Immunoglobulin as a vehicle for foreign antigenic peptides immunogenic to T cells

Molecular Immunology

Volumn 34, Issue 16-17, 1997, Pages 1167-1176

  Lunde, Elin ^a,b   Bogen, Bjarne ^a   Sandlie, Inger ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Antibody; Antigen presentation; Immunization; T cell epitope; Vaccination

Indexed keywords

CARRIER PROTEIN; CD4 ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CHO CELL; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DNA FLANKING REGION; DRUG TARGETING; IMMUNOGENICITY; IMMUNOGLOBULIN CONSTANT REGION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0344157386     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00143-0     Document Type: Article

References (59)

1. Baier, G., Baier-Bitterlich. G., Looney, D. J. and Altman, A. (1995) Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric antiHLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro. J. Virol. 69, 2357-2365.
2. Berzofsky, J. A., Brett, S. J., Streicher, H. Z. arid Takahashi, H. (1988) Antigen processing for presentation to T lymphocytes: function, mechanisms, and implications for the T-cell repertoire. [Review], Immunol. Rev. 106, 5-31.
3. Bijlmakers, M. J., Benaroch, P. and Ploegh, H. L. (1994) Assembly of HLA DRI molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J. 13, 2699-2707.
4. Bikoff, E. K., Yu, H. and Eckhardt, L. A. (1988) T cell recognition of endogenous IgG2a expressed in B lymphoma cells. Eur. J. Immunol. 18, 341-348.
5. Billetta, R., Hollingdale, M. R. and Zanetti, M. (1991) Immunogenicity of an engineered internal image antibody. Proc. Nail. Acad. Sci. U.S.A. 88, 4713-4717.
6. Billetta, R., Filaci, G. and Zanetti, M. (1995) Major histocompatibility complex class I-restricted presentation of influenza virus nucleoprotein peptide by B lymphoma cells harboring an antibody gene antigenized with the virus peptide. Eur. J. Immunol. 25, 776-783.
7. Bogen, B., Malissen, B. and Haas, W. (1986a) Idiotope-specific T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules. Eur. J. Immunol. 16, 1373-1378.
8. Bogen, B., Snodgrass, R., Briand, J. P. and Hannestad, K. (1986b) Synthetic peptides and beta-chain gene rearrangements reveal a diversified T cell repertoire for a lambda light chain third hypervariable region. Eur. J. Immunol. 16, 1379-1384.
9. Bogen, B., Gleditsch, L., Weiss, S. and Dembic, Z. (1992) Weak positive selection of transgenic T cell receptor-bearing thymocytes: importance of major histocomaatibility complex class II, T cell receptor and CD4 surface molecule densities. Eur. J. Immunol. 22, 703-709.
10. Bogen, B. and Lambris J. D. (1989) Minimum length of an idiotypic peptide and a model for its binding to a major histocompatibility complex class II molecule. EMBO J. 8, 1947-1952.
11. Bole, D. G., Hendershot, L. M. and Kearney J. F. (1986) Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. J. Cell Biol. 102, 1558-1566.
12. Bona, C., Brumeanu, T. D. and Zaghouani, H. (1994) Immunogenicity of microbial peptides grafted in self immunoglobulin molecules. [Review]. Cellular & Molecular Biology 40(Suppl. 1), 21-30.
13. Bonifacino, J. S. and Lippincott-Schwartz, J. (1991) Degradation of proteins within the endoplasmic reticulum. [Review]. Curr. Opin. Cell Biol. 3, 592-600.
14. Brooks, A., Hartley, S., Kjer-Nielsen, L., Perera, J., Goodnow, C. C., Basten, A. and McCluskey, J. (1991) Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme. Proc. Natl. Acad. Sci. U.S.A. 88, 3290-3294.
15. Brumeanu, T. D., Swiggard, W. J., Steinman, R. M., Bona, C. A. and Zaghouani, H. (1993) Efficient loading of identical viral peptide onto class II molecules by antigenized immunoglobulin and influenza virus. J. Exp. Med. 178, 1795-1799.
16. Carayannopoulos, L. and Capra, J. D. (1993) Immunoglobulins: Structure and Function. In Fundamental Immunology, ed. W. E. Paul, p. 283. Raven Press, New York.
17. Chicz, R. M., Urban, R. G., Gorga, J. C., Vignali, D. A., Lane, W. S. and Strominger, J. L. (1993) Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178, 27-47.
18. Chothia, C., Lesk, A. M., Gherardi, E., Tomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B. and Winter, G. (1992) Structural repertoire of the human VH segments. J. Mol. Biol. 227, 799-817.
19. Cook, J. and Barber, B. H. (1995) Recombinant antibodies containing an engineered B-cell epitope capable of eliciting conformation-specific antibody responses. Vaccine 13, 1770-1778.
20. Crowley, M., Inaba, K., Witmer-Pack, M. and Steinman, R. M. (1989) The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell Immunol. 118, 108-125.
21. Dodi, A. I., Brett, S., Nordeng, T., Sidhu, S., Batchelor, R. J., Lombardi, G., Bakke, O. and Lechler R. I. (1994) The invariant chain inhibits presentation of endogenous antigens by a human fibroblast cell line. Eur. J. Immunol. 24, 1632-1639.
22. Ertl, H. C. J. and Xiang, Z. (1996) Novel Vaccine Approaches. J. Immunol. 156, 3579-3582.
23. Fossum, S., Berg, S. F. and Mjaaland, S. (1992) Targeting antigens to antigen presenting cells. [Review] [62 refs]. Semin. Immunol. 4, 275-283.
24. Fremont, D. H., Hendrickson, W. A., Marrack, P. and Kappler, J. (1996) Structures of an MHC class II Molecule with Covalently Bound Single Peptides. Science 272, 1001-1004.
25. Germain, R. N., Castellino, F., Han, R., Reis e Sousa, C., Romagnoli, P., Sadegh-Nasseri, S. and Zhong, G.-M. (1996) Processing and Presentation of Endocytically Acquired Protein Antigens by MHC Class II and Class I Molecules. Immunol. Rev. 151, 5-30.
26. Haas, I. G. and Wabl, M. (1983) Immunoglobulin heavy chain binding protein. Nature 306, 387-389.
27. Hedley, M. L., Urban, R. G. and Strominger, J. L. (1994) Assembly and peptide binding of major histocompatibility complex class II heterodimers in an in vitro translation system. Proc. Natl. Acad. Sci. U.S.A. 91, 10479-10483.
28. Hendershot, L., Bote, D., Kohler, G. and Kearney, J. F. (1987) Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein. J. Cell Biol. 104, 761-767.
29. Huck, S., Fort, P., Crawford, D. H., Lefranc, M. P. and Lefranc, G. (1986) Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes. Nucleic Acids Res. 14, 1779-1789.
30. Jensen, P. E. (1990) Regulation of antigen presentation by acidic pH. J. Exp. Med. 171, 1779-1784.
31. Kittlesen, D. J., Brown, L. R., Braciale, V. L., Sambrook, J. P., Gething, M. J. and Braciale, T. (1993) Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants. J. Exp. Med. 177, 1021-1030.
32. Kunkel, T. A., Roberts, J. D. and Zakour, R. A. (1987) Rapid and efficient site-specific mutageresis without phenotypic selection. Methods Enzymol. 154, 367-382.
33. Lauritzsen, G. F. and Bogen, B. (1991) Idiotype-specific, major histocompatibility complex restricted T cells are of both Thl and Th2 type. Scand. J. Immunol. 33, 647-656.
34. Lauritzsen, G. F. and Bogen, B. (1993) The role of idiotypespecific, CD4+ T cells in tumor resistance against major histocompatibility complex class II molecule negative plasmacytoma cells. Cell. Immunol. 148, 177-188.
35. Lemke, H., Hammerling, G. J. and Hammerling, U. (1979) Fine specificity analysis with monoclonal antibodies of antigens controlled by the major histocompatibility complex and by the Qa/TL region in mice. [Review]. Immunol. Rev. 47, 175-206.
36. Lesk and Tramontano (1992) Antibody engineering, a practical guide, ed. C. A. K. Borebaeck. W. H. Freeman and Co, New York.
37. Lewis, M. J. and Pelham, H. R. (1992) Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. Cell 68, 353-364.
38. Liang, M. N., Beeson, C., Mason, K. and McConnell, H. M. (1995) Kinetics of the reactions between the invariant chain (85-99) peptide and proteins of the murine class II MHC. Int. Immunol. 7, 1397-1404.
39. Melnick, J., Aviel, S. and Argon, Y. (1992) The endoplasmic reticulum stress protein GRP94, in addition to BiP. associates with unassembled immunoglobulin chains. J. Biol. Chem. 267, 21303-21306.
40. Melnick, J., Dul, J. L. and Argon, Y. (1994) Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasrnic reticulum. Nature 370, 373-375.
41. Michaelsen, T. E., Aase, A., Westby, C. and Sandlie, I. (1990) Enhancement of Complement Activation and Cytolysis of Human IgG3 by Deletion of Hinge Exons. Scand. J. Immunol. 32, 517-528
42. Morton, H. C., Atkin, J. D., Owens, R. J. and Woof, J. M. (1993) Purification and characterization of chimeric human IgAl and IgA2 expressed in COS and Chinese hamster ovary cells. J. Immunol. 151, 4743-4752.
43. Munthe, L., Sollien, A., Dembic, Z. and Bogen, B. ( 1995) Preferential positive selection of T lymphocytes which express two different TCRa chains, an endogenous and a transgenic. Scand. J. Immunol. 42, 651-661.
44. Nelson, C. A., Roof, R. W., McCourt, D. W. and Unanue, E. R. (1992) Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak. Proc. Natl. Acad. Sci. U.S.A. 89, 7380-7383.
45. Neuberger, M. S. (1983) Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J. 2, 1373-1378.
46. Neuberger, M. S., Williams, G. T. and Fox, R. O. (1984) Recombinant antibodies possessing novel effector functions. Nature 312, 604-608.
47. Newcomb, J. R. and Cresswell, P. (1993) Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers. J. Immunol. 150, 499-507.
48. Pelham, H. R. (1991) Recycling of proteins between the endoplasmic reticulum and Golgi complex. [Review]. Curr. Opin. Cell Biol. 3, 585-591.
49. Potter, H., Weir, L. and Leder, P. (1984) Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc. Natl. Acad. Sci. U.S.A. 81, 7161-7165.
50. Roche, P. A. and Cresswell, P. (1990) Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature 345, 615-618.
51. Rudensky, A. Y., Preston-Hurlburt, P., Hong, S. C., Barlow, A. and Janeway, C. A., Jr. (1991) Sequence analysis of peptides bound to MHC class II molecules (see comments). Nature 353, 622-627.
52. Schild, H., Gruneberg, U., Pougialis, G., Wallny, H. J., Keilholz, W., Stevanovic, S. and Rammensee, H. G. (1995) Natural ligand motifs of H-2E molecules are allele specific and illustrate homology to HLA-DR molecules. Int. Immunol. 7, 1957-1965.
53. Snodgrass, H. R., Fisher, A. M., Bruyns, E. and Bogen, B. (1992) Restricted alpha/beta receptor gene usage of idiotypespecific major histocompatibility complex-restricted T cells: selection for CDR3-related sequences. Eur. J. Immunol. 22, 2169-2172.
54. Sonnichsen, B., Fullekrug, J., Nguyen, Van P., Diekmann, W., Robinson, D. G. and Mieskes, G. (1994) Retention and retrieval: both mechanisms co-operate to maintain calreticulin in the endoplasmic reticulum. J. Cell Sci. 107, 2705-2717.
55. Townsley, F. M., Wilson, D. W. and Pelham, H. R. (1993) Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport. EMBO J. 12, 2821-2829.
56. Weiss, S. and Bogen, B. (1989) B-Iymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells. Proc. Natl. Acad. Sci. U.S.A. 86, 282-286.
57. Weiss, S. and Bogen, B. (1991) MHC class II-restricted presentation of intracellular antigen. Cell 64, 767-776.
58. Zaghouani, H., Steinman, R., Nonacs, R., Shah, H., Gerhard, W. and Bona, C. (1993) Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule. Science 259, 224-227.
59. Zanetti, M. (1992) Antigenized antibodies. Nature 355, 476-477.