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Volumn 32, Issue 1, 2005, Pages 85-97

Chronic lymphocytic leukemia: A review of some new aspects of the biology, factors influencing prognosis and therapeutic options

Author keywords

Biology; Chronic lymphocytic leukemia; Pathogenesis; Prognostic factors; Treatment options

Indexed keywords

ALEMTUZUMAB; CD5 ANTIGEN; CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; DNA VACCINE; FLUDARABINE; MITOXANTRONE; MONOCLONAL ANTIBODY; PURINE DERIVATIVE; RITUXIMAB;

EID: 14344264726     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transci.2004.10.012     Document Type: Conference Paper
Times cited : (19)

References (122)
  • 1
    • 0032941221 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia: A bird of a different feather
    • F. Caligaris-Cappio, and T.J. Hamblin B-cell chronic lymphocytic leukemia: a bird of a different feather J Clin Oncol 17 1 1999 399 408
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 399-408
    • Caligaris-Cappio, F.1    Hamblin, T.J.2
  • 2
    • 0003012025 scopus 로고
    • Chronic lymphocytic leukemia
    • A. Polliack D. Catovsky Harwood Academic Publishers Chur
    • M.S. Linet Chronic lymphocytic leukemia A. Polliack D. Catovsky The epidemiology of chronic lymphocytic leukemia 1988 Harwood Academic Publishers Chur 11 32
    • (1988) The Epidemiology of Chronic Lymphocytic Leukemia , pp. 11-32
    • Linet, M.S.1
  • 3
    • 14344255537 scopus 로고    scopus 로고
    • Chronic lymphoid leukemias
    • B.D. Cheson 2nd ed M. Dekker New York
    • M. Sgambati, M.S. Linet, and S. Devesa Chronic lymphoid leukemias B.D. Cheson Chronic lymphoid leukemias 2nd ed 2003 M. Dekker New York 33 62
    • (2003) Chronic Lymphoid Leukemias , pp. 33-62
    • Sgambati, M.1    Linet, M.S.2    Devesa, S.3
  • 4
    • 3242736321 scopus 로고    scopus 로고
    • Familial Risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: Results from the Swedish family-cancer database
    • L.R. Goldin, R.M. Pfeiffer, X. Li, and K. Hemminki Familial Risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: Results from the Swedish family-cancer database Blood 2004
    • (2004) Blood
    • Goldin, L.R.1    Pfeiffer, R.M.2    Li, X.3    Hemminki, K.4
  • 5
    • 0036785288 scopus 로고    scopus 로고
    • Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion
    • A.C. Rawstron, M.R. Yuille, and J. Fuller Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion Blood 100 7 2002 2289 2290
    • (2002) Blood , vol.100 , Issue.7 , pp. 2289-2290
    • Rawstron, A.C.1    Yuille, M.R.2    Fuller, J.3
  • 6
    • 2942605693 scopus 로고    scopus 로고
    • Familial B-cell chronic lymphocytic leukemia in a population of patients from Southern Italy
    • S. Capalbo, V. Callea, and C. Musolino Familial B-cell chronic lymphocytic leukemia in a population of patients from Southern Italy Int J Hematol 79 4 2004 354 357
    • (2004) Int J Hematol , vol.79 , Issue.4 , pp. 354-357
    • Capalbo, S.1    Callea, V.2    Musolino, C.3
  • 8
    • 0037100421 scopus 로고    scopus 로고
    • Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts
    • A.C. Rawstron, M.J. Green, and A. Kuzmicki Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts Blood 100 2 2002 635 639
    • (2002) Blood , vol.100 , Issue.2 , pp. 635-639
    • Rawstron, A.C.1    Green, M.J.2    Kuzmicki, A.3
  • 9
    • 1542283720 scopus 로고    scopus 로고
    • Monoclonal CD5+ and CD5-B-lymphocyte expansions are frequent in the peripheral blood of the elderly
    • P. Ghia, G. Prato, and C. Scielzo Monoclonal CD5+ and CD5-B-lymphocyte expansions are frequent in the peripheral blood of the elderly Blood 103 6 2004 2337 2342
    • (2004) Blood , vol.103 , Issue.6 , pp. 2337-2342
    • Ghia, P.1    Prato, G.2    Scielzo, C.3
  • 10
    • 3242693959 scopus 로고    scopus 로고
    • Demonstration of the genotypic relationship between CLUS and clinical B-CLL
    • S. O'Connor, A. RAwstron, M. Plummer, P. Hillmen, R. Owen, and A. Jack Demonstration of the genotypic relationship between CLUS and clinical B-CLL Leuk Lymphoma 44 Suppl 2 2003 S13
    • (2003) Leuk Lymphoma , vol.44 , Issue.SUPPL. 2 , pp. 13
    • O'Connor, S.1    Rawstron, A.2    Plummer, M.3    Hillmen, P.4    Owen, R.5    Jack, A.6
  • 11
    • 0018084656 scopus 로고
    • Subsequent cancer in patients with chronic lymphocytic leukemia-a possible immunologic mechanism
    • M.H. Greene, R.N. Hoover, and J.F. Fraumeni Jr. Subsequent cancer in patients with chronic lymphocytic leukemia-a possible immunologic mechanism J Natl Cancer Inst 61 2 1978 337 340
    • (1978) J Natl Cancer Inst , vol.61 , Issue.2 , pp. 337-340
    • Greene, M.H.1    Hoover, R.N.2    Fraumeni Jr., J.F.3
  • 14
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • F. Fais, F. Ghiotto, and S. Hashimoto Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors J Clin Invest 102 8 1998 1515 1525
    • (1998) J Clin Invest , vol.102 , Issue.8 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3
  • 15
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • R.N. Damle, T. Wasil, and F. Fais Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia Blood 94 6 1999 1840 1847
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 16
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • T.J. Hamblin, Z. Davis, A. Gardiner, D.G. Oscier, and F.K. Stevenson Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia Blood 94 6 1999 1848 1854
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 17
    • 0026696155 scopus 로고
    • Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells
    • M. Schena, L.G. Larsson, and D. Gottardi Growth- and differentiation- associated expression of bcl-2 in B-chronic lymphocytic leukemia cells Blood 79 11 1992 2981 2989
    • (1992) Blood , vol.79 , Issue.11 , pp. 2981-2989
    • Schena, M.1    Larsson, L.G.2    Gottardi, D.3
  • 18
    • 0035803464 scopus 로고    scopus 로고
    • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    • U. Klein, Y. Tu, and G.A. Stolovitzky Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells J Exp Med 194 11 2001 1625 1638
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1625-1638
    • Klein, U.1    Tu, Y.2    Stolovitzky, G.A.3
  • 19
    • 0036624881 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
    • R.N. Damle, F. Ghiotto, and A. Valetto B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes Blood 99 11 2002 4087 4093
    • (2002) Blood , vol.99 , Issue.11 , pp. 4087-4093
    • Damle, R.N.1    Ghiotto, F.2    Valetto, A.3
  • 20
    • 0037103272 scopus 로고    scopus 로고
    • Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia
    • K. Lin, P.D. Sherrington, M. Dennis, Z. Matrai, J.C. Cawley, and A.R. Pettitt Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia Blood 100 4 2002 1404 1409
    • (2002) Blood , vol.100 , Issue.4 , pp. 1404-1409
    • Lin, K.1    Sherrington, P.D.2    Dennis, M.3    Matrai, Z.4    Cawley, J.C.5    Pettitt, A.R.6
  • 21
    • 0037103212 scopus 로고    scopus 로고
    • V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
    • A. Krober, T. Seiler, and A. Benner V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia Blood 100 4 2002 1410 1416
    • (2002) Blood , vol.100 , Issue.4 , pp. 1410-1416
    • Krober, A.1    Seiler, T.2    Benner, A.3
  • 22
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • A. Rosenwald, A.A. Alizadeh, and G. Widhopf Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia J Exp Med 194 11 2001 1639 1647
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3
  • 23
    • 0037085801 scopus 로고    scopus 로고
    • Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
    • G. Tobin, U. Thunberg, and A. Johnson Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia Blood 99 6 2002 2262 2264
    • (2002) Blood , vol.99 , Issue.6 , pp. 2262-2264
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3
  • 24
    • 0842276675 scopus 로고    scopus 로고
    • ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia
    • J. Durig, H. Nuckel, and M. Cremer ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia Leukemia 17 12 2003 2426 2434
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2426-2434
    • Durig, J.1    Nuckel, H.2    Cremer, M.3
  • 25
    • 0037406968 scopus 로고    scopus 로고
    • ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • M. Crespo, F. Bosch, and N. Villamor ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia N Engl J Med 348 18 2003 1764 1775
    • (2003) N Engl J Med , vol.348 , Issue.18 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 26
    • 0347318114 scopus 로고    scopus 로고
    • ZAP-70 expression and prognosis in chronic lymphocytic leukaemia
    • J.A. Orchard, R.E. Ibbotson, and Z. Davis ZAP-70 expression and prognosis in chronic lymphocytic leukaemia Lancet 363 9403 2004 105 111
    • (2004) Lancet , vol.363 , Issue.9403 , pp. 105-111
    • Orchard, J.A.1    Ibbotson, R.E.2    Davis, Z.3
  • 27
    • 10744222814 scopus 로고    scopus 로고
    • ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
    • A. Wiestner, A. Rosenwald, and T.S. Barry ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile Blood 101 12 2003 4944 4951
    • (2003) Blood , vol.101 , Issue.12 , pp. 4944-4951
    • Wiestner, A.1    Rosenwald, A.2    Barry, T.S.3
  • 28
    • 14344257296 scopus 로고    scopus 로고
    • ZAP-70 methylation correlates with ZAP-70 protien expression and with IgVH gene mutational status in chronic lymphocytic leukemia
    • M. Corcoran, J. Orchard, Z. Davis, and D. Oscier ZAP-70 methylation correlates with ZAP-70 protien expression and with IgVH gene mutational status in chronic lymphocytic leukemia Leuk Lymphoma 44 Suppl 2 2003 S15
    • (2003) Leuk Lymphoma , vol.44 , Issue.SUPPL. 2 , pp. 15
    • Corcoran, M.1    Orchard, J.2    Davis, Z.3    Oscier, D.4
  • 30
    • 0025253488 scopus 로고
    • Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C
    • C. Hivroz, B. Geny, J.C. Brouet, and C. Grillot-Courvalin Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C J Immunol 144 6 1990 2351 2358
    • (1990) J Immunol , vol.144 , Issue.6 , pp. 2351-2358
    • Hivroz, C.1    Geny, B.2    Brouet, J.C.3    Grillot-Courvalin, C.4
  • 31
    • 0027318287 scopus 로고
    • Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx
    • F. Michel, H. Merle-Beral, E. Legac, A. Michel, P. Debre, and G. Bismuth Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx J Immunol 150 8 Pt 1 1993 3624 3633
    • (1993) J Immunol , vol.150 , Issue.8 PART 1 , pp. 3624-3633
    • Michel, F.1    Merle-Beral, H.2    Legac, E.3    Michel, A.4    Debre, P.5    Bismuth, G.6
  • 33
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • L. Chen, G. Widhopf, and L. Huynh Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia Blood 100 13 2002 4609 4614
    • (2002) Blood , vol.100 , Issue.13 , pp. 4609-4614
    • Chen, L.1    Widhopf, G.2    Huynh, L.3
  • 34
    • 0029836635 scopus 로고    scopus 로고
    • CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis
    • S. Zupo, L. Isnardi, and M. Megna CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis Blood 88 4 1996 1365 1374
    • (1996) Blood , vol.88 , Issue.4 , pp. 1365-1374
    • Zupo, S.1    Isnardi, L.2    Megna, M.3
  • 35
    • 0034651926 scopus 로고    scopus 로고
    • Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD
    • S. Zupo, R. Massara, and M. Dono Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD Blood 95 4 2000 1199 1206
    • (2000) Blood , vol.95 , Issue.4 , pp. 1199-1206
    • Zupo, S.1    Massara, R.2    Dono, M.3
  • 36
    • 0037306842 scopus 로고    scopus 로고
    • Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
    • S. Lanham, T. Hamblin, D. Oscier, R. Ibbotson, F. Stevenson, and G. Packham Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia Blood 101 3 2003 1087 1093
    • (2003) Blood , vol.101 , Issue.3 , pp. 1087-1093
    • Lanham, S.1    Hamblin, T.2    Oscier, D.3    Ibbotson, R.4    Stevenson, F.5    Packham, G.6
  • 37
    • 0024556599 scopus 로고
    • Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro
    • R.J. Collins, L.A. Verschuer, B.V. Harmon, R.L. Prentice, J.H. Pope, and J.F. Kerr Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro Br J Haematol 71 3 1989 343 350
    • (1989) Br J Haematol , vol.71 , Issue.3 , pp. 343-350
    • Collins, R.J.1    Verschuer, L.A.2    Harmon, B.V.3    Prentice, R.L.4    Pope, J.H.5    Kerr, J.F.6
  • 38
    • 0030048565 scopus 로고    scopus 로고
    • Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
    • P. Panayiotidis, D. Jones, K. Ganeshaguru, L. Foroni, and A.V. Hoffbrand Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro Br J Haematol 92 1 1996 97 103
    • (1996) Br J Haematol , vol.92 , Issue.1 , pp. 97-103
    • Panayiotidis, P.1    Jones, D.2    Ganeshaguru, K.3    Foroni, L.4    Hoffbrand, A.V.5
  • 39
    • 0032055818 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells
    • L. Lagneaux, A. Delforge, D. Bron, C. De Bruyn, and P. Stryckmans Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells Blood 91 7 1998 2387 2396
    • (1998) Blood , vol.91 , Issue.7 , pp. 2387-2396
    • Lagneaux, L.1    Delforge, A.2    Bron, D.3    De Bruyn, C.4    Stryckmans, P.5
  • 40
    • 0034051534 scopus 로고    scopus 로고
    • The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms
    • P. Ghia, and F. Caligaris-Cappio The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms Adv Cancer Res 79 2000 157 173
    • (2000) Adv Cancer Res , vol.79 , pp. 157-173
    • Ghia, P.1    Caligaris-Cappio, F.2
  • 42
    • 0242298176 scopus 로고    scopus 로고
    • Role of the microenvironment in chronic lymphocytic leukaemia
    • F. Caligaris-Cappio Role of the microenvironment in chronic lymphocytic leukaemia Br J Haematol 123 3 2003 380 388
    • (2003) Br J Haematol , vol.123 , Issue.3 , pp. 380-388
    • Caligaris-Cappio, F.1
  • 43
    • 0026754538 scopus 로고
    • Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression
    • M. Dancescu, M. Rubio-Trujillo, G. Biron, D. Bron, G. Delespesse, and M. Sarfati Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression J Exp Med 176 5 1992 1319 1326
    • (1992) J Exp Med , vol.176 , Issue.5 , pp. 1319-1326
    • Dancescu, M.1    Rubio-Trujillo, M.2    Biron, G.3    Bron, D.4    Delespesse, G.5    Sarfati, M.6
  • 44
    • 0027455756 scopus 로고
    • Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia
    • M. Buschle, D. Campana, S.R. Carding, C. Richard, A.V. Hoffbrand, and M.K. Brenner Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia J Exp Med 177 1 1993 213 218
    • (1993) J Exp Med , vol.177 , Issue.1 , pp. 213-218
    • Buschle, M.1    Campana, D.2    Carding, S.R.3    Richard, C.4    Hoffbrand, A.V.5    Brenner, M.K.6
  • 45
    • 0023937119 scopus 로고
    • Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies
    • F.T. Cordingley, A. Bianchi, and A.V. Hoffbrand Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies Lancet 1 8592 1988 969 971
    • (1988) Lancet , vol.1 , Issue.8592 , pp. 969-971
    • Cordingley, F.T.1    Bianchi, A.2    Hoffbrand, A.V.3
  • 46
    • 0025673975 scopus 로고
    • Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders
    • H.E. Heslop, A.C. Bianchi, and F.T. Cordingley Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders J Exp Med 172 6 1990 1729 1734
    • (1990) J Exp Med , vol.172 , Issue.6 , pp. 1729-1734
    • Heslop, H.E.1    Bianchi, A.C.2    Cordingley, F.T.3
  • 47
    • 0026674624 scopus 로고
    • Interleukin-4 inhibits both paracrine and autocrine tumor necrosis factor-alpha-induced proliferation of B chronic lymphocytic leukemia cells
    • C. van Kooten, I. Rensink, L. Aarden, and R. van Oers Interleukin-4 inhibits both paracrine and autocrine tumor necrosis factor-alpha-induced proliferation of B chronic lymphocytic leukemia cells Blood 80 5 1992 1299 1306
    • (1992) Blood , vol.80 , Issue.5 , pp. 1299-1306
    • Van Kooten, C.1    Rensink, I.2    Aarden, L.3    Van Oers, R.4
  • 48
    • 0035195486 scopus 로고    scopus 로고
    • Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D
    • A. Olsson, T. Diaz, and M. Aguilar-Santelises Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D Leukemia 15 12 2001 1868 1877
    • (2001) Leukemia , vol.15 , Issue.12 , pp. 1868-1877
    • Olsson, A.1    Diaz, T.2    Aguilar-Santelises, M.3
  • 49
    • 0037015675 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia
    • M. MacFarlane, N. Harper, and R.T. Snowden Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia Oncogene 21 44 2002 6809 6818
    • (2002) Oncogene , vol.21 , Issue.44 , pp. 6809-6818
    • MacFarlane, M.1    Harper, N.2    Snowden, R.T.3
  • 50
    • 0029145624 scopus 로고
    • Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia
    • P. Panayiotidis, K. Ganeshaguru, L. Foroni, and A.V. Hoffbrand Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia Leukemia 9 7 1995 1227 1232
    • (1995) Leukemia , vol.9 , Issue.7 , pp. 1227-1232
    • Panayiotidis, P.1    Ganeshaguru, K.2    Foroni, L.3    Hoffbrand, A.V.4
  • 51
    • 0030971074 scopus 로고    scopus 로고
    • Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies
    • D. Wang, G.J. Freeman, H. Levine, J. Ritz, and M.J. Robertson Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies Br J Haematol 97 2 1997 409 417
    • (1997) Br J Haematol , vol.97 , Issue.2 , pp. 409-417
    • Wang, D.1    Freeman, G.J.2    Levine, H.3    Ritz, J.4    Robertson, M.J.5
  • 52
    • 0032710091 scopus 로고    scopus 로고
    • Fas-mediated lysis of chronic lymphocytic leukaemia cells: Role of type I versus type II cytokines and autologous fasL-expressing T cells
    • J.F. Williams, M.J. Petrus, and J.A. Wright Fas-mediated lysis of chronic lymphocytic leukaemia cells: role of type I versus type II cytokines and autologous fasL-expressing T cells Br J Haematol 107 1 1999 99 105
    • (1999) Br J Haematol , vol.107 , Issue.1 , pp. 99-105
    • Williams, J.F.1    Petrus, M.J.2    Wright, J.A.3
  • 53
    • 0034796299 scopus 로고    scopus 로고
    • Upstream mediators of the Fas apoptotic transduction pathway are defective in B-chronic lymphocytic leukemia
    • G. Roue, L. Lancry, F. Duquesne, V. Salaun, X. Troussard, and B. Sola Upstream mediators of the Fas apoptotic transduction pathway are defective in B-chronic lymphocytic leukemia Leuk Res 25 11 2001 967 980
    • (2001) Leuk Res , vol.25 , Issue.11 , pp. 967-980
    • Roue, G.1    Lancry, L.2    Duquesne, F.3    Salaun, V.4    Troussard, X.5    Sola, B.6
  • 54
    • 0037133603 scopus 로고    scopus 로고
    • Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia
    • P. Chu, D. Deforce, and I.M. Pedersen Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia Proc Natl Acad Sci USA 99 6 2002 3854 3859
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.6 , pp. 3854-3859
    • Chu, P.1    Deforce, D.2    Pedersen, I.M.3
  • 55
    • 0028998314 scopus 로고
    • Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells
    • T. Mainou-Fowler, J.A. Copplestone, and A.G. Prentice Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells J Clin Pathol 48 5 1995 482 487
    • (1995) J Clin Pathol , vol.48 , Issue.5 , pp. 482-487
    • Mainou-Fowler, T.1    Copplestone, J.A.2    Prentice, A.G.3
  • 56
    • 0027379859 scopus 로고
    • Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro
    • P. Panayiotidis, K. Ganeshaguru, S.A. Jabbar, and A.V. Hoffbrand Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro Br J Haematol 85 3 1993 439 445
    • (1993) Br J Haematol , vol.85 , Issue.3 , pp. 439-445
    • Panayiotidis, P.1    Ganeshaguru, K.2    Jabbar, S.A.3    Hoffbrand, A.V.4
  • 57
    • 0035106335 scopus 로고    scopus 로고
    • Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B-CLL patients: Impact on clonal B-cell apoptosis
    • N.E. Kay, L. Han, N. Bone, and G. Williams Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B-CLL patients: impact on clonal B-cell apoptosis Br J Haematol 112 3 2001 760 767
    • (2001) Br J Haematol , vol.112 , Issue.3 , pp. 760-767
    • Kay, N.E.1    Han, L.2    Bone, N.3    Williams, G.4
  • 58
    • 0029930173 scopus 로고    scopus 로고
    • Interleukin-8 induces the accumulation of B-cell chronic lymphocytic leukemia cells by prolonging survival in an autocrine fashion
    • P. Francia di Celle, S. Mariani, L. Riera, A. Stacchini, G. Reato, and R. Foa Interleukin-8 induces the accumulation of B-cell chronic lymphocytic leukemia cells by prolonging survival in an autocrine fashion Blood 87 10 1996 4382 4389
    • (1996) Blood , vol.87 , Issue.10 , pp. 4382-4389
    • Francia Di Celle, P.1    Mariani, S.2    Riera, L.3    Stacchini, A.4    Reato, G.5    Foa, R.6
  • 59
    • 0029821199 scopus 로고    scopus 로고
    • Inhibition of apoptotic cell death in B-CLL by interferon gamma correlates with clinical stage
    • R. Rojas, J. Roman, and A. Torres Inhibition of apoptotic cell death in B-CLL by interferon gamma correlates with clinical stage Leukemia 10 11 1996 1782 1788
    • (1996) Leukemia , vol.10 , Issue.11 , pp. 1782-1788
    • Rojas, R.1    Roman, J.2    Torres, A.3
  • 60
    • 0032705222 scopus 로고    scopus 로고
    • Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia
    • S. Molica, G. Vitelli, D. Levato, G.M. Gandolfo, and V. Liso Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia Br J Haematol 107 3 1999 605 610
    • (1999) Br J Haematol , vol.107 , Issue.3 , pp. 605-610
    • Molica, S.1    Vitelli, G.2    Levato, D.3    Gandolfo, G.M.4    Liso, V.5
  • 61
    • 0036099832 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    • P. Ghia, G. Strola, and L. Granziero Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22 Eur J Immunol 32 5 2002 1403 1413
    • (2002) Eur J Immunol , vol.32 , Issue.5 , pp. 1403-1413
    • Ghia, P.1    Strola, G.2    Granziero, L.3
  • 62
    • 0035353212 scopus 로고    scopus 로고
    • Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
    • L. Granziero, P. Ghia, and P. Circosta Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia Blood 97 9 2001 2777 2783
    • (2001) Blood , vol.97 , Issue.9 , pp. 2777-2783
    • Granziero, L.1    Ghia, P.2    Circosta, P.3
  • 63
    • 0033485625 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
    • J.A. Burger, M. Burger, and T.J. Kipps Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells Blood 94 11 1999 3658 3667
    • (1999) Blood , vol.94 , Issue.11 , pp. 3658-3667
    • Burger, J.A.1    Burger, M.2    Kipps, T.J.3
  • 64
    • 0344577963 scopus 로고    scopus 로고
    • Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)
    • R. Mohle, C. Failenschmid, F. Bautz, and L. Kanz Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1) Leukemia 13 12 1999 1954 1959
    • (1999) Leukemia , vol.13 , Issue.12 , pp. 1954-1959
    • Mohle, R.1    Failenschmid, C.2    Bautz, F.3    Kanz, L.4
  • 65
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • J.A. Burger, N. Tsukada, M. Burger, N.J. Zvaifler, M. Dell'Aquila, and T.J. Kipps Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1 Blood 96 8 2000 2655 2663
    • (2000) Blood , vol.96 , Issue.8 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3    Zvaifler, N.J.4    Dell'Aquila, M.5    Kipps, T.J.6
  • 66
    • 0024546379 scopus 로고
    • Chronic lymphocytic leukemia: recommendations for diagnosis, staging, and response criteria. International Workshop on Chronic Lymphocytic Leukemia
    • Chronic lymphocytic leukemia: recommendations for diagnosis, staging, and response criteria. International Workshop on Chronic Lymphocytic Leukemia. Ann Intern Med 1989;110(3):236-8
    • (1989) Ann Intern Med , vol.110 , Issue.3 , pp. 236-238
  • 67
    • 0023717101 scopus 로고
    • Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the National Cancer Institute-sponsored working group
    • B.D. Cheson, J.M. Bennett, and K.R. Rai Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group Am J Hematol 29 3 1988 152 163
    • (1988) Am J Hematol , vol.29 , Issue.3 , pp. 152-163
    • Cheson, B.D.1    Bennett, J.M.2    Rai, K.R.3
  • 68
    • 2442554041 scopus 로고    scopus 로고
    • Guidelines on the diagnosis and management of chronic lymphocytic leukaemia
    • D. Oscier, C. Fegan, and P. Hillmen Guidelines on the diagnosis and management of chronic lymphocytic leukaemia Br J Haematol 125 3 2004 294 317
    • (2004) Br J Haematol , vol.125 , Issue.3 , pp. 294-317
    • Oscier, D.1    Fegan, C.2    Hillmen, P.3
  • 69
    • 0028149568 scopus 로고
    • The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL
    • E. Matutes, K. Owusu-Ankomah, and R. Morilla The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL Leukemia 8 10 1994 1640 1645
    • (1994) Leukemia , vol.8 , Issue.10 , pp. 1640-1645
    • Matutes, E.1    Owusu-Ankomah, K.2    Morilla, R.3
  • 70
    • 0030820069 scopus 로고    scopus 로고
    • Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)
    • E.J. Moreau, E. Matutes, and R.P. A'Hern Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b) Am J Clin Pathol 108 4 1997 378 382
    • (1997) Am J Clin Pathol , vol.108 , Issue.4 , pp. 378-382
    • Moreau, E.J.1    Matutes, E.2    A'Hern, R.P.3
  • 71
    • 0024318576 scopus 로고
    • Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group
    • J.M. Bennett, D. Catovsky, and M.T. Daniel Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group J Clin Pathol 42 6 1989 567 584
    • (1989) J Clin Pathol , vol.42 , Issue.6 , pp. 567-584
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 72
    • 0027284001 scopus 로고
    • Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: Analysis by stage, immunophenotype, and morphology
    • T.H. Que, J.G. Marco, and J. Ellis Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: analysis by stage, immunophenotype, and morphology Blood 82 2 1993 571 575
    • (1993) Blood , vol.82 , Issue.2 , pp. 571-575
    • Que, T.H.1    Marco, J.G.2    Ellis, J.3
  • 73
    • 0027288539 scopus 로고
    • Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia
    • S.M. Escudier, J.M. Pereira-Leahy, and J.W. Drach Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia Blood 81 10 1993 2702 2707
    • (1993) Blood , vol.81 , Issue.10 , pp. 2702-2707
    • Escudier, S.M.1    Pereira-Leahy, J.M.2    Drach, J.W.3
  • 74
    • 14344259743 scopus 로고    scopus 로고
    • Differential diagnosis of the chronic B-cell lymphoid leukemias
    • B.D. Cheson 2nd ed. Marcel Dekker New York
    • R. Gascoyne Differential diagnosis of the chronic B-cell lymphoid leukemias B.D. Cheson Chronic Lymphoid Leukemias 2nd ed. 2001 Marcel Dekker New York 209 230
    • (2001) Chronic Lymphoid Leukemias , pp. 209-230
    • Gascoyne, R.1
  • 76
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • J.L. Binet, A. Auquier, and G. Dighiero A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis Cancer 48 1 1981 198 206
    • (1981) Cancer , vol.48 , Issue.1 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3
  • 77
    • 0026091985 scopus 로고
    • Progression and survival studies in early chronic lymphocytic leukemia
    • S. Molica Progression and survival studies in early chronic lymphocytic leukemia Blood 78 4 1991 895 899
    • (1991) Blood , vol.78 , Issue.4 , pp. 895-899
    • Molica, S.1
  • 78
    • 0027303335 scopus 로고
    • Prognostic features and survival in young adults with early/intermediate chronic lymphocytic leukemia (B-CLL): A single institution study
    • M. Dhodapkar, A. Tefferi, J. Su, and R.L. Phyliky Prognostic features and survival in young adults with early/intermediate chronic lymphocytic leukemia (B-CLL): a single institution study Leukemia 7 8 1993 1232 1235
    • (1993) Leukemia , vol.7 , Issue.8 , pp. 1232-1235
    • Dhodapkar, M.1    Tefferi, A.2    Su, J.3    Phyliky, R.L.4
  • 79
    • 0033566295 scopus 로고    scopus 로고
    • Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: A single institution study of 204 cases
    • F.R. Mauro, R. Foa, and D. Giannarelli Clinical characteristics and outcome of young chronic lymphocytic leukemia patients: a single institution study of 204 cases Blood 94 2 1999 448 454
    • (1999) Blood , vol.94 , Issue.2 , pp. 448-454
    • Mauro, F.R.1    Foa, R.2    Giannarelli, D.3
  • 80
    • 0842285686 scopus 로고    scopus 로고
    • Prognosis at diagnosis: Integrating molecular biologic insights into clinical practice for patients with CLL
    • T.D. Shanafelt, S.M. Geyer, and N.E. Kay Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL Blood 103 4 2004 1202 1210
    • (2004) Blood , vol.103 , Issue.4 , pp. 1202-1210
    • Shanafelt, T.D.1    Geyer, S.M.2    Kay, N.E.3
  • 81
    • 0038038462 scopus 로고    scopus 로고
    • Current therapeutic options for subgroups of chronic lymphocytic leukemia. Planning risk-adapted treatment according to recognized prognostic factors
    • A. Polliack Current therapeutic options for subgroups of chronic lymphocytic leukemia. Planning risk-adapted treatment according to recognized prognostic factors Haematologica 88 7 2003 726 729
    • (2003) Haematologica , vol.88 , Issue.7 , pp. 726-729
    • Polliack, A.1
  • 82
    • 0024255987 scopus 로고
    • Natural history of chronic lymphocytic leukemia: On the progression and progression and prognosis of early clinical stages
    • E. Montserrat, N. Vinolas, J.C. Reverter, and C. Rozman Natural history of chronic lymphocytic leukemia: on the progression and progression and prognosis of early clinical stages Nouv Rev Fr Hematol 30 5-6 1988 359 361
    • (1988) Nouv Rev Fr Hematol , vol.30 , Issue.5-6 , pp. 359-361
    • Montserrat, E.1    Vinolas, N.2    Reverter, J.C.3    Rozman, C.4
  • 83
    • 0025132331 scopus 로고
    • Natural history of stage a chronic lymphocytic leukaemia untreated patients. French Cooperative Group on Chronic Lymphocytic Leukaemia
    • Natural history of stage A chronic lymphocytic leukaemia untreated patients. French Cooperative Group on Chronic Lymphocytic Leukaemia. Br J Haematol 1990;76(1):45-57
    • (1990) Br J Haematol , vol.76 , Issue.1 , pp. 45-57
  • 84
    • 0022569746 scopus 로고
    • Lymphocyte doubling time in chronic lymphocytic leukaemia: Analysis of its prognostic significance
    • E. Montserrat, J. Sanchez-Bisono, N. Vinolas, and C. Rozman Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance Br J Haematol 62 3 1986 567 575
    • (1986) Br J Haematol , vol.62 , Issue.3 , pp. 567-575
    • Montserrat, E.1    Sanchez-Bisono, J.2    Vinolas, N.3    Rozman, C.4
  • 85
    • 0021270274 scopus 로고
    • Bone marrow histologic pattern-the best single prognostic parameter in chronic lymphocytic leukemia: A multivariate survival analysis of 329 cases
    • C. Rozman, E. Montserrat, and J.M. Rodriguez-Fernandez Bone marrow histologic pattern-the best single prognostic parameter in chronic lymphocytic leukemia: a multivariate survival analysis of 329 cases Blood 64 3 1984 642 648
    • (1984) Blood , vol.64 , Issue.3 , pp. 642-648
    • Rozman, C.1    Montserrat, E.2    Rodriguez-Fernandez, J.M.3
  • 86
    • 0028959982 scopus 로고
    • Chronic lymphocytic leukemia: Present status
    • E. Montserrat, and C. Rozman Chronic lymphocytic leukemia: present status Ann Oncol 6 3 1995 219 235
    • (1995) Ann Oncol , vol.6 , Issue.3 , pp. 219-235
    • Montserrat, E.1    Rozman, C.2
  • 87
    • 0029912022 scopus 로고    scopus 로고
    • Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia
    • M. Sarfati, S. Chevret, and C. Chastang Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia Blood 88 11 1996 4259 4264
    • (1996) Blood , vol.88 , Issue.11 , pp. 4259-4264
    • Sarfati, M.1    Chevret, S.2    Chastang, C.3
  • 88
    • 0033106396 scopus 로고    scopus 로고
    • Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia
    • M. Hallek, I. Langenmayer, and C. Nerl Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia Blood 93 5 1999 1732 1737
    • (1999) Blood , vol.93 , Issue.5 , pp. 1732-1737
    • Hallek, M.1    Langenmayer, I.2    Nerl, C.3
  • 89
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • H. Dohner, S. Stilgenbauer, and A. Benner Genomic aberrations and survival in chronic lymphocytic leukemia N Engl J Med 343 26 2000 1910 1916
    • (2000) N Engl J Med , vol.343 , Issue.26 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 90
    • 0037103257 scopus 로고    scopus 로고
    • Multivariate analysis of prognostic factors in CLL: Clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors
    • D.G. Oscier, A.C. Gardiner, and S.J. Mould Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors Blood 100 4 2002 1177 1184
    • (2002) Blood , vol.100 , Issue.4 , pp. 1177-1184
    • Oscier, D.G.1    Gardiner, A.C.2    Mould, S.J.3
  • 91
    • 0000585311 scopus 로고
    • The serum beta-2-microglobulin level is more powerful than stage in predicting response and survival in CLL
    • M.L. Keating, and S.H.M. Kantarjian The serum beta-2-microglobulin level is more powerful than stage in predicting response and survival in CLL Blood 86 1995 606a
    • (1995) Blood , vol.86
    • Keating, M.L.1    Kantarjian, S.H.M.2
  • 92
    • 0036464608 scopus 로고    scopus 로고
    • CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease
    • T.J. Hamblin, J.A. Orchard, and R.E. Ibbotson CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease Blood 99 3 2002 1023 1029
    • (2002) Blood , vol.99 , Issue.3 , pp. 1023-1029
    • Hamblin, T.J.1    Orchard, J.A.2    Ibbotson, R.E.3
  • 93
    • 0025112785 scopus 로고
    • Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities
    • G. Juliusson, D.G. Oscier, and M. Fitchett Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities N Engl J Med 323 11 1990 720 724
    • (1990) N Engl J Med , vol.323 , Issue.11 , pp. 720-724
    • Juliusson, G.1    Oscier, D.G.2    Fitchett, M.3
  • 94
    • 1842328565 scopus 로고    scopus 로고
    • 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
    • H. Dohner, S. Stilgenbauer, and M.R. James 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis Blood 89 7 1997 2516 2522
    • (1997) Blood , vol.89 , Issue.7 , pp. 2516-2522
    • Dohner, H.1    Stilgenbauer, S.2    James, M.R.3
  • 95
    • 0027436745 scopus 로고
    • P53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • S. el Rouby, A. Thomas, and D. Costin p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression Blood 82 11 1993 3452 3459
    • (1993) Blood , vol.82 , Issue.11 , pp. 3452-3459
    • El Rouby, S.1    Thomas, A.2    Costin, D.3
  • 96
    • 0028987180 scopus 로고
    • P53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • H. Dohner, K. Fischer, and M. Bentz p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias Blood 85 6 1995 1580 1589
    • (1995) Blood , vol.85 , Issue.6 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3
  • 97
    • 14344251191 scopus 로고    scopus 로고
    • Proceedings of the meeting on chronic lymphocytic leukemia: Is it a curable disease?
    • Proceedings of the meeting on chronic lymphocytic leukemia: Is it a curable disease? Haematologica 2002;87(Suppl 10):1-79
    • (2002) Haematologica , vol.87 , Issue.10 SUPPL. , pp. 1-79
  • 98
    • 0038198186 scopus 로고    scopus 로고
    • Risk- and age-adapted management of CLL: Current and future clinical trials of the German CLL study group
    • M. Hallek Risk- and age-adapted management of CLL: current and future clinical trials of the German CLL study group Hematologica 87 Suppl 11 2002 37 38
    • (2002) Hematologica , vol.87 , Issue.SUPPL. 11 , pp. 37-38
    • Hallek, M.1
  • 99
    • 0037860443 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia: Different therapies for different diseases?
    • M. Brugiatelli, M. Domenico, M. Donato, and S. Neri B-cell chronic lymphocytic leukemia: different therapies for different diseases? Hematologica 87 Suppl 11 2002 34 36
    • (2002) Hematologica , vol.87 , Issue.SUPPL. 11 , pp. 34-36
    • Brugiatelli, M.1    Domenico, M.2    Donato, M.3    Neri, S.4
  • 100
    • 0025847778 scopus 로고
    • Chronic lymphocytic leukaemia: Prognostic value of lymphocyte morphological subtypes. a multivariate survival analysis in 146 patients
    • T. Vallespi, E. Montserrat, and M.A. Sanz Chronic lymphocytic leukaemia: prognostic value of lymphocyte morphological subtypes. A multivariate survival analysis in 146 patients Br J Haematol 77 4 1991 478 485
    • (1991) Br J Haematol , vol.77 , Issue.4 , pp. 478-485
    • Vallespi, T.1    Montserrat, E.2    Sanz, M.A.3
  • 101
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • J.C. Byrd, T. Murphy, and R.S. Howard Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity J Clin Oncol 19 8 2001 2153 2164
    • (2001) J Clin Oncol , vol.19 , Issue.8 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 102
    • 0036839469 scopus 로고    scopus 로고
    • Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
    • H. Schulz, S.K. Klein, and U. Rehwald Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia Blood 100 9 2002 3115 3120
    • (2002) Blood , vol.100 , Issue.9 , pp. 3115-3120
    • Schulz, H.1    Klein, S.K.2    Rehwald, U.3
  • 103
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • J.C. Byrd, B.L. Peterson, and V.A. Morrison Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712) Blood 101 1 2003 6 14
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 104
    • 0037522838 scopus 로고    scopus 로고
    • Mabthera in chronic lymphocytic leukemia
    • S. O'Brien Mabthera in chronic lymphocytic leukemia Hematologica 87 Suppl 11 2002 50 53
    • (2002) Hematologica , vol.87 , Issue.SUPPL. 11 , pp. 50-53
    • O'Brien, S.1
  • 105
    • 0037522837 scopus 로고    scopus 로고
    • A high proportion of molecular remission can be obtained with a fludarabine, cyclophosphamide, rituximab combination (FCR) in chronic lymphocytic leukemia (CLL)
    • M. Keating, T. Manshouri, and S. O'Brien A high proportion of molecular remission can be obtained with a fludarabine, cyclophosphamide, rituximab combination (FCR) in chronic lymphocytic leukemia (CLL) Blood 100 11 2002 205a
    • (2002) Blood , vol.100 , Issue.11
    • Keating, M.1    Manshouri, T.2    O'Brien, S.3
  • 106
    • 0037860441 scopus 로고    scopus 로고
    • A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia (CLL) patients with active disease: Cancer and Leukemia Group B (CALGB) Study 19901
    • K. Rai, J. Byrd, B. Peterson, and R. Larson A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia (CLL) patients with active disease: Cancer and Leukemia Group B (CALGB) Study 19901 Blood 100 11 2002 205a
    • (2002) Blood , vol.100 , Issue.11
    • Rai, K.1    Byrd, J.2    Peterson, B.3    Larson, R.4
  • 107
    • 0037860440 scopus 로고    scopus 로고
    • MabCampath in chronic lymphocytic leukemia
    • P. Hillmen MabCampath in chronic lymphocytic leukemia Hematologica 87 Suppl 11 2002 47 49
    • (2002) Hematologica , vol.87 , Issue.SUPPL. 11 , pp. 47-49
    • Hillmen, P.1
  • 108
    • 9544236183 scopus 로고    scopus 로고
    • Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation
    • D. Provan, L. Bartlett-Pandite, and C. Zwicky Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation Blood 88 6 1996 2228 2235
    • (1996) Blood , vol.88 , Issue.6 , pp. 2228-2235
    • Provan, D.1    Bartlett-Pandite, L.2    Zwicky, C.3
  • 109
    • 0030665507 scopus 로고    scopus 로고
    • Analysis of residual disease in chronic lymphocytic leukemia by flow cytometry
    • E. Cabezudo, E. Matutes, M. Ramrattan, R. Morilla, and D. Catovsky Analysis of residual disease in chronic lymphocytic leukemia by flow cytometry Leukemia 11 11 1997 1909 1914
    • (1997) Leukemia , vol.11 , Issue.11 , pp. 1909-1914
    • Cabezudo, E.1    Matutes, E.2    Ramrattan, M.3    Morilla, R.4    Catovsky, D.5
  • 110
    • 0035412369 scopus 로고    scopus 로고
    • Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy
    • A.C. Rawstron, B. Kennedy, and P.A. Evans Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy Blood 98 1 2001 29 35
    • (2001) Blood , vol.98 , Issue.1 , pp. 29-35
    • Rawstron, A.C.1    Kennedy, B.2    Evans, P.A.3
  • 111
    • 0013253465 scopus 로고    scopus 로고
    • Genasense (Bcl-2 Antisense) Monotherapy in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Phase 1 and 2 Results
    • K. Rai, S. O'Brien, and C. Cunningham Genasense (Bcl-2 Antisense) Monotherapy in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Phase 1 and 2 Results Blood 100 11 2002 384a
    • (2002) Blood , vol.100 , Issue.11
    • Rai, K.1    O'Brien, S.2    Cunningham, C.3
  • 112
    • 0038536846 scopus 로고    scopus 로고
    • New drugs: Can they cure CLL?
    • B. Cheson New drugs: can they cure CLL? Hematologica 87 Suppl 11 2002 56 58
    • (2002) Hematologica , vol.87 , Issue.SUPPL. 11 , pp. 56-58
    • Cheson, B.1
  • 113
    • 0035084795 scopus 로고    scopus 로고
    • Stem cell transplantation for chronic lymphocytic leukemia: Different outcome after autologous and allogeneic transplantation and correlation with minimal residual disease status
    • J. Esteve, N. Villamor, and D. Colomer Stem cell transplantation for chronic lymphocytic leukemia: different outcome after autologous and allogeneic transplantation and correlation with minimal residual disease status Leukemia 15 3 2001 445 451
    • (2001) Leukemia , vol.15 , Issue.3 , pp. 445-451
    • Esteve, J.1    Villamor, N.2    Colomer, D.3
  • 114
    • 0035895068 scopus 로고    scopus 로고
    • Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: Low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality
    • I.F. Khouri, R.M. Saliba, and S.A. Giralt Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality Blood 98 13 2001 3595 3599
    • (2001) Blood , vol.98 , Issue.13 , pp. 3595-3599
    • Khouri, I.F.1    Saliba, R.M.2    Giralt, S.A.3
  • 115
    • 0035995199 scopus 로고    scopus 로고
    • Long-term follow-up of patients with CLL treated with allogeneic hematopoietic transplantation
    • I.F. Khouri, M.J. Keating, R.M. Saliba, and R.E. Champlin Long-term follow-up of patients with CLL treated with allogeneic hematopoietic transplantation Cytotherapy 4 3 2002 217 221
    • (2002) Cytotherapy , vol.4 , Issue.3 , pp. 217-221
    • Khouri, I.F.1    Keating, M.J.2    Saliba, R.M.3    Champlin, R.E.4
  • 116
    • 0037522840 scopus 로고    scopus 로고
    • Reduced intensity regimens for CLL: The MD Anderson experience
    • I. Khouri Reduced intensity regimens for CLL: The MD Anderson experience Hematologica 87 Suppl 11 2002 76 77
    • (2002) Hematologica , vol.87 , Issue.SUPPL. 11 , pp. 76-77
    • Khouri, I.1
  • 117
    • 0038198179 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation for CLL: Background and results from the EBMT Registry
    • G. Bandini, F. Bonifazi, and S. Falcioni Allogeneic hematopoietic stem cell transplantation for CLL: Background and results from the EBMT Registry Hematologica 87 11 2002 68 75
    • (2002) Hematologica , vol.87 , Issue.11 , pp. 68-75
    • Bandini, G.1    Bonifazi, F.2    Falcioni, S.3
  • 118
    • 0034128720 scopus 로고    scopus 로고
    • Peripheral blood stem cell (PBSC) mobilization and transplantation after fludarabine therapy in chronic lymphocytic leukaemia (CLL): A report of the European Blood and Marrow Transplantation (EBMT) CLL subcommittee on behalf of the EBMT Chronic Leukaemias Working Party (CLWP)
    • M. Michallet, A. Thiebaut, and P. Dreger Peripheral blood stem cell (PBSC) mobilization and transplantation after fludarabine therapy in chronic lymphocytic leukaemia (CLL): a report of the European Blood and Marrow Transplantation (EBMT) CLL subcommittee on behalf of the EBMT Chronic Leukaemias Working Party (CLWP) Br J Haematol 108 3 2000 595 601
    • (2000) Br J Haematol , vol.108 , Issue.3 , pp. 595-601
    • Michallet, M.1    Thiebaut, A.2    Dreger, P.3
  • 119
    • 19944428329 scopus 로고    scopus 로고
    • Results of the MRC pilot study show autografting for younger patients with chronic lymphocytic leukemia is safe and achieves a high percentage of molecular responses
    • D.W. Milligan, S. Fernandes, and R. Dasgupta Results of the MRC pilot study show autografting for younger patients with chronic lymphocytic leukemia is safe and achieves a high percentage of molecular responses Blood 105 1 2005 397 404
    • (2005) Blood , vol.105 , Issue.1 , pp. 397-404
    • Milligan, D.W.1    Fernandes, S.2    Dasgupta, R.3
  • 120
    • 0038528397 scopus 로고    scopus 로고
    • Treatment-related mortality and graft-versus-leukemia activity after allogeneic stem cell transplantation for chronic lymphocytic leukemia using intensity-reduced conditioning
    • P. Dreger, R. Brand, and J. Hansz Treatment-related mortality and graft-versus-leukemia activity after allogeneic stem cell transplantation for chronic lymphocytic leukemia using intensity-reduced conditioning Leukemia 17 5 2003 841 848
    • (2003) Leukemia , vol.17 , Issue.5 , pp. 841-848
    • Dreger, P.1    Brand, R.2    Hansz, J.3
  • 121
    • 0042130360 scopus 로고    scopus 로고
    • Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: The Cooperative German Transplant Study Group
    • J. Schetelig, C. Thiede, and M. Bornhauser Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group J Clin Oncol 21 14 2003 2747 2753
    • (2003) J Clin Oncol , vol.21 , Issue.14 , pp. 2747-2753
    • Schetelig, J.1    Thiede, C.2    Bornhauser, M.3
  • 122
    • 0028822481 scopus 로고
    • Chronic lymphocytic leukemia
    • C. Rozman, and E. Montserrat Chronic lymphocytic leukemia N Engl J Med 333 16 1995 1052 1057
    • (1995) N Engl J Med , vol.333 , Issue.16 , pp. 1052-1057
    • Rozman, C.1    Montserrat, E.2


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