NF-κB pathway protects cochlear hair cells from aminoglycoside- induced ototoxicity

Journal of Neuroscience Research

Volumn 79, Issue 5, 2005, Pages 644-651

  Jiang, Hongyan ^a   Sha, Su Hua ^a   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

I B; Kanamycin; Lipid peroxidation; Reactive oxygen species; Redox signaling

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; 3 NITROTYROSINE; 4 HYDROXYNONENAL; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIOXIDANT; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KANAMYCIN; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SALICYLIC ACID; 2 PYROCATECHUIC ACID; 2-PYROCATECHUIC ACID; 3-NITROTYROSINE; 4-HYDROXY-2-NONENAL; ALDEHYDE; ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; CALCIUM BINDING PROTEIN; CDC37 PROTEIN, MOUSE; CELL CYCLE PROTEIN; CHAPERONE; DROSOPHILA PROTEIN; DRUG DERIVATIVE; HOE 33342; HYDROXYBENZOIC ACID DERIVATIVE; IRON CHELATING AGENT; MEMBRANE PROTEIN; MESSENGER RNA; NERVE PROTEIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTECTIVE AGENT; SALICYLIC ACID DERIVATIVE; SYNAPTOTAGMIN; SYNAPTOTAGMIN I; TYROSINAMIDE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL SURVIVAL; COCHLEA; CONTROLLED STUDY; HAIR CELL; HEARING; IMMUNOHISTOCHEMISTRY; INNER EAR; LIPID PEROXIDATION; MALE; MAMMAL; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OTOTOXICITY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; ANIMAL; AUDITORY THRESHOLD; BIOSYNTHESIS; CBA MOUSE; CELL DEATH; CELL FRACTIONATION; COMPARATIVE STUDY; CYTOLOGY; DNA REPLICATION TIMING; DRUG ADMINISTRATION; DRUG EFFECT; DRUG INTERACTION; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; IMMUNOPRECIPITATION; METABOLISM; METHODOLOGY; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME; WESTERN BLOTTING;

ALDEHYDES; ANIMALS; ANTI-BACTERIAL AGENTS; AUDITORY THRESHOLD; BENZIMIDAZOLES; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL DEATH; CELL FRACTIONATION; COCHLEA; CYCLOOXYGENASE INHIBITORS; DNA REPLICATION TIMING; DROSOPHILA PROTEINS; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME ACTIVATION; HAIR CELLS; HYDROXYBENZOIC ACIDS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IRON CHELATING AGENTS; KANAMYCIN; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED CBA; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NF-KAPPA B; PHOSPHORYLATION; PROTECTIVE AGENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALICYLATES; SIGNAL TRANSDUCTION; SYNAPTOTAGMIN I; SYNAPTOTAGMINS; TIME FACTORS; TYROSINE;

EID: 13844303837     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20392     Document Type: Article

References (26)

1. Bonizzi G, Piette J, Merville MP, Bours V. 2000. Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by interleukin-1. Biochem Pharmacol 59:7-11.
2. Bonizzi G, Piette J, Schoonbroodt S, Greimers R, Havard L, Merville MP, Bours V. 1999. Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity. Mol Cell Biol 19:1950-1960.
3. Bowie A, O'Neill LA. 2000. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59:13-23.
4. Cohen SM, Petoud S, Raymond KN. 2001. Synthesis and metal binding properties of salicylate-, catecholate-, and hydroxypyridinonate-functionalized dendrimers. Chemistry 7:272-279.
5. Conlon BJ, Aran JM, Erre JP, Smith DW. 1999. Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid. Hear Res 128:40-44.
6. Coudray C, Favier A. 2000. Determination of salicylate hydroxylation products as an in vivo oxidative stress marker. Free Radic Biol Med 29:1064-1070.
7. Droge W. 2002. Free radicals in the physiological control of cell function. Physiol Rev 82:47-95.
8. Forge A, Schacht J. 2000. Aminoglycoside antibiotics. Audiol Neurootol 5:3-22.
9. Gavnlyuk V, Dello Russo C, Heneka MT, Pelligrino D, Weinberg G, Feinstein DL. 2002. Norepinephrine increases I kappa B alpha expression in astrocytes. J Biol Chem 277:29662-29668.
10. Haddad JJ. 2002. Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. Cell Signal 14:879-897.
11. Hehner SP, Breitkreutz R, Shubinsky G, Unsoeld H, Schulze-Osthoff K, Schmitz ML, Droge W. 2000. Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool. J Immunol 165:4319-4328.
12. Janssen-Heininger YM, Poynter ME, Baeuerle PA. 2000. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 28:1317-1327.
13. Lee PJ, Choi AM. 2003. Pathways of cell signaling in hyperoxia. Free Radic Biol Med 200335:341-350.
14. Priuska E, Schacht J. 1995. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 50:1749-1752.
15. Sha SH, Schacht J. 1999a. Formation of reactive oxygen species following bioactivation of gentamicin. Free Rad Biol Med 26:341-347.
16. Sha SH, Schacht J. 1999b. Salicylate attenuates gentamicin-induced ototoxicity. Lab Invest 79:807-813.
17. Sha SH, Taylor R, Forge A, Schacht J. 2001a. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 155:1-8.
18. Sha SH, Zajic G, Epstein CJ, Schacht J. 2001b. Overexpression of copper/ zinc-superoxide dismutase protects from kanamycin-induced hearing loss. Audiol Neurootol 6:117-123.
19. Song BB, Anderson DJ, Schacht J. 1997. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J Pharmacol Exp Ther 282:369-377.
20. Song BB, Schacht J. 1996. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear Res 94:87-93.
21. Takumida M, Popa R, Anniko M. 1999. Free radicals in the guinea pig inner ear following gentamicin exposure. ORL J Otorhinolaryngol Relat Spec 61:63-70.
22. Toledano MB, Leonard WJ. 1991. Modulation of transcription factor NFκB binding activity by oxidation-reduction in vitro. Proc Natl Acad Sci USA 88:4328-4332.
23. Wu WJ, Sha SH, McLaren JD, Kawamoto K, Raphael Y, Schacht J. 2001. Ammoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hear Res 158:165-178.
24. Wu WJ, Sha SH, Schacht J. 2002. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiol Neurootol 7:171-174.
25. Yin MJ, Yamamoto Y, Gaynor RB. 1998. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396:77-80.
26. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. 2001. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 293:1673-1677.