메뉴 건너뛰기




Volumn 77, Issue 3, 2005, Pages 303-310

Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes

Author keywords

Ab; Antigen presentation; CD4+ T cells; MHC class II; Monocyte

Indexed keywords

CALCIUM; CD14 ANTIGEN; EPITOPE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3C10; RECOMBINANT ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VACCINE;

EID: 14244269001     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0804480     Document Type: Article
Times cited : (6)

References (54)
  • 1
    • 0034919646 scopus 로고    scopus 로고
    • The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity
    • Wang, R. F. (2001) The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity. Trends Immunol. 22, 269-276.
    • (2001) Trends Immunol. , vol.22 , pp. 269-276
    • Wang, R.F.1
  • 2
    • 0029009977 scopus 로고
    • The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    • Jiang, W., Swiggard, W. J., Heufler, C., Peng, M., Mirza, A., Steinman, R. M., Nussenzweig, M. C. (1995) The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375, 151-155.
    • (1995) Nature , vol.375 , pp. 151-155
    • Jiang, W.1    Swiggard, W.J.2    Heufler, C.3    Peng, M.4    Mirza, A.5    Steinman, R.M.6    Nussenzweig, M.C.7
  • 4
    • 0030772131 scopus 로고    scopus 로고
    • The mannose receptor functions as a high-capacity and broad-specificity antigen receptor in human dendritic cells
    • Engering, A. J., Cella, M., Fluitsma, D., Brockhaus, M., Hoefsmit, E. C., Lanzavecchia, A., Pieters, J. (1997) The mannose receptor functions as a high-capacity and broad-specificity antigen receptor in human dendritic cells. Eur. J. Immunol. 27, 2417-2425.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2417-2425
    • Engering, A.J.1    Cella, M.2    Fluitsma, D.3    Brockhaus, M.4    Hoefsmit, E.C.5    Lanzavecchia, A.6    Pieters, J.7
  • 6
    • 0036915204 scopus 로고    scopus 로고
    • A mouse C-κ-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation
    • Schjetne, K. W., Thompson, K. M., Aarvak, T., Fleckenstein, B., Sollid, L. M., Bogen, B. (2002) A mouse C-κ-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation. Int. Immunol. 14, 1423-1430.
    • (2002) Int. Immunol. , vol.14 , pp. 1423-1430
    • Schjetne, K.W.1    Thompson, K.M.2    Aarvak, T.3    Fleckenstein, B.4    Sollid, L.M.5    Bogen, B.6
  • 7
    • 0038545563 scopus 로고    scopus 로고
    • Cutting edge: Link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target
    • Schjetne, K. W., Thompson, K. M., Nilsen, N., Flo, T. H., Fleckenstein, B., Iversen, J. G., Espevik, T., Bogen, B. (2003) Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target. J. Immunol. 171, 32-36.
    • (2003) J. Immunol. , vol.171 , pp. 32-36
    • Schjetne, K.W.1    Thompson, K.M.2    Nilsen, N.3    Flo, T.H.4    Fleckenstein, B.5    Iversen, J.G.6    Espevik, T.7    Bogen, B.8
  • 8
    • 0242643733 scopus 로고    scopus 로고
    • Antibody-mediated delivery of antigen to chemokine receptors on antigen-presenting cells results in enhanced CD4+ T cell responses
    • Schjetne, K. W., Gundersen, H. T., Iversen, J. G., Thompson, K. M., Bogen, B. (2003) Antibody-mediated delivery of antigen to chemokine receptors on antigen-presenting cells results in enhanced CD4+ T cell responses. Eur. J. Immunol. 33, 3101-3108.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 3101-3108
    • Schjetne, K.W.1    Gundersen, H.T.2    Iversen, J.G.3    Thompson, K.M.4    Bogen, B.5
  • 9
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K., Kaisho, T. (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2, 675-680.
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 11
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J., Mathison, J. C. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 13
    • 0029814185 scopus 로고    scopus 로고
    • CD14 is a cell-activating receptor for bacterial peptidoglycan
    • Gupta, D., Kirkland, T. N., Viriyakosol, S., Dziarski, R. (1996) CD14 is a cell-activating receptor for bacterial peptidoglycan. J. Biol. Chem. 271, 23310-23316.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23310-23316
    • Gupta, D.1    Kirkland, T.N.2    Viriyakosol, S.3    Dziarski, R.4
  • 14
    • 12844287799 scopus 로고    scopus 로고
    • CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan-polysaccharide complexes of Gram-positive bacterial cell walls
    • Li, X., Bradford, B. U., Dalldorf, F., Goyert, S. M., Stimpson, S. A., Thurman, R. G., Makarov, S. S. (2004) CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan-polysaccharide complexes of Gram-positive bacterial cell walls. Arthritis Res. Ther. 6, R273-R281.
    • (2004) Arthritis Res. Ther. , vol.6
    • Li, X.1    Bradford, B.U.2    Dalldorf, F.3    Goyert, S.M.4    Stimpson, S.A.5    Thurman, R.G.6    Makarov, S.S.7
  • 15
    • 0041633850 scopus 로고    scopus 로고
    • Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-α and IL-8 secretion by a CD14-Toll-like receptor 2-dependent mechanism
    • Vignal, C., Guerardel, Y., Kremer, L., Masson, M., Legrand, D., Mazurier, J., Elass, E. (2003) Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-α and IL-8 secretion by a CD14-Toll-like receptor 2-dependent mechanism. J. Immunol. 171, 2014-2023.
    • (2003) J. Immunol. , vol.171 , pp. 2014-2023
    • Vignal, C.1    Guerardel, Y.2    Kremer, L.3    Masson, M.4    Legrand, D.5    Mazurier, J.6    Elass, E.7
  • 18
    • 2642614881 scopus 로고
    • Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures
    • Casten, L. A., Pierce, S. K. (1988) Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures. J. Immunol. 140, 404-410.
    • (1988) J. Immunol. , vol.140 , pp. 404-410
    • Casten, L.A.1    Pierce, S.K.2
  • 19
    • 0023647124 scopus 로고
    • Adjuvant-free IgG responses induced with antigen coupled to antibodies against class II MHC
    • Carayanniotis, G., Barber, B. H. (1987) Adjuvant-free IgG responses induced with antigen coupled to antibodies against class II MHC. Nature 327, 59-61.
    • (1987) Nature , vol.327 , pp. 59-61
    • Carayanniotis, G.1    Barber, B.H.2
  • 20
    • 0027129063 scopus 로고
    • Antigenized antibodies
    • Zanetti, M. (1992) Antigenized antibodies. Nature 355, 476-477.
    • (1992) Nature , vol.355 , pp. 476-477
    • Zanetti, M.1
  • 21
    • 0002800589 scopus 로고
    • Immunogenicity of microbial peptides grafted in self immunoglobulin molecules
    • Bona, C., Brumeanu, T. D., Zaghouani, H. (1994) Immunogenicity of microbial peptides grafted in self immunoglobulin molecules. Cell. Mol. Biol. (Noisy-le-grand) 40 (Suppl. 1), 21-30.
    • (1994) Cell. Mol. Biol. (Noisy-le-grand) , vol.40 , Issue.1 SUPPL. , pp. 21-30
    • Bona, C.1    Brumeanu, T.D.2    Zaghouani, H.3
  • 22
    • 0033051777 scopus 로고    scopus 로고
    • Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells
    • Lunde, E., Munthe, L. A., Vabo, A., Sandlie, I., Bogen, B. (1999) Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells. Nat. Biotechnol. 17, 670-675.
    • (1999) Nat. Biotechnol. , vol.17 , pp. 670-675
    • Lunde, E.1    Munthe, L.A.2    Vabo, A.3    Sandlie, I.4    Bogen, B.5
  • 23
    • 0036498877 scopus 로고    scopus 로고
    • Efficient delivery of T cell epitopes to APC by use of MHC class II-specific Troybodies
    • Lunde, E., Western, K. H., Rasmussen, I. B., Sandlie, I., Bogen, B. (2002) Efficient delivery of T cell epitopes to APC by use of MHC class II-specific Troybodies. J. Immunol. 168, 2154-2162.
    • (2002) J. Immunol. , vol.168 , pp. 2154-2162
    • Lunde, E.1    Western, K.H.2    Rasmussen, I.B.3    Sandlie, I.4    Bogen, B.5
  • 24
    • 0034333223 scopus 로고    scopus 로고
    • Recombinant antibodies as carrier proteins for sub-unit vaccines: Influence of mode of fusion on protein production and T-cell activation
    • Eidem, J. K., Rasmussen, I. B., Lunde, E., Gregers, T. F., Rees, A. R., Bogen, B., Sandlie, I. (2000) Recombinant antibodies as carrier proteins for sub-unit vaccines: influence of mode of fusion on protein production and T-cell activation. J. Immunol. Methods 245, 119-131.
    • (2000) J. Immunol. Methods , vol.245 , pp. 119-131
    • Eidem, J.K.1    Rasmussen, I.B.2    Lunde, E.3    Gregers, T.F.4    Rees, A.R.5    Bogen, B.6    Sandlie, I.7
  • 25
    • 0035964320 scopus 로고    scopus 로고
    • The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: Implications for peptide vaccination
    • Rasmussen, I. B., Lunde, E., Michaelsen, T. E., Bogen, B., Sandlie, I. (2001) The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: implications for peptide vaccination. Proc. Natl. Acad. Sci. USA 98, 10296-10301.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10296-10301
    • Rasmussen, I.B.1    Lunde, E.2    Michaelsen, T.E.3    Bogen, B.4    Sandlie, I.5
  • 26
    • 0028174241 scopus 로고
    • Ca2+ mobilization in physiologically stimulated single T cells gradually increases with peptide concentration (analog signaling)
    • Røtnes, J. S., Bogen, B. (1994) Ca2+ mobilization in physiologically stimulated single T cells gradually increases with peptide concentration (analog signaling). Eur. J. Immunol. 24, 851-858.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 851-858
    • Røtnes, J.S.1    Bogen, B.2
  • 27
    • 0344157386 scopus 로고    scopus 로고
    • Immunoglobulin as a vehicle for foreign antigenic peptides immunogenic to T cells
    • Lunde, E., Bogen, B., Sandlie, I. (1997) Immunoglobulin as a vehicle for foreign antigenic peptides immunogenic to T cells. Mol. Immunol. 34, 1167-1176.
    • (1997) Mol. Immunol. , vol.34 , pp. 1167-1176
    • Lunde, E.1    Bogen, B.2    Sandlie, I.3
  • 28
    • 0030972407 scopus 로고    scopus 로고
    • Versatile vectors for transient and stable expression of recombinant antibody molecules in mammalian cells
    • Norderhaug, L., Olafsen, T., Michaelsen, T. E., Sandlie, I. (1997) Versatile vectors for transient and stable expression of recombinant antibody molecules in mammalian cells. J. Immunol. Methods 204, 77-87.
    • (1997) J. Immunol. Methods , vol.204 , pp. 77-87
    • Norderhaug, L.1    Olafsen, T.2    Michaelsen, T.E.3    Sandlie, I.4
  • 29
    • 0021092716 scopus 로고
    • Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells
    • Neuberger, M. S. (1983) Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J. 2, 1373-1378.
    • (1983) EMBO J. , vol.2 , pp. 1373-1378
    • Neuberger, M.S.1
  • 30
    • 0020533567 scopus 로고
    • Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages
    • Van Voorhis, W. C., Steinman, R. M., Hair, L. S., Luban, J., Witmer, M. D., Koide, S., Cohn, Z. A. (1983) Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages. J. Exp. Med. 158, 126-145.
    • (1983) J. Exp. Med. , vol.158 , pp. 126-145
    • Van Voorhis, W.C.1    Steinman, R.M.2    Hair, L.S.3    Luban, J.4    Witmer, M.D.5    Koide, S.6    Cohn, Z.A.7
  • 31
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α
    • Sallusto, F., Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179, 1109-1118.
    • (1994) J. Exp. Med. , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 32
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., Kimoto, M. (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189, 1777-1782.
    • (1999) J. Exp. Med. , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 33
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia, A. (1985) Antigen-specific interaction between T and B cells. Nature 314, 537-539.
    • (1985) Nature , vol.314 , pp. 537-539
    • Lanzavecchia, A.1
  • 34
    • 0025369621 scopus 로고
    • MHC class II-restricted presentation of native protein antigen by B cells is inhibitable by cycloheximide and brefeldin A
    • St Pierre, Y., Watts, T. H. (1990) MHC class II-restricted presentation of native protein antigen by B cells is inhibitable by cycloheximide and brefeldin A. J. Immunol. 145, 812-818.
    • (1990) J. Immunol. , vol.145 , pp. 812-818
    • St Pierre, Y.1    Watts, T.H.2
  • 35
    • 0023850125 scopus 로고
    • Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets
    • Lanzavecchia, A., Abrignani, S., Scheidegger, D., Obrist, R., Dorken, B., Moldenhauer, G. (1988) Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets. J. Exp. Med. 167, 345-352.
    • (1988) J. Exp. Med. , vol.167 , pp. 345-352
    • Lanzavecchia, A.1    Abrignani, S.2    Scheidegger, D.3    Obrist, R.4    Dorken, B.5    Moldenhauer, G.6
  • 36
    • 0001330731 scopus 로고
    • B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells
    • Weiss, S., Bogen, B. (1989) B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells. Proc. Natl. Acad. Sci. USA 86, 282-286.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 282-286
    • Weiss, S.1    Bogen, B.2
  • 37
    • 0034651729 scopus 로고    scopus 로고
    • Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
    • Flo, T. H., Halaas, O., Lien, E., Ryan, L., Teti, G., Golenbock, D. T., Sundan, A., Espevik, T. (2000) Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J. Immunol. 164, 2064-2069.
    • (2000) J. Immunol. , vol.164 , pp. 2064-2069
    • Flo, T.H.1    Halaas, O.2    Lien, E.3    Ryan, L.4    Teti, G.5    Golenbock, D.T.6    Sundan, A.7    Espevik, T.8
  • 38
    • 0035854686 scopus 로고    scopus 로고
    • The role of Toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2
    • Michelsen, K. S., Aicher, A., Mohaupt, M., Hartung, T., Dimmeler, S., Kirschning, C. J., Schumann, R. R. (2001) The role of Toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J. Biol. Chem. 276, 25680-25686.
    • (2001) J. Biol. Chem. , vol.276 , pp. 25680-25686
    • Michelsen, K.S.1    Aicher, A.2    Mohaupt, M.3    Hartung, T.4    Dimmeler, S.5    Kirschning, C.J.6    Schumann, R.R.7
  • 40
    • 0037033073 scopus 로고    scopus 로고
    • Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the Toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction
    • Latz, E., Visintin, A., Lien, E., Fitzgerald, K. A., Monks, B. G., Kurt-Jones, E. A., Golenbock, D. T., Espevik, T. (2002) Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the Toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J. Biol. Chem. 277, 47834-47843.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47834-47843
    • Latz, E.1    Visintin, A.2    Lien, E.3    Fitzgerald, K.A.4    Monks, B.G.5    Kurt-Jones, E.A.6    Golenbock, D.T.7    Espevik, T.8
  • 41
    • 0032493633 scopus 로고    scopus 로고
    • CD14-dependent endotoxin internalization via a macropinocytic pathway
    • Poussin, C., Foti, M., Carpentier, J. L., Pugin, J. (1998) CD14-dependent endotoxin internalization via a macropinocytic pathway. J. Biol. Chem. 273, 20285-20291.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20285-20291
    • Poussin, C.1    Foti, M.2    Carpentier, J.L.3    Pugin, J.4
  • 43
    • 0036569658 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: A critical role for monocytes in leukocyte lipopolysaccharide responses
    • Sabroe, I., Jones, E. C., Usher, L. R., Whyte, M. K., Dower, S. K. (2002) Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J. Immunol. 168, 4701-4710.
    • (2002) J. Immunol. , vol.168 , pp. 4701-4710
    • Sabroe, I.1    Jones, E.C.2    Usher, L.R.3    Whyte, M.K.4    Dower, S.K.5
  • 44
    • 0842265548 scopus 로고    scopus 로고
    • Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: Integrity of microtubules is required for interleukin-12 production in response to internalized bacteria
    • Uronen-Hansson, H., Allen, J., Osman, M., Squires, G., Klein, N., Callard, R. E. (2004) Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria. Immunology 111, 173-178.
    • (2004) Immunology , vol.111 , pp. 173-178
    • Uronen-Hansson, H.1    Allen, J.2    Osman, M.3    Squires, G.4    Klein, N.5    Callard, R.E.6
  • 45
    • 3142690482 scopus 로고    scopus 로고
    • TLR4 is the signaling but not the lipopolysaccharide uptake receptor
    • Dunzendorfer, S., Lee, H. K., Soldau, K., Tobias, P. S. (2004) TLR4 is the signaling but not the lipopolysaccharide uptake receptor. J. Immunol. 173, 1166-1170.
    • (2004) J. Immunol. , vol.173 , pp. 1166-1170
    • Dunzendorfer, S.1    Lee, H.K.2    Soldau, K.3    Tobias, P.S.4
  • 46
    • 0345374586 scopus 로고    scopus 로고
    • Phosphatidylserine receptor is required for clearance of apoptotic cells
    • Li, M. O., Sarkisian, M. R., Mehal, W. Z., Rakic, P., Flavell, R. A. (2003) Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 302, 1560-1563.
    • (2003) Science , vol.302 , pp. 1560-1563
    • Li, M.O.1    Sarkisian, M.R.2    Mehal, W.Z.3    Rakic, P.4    Flavell, R.A.5
  • 47
    • 0030603986 scopus 로고    scopus 로고
    • Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
    • Bender, A., Sapp, M., Schuler, G., Steinman, R. M., Bhardwaj, N. (1996) Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods 196, 121-135.
    • (1996) J. Immunol. Methods , vol.196 , pp. 121-135
    • Bender, A.1    Sapp, M.2    Schuler, G.3    Steinman, R.M.4    Bhardwaj, N.5
  • 48
    • 0030937833 scopus 로고    scopus 로고
    • Capture and processing of exogenous antigens for presentation on MHC molecules
    • Watts, C. (1997) Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 15, 821-850.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 821-850
    • Watts, C.1
  • 49
    • 0030060413 scopus 로고    scopus 로고
    • Monoclonal IgG as antigens: Reduction is an early intracellular event of their processing by antigen-presenting cells
    • Santoro, L., Reboul, A., Kerblat, I., Drouet, C., Colomb, M. G. (1996) Monoclonal IgG as antigens: reduction is an early intracellular event of their processing by antigen-presenting cells. Int. Immunol. 8, 211-219.
    • (1996) Int. Immunol. , vol.8 , pp. 211-219
    • Santoro, L.1    Reboul, A.2    Kerblat, I.3    Drouet, C.4    Colomb, M.G.5
  • 50
    • 0027398099 scopus 로고
    • Presentation of a viral T cell epitope expressed in the CDR3 region of a self-immunoglobulin molecule
    • Zaghouani, H., Steinman, R., Nonacs, R., Shah, H., Gerhard, W., Bona, C. (1993) Presentation of a viral T cell epitope expressed in the CDR3 region of a self-immunoglobulin molecule. Science 259, 224-227.
    • (1993) Science , vol.259 , pp. 224-227
    • Zaghouani, H.1    Steinman, R.2    Nonacs, R.3    Shah, H.4    Gerhard, W.5    Bona, C.6
  • 51
    • 0030828486 scopus 로고    scopus 로고
    • Engineering vaccines with heterologous B and T cell epitopes using immunoglobulin genes
    • Xiong, S., Gerloni, M., Zanetti, M. (1997) Engineering vaccines with heterologous B and T cell epitopes using immunoglobulin genes. Nat. Biotechnol. 15, 882-886.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 882-886
    • Xiong, S.1    Gerloni, M.2    Zanetti, M.3
  • 52
    • 0025605527 scopus 로고
    • Insertion of myoglobin T-cell epitopes into the Escherichia coli alkaline phosphatase
    • Freimuth, P., Steinman, R. M. (1990) Insertion of myoglobin T-cell epitopes into the Escherichia coli alkaline phosphatase. Res. Microbiol. 141, 995-1001.
    • (1990) Res. Microbiol. , vol.141 , pp. 995-1001
    • Freimuth, P.1    Steinman, R.M.2
  • 54
    • 0023200632 scopus 로고
    • Targeted antigen presentation using crosslinked antibody heteroaggregates
    • Snider, D. P., Segal, D. M. (1987) Targeted antigen presentation using crosslinked antibody heteroaggregates. J. Immunol. 139, 1609-1616.
    • (1987) J. Immunol. , vol.139 , pp. 1609-1616
    • Snider, D.P.1    Segal, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.