 309-315
13. de Miranda, P., Good, S. S., Laskin, O. L., Krasny, H. C., Connors, J. D., Lietman, P. S. (1981b) Disposition of intravenous radioactive acyclovir. Clin. Pharmacol. Ther. 30: 662-672
14. Dresser, G. K., Spence, J. D., Bailey, D. G. (2000) Pharmacokinetic- pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin. Pharmacokinet. 38: 41-57
15. Hitchcock, M. J. M., Jaffe, H. S., Martin, J. C., Stagg, R. J. (1996) Cidofovir, a new agent with potent anti-herpesvirus activity. Antiviral Chem. Chemother. 7: 115-127
16. Ho, E. S., Lin, D. C., Mendel, D. B., Cihlar, T. (2000) Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J. Am. Soc. Nephrol. 11: 383-393
17. Hosoyamada, M., Sekine, T., Kanai, Y., Endou, H. (1999). Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am. J. Physiol. 276: F122-F128
18. Jariyawat, S., Sekine, T., Takeda, M., Apiwattanakul, N., Kanai, Y., Sophasan, S., Endou, H. (1999) The interaction and transport of β-lactam antibiotics with the cloned rat renal organic anion transporter 1. J. Pharmacol. Exp. Ther. 290: 672-677
19. Kim, R. B. (2000) Transporters in drug disposition. Curr. Opin. Drug Discov. Devel. 3: 94-101
20. Lacy, S. A., Hitchcock, M. J. M., Lee, W. A., Tellier, P., Cundy, K. C. (1998) Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys. Toxicol. Sci. 4: 97-106
21. Laskin, O. L., Longstreth, J. A., Saral, R., de Miranda, P., Keeney, R., Lietman, P. S. (1982a) Pharmacokinetics and tolerance of acyclovir, a new anti-herpesvirus agent, in humans. Antimicrob. Agents Chemother. 21: 393-398
22. Laskin, O. L., de Miranda, P., King, D. H., Page, D. A., Longstreth, J. A., Rocco, L., Lietman, P. S. (1982b) Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans. Antimicrob. Agents Chemother. 21: 804-807
23. Masuda, S., Saito, H., Inui, K. I. (1997) Interactions of non-steroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1. J. Pharmacol. Exp. Ther. 283: 1039-1042
24. Meijer, D. K. F., Mol, W. E. M., Muller, M., Kurz, G. (1990) Carrier-mediated transport in the hepatic distribution and elimination of drugs with special reference to the category of organic cations. J. Pharm. Biopharm. 18: 35-70
25. Mulato, A. S., Ho, E. S., Cihlar, T. (2000) Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J. Pharmacol. Exp. Ther. 295: 10-15
26. Müller, M., Jansen, P. L. M. (1997) Molecular aspects of hepatobiliary transport. Am. J. Physiol. 272: G1285-G1303
27. Satterwhite, J. H., Boudinot, F. D. (1991) Age- and dose-dependent naproxen disposition in Fischer 344 rats. J. Gerontol. 46: 222-227
28. Satterwhite, J. H., Boudinot, F. D. (1992) Pharmacokinetics of ketoprofen in rats: effect of age and dose. Biopharm. Drug Dispos. 13: 197-212
29. Sekine, T., Watanabe, N., Hosoyamada, M., Kainai, Y., Endou, H. (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272: 18526-18529
30. Sweet, D. H., Pritchard, J. B. (1999) The molecular biology of renal organic anion and organic cation transporters. Cell Biochem. Biophys. 31: 89-118
31. Takeda, M., Tojo, A., Sekine, T., Hosoyamada, M., Kanai, Y., Endou, H. (1999) Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney Int. 56: 2128-2136
32. Takeda, M., Khamdang, S., Narikawa, S., Kimura, H., Kobayashi, Y., Yamamoto, T., Cha, S. H., Sekine, T., Endou, H. (2002) Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J. Pharmacol. Exp. Ther. 300: 918-924
33. Tojo, A., Sekine, T., Nakajima, N., Hosoyamada, M., Kanai, Y., Kimura, K., Endou, H. (1999) Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J. Am. Soc. Nephrol. 10: 464-471
34. Tune, B. M. (1994) Renal tubular transport and nephrotoxicity of beta lactam antibiotics: structure-activity relationships. Miner. Electrolyte Metab. 20: 221-231
35. Tune, B. M. (1997) Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention. Pediatr. Nephrol. 11: 768-772
36. Ullrich, K. J. (1997) Renal transporters for organic anions and organic cations. Structural requirements for substrates. J. Membr. Biol. 158: 95-107
37. Uwai, Y., Okuda, M., Takami, K., Hashimoto, Y., Inui, K. I. (1998) Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 438: 321-324
38. Uwai, Y., Saito, H., Hashimoto, Y., Inui, K. I. (2000) Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J. Pharmacol. Exp. Ther. 295: 261-265
39. Verschraagen, M., Koks, C. H. W., Schellens, J. H. M., Beijnen, J. H. (1999) P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil. Pharmacol. Res. 40: 301-306
40. Von Moltke, L. L., Greenblatt, D. J., Schmider, J., Wright, C. E., Harmatz, J. S., Shader, R. I. (1998) In vitro approaches to predicting drug interactions in vivo. Biochem. Pharmacol. 55: 113-122
41. Wada, S., Tsuda, M., Sekine, T., Cha, S. H., Kimura, M., Kanai, Y., Endou, H. (2000) Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J. Pharmacol. Exp. Ther. 294: 844-849
42. Watkins, P. B. (1999) Approaches to studying the role of transporters in drug interactions in man. International Congress Series 1178 (Variability in human drug response), pp 55-67
43. Westphal, K., Weinbrenner, A., Giessmann, T., Stuhr, M., Franke, G., Zschiesche, M., Oertel, R., Terhaag, B., Kroemer, H. K., Siegmund, W. (2000) Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein. Clin. Pharmacol. Ther. 68: 6-12
44. Yamazaki, M., Suzuki, H., Sugiyama, Y. (1996) Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res. 13: 497-513