-
1
-
-
0028929923
-
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates
-
Aduma, P., Connelly, M. C., Srinivas, R. V., and Fridland, A. (1995) Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates. Mol Pharmacol 47: 816-822.
-
(1995)
Mol Pharmacol
, vol.47
, pp. 816-822
-
-
Aduma, P.1
Connelly, M.C.2
Srinivas, R.V.3
Fridland, A.4
-
2
-
-
0026342128
-
Comparative activity of selected antiviral compounds against clinical isolates of human cytomegalovirus
-
Andrei, G., Snoeck, R., Schols, D., Goubau, P., Desmyter, J., and De Clercq, E. (1991) Comparative activity of selected antiviral compounds against clinical isolates of human cytomegalovirus. Eur J Clin Microbiol Infect Dis 10: 1026-1033.
-
(1991)
Eur J Clin Microbiol Infect Dis
, vol.10
, pp. 1026-1033
-
-
Andrei, G.1
Snoeck, R.2
Schols, D.3
Goubau, P.4
Desmyter, J.5
De Clercq, E.6
-
3
-
-
0021807545
-
Metabolic activation of the nucleoside analog 9- ([2-hydroxy-1-(hydroxymethyl)-ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus
-
Biron, K.K., Stanat, S.C., Sorrell, J.B., Fyfe, J.A., Keller, P.M., Lambe, C.U., and Nelson, D.J. (1985) Metabolic activation of the nucleoside analog 9- ([2-hydroxy-1-(hydroxymethyl)-ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus. Proc Natl Acad Sci USA 82: 2473-2477.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 2473-2477
-
-
Biron, K.K.1
Stanat, S.C.2
Sorrell, J.B.3
Fyfe, J.A.4
Keller, P.M.5
Lambe, C.U.6
Nelson, D.J.7
-
4
-
-
0024373015
-
Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine
-
Bronson, J.J., Ghazzouli, I., Hitchcock, M.J.M., Webb, R.R., and Martin, J.C. (1989) Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. J Med Chem 32: 1457-1463.
-
(1989)
J Med Chem
, vol.32
, pp. 1457-1463
-
-
Bronson, J.J.1
Ghazzouli, I.2
Hitchcock, M.J.M.3
Webb, R.R.4
Martin, J.C.5
-
5
-
-
0025201125
-
(S)-1-(3-hydroxy-2-(phosphonyl-methoxy)propyl)-cytosine (HPMPC): A potent anti-herpesvirus agent
-
Lopez, C. et al. (eds). New York:Plenum Press
-
Bronson, J.J., Ferrara, L.M., Hitchcock, M.J.M., Ho, H., Woods, K.L., Ghazzouli, I., Kern, E.R., Soike, K.F., and Martin, J.C. (1990) (S)-1-(3-hydroxy-2-(phosphonyl-methoxy)propyl)-cytosine (HPMPC): A potent anti-herpesvirus agent. In Immunobiology and prophylaxis of human herpesvirus infections. Lopez, C. et al. (eds). New York:Plenum Press, pp. 277-283
-
(1990)
Immunobiology and Prophylaxis of Human Herpesvirus Infections
, pp. 277-283
-
-
Bronson, J.J.1
Ferrara, L.M.2
Hitchcock, M.J.M.3
Ho, H.4
Woods, K.L.5
Ghazzouli, I.6
Kern, E.R.7
Soike, K.F.8
Martin, J.C.9
-
6
-
-
0027939507
-
Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl) cytosine, zalcitabineTP, zidovudineTP, and FIAUTP with human DNA polymerases β and γ
-
Cherrington, J.M., Allen, S.J.W., and Chen, M.S. (1994) Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl) cytosine, zalcitabineTP, zidovudineTP, and FIAUTP with human DNA polymerases β and γ. Biochem Pharmacol 48:1986-1988.
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 1986-1988
-
-
Cherrington, J.M.1
Allen, S.J.W.2
Chen, M.S.3
-
7
-
-
0009575961
-
Sensitivities of human cytomegalovirus (HCMV) clinical isolates to cidofovir
-
Cherrington, J.M., Allen, S.J.W., Mulato, A.S., Miner, R., Drew, W.L., and Chen, M.S. (1995) Sensitivities of human cytomegalovirus (HCMV) clinical isolates to cidofovir. Antiviral Res 26: A319.
-
(1995)
Antiviral Res
, vol.26
-
-
Cherrington, J.M.1
Allen, S.J.W.2
Mulato, A.S.3
Miner, R.4
Drew, W.L.5
Chen, M.S.6
-
8
-
-
0029997824
-
Susceptibility of human cytomegalovirus (HCMV) to cidofovir is unchanged after limited exposure in vivo to various clinical regimens of drug
-
in press
-
Cherrington, J.M., Miner, R., Lalezari, J., Hitchcock, M.J.M., and Drew, W.L. (1996) Susceptibility of human cytomegalovirus (HCMV) to cidofovir is unchanged after limited exposure in vivo to various clinical regimens of drug. J Infect Dis (in press).
-
(1996)
J Infect Dis
-
-
Cherrington, J.M.1
Miner, R.2
Lalezari, J.3
Hitchcock, M.J.M.4
Drew, W.L.5
-
9
-
-
0028940302
-
Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
-
Chou, S., Erice, A., Jordan, M.C., Vercellotti, G.M., Michels, K.R., Talarico, C.L., Stanat, S.C., and Biron, K.K. (1995) Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance. J Infect Dis 171: 576-583.
-
(1995)
J Infect Dis
, vol.171
, pp. 576-583
-
-
Chou, S.1
Erice, A.2
Jordan, M.C.3
Vercellotti, G.M.4
Michels, K.R.5
Talarico, C.L.6
Stanat, S.C.7
Biron, K.K.8
-
10
-
-
0001003712
-
Metabolism of 1-(S)-(3-hydroxy-2-phosphonomethoxypropyl)cytosine (HPMPC) in human embryonic lung cells
-
Cihlar, T., Votruba, I., Horska, K., and Liboska, R. (1992) Metabolism of 1-(S)-(3-hydroxy-2-phosphonomethoxypropyl)cytosine (HPMPC) in human embryonic lung cells. Collect Czech Chem Commun 57: 661-672.
-
(1992)
Collect Czech Chem Commun
, vol.57
, pp. 661-672
-
-
Cihlar, T.1
Votruba, I.2
Horska, K.3
Liboska, R.4
-
11
-
-
0027172325
-
Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells
-
Connelly, M.C., Robbins, B.L., and Fridland, A. (1993) Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells. Biochem Pharmacol 46: 1053-1057.
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 1053-1057
-
-
Connelly, M.C.1
Robbins, B.L.2
Fridland, A.3
-
12
-
-
0038023667
-
Effect of concomitant probenecid on the tissue distribution and urinary excretion of HPMPC in preclinical models
-
Cundy, K.C., Li, Z.-H., and Lee, W.A. (1994) Effect of concomitant probenecid on the tissue distribution and urinary excretion of HPMPC in preclinical models. Pharm Res 11 (Suppl.): S-449.
-
(1994)
Pharm Res
, vol.11
, Issue.SUPPL.
-
-
Cundy, K.C.1
Li, Z.-H.2
Lee, W.A.3
-
13
-
-
0029000871
-
Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients
-
Cundy, K.C., Petty, B.G., Flaherty, J., Fisher, P.E., Polis, M.A., Wachsman, M., Lietman, P.S., Lalezari, J.P., Hitchcock, M.J.M., and Jaffe, H.S. (1995) Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 39: 1247-1252.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 1247-1252
-
-
Cundy, K.C.1
Petty, B.G.2
Flaherty, J.3
Fisher, P.E.4
Polis, M.A.5
Wachsman, M.6
Lietman, P.S.7
Lalezari, J.P.8
Hitchcock, M.J.M.9
Jaffe, H.S.10
-
14
-
-
0030055492
-
Pharmacokinetics of cidofovir in monkeys: Evidence for a prolonged elimination phase represents phosphorylated drug
-
in press
-
Cundy, K.C., Li, Z., Hitchcock, M.J.M., and Lee, W.L. (1996) Pharmacokinetics of cidofovir in monkeys: evidence for a prolonged elimination phase represents phosphorylated drug. Drug Metab Dispos (in press).
-
(1996)
Drug Metab Dispos
-
-
Cundy, K.C.1
Li, Z.2
Hitchcock, M.J.M.3
Lee, W.L.4
-
15
-
-
0022450584
-
A novel selective broad-spectrum anti-DNA virus agent
-
De Clercq, E., Holy, A., Rosenberg, I., Sakuma, T., Baizarini, J., and Maudgal, P.C. (1986) A novel selective broad-spectrum anti-DNA virus agent. Nature 323: 464-467.
-
(1986)
Nature
, vol.323
, pp. 464-467
-
-
De Clercq, E.1
Holy, A.2
Rosenberg, I.3
Sakuma, T.4
Baizarini, J.5
Maudgal, P.C.6
-
16
-
-
0023607245
-
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines
-
De Clercq, E., Sakuma, T., Baba, M., Pauwels, R., Balzarini, J., Rosenberg, I., and Holy, A. (1987) Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral Res 8: 261-272.
-
(1987)
Antiviral Res
, vol.8
, pp. 261-272
-
-
De Clercq, E.1
Sakuma, T.2
Baba, M.3
Pauwels, R.4
Balzarini, J.5
Rosenberg, I.6
Holy, A.7
-
17
-
-
0024574822
-
Progressive disease due to ganciclovir resistant cytomegalovirus in immunocompromised patients
-
Erice, A., Chou, S., Biron, K.K., Stanat, S.C., Balfour, H.H., and Jordan, M.C. (1989) Progressive disease due to ganciclovir resistant cytomegalovirus in immunocompromised patients. New Eng J Med 320: 289-293.
-
(1989)
New Eng J Med
, vol.320
, pp. 289-293
-
-
Erice, A.1
Chou, S.2
Biron, K.K.3
Stanat, S.C.4
Balfour, H.H.5
Jordan, M.C.6
-
18
-
-
0028153740
-
Long-acting therapy of viral retinitis with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine
-
Flores-Aguilar, M., Huang, J., Wiley, C.A., De Clercq, E., Vuong, C., Bergeron-Lynn. G., Chandler, B., Munguia, D., and Freeman, W.R. (1994) Long-acting therapy of viral retinitis with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine. J Infect Dis 169: 642-647.
-
(1994)
J Infect Dis
, vol.169
, pp. 642-647
-
-
Flores-Aguilar, M.1
Huang, J.2
Wiley, C.A.3
De Clercq, E.4
Vuong, C.5
Bergeron-Lynn, G.6
Chandler, B.7
Munguia, D.8
Freeman, W.R.9
-
19
-
-
0026706359
-
Pretreatment with topical 0.1% (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)cytosine inhibits adenovirus type 5 replication in the New Zealand rabbit ocular model
-
Gordon, Y.J., Romanowski, E., Araullo-Cruz, T., and De Clercq, E. (1992) Pretreatment with topical 0.1% (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)cytosine inhibits adenovirus type 5 replication in the New Zealand rabbit ocular model. Cornea 11: 529-533.
-
(1992)
Cornea
, vol.11
, pp. 529-533
-
-
Gordon, Y.J.1
Romanowski, E.2
Araullo-Cruz, T.3
De Clercq, E.4
-
20
-
-
0028047056
-
Topical HPMPC inhibits adenovirus type 5 in the New Zealand rabbit ocular replication model
-
Gordon, V.J., Romanowski, E., and Araullo-Cruz, T. (1994) Topical HPMPC inhibits adenovirus type 5 in the New Zealand rabbit ocular replication model. Invest Ophthal Vis Sci 35: 4135-4143.
-
(1994)
Invest Ophthal Vis Sci
, vol.35
, pp. 4135-4143
-
-
Gordon, V.J.1
Romanowski, E.2
Araullo-Cruz, T.3
-
21
-
-
0028130055
-
Inhibitory effects of acyclic nucleoside phosphonates on Human Hepatitis B Virus and Duck Hepatitis B Virus infections in tissue culture
-
Heijtink, R.A., Kruining, J., De Wilde, G.A., Balzarini, J , De Clercq, E., and Schalm, S.W. (1994) Inhibitory effects of acyclic nucleoside phosphonates on Human Hepatitis B Virus and Duck Hepatitis B Virus infections in tissue culture. Antimicrob Agents Chemother 38: 2180-2182.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 2180-2182
-
-
Heijtink, R.A.1
Kruining, J.2
De Wilde, G.A.3
Balzarini, J.4
De Clercq, E.5
Schalm, S.W.6
-
22
-
-
0000055156
-
The cyclic congener of cidofovir has reduced nephrotoxicity in three species
-
Hitchcock, M.J.M., Lacy, S.A., Lindsey, J.R., and Kern, E.R. (1995) The cyclic congener of cidofovir has reduced nephrotoxicity in three species. Antiviral Res 26: A358.
-
(1995)
Antiviral Res
, vol.26
-
-
Hitchcock, M.J.M.1
Lacy, S.A.2
Lindsey, J.R.3
Kern, E.R.4
-
23
-
-
0026537658
-
Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine
-
Ho, H.-T., Woods, K.L, Bronson, J.J., De Boeck, H., Martin, J.C., and Hitchcock, M.J.M. (1992) Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Mol Pharmacol 41: 197-202.
-
(1992)
Mol Pharmacol
, vol.41
, pp. 197-202
-
-
Ho, H.-T.1
Woods, K.L.2
Bronson, J.J.3
De Boeck, H.4
Martin, J.C.5
Hitchcock, M.J.M.6
-
24
-
-
0025372944
-
Acyclic nucleotide analogues: Synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro
-
Holy, A., Votruba, I., Merta, A., Cerny, J., Vesely, J., Vlach, J., Sediva, K., Rosenberg, I., Otmar, M., Hrebabecky, H., Travnicek, M., Vonka, V., Snoeck, R., and De Clercq, E. (1990) Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. Antiviral Res 13: 295-312.
-
(1990)
Antiviral Res
, vol.13
, pp. 295-312
-
-
Holy, A.1
Votruba, I.2
Merta, A.3
Cerny, J.4
Vesely, J.5
Vlach, J.6
Sediva, K.7
Rosenberg, I.8
Otmar, M.9
Hrebabecky, H.10
Travnicek, M.11
Vonka, V.12
Snoeck, R.13
De Clercq, E.14
-
25
-
-
0025825961
-
Value of animal models to evaluate agents with potential activity against human cytomegalovirus
-
Kern, E.R. (1991) Value of animal models to evaluate agents with potential activity against human cytomegalovirus. Transplant Proc 23: 152-155.
-
(1991)
Transplant Proc
, vol.23
, pp. 152-155
-
-
Kern, E.R.1
-
26
-
-
0009577957
-
Comparison of efficacy and toxicity of HPMPC and cyclic HPMPC in animal models for severe herpesvirus infections
-
Abstract 195
-
Kern, E.R., Palmer, J., Hartline, C., and Vogt, P.E. (1995) Comparison of efficacy and toxicity of HPMPC and cyclic HPMPC in animal models for severe herpesvirus infections. Antiviral Res 26: A329, Abstract 195.
-
(1995)
Antiviral Res
, vol.26
-
-
Kern, E.R.1
Palmer, J.2
Hartline, C.3
Vogt, P.E.4
-
27
-
-
0028064563
-
Treatment with intravenous (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine of acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with AIDS
-
Lalezari, J.P., Drew, W.L., Glutzer, E., Miner, D., Safrin, S., Owen, W.F., Davidson, J.M., Fisher P.E., and Jaffe, H.S. (1994) Treatment with intravenous (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine of acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with AIDS. J Infect Dis 170: 570-572.
-
(1994)
J Infect Dis
, vol.170
, pp. 570-572
-
-
Lalezari, J.P.1
Drew, W.L.2
Glutzer, E.3
Miner, D.4
Safrin, S.5
Owen, W.F.6
Davidson, J.M.7
Fisher, P.E.8
Jaffe, H.S.9
-
28
-
-
0028936048
-
(S)-1-[3-Hydroxy-2-(Phosphonylmethoxy)propyl]cytosine (cidofovir): Results of a Phase I/II study of a novel antiviral nucleotide analogue
-
Lalezari, J.P., Drew, W.L., Glutzer, E., James, C., Miner, D., Flaherty, J., Fisher, P.E., Cundy, K., Hannigan, J., Martin, J.C., and Jaffe, H.S (1995) (S)-1-[3-Hydroxy-2-(Phosphonylmethoxy)propyl]cytosine (cidofovir): results of a Phase I/II study of a novel antiviral nucleotide analogue. J Infect Dis 171: 788-796.
-
(1995)
J Infect Dis
, vol.171
, pp. 788-796
-
-
Lalezari, J.P.1
Drew, W.L.2
Glutzer, E.3
James, C.4
Miner, D.5
Flaherty, J.6
Fisher, P.E.7
Cundy, K.8
Hannigan, J.9
Martin, J.C.10
Jaffe, H.S.11
-
29
-
-
0025367013
-
Activity of (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (HPMPC) against guinea pig cytomegalovirus infection in cultured cells and in guinea pigs
-
Li, S.B., Yang, Z.H., Feng, J.S., Fong, C.K.Y., Lucia, H.L., and Hsiung, G.D. (1990) Activity of (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (HPMPC) against guinea pig cytomegalovirus infection in cultured cells and in guinea pigs. Antiviral Res 13: 237-252.
-
(1990)
Antiviral Res
, vol.13
, pp. 237-252
-
-
Li, S.B.1
Yang, Z.H.2
Feng, J.S.3
Fong, C.K.Y.4
Lucia, H.L.5
Hsiung, G.D.6
-
30
-
-
0026095439
-
Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication
-
Lin, J., De Clercq. E., and Pagano, J.S. (1991) Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication. Antimicrob Agents Chemother 35: 2440-2443.
-
(1991)
Antimicrob Agents Chemother
, vol.35
, pp. 2440-2443
-
-
Lin, J.1
De Clercq, E.2
Pagano, J.S.3
-
31
-
-
0026664424
-
Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir
-
Littler, D., Stuart, A.D., and Chee, M.S. (1992) Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature 358: 160-162.
-
(1992)
Nature
, vol.358
, pp. 160-162
-
-
Littler, D.1
Stuart, A.D.2
Chee, M.S.3
-
32
-
-
0026476302
-
Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents
-
Lurain, N.S., Thompson, K.D., Holmes, E.W., and Read, G.S. (1992) Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents. J Virol 66: 7146-7152.
-
(1992)
J Virol
, vol.66
, pp. 7146-7152
-
-
Lurain, N.S.1
Thompson, K.D.2
Holmes, E.W.3
Read, G.S.4
-
33
-
-
0028271126
-
Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir
-
Lurain, N.S., Spafford, L.E., and Thompson, K.D. (1994) Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir. J Virol 68: 4427-4431.
-
(1994)
J Virol
, vol.68
, pp. 4427-4431
-
-
Lurain, N.S.1
Spafford, L.E.2
Thompson, K.D.3
-
34
-
-
0025833252
-
Phosphonomethylether compounds as antiviral agents
-
Martin, J.C., and Hitc̀hcock, M.J.M. (1991) Phosphonomethylether compounds as antiviral agents. Transplant Proc 23: 156-158.
-
(1991)
Transplant Proc
, vol.23
, pp. 156-158
-
-
Martin, J.C.1
Hitc̀hcock, M.J.M.2
-
35
-
-
0029145656
-
Biochemical basis for increased susceptibility to cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity
-
Mendel, D.B., Barkhimer, D.B., and Chen, M.S. (1995a) Biochemical basis for increased susceptibility to cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity. Antimicrob Agents Chemother 39: 2120-2122.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 2120-2122
-
-
Mendel, D.B.1
Barkhimer, D.B.2
Chen, M.S.3
-
36
-
-
1842265993
-
Isolation and initial characterization of a herpes simplex virus type 2 (HSV-2) strain with decreased sensitivity to cidofovir
-
Mendel, D.B., Barkhimer, D.B., Kern, E.R., and Chen, M.S. (1995b) Isolation and initial characterization of a herpes simplex virus type 2 (HSV-2) strain with decreased sensitivity to cidofovir. Antiviral Res 26: A312.
-
(1995)
Antiviral Res
, vol.26
-
-
Mendel, D.B.1
Barkhimer, D.B.2
Kern, E.R.3
Chen, M.S.4
-
37
-
-
0025026393
-
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1, 3-dihydroxy-2-propoxymethyl)guanine (DHPG)
-
Neyts, J., Snoeck, R., Schols, D., Balzarini, J., and De Clercq, E. (1990) Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1, 3-dihydroxy-2-propoxymethyl)guanine (DHPG). Virology 179: 41-50.
-
(1990)
Virology
, vol.179
, pp. 41-50
-
-
Neyts, J.1
Snoeck, R.2
Schols, D.3
Balzarini, J.4
De Clercq, E.5
-
38
-
-
0025880030
-
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine (HPMPC) in vitro
-
Neyts, J., Snoeck, R., Balzarini, J., and De Clercq, E. (1991a) Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine (HPMPC) in vitro. Antiviral Res 16: 41-52.
-
(1991)
Antiviral Res
, vol.16
, pp. 41-52
-
-
Neyts, J.1
Snoeck, R.2
Balzarini, J.3
De Clercq, E.4
-
39
-
-
0026012486
-
Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anticytomegalovirus agents
-
Neyts, J., Snoeck, R., Schols, D., Himpens, B., and De Clercq, E. (1991b) Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anticytomegalovirus agents. J Virol Methods 35: 27-38.
-
(1991)
J Virol Methods
, vol.35
, pp. 27-38
-
-
Neyts, J.1
Snoeck, R.2
Schols, D.3
Himpens, B.4
De Clercq, E.5
-
40
-
-
0026574462
-
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and ganciclovir for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice
-
Neyts, J., Balzarini, J., Naesens, L., and De Clercq, E. (1992) Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and ganciclovir for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice. J Med Virol 37: 67-71.
-
(1992)
J Med Virol
, vol.37
, pp. 67-71
-
-
Neyts, J.1
Balzarini, J.2
Naesens, L.3
De Clercq, E.4
-
41
-
-
0026742713
-
Pretreatment of the host cell with 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is sufficient for its antiviral effect
-
Otova, B., Votruba, I., and Holy, A. (1992) Pretreatment of the host cell with 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is sufficient for its antiviral effect. Acta Virol 36: 313-319.
-
(1992)
Acta Virol
, vol.36
, pp. 313-319
-
-
Otova, B.1
Votruba, I.2
Holy, A.3
-
42
-
-
0025955785
-
A randomized, controlled trial of foscamet in the treatment of cytomegalovirus retinitis in patients with AIDS
-
Palestine, A.G., Polis, M.A., DeSmet M.D. et al. (1991) A randomized, controlled trial of foscamet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Intern Med 115: 665-673.
-
(1991)
Ann Intern Med
, vol.115
, pp. 665-673
-
-
Palestine, A.G.1
Polis, M.A.2
DeSmet, M.D.3
-
43
-
-
0026719113
-
Foscarnet and ganciclovir in the treatment of cytomegalovirus retinitis
-
Polis, M.A. (1992) Foscarnet and ganciclovir in the treatment of cytomegalovirus retinitis. J Acquir Immune Defic Syndr 5: S3-S10.
-
(1992)
J Acquir Immune Defic Syndr
, vol.5
-
-
Polis, M.A.1
-
44
-
-
0028933876
-
Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria
-
Polis, M.A., Spooner, K.M., Baird, B.F., Manischewitz, J.F., Jaffe, H.S., Fisher, P.E., Falloon, J., Davey, R.T., Kovacs, J.A., Walker, R.E., Whitcup, S.M., Nussenblatt, R.B., Lane, H.C., and Masur, H. (1995) Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria. Antimicrob Agents Chemother 39: 882-686.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 882-1686
-
-
Polis, M.A.1
Spooner, K.M.2
Baird, B.F.3
Manischewitz, J.F.4
Jaffe, H.S.5
Fisher, P.E.6
Falloon, J.7
Davey, R.T.8
Kovacs, J.A.9
Walker, R.E.10
Whitcup, S.M.11
Nussenblatt, R.B.12
Lane, H.C.13
Masur, H.14
-
45
-
-
0023840835
-
Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human α and human β polymerases
-
Reid, R., Mar, E.-C., Huang, E.-S., and Topal, M.D. (1988) Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human α and human β polymerases. J Biol Chem 263: 3898-3904.
-
(1988)
J Biol Chem
, vol.263
, pp. 3898-3904
-
-
Reid, R.1
Mar, E.-C.2
Huang, E.-S.3
Topal, M.D.4
-
46
-
-
14444278509
-
Antiviral activity of selected nucleoside analogues against human herpes virus type 6
-
Reyman, D., Naesens, L., Balzarini, J., Holy, A., and De Clercq, E. (1995) Antiviral activity of selected nucleoside analogues against human herpes virus type 6. Antiviral Res 26: A326.
-
(1995)
Antiviral Res
, vol.26
-
-
Reyman, D.1
Naesens, L.2
Balzarini, J.3
Holy, A.4
De Clercq, E.5
-
47
-
-
0026016282
-
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro
-
Shigeta, S., Konno, K., Baba, M., Yokota, T., and De Clercq, E. (1991) Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro. J Infect Dis 163: 270-275.
-
(1991)
J Infect Dis
, vol.163
, pp. 270-275
-
-
Shigeta, S.1
Konno, K.2
Baba, M.3
Yokota, T.4
De Clercq, E.5
-
48
-
-
0026767528
-
Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir (S)-1-[3-hydroxy-2-(phosphonylmethoxy)-propyl]cytosine, interferon, and bropirimine
-
Smee, D.F., Morris, J.B., Leonhardt, J.A., Mead, J.R., Holy, A., and Sidwell, R.W. (1992) Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir (S)-1-[3-hydroxy-2-(phosphonylmethoxy)-propyl]cytosine, interferon, and bropirimine. Antimicrob Agents Chemother 36: 1837-1842.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 1837-1842
-
-
Smee, D.F.1
Morris, J.B.2
Leonhardt, J.A.3
Mead, J.R.4
Holy, A.5
Sidwell, R.W.6
-
49
-
-
0028102177
-
Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice
-
Smee, D.F., Sugiyama, S.T., and Reist, E.J. (1994) Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice. Antimicrob Agents Chemother 38: 2165-2168.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 2165-2168
-
-
Smee, D.F.1
Sugiyama, S.T.2
Reist, E.J.3
-
50
-
-
0028809242
-
Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus
-
Smee, D.F., Barnett, B.B., Sidwell, R.W., Reist, E.J., and Holy, A. (1995) Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. Antiviral Res 26: 1-9.
-
(1995)
Antiviral Res
, vol.26
, pp. 1-9
-
-
Smee, D.F.1
Barnett, B.B.2
Sidwell, R.W.3
Reist, E.J.4
Holy, A.5
-
51
-
-
0023763320
-
(S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)-cytosine, a potent and selective inhibitor of human cytomegalovirus replication
-
Snoeck, R., Sakuma, T., De Clercq, E., Rosenberg, I., and Holy A. (1988) (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)-cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob Agents Chemother 32: 1839-1844.
-
(1988)
Antimicrob Agents Chemother
, vol.32
, pp. 1839-1844
-
-
Snoeck, R.1
Sakuma, T.2
De Clercq, E.3
Rosenberg, I.4
Holy, A.5
-
52
-
-
0025835777
-
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique
-
Snoeck, R., Schols, D., Andrei, G., Neyts, J., and De Clercq, E. (1991) Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. Antiviral Res 16: 1-9.
-
(1991)
Antiviral Res
, vol.16
, pp. 1-9
-
-
Snoeck, R.1
Schols, D.2
Andrei, G.3
Neyts, J.4
De Clercq, E.5
-
53
-
-
0028327303
-
Successful treatment of progressive mucocutaneous infection due to acyclovir- And foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC)
-
Snoeck, R., Andrei, G., Gerard, M., Silverman, A., Hedderman, A., Balzarini, J., Sadzot-Delvaux, C., Tricot, G., Clumeck, N., and De Clercq, E. (1994) Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC). Clin Infect Dis 18: 570-578.
-
(1994)
Clin Infect Dis
, vol.18
, pp. 570-578
-
-
Snoeck, R.1
Andrei, G.2
Gerard, M.3
Silverman, A.4
Hedderman, A.5
Balzarini, J.6
Sadzot-Delvaux, C.7
Tricot, G.8
Clumeck, N.9
De Clercq, E.10
-
54
-
-
0009589519
-
Human cytomegalovirus (HCMV) strains selected under selective pressure of phosphonoformate (PFA) are resistant for both PFA and phosphonylmethoxyethyl (PME) derivatives in vitro
-
Snoeck, R., Andrei, G., and De Clercq, E. (1995a) Human cytomegalovirus (HCMV) strains selected under selective pressure of phosphonoformate (PFA) are resistant for both PFA and phosphonylmethoxyethyl (PME) derivatives in vitro. Antiviral Res 26: A320.
-
(1995)
Antiviral Res
, vol.26
-
-
Snoeck, R.1
Andrei, G.2
De Clercq, E.3
-
55
-
-
0029163498
-
Treatment of anogenital papillomavirus infections with an acyclic nucleoside phosphonate analogue
-
Snoeck, R., Van Ranst, M., Andrei, G., De Clercq, E., De Wit, S., Poncin, M., and Clumeck, N. (1995b) Treatment of anogenital papillomavirus infections with an acyclic nucleoside phosphonate analogue. New Engl J Med 333: 943-944.
-
(1995)
New Engl J Med
, vol.333
, pp. 943-944
-
-
Snoeck, R.1
Van Ranst, M.2
Andrei, G.3
De Clercq, E.4
De Wit, S.5
Poncin, M.6
Clumeck, N.7
-
56
-
-
0025880029
-
Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on Simian Varicella Infection in monkeys
-
Soike, K.F., Huang, J.-L. Zhang, J.-Y., Bohm, R., Hitchcock. M.J.M., and Martin, J.C. (1991) Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on Simian Varicella Infection in monkeys. Antiviral Res 16: 17-28.
-
(1991)
Antiviral Res
, vol.16
, pp. 17-28
-
-
Soike, K.F.1
Huang, J.-L.2
Zhang, J.-Y.3
Bohm, R.4
Hitchcock, M.J.M.5
Martin, J.C.6
-
57
-
-
0027320067
-
A randomized, controlled study of intravenous ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS
-
Spector, S.A., Weingeist, T., Pollard, R.B., Dieterich, D.T., Samo, T., Benson, C.A., Busch, D.F., Freeman, W.R., Montague, P., Kaplan, H.J., Kellerman, L., Crager, M., De Armond, B., Buhles, W., Feinberg, J., AIDS Clinical Trials Group, and Cytomegalovirus Cooperative Study Group. (1993) A randomized, controlled study of intravenous ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS. J Infect Dis 168: 557-563.
-
(1993)
J Infect Dis
, vol.168
, pp. 557-563
-
-
Spector, S.A.1
Weingeist, T.2
Pollard, R.B.3
Dieterich, D.T.4
Samo, T.5
Benson, C.A.6
Busch, D.F.7
Freeman, W.R.8
Montague, P.9
Kaplan, H.J.10
Kellerman, L.11
Crager, M.12
De Armond, B.13
Buhles, W.14
Feinberg, J.15
-
58
-
-
0025945734
-
Comparative activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1, 3-dihydroxy-2-propoxymethyl) guanine against rat cytomegalovirus infection in vitro and in vivo
-
Stals, F.S., De Clercq, E., and Bruggeman, C.A. (1991) Comparative activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1, 3-dihydroxy-2-propoxymethyl) guanine against rat cytomegalovirus infection in vitro and in vivo. Antimicrob Agents Chemother 35: 2262-2266.
-
(1991)
Antimicrob Agents Chemother
, vol.35
, pp. 2262-2266
-
-
Stals, F.S.1
De Clercq, E.2
Bruggeman, C.A.3
-
59
-
-
0027465190
-
Rat cytomegalovirus-induced pneumonitis after allogeneic bone marrow transplantation: Effective treatment with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
-
Stals, P.S., Zeytinoglu, A., Havenith, M., De Clercq, E., and Bruggeman, C.A. (1993a) Rat cytomegalovirus-induced pneumonitis after allogeneic bone marrow transplantation: effective treatment with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine. Antimicrob Agents Chemother 37: 218-223.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 218-223
-
-
Stals, P.S.1
Zeytinoglu, A.2
Havenith, M.3
De Clercq, E.4
Bruggeman, C.A.5
-
60
-
-
0027447557
-
Comparative effect of (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and 9- (1, 3-dihydroxy-2-propoxymethyl)guanine treatment on cytomegalovirus-induced interstitial pneumonitis in allogeneic bone marrow transplant recipient rats
-
Stals, F.S., Zeytinoglu, A., Havenith, M., De Clercq, E., and Bruggeman, C.A. (1993b) Comparative effect of (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and 9- (1, 3-dihydroxy-2-propoxymethyl)guanine treatment on cytomegalovirus-induced interstitial pneumonitis in allogeneic bone marrow transplant recipient rats. Transplant Proc 25: 1248-1249.
-
(1993)
Transplant Proc
, vol.25
, pp. 1248-1249
-
-
Stals, F.S.1
Zeytinoglu, A.2
Havenith, M.3
De Clercq, E.4
Bruggeman, C.A.5
-
61
-
-
0026077654
-
Ganciclovir-resistant cytomegalovirus clinical isolates: Mode of resistance to ganciclovir
-
Stanat, S.C., Reardon, J.E., Erice, A., Jordan, M.C., Drew, W.L., and Biron, K.K. (1991) Ganciclovir-resistant cytomegalovirus clinical isolates: mode of resistance to ganciclovir. Antimicrob Agents Chemother 35: 2191-2197.
-
(1991)
Antimicrob Agents Chemother
, vol.35
, pp. 2191-2197
-
-
Stanat, S.C.1
Reardon, J.E.2
Erice, A.3
Jordan, M.C.4
Drew, W.L.5
Biron, K.K.6
-
62
-
-
0028066818
-
Foscarnet-ganciclovir cytomegalovirus retinitis trial. 4. Visual outcomes
-
Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. (1994) Foscarnet-ganciclovir cytomegalovirus retinitis trial. 4. Visual outcomes. Ophthalmology 101: 1250-1261.
-
(1994)
Ophthalmology
, vol.101
, pp. 1250-1261
-
-
-
63
-
-
0025992797
-
Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs
-
Sullivan, V., and Coen, D.M. (1991) Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs. J Infect Dis 164: 781-784.
-
(1991)
J Infect Dis
, vol.164
, pp. 781-784
-
-
Sullivan, V.1
Coen, D.M.2
-
64
-
-
0026720227
-
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
-
Sullivan, V., Talarico, C.L., Stanat, S.C., Davis, M., Coen, D.M., and Biron, K.K. (1992) A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 358: 162-164.
-
(1992)
Nature
, vol.358
, pp. 162-164
-
-
Sullivan, V.1
Talarico, C.L.2
Stanat, S.C.3
Davis, M.4
Coen, D.M.5
Biron, K.K.6
-
65
-
-
0027473447
-
A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives
-
Sullivan, V., Biron, K.K., Talarico, C., Stanat, S.C., Davis, M., POZZI, L.M., and Coen, D.M. (1993) A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob Agents Chemother 37: 19-25.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 19-25
-
-
Sullivan, V.1
Biron, K.K.2
Talarico, C.3
Stanat, S.C.4
Davis, M.5
Pozzi, L.M.6
Coen, D.M.7
-
66
-
-
0026782503
-
A ganciclovir-resistant clinical isolate of human cytomegalovirus exhibiting cross-resistance to other DNA polymerase inhibitors
-
Tatarowicz, W.A., Lurain, N.S., and Thompson, K.D. (1992) A ganciclovir-resistant clinical isolate of human cytomegalovirus exhibiting cross-resistance to other DNA polymerase inhibitors. J Infect Dis 166: 904-907.
-
(1992)
J Infect Dis
, vol.166
, pp. 904-907
-
-
Tatarowicz, W.A.1
Lurain, N.S.2
Thompson, K.D.3
-
67
-
-
0028936680
-
Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1 -(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
-
Van Cutsem, E., Snoeck, R., Van Ranst, M., Fiten, P., Opdenakker, G., Geboes, K., Janssens, J., Rutgeerts, P., Vantrappen, G., and De Clercq, E. (1994) Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1 -(3-hydroxy-2-phosphonylmethoxypropyl)cytosine. J Med Virol 45: 230-235.
-
(1994)
J Med Virol
, vol.45
, pp. 230-235
-
-
Van Cutsem, E.1
Snoeck, R.2
Van Ranst, M.3
Fiten, P.4
Opdenakker, G.5
Geboes, K.6
Janssens, J.7
Rutgeerts, P.8
Vantrappen, G.9
De Clercq, E.10
-
68
-
-
15844427342
-
Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in HIV-infected subjects
-
in press
-
Wachsman, M., Petty, B.G., Cundy, K.C., Jaffe, H.S., Fisher, P.E., Pastelak, A., and Lietman, P.S. (1996) Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in HIV-infected subjects. Antiviral Res (in press).
-
(1996)
Antiviral Res
-
-
Wachsman, M.1
Petty, B.G.2
Cundy, K.C.3
Jaffe, H.S.4
Fisher, P.E.5
Pastelak, A.6
Lietman, P.S.7
-
69
-
-
0342473537
-
The consequence of incorporation of (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)cytosine by human cytomegalovirus DNA polymerase on DNA elongation
-
Xiong, X., Smith, J.L., and Chen, M.S. (1995) The consequence of incorporation of (S)-1- (3-hydroxy-2-phosphonylmethoxypropyl)cytosine by human cytomegalovirus DNA polymerase on DNA elongation. Antiviral Res 26: A321.
-
(1995)
Antiviral Res
, vol.26
-
-
Xiong, X.1
Smith, J.L.2
Chen, M.S.3
-
70
-
-
0025985990
-
Prolonged and potent therapeutic and prophylactic effects of (S)-1-[ (3-hydroxy-2-phosphonylmethoxy)propyl]cytosine against Herpes Simplex Virus Type 2 infections in mice
-
Yang, H., and Datema, R. (1991) Prolonged and potent therapeutic and prophylactic effects of (S)-1-[ (3-hydroxy-2-phosphonylmethoxy)propyl]cytosine against Herpes Simplex Virus Type 2 infections in mice. Antimicrob Agents Chemother 35: 1596-1600.
-
(1991)
Antimicrob Agents Chemother
, vol.35
, pp. 1596-1600
-
-
Yang, H.1
Datema, R.2
|