Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations

Journal of Pharmaceutical Sciences

Volumn 94, Issue 2, 2005, Pages 382-396

  Roy, Shouvik ^a   Jung, Rose ^a   Kerwin, Bruce A ^b   Randolph, Theodore W ^c   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b AMGEN INC   (United States)

^c UCB 450   (United States)

Author keywords

Aggregation; Benzyl alcohol; rhIL 1ra

Indexed keywords

BENZYL ALCOHOL; PRESERVATIVE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SODIUM CHLORIDE; SUCROSE; WATER;

ARTICLE; BACTERIOSTASIS; DRUG FORMULATION; DRUG STORAGE; FREEZE DRYING; INFRARED SPECTROSCOPY; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; ROOM TEMPERATURE; SOLID;

EID: 14344261247     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20258     Document Type: Article

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