Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction

Oncogene

Volumn 23, Issue 5, 2004, Pages 1021-1029

  Kuang, Chenzhong ^a   Chen, Yan ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Cancer; Mutations; Smad4; TGF

Indexed keywords

DNA; HYBRID PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; ASSOCIATION; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA BINDING; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR;

AMINO ACID SEQUENCE; CELL LINE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; GENES, REPORTER; GENES, TUMOR SUPPRESSOR; GLUTATHIONE TRANSFERASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 1442352122     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207219     Document Type: Article

References (29)

1. Andrews NC and Faller DV. (1991). Nucleic Acids Res., 19, 2499.
2. Chacko BM, Qin B, Correia JJ, Lam SS, de Caestecker MP and Lin K. (2001). Nat. Struct. Biol., 8, 248-253.
3. Chen CR, Kang Y, Siegel PM and Massague J. (2002). Cell, 110, 19-32.
4. Chen Y, Bhushan A and Vale W. (1997). Proc. Natl. Acad. Sci. USA, 94, 12938-12943.
5. Datto MB, Yu Y and Wang XF. (1995). J. Biol. Chem., 270, 28623-28628.
6. de Caestecker MP, Piek E and Roberts AB. (2000). J. Natl. Cancer Inst., 92, 1388-1402.
7. Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH and Kern SE. (1996). Science, 271, 350-353.
8. Hannon GJ and Beach D. (1994). Nature, 371, 257-261.
9. Hata A, Lo RS, Wotton D, Lagna G and Massague J. (1997). Nature, 388, 82-87.
10. Heldin CH, Miyazono K and ten Dijke P. (1997). Nature, 390, 465-471.
11. Howe JR, Roth S, Ringold JC, Summers RW, Jarvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM and Aaltonen LA. (1998). Science, 280, 1086-1088.
12. Lagna G, Hata A, Hemmati-Brivanlou A and Massague J. (1996). Nature, 383, 832-836.
13. Li W, Chen F, Nagarajan RP, Liu X and Chen Y. (2001). Biochem. Biophys. Res. Commun., 286, 1163-1169.
14. Liu F, Pouponnot C and Massague J. (1997). Genes Dev., 11, 3157-3167.
15. Lo RS, Chen YG, Shi Y, Pavletich NP and Massague J. (1998). EMBO J., 17, 996-1005.
16. Massague J. (1998). Annu. Rev. Biochem., 67, 753-791.
17. Massague J and Wotton D. (2000). EMBO J., 19, 1745-1754.
18. Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, Yasuno M, Hishima T, Koike M, Shitara N, Iwama T, Utsunomiya J, Kuroki T and Mon T. (1999). Oncogene, 18, 3098-3103.
19. Miyazono K, Kusanagi K and Inoue H. (2001). J. Cell Physiol., 187, 265-276.
20. Moren A, Itoh S, Moustakas A, Dijke P and Heldin CH. (2000). Oncogene, 19, 4396-4404.
21. Moustakas A and Kardassis D. (1998). Proc. Natl. Acad. Sci. USA, 95, 6733-6738.
22. Nagarajan RP and Chen Y. (2000). Biochem. J., 350 (Part 1), 253-259.
23. Nagarajan RP, Zhang J, Li W and Chen Y. (1999). J. Biol. Chem., 274, 33412-33418.
24. Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM and Koff A. (1994). Genes Dev., 8, 9-22.
25. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero Jr RA, Meltzer PS, Hahn SA and Kern SE. (1996). Cancer Res., 56, 2527-2530.
26. Shi Y, Hata A, Lo RS, Massague J and Pavletich NP. (1997). Nature, 388, 87-93.
27. Shi Y, Wang YF, Jayaraman L, Yang H, Massague J and Pavletich NP. (1998). Cell, 94, 585-594.
28. Wrana JL, Attisano L, Wieser R, Ventura F and Massague J. (1994). Nature, 370, 341-347.
29. Xiao Z, Latek R and Lodish HF. (2003). Oncogene, 22, 1057-1069.