Irregular circulating insulin concentrations in type 2 diabetes mellitus: An inverse relationship between circulating free fatty acid and the disorderliness of an insulin time series in diabetic and healthy individuals

Metabolism: Clinical and Experimental

Volumn 50, Issue 1, 2001, Pages 41-46

  Schmitz, Ole ^a,b,c   Juhl, Claus B ^a,b,c   Hollingdal, Malene ^a,b,c   Veldhuis, Johannes D ^a,b,c   Porksen, Niels ^a,b,c   Pincus, Steven M ^a,b,c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN;

ADULT; ARTICLE; CELL FUNCTION; CIRCULATION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ASSOCIATION; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN METABOLISM; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS CELL; PRIORITY JOURNAL; STATISTICAL PARAMETERS;

EID: 0035176023     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2001.19524     Document Type: Article

References (41)

1. Immunoassay of endogenous plasma insulin in man
2. Natural history of beta-cell dysfunction in NIDDM
3. Beta-cells in type II diabetes mellitus
4. Non-insulin-dependent diabetes mellitus - A genetically programmed failure of the beta cell to compensate for insulin resistance
5. Regulation of beta cell function in vivo. From health to disease
6. Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys
7. Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings
8. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting
9. In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts
10. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects
11. Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration
12. Oscillations in insulin secretion during constant glucose infusion in normal man: Relationship to changes in plasma glucose
13. Pulsatile insulin has greater hypoglycemic effect than continuous delivery
14. Greater efficacy of pulsatile insulin in type I diabetics critically depends on plasma glucagon levels
15. 3H]glucose studies in healthy subjects
16. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man
17. Enzyme immunoassay for intact human insulin in serum or plasma
18. Approximate entropy as a measure of system complexity
19. Randomness and degrees of irregularity
20. Follicle-stimulating hormone is secreted more irregularly than luteinizing hormone in both humans and sheep
21. Quantification of hormone pulsatility via an approximate entropy algorithm
22. Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals
23. Disorderly and non-stationary insulin secretion in relatives of patients with NIDDM
24. Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males
25. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
26. Physiological time-series analysis: What does regularity quantify?
27. Approximate entropy: Statistical properties and applications
28. Are metabolic oscillations responsible for normal oscillatory insulin secretion?
29. Role of plasma free fatty acids in the control of insulin secretion in man
30. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
31. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
32. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation
33. A fatty acid-dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion
34. Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects
35. Circulating fatty acids are essential for efficiency glucose-stimulated insulin secretion after prolonged fasting in humans
36. Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes
37. Fatty acids, lipotoxicity and insulin secretion
38. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
39. Fatty acids and beta-cell function
40. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications