Metabolic consequences of overfeeding in humans

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 7, Issue 6, 2004, Pages 623-628

  Tappy, Luc ^a,b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

De novo lipogenesis; Orexins; Physical activity; Thermogenesis; Thyroid hormones

Indexed keywords

CARBOHYDRATE METABOLISM; DISORDERS OF CARBOHYDRATE METABOLISM; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ENERGY EXPENDITURE; FATTY LIVER; GENETIC ASSOCIATION; GLUCOSE TOLERANCE TEST; GLYCOGEN METABOLISM; HUMAN; LIPOGENESIS; METABOLIC DISORDER; NEUROENDOCRINE SYSTEM; OBESITY; OVERNUTRITION; PHYSICAL ACTIVITY; REVIEW; SYMPATHETIC TONE; WEIGHT GAIN;

ADAPTATION, PHYSIOLOGICAL; ADIPOSE TISSUE; ENERGY INTAKE; ENERGY METABOLISM; HUMANS; LIVER; OBESITY; SYMPATHETIC NERVOUS SYSTEM;

EID: 14244260944     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200411000-00006     Document Type: Review

References (57)

1. Plank LD, Hill GL. Energy balance in critical illness. Proc Nutr Soc 2003; 62:545-552.
2. Baudouin SV, Evans TW. Nutritional support in critical care. Clin Chest Med 2003; 24:633-644.
3. Mechanick JI, Brett EM. Nutrition support of the chronically critically ill patient. Crit Care Clin 2002; 18:597-618.
4. Compher C, Cato R, Bader J, Kinosian B. Harris-Benedict equations do not adequately predict energy requirements in elderly hospitalized African Americans. J Nat Med Ass 2004; 96:209-214.
5. Kan MN, Chang HH, Sheu WF, et al. Estimation of energy requirements for mechanically ventilated, critically ill patients using nutritional status. Crit Care 2003; 7:R108-R115.
6. Duggan C, Bechard L, Donovan K, et al. Changes in resting energy expenditure among children undergoing allogeneic stem cell transplantation. Am J Clin Nutr 2003; 78:104-109.
7. Jéquier E, Tappy L. Regulation of body weight in humans. Physiol Rev 1999; 79:451-480.
8. Rosenbaum M, Leibel RL, Hirsch J. Obesity. N Engl J Med 1997; 337:397-407.
9. Kelley DE, Wing RR, Buonocore C, et al. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1993; 77:1287-1293.
10. Klein S, Fontana L, Young VL, et al. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med 2004; 350:2549-2557. This elegant study shows that reduction of fat mass per se does not improve glucose homeostasis in obese women, and hence that energy restriction (or reduction of visceral fat) is most likely involved in the beneficial effects of weight loss.
11. Kelley DE. Thermodynamics, liposuction, and metabolism [editorial]. N Engl J Med 2004; 350:2542-2544. In this editorial, associated with Ref. [10Asterisk inside a circle signAsterisk inside a circle sign], the respective roles of energy balance and fat mass on glucose homeostasis are nicely put into perspective.
12. Owen O, Kavle E, Owen R, et al. A reappraisal of caloric requirements in healthy women. Am J Clin Nutr 1986; 44:1-19.
13. Heilbronn LK. Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr 2003; 78:361-369. Nice review on the relationship between caloric intake and disease, from animals to man.
14. Austad SN, Kristan DM. Are mice calorically restricted in nature? Aging Cell 2003; 2:201-207.
15. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 2000; 404:652-660.
16. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995; 332:621-628.
17. Salzman E, Roberts SB. Effects of energy imbalance on energy expenditure and respiratory quotient in young and older men: a summary of data from two metabolic studies. Aging Clin Exp Res 1996; 8:370-378.
18. Roberts SB, Fuss P, Dallal GE, et al. Effects of age on energy expenditure and substrate oxidation during experimental overfeeding in healthy men. J Gerontol Biol Sci 1996; 51A:B148-B157.
19. Levine JA, Eberhardt NL, Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 1999; 283:212-214.
20. Levine JA, Weisell R, Chevassus S, et al. The work burden of women. Science 2001; 294:812.
21. Weyer C, Pratley RE, Salbe AD, et al. Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change. J Clin Endocrinol Metab 2000; 85:1087-1094.
22. Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86:1930-1935.
23. Dirlewanger M, Di Vetta V, Guenat E, et al. Effects of short term carbohydrate or fat overfeeding on energy expenditure and plasma leptin concentrations in healthy female subjects. Int J Obes 2000; 24:1413-1418.
24. Tentolouris N, Tsigos C, Perea D, et al. Differential effects of high-fat and high-carbohydrate isoenergetic meals on cardiac autonomic nervous system activity in lean and obese women. Metab Clin Exp 2003; 52:1426-1432.
25. Marques-Lopes I, Forga L, Martinez JA. Thermogenesis induced by a high-carbohydrate meal in fasted lean and overweight young men: insulin, body fat, and sympathetic nervous system. Nutrition 2003; 19:25-29.
26. Tataranni PA. From physiology to neuroendocrinology: a reappraisal of risk factors of body weight gain in humans. Diabetes Metab 1998; 24:108-115.
27. Macias AE. Experimental demonstration of human weight homeostasis: implications for understanding obesity. Br J Nutr 2004; 91:479-484.
28. Levine JA. Nonexercise activity thermogenesis (NEAT): environment and biology. Am J Physiol Endocrinol Metab 2004; 286:E675-E685. An extensive review of the whole concept of nonvoluntary physical exercise and its potential role in energy balance.
29. Levine JA, Nygren J, Short KR, Nair KS. Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats. J Appl Physiol 2003; 94:165-170. Experimental evidence in rats that the thyroid hormones stimulate spontaneous physical activity.
30. Danforth E, Burger A. The role of thyroid hormones in the control of energy expenditure. Clin Endocrinol Metab 1984; 13:581-595.
31. Kiwaki K, Kotz CM, Wang CL, et al. Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats. Am J Physiol Endocrinol Metab 2004; 286:E551-E559. Experimental evidence that intracerebral orexin increases spontaneous physical activity in rats. This raises the possibility that orexin may be one of the mediators linking energy intake to spontaneous activity.
32. Kotz CM, Teske JA, Levine JA, Wang CL. Feeding and activity induced by orexin A in the lateral hypothalamus in rats. Regul Peptides 2002; 104:27-32.
33. Ferguson AV, Samson WK. The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function. Frontiers Neuroendocrinol 2003; 24:141-150.
34. Sjöstrom L, Schutz Y, Gudinchet F, et al. Epinephrine sensitivity with respect to metabolic rate and other variables in women. Am J Physiol Endocrinol Metab 1983; 245:E431-E442.
35. Acheson KJ, Jéquier E, Wahren J. Influence of β-adrenergic blockade on glucose-induced thermogenesis in man. J Clin Invest 1983; 72:981-986.
36. Breitenstein E, Chioléro R, Jéquier E, et al. Effects of beta-blockade on energy metabolism following burns. Burns 1990; 16:259-264.
37. Tappy L, Girardet K, Schwaller N, et al. Metabolic effects of an increase of sympathetic activity in healthy humans. Int J Obes 1995; 19:419-422.
38. Seematter G, Guenat E, Schneller P, et al. Effects of mental stress on insulin-mediated glucose metabolism and energy expenditure in lean and obese women. Am J Physiol Endocrinol Metab 2000; 279:E799-E805.
39. DeRosa MA, Cryer PE. Hypoglycemia and the sympathoadrenal system: neurogenic symptoms are largely the result of sympathetic neural, rather than adrenomedullary, activation. Am J Physiol Endocrinol Metab 2004; 287:E32-E41.
40. Seematter G, Dirlewanger M, Rey V, et al. Metabolic effects of mental stress during over- and underfeeding in healthy females. Obes Res 2002; 10:49-55.
41. Acheson K, Schutz Y, Bessard T, et al. Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. Am J Clin Nutr 1988; 48:240-247.
42. Flatt JP. The biochemistry of energy expenditure. In: Bray G, editor. Recent advances in obesity research II. London: John Libbey; 1980. pp. 211-218.
43. Pasquet P, Apfelbaum M. Recovery of initial body weight and composition after long-term massive overfeeding in men. Am J Clin Nutr 1994; 60:861-863.
44. Hellerstein M, Schwarz J, Nees R. Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr 1996; 16:523-557.
45. Hudgins LC, Hellerstein M, Seidman C, et al. Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest 1996; 97:2081-2091.
46. Hudgins LC, Seidman CE, Diakun J, Hirsch J. Human fatly acid synthesis is reduced after the substitution of dietary starch for sugar. Am J Clin Nutr 1998; 67:631-639.
47. Tappy L, Schwarz JM, Schneiter P, et al. Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. Crit Care Med 1998; 26:860-867.
48. Aarsland A, Chinkes D, Wolfe RR. Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding. Am J Clin Nutr 1997; 65:1774-1782.
49. Minehira K, Bettschart V, Vidal H, et al. Effect of carbohydrate overfeeding on whole body and adipose tissue metabolism in humans. Obesity Res 2003; 11:1096-1103. Indirect evidence that the adipose tissue is involved in de-novo lipogenesis in overfed humans.
50. Minehira K, Vega N, Vidal H, et al. Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans. Int J Obes Rel Metab Dis 2004, 10 August [epub ahead of print]. This study indicates that stimulation of de-novo lipogenesis during carbohydrate overfeeding is not increased in overweight individuals.
51. Ukkola O, Tremblay A, Bouchard C. Beta-2 adrenergic receptor variants are associated with subcutaneous fat accumulation in response to long-term overfeeding. Int J Obes Rel Metab Dis 2001; 25:1604-1608.
52. +-ATPase alpha 2-gene and skeletal muscle characteristics in response to long-term overfeeding. J Appl Physiol 2003; 94:1870-1874. A very informative overview of one of the key studies on the genetics of obesity.
53. Ukkola O, Bouchard C. Role of candidate genes in the responses to long-term overfeeding: review of findings. Obesity Rev 2004; 5:3-12.
54. Jéquier E, Schutz Y. Energy expenditure in obesity and diabetes. Diabetes Metab Rev 1988; 4:583-593.
55. Randin JP, Scazziga B, Jéquier E, Felber JP. Study of glucose and lipid metabolism by continuous indirect calorimetry in Graves' disease: effect of an oral glucose load. J Clin Endocrinol Metab 1985; 61:1165-1171.
56. Acheson KJ, Ravussin E, Wahren J, Jéquier E. Thermic effect of glucose in man: obligatory and facultative thermogenesis. J Clin Invest 1984; 74:1572-1580.
57. Hoos MB, Gerver WJ, Kester AD, Westerterp KR. Physical activity levels in children and adolescents. Int J Obes Rel Metab Dis 2003; 27:605-609.