메뉴 건너뛰기




Volumn 42, Issue 3, 2005, Pages 297-300

Cholestatic hepatocellular injury: What do we know and how should we proceed

Author keywords

[No Author keywords available]

Indexed keywords

DEATH RECEPTOR 5; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; PROTEIN BCL 2;

EID: 13844275260     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2004.12.014     Document Type: Editorial
Times cited : (30)

References (44)
  • 1
    • 0346690402 scopus 로고    scopus 로고
    • Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
    • Y. Liu, J. Binz, M.J. Numerick, S. Dennis, G. Luo, and B. Desai Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis J Clin Invest 112 2003 1678 1687
    • (2003) J Clin Invest , vol.112 , pp. 1678-1687
    • Liu, Y.1    Binz, J.2    Numerick, M.J.3    Dennis, S.4    Luo, G.5    Desai, B.6
  • 2
    • 0037101810 scopus 로고    scopus 로고
    • 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
    • R. Pellicciari, S. Fiorucci, E. Camaioni, C. Clerici, G. Costantino, and P.R. Maloney 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity J Med Chem 45 2002 3569 3572
    • (2002) J Med Chem , vol.45 , pp. 3569-3572
    • Pellicciari, R.1    Fiorucci, S.2    Camaioni, E.3    Clerici, C.4    Costantino, G.5    Maloney, P.R.6
  • 3
    • 0042825756 scopus 로고    scopus 로고
    • Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
    • M. Wagner, P. Fickert, G. Zollner, A. Fuchsbichler, D. Silbert, and O. Tsybrovskyy Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice Gastroenterology 125 2003 825 838
    • (2003) Gastroenterology , vol.125 , pp. 825-838
    • Wagner, M.1    Fickert, P.2    Zollner, G.3    Fuchsbichler, A.4    Silbert, D.5    Tsybrovskyy, O.6
  • 4
    • 0034466173 scopus 로고    scopus 로고
    • Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis
    • J.M. De Vree, R. Ottenhoff, P.J. Bosma, A.J. Smith, J. Aten, and R.P. Oude Elferink Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis Gastroenterology 119 2000 1720 1730
    • (2000) Gastroenterology , vol.119 , pp. 1720-1730
    • De Vree, J.M.1    Ottenhoff, R.2    Bosma, P.J.3    Smith, A.J.4    Aten, J.5    Oude Elferink, R.P.6
  • 5
    • 3242727039 scopus 로고    scopus 로고
    • Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    • P. Fickert, A. Fuchsbichler, M. Wagner, G. Zollner, A. Kaser, and H. Tilg Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice Gastroenterology 127 2004 261 274
    • (2004) Gastroenterology , vol.127 , pp. 261-274
    • Fickert, P.1    Fuchsbichler, A.2    Wagner, M.3    Zollner, G.4    Kaser, A.5    Tilg, H.6
  • 6
    • 0017345201 scopus 로고
    • Subcellular pathology of rat liver in cholestasis and choleresis induced by bile salts. 1. Effects of lithocholic, 3beta-hydroxy-5- cholenoic, cholic, and dehydrocholic acids
    • K. Miyai, A.L. Richardson, W. Mayr, and N.B. Javitt Subcellular pathology of rat liver in cholestasis and choleresis induced by bile salts. 1. Effects of lithocholic, 3beta-hydroxy-5- cholenoic, cholic, and dehydrocholic acids Lab Invest 36 1977 249 258
    • (1977) Lab Invest , vol.36 , pp. 249-258
    • Miyai, K.1    Richardson, A.L.2    Mayr, W.3    Javitt, N.B.4
  • 7
    • 0025247125 scopus 로고
    • Hepatic injury induced by bile salts: Correlation between biochemical and morphological events
    • D.L. Schmucker, M. Ohta, S. Kanai, Y. Sato, and K. Kitani Hepatic injury induced by bile salts: correlation between biochemical and morphological events Hepatology 12 1990 1216 1221
    • (1990) Hepatology , vol.12 , pp. 1216-1221
    • Schmucker, D.L.1    Ohta, M.2    Kanai, S.3    Sato, Y.4    Kitani, K.5
  • 8
    • 17344366172 scopus 로고    scopus 로고
    • A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
    • S.S. Strautnieks, L.N. Bull, A.S. Knisely, S.A. Kocoshis, N. Dahl, and H. Arnell A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis Nat Genet 20 1998 233 238
    • (1998) Nat Genet , vol.20 , pp. 233-238
    • Strautnieks, S.S.1    Bull, L.N.2    Knisely, A.S.3    Kocoshis, S.A.4    Dahl, N.5    Arnell, H.6
  • 9
    • 0035203879 scopus 로고    scopus 로고
    • BSEP: Function and role in progressive familial intrahepatic cholestasis
    • R. Thompson, and S. Strautnieks BSEP: function and role in progressive familial intrahepatic cholestasis Semin Liver Dis 21 2001 545 550
    • (2001) Semin Liver Dis , vol.21 , pp. 545-550
    • Thompson, R.1    Strautnieks, S.2
  • 11
    • 0032711405 scopus 로고    scopus 로고
    • Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis
    • P.L. Jansen, S.S. Strautnieks, E. Jacquemin, M. Hadchouel, E.M. Sokal, and G.J. Hooiveld Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis Gastroenterology 117 1999 1370 1379
    • (1999) Gastroenterology , vol.117 , pp. 1370-1379
    • Jansen, P.L.1    Strautnieks, S.S.2    Jacquemin, E.3    Hadchouel, M.4    Sokal, E.M.5    Hooiveld, G.J.6
  • 12
    • 0030027622 scopus 로고    scopus 로고
    • Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis
    • C. Gartung, M. Ananthanarayanan, M.A. Rahman, S. Schuele, S. Nundy, and C.J. Soroka Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis Gastroenterology 110 1996 199 209
    • (1996) Gastroenterology , vol.110 , pp. 199-209
    • Gartung, C.1    Ananthanarayanan, M.2    Rahman, M.A.3    Schuele, S.4    Nundy, S.5    Soroka, C.J.6
  • 13
    • 0000904366 scopus 로고
    • Metabolism of bile salts in cholestasis in humans
    • N. Tavoloni P. Berk Raven Press New York, NY
    • J.D. Ostrow Metabolism of bile salts in cholestasis in humans N. Tavoloni P. Berk Hepatic transport and bile secretion 1993 Raven Press New York, NY 673 712
    • (1993) Hepatic Transport and Bile Secretion , pp. 673-712
    • Ostrow, J.D.1
  • 14
    • 0034928631 scopus 로고    scopus 로고
    • Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver
    • M.G. Donner, and D. Keppler Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver Hepatology 34 2001 351 359
    • (2001) Hepatology , vol.34 , pp. 351-359
    • Donner, M.G.1    Keppler, D.2
  • 15
    • 0035080391 scopus 로고    scopus 로고
    • Cellular localization and up-regulation of multidrug resistance- associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
    • C.J. Soroka, J.M. Lee, F. Azzaroli, and J.L. Boyer Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver Hepatology 33 2001 783 791
    • (2001) Hepatology , vol.33 , pp. 783-791
    • Soroka, C.J.1    Lee, J.M.2    Azzaroli, F.3    Boyer, J.L.4
  • 16
    • 0345732179 scopus 로고    scopus 로고
    • Molecular aspects of bile formation and cholestasis
    • M. Arrese, and M. Trauner Molecular aspects of bile formation and cholestasis Trends Mol Med 9 2003 558 564
    • (2003) Trends Mol Med , vol.9 , pp. 558-564
    • Arrese, M.1    Trauner, M.2
  • 17
    • 17844384799 scopus 로고    scopus 로고
    • Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans
    • M. Bertolotti, L. Carulli, M. Concari, P. Martella, P. Loria, and E. Tagliafico Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans Hepatology 34 2001 234 242
    • (2001) Hepatology , vol.34 , pp. 234-242
    • Bertolotti, M.1    Carulli, L.2    Concari, M.3    Martella, P.4    Loria, P.5    Tagliafico, E.6
  • 19
    • 10744225137 scopus 로고    scopus 로고
    • Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
    • M.H. Schoemaker, W.M. Gommans, L.C. de la Rosa, M. Homan, P. Klok, and C. Trautwein Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation J Hepatol 39 2003 153 161
    • (2003) J Hepatol , vol.39 , pp. 153-161
    • Schoemaker, M.H.1    Gommans, W.M.2    De La Rosa, L.C.3    Homan, M.4    Klok, P.5    Trautwein, C.6
  • 20
  • 21
    • 0142151769 scopus 로고    scopus 로고
    • Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
    • A. Canbay, A.E. Feldstein, H. Higuchi, N. Werneburg, A. Grambihler, and S.F. Bronk Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression Hepatology 38 2003 1188 1198
    • (2003) Hepatology , vol.38 , pp. 1188-1198
    • Canbay, A.1    Feldstein, A.E.2    Higuchi, H.3    Werneburg, N.4    Grambihler, A.5    Bronk, S.F.6
  • 22
    • 0042766884 scopus 로고    scopus 로고
    • Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice
    • J.S. Gujral, A. Farhood, M.L. Bajt, and H. Jaeschke Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice Hepatology 38 2003 355 363
    • (2003) Hepatology , vol.38 , pp. 355-363
    • Gujral, J.S.1    Farhood, A.2    Bajt, M.L.3    Jaeschke, H.4
  • 23
    • 0036080253 scopus 로고    scopus 로고
    • Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease
    • M.E. Guicciardi, and G.J. Gores Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease Digest Liver Dis 34 2002 387 392
    • (2002) Digest Liver Dis , vol.34 , pp. 387-392
    • Guicciardi, M.E.1    Gores, G.J.2
  • 26
    • 1242294416 scopus 로고    scopus 로고
    • Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase- mediated ceramide generation in FAS receptor activation
    • S. Gupta, R. Natarajan, S.G. Payne, E.J. Studer, S. Spiegel, and P. Dent Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation J Biol Chem 279 2004 5821 5828
    • (2004) J Biol Chem , vol.279 , pp. 5821-5828
    • Gupta, S.1    Natarajan, R.2    Payne, S.G.3    Studer, E.J.4    Spiegel, S.5    Dent, P.6
  • 27
    • 0035167269 scopus 로고    scopus 로고
    • Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and Fas receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis
    • L. Qiao, E. Studer, K. Leach, R. McKinstry, S. Gupta, and R. Decker Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and Fas receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis Mol Biol Cell 12 2001 2629 2645
    • (2001) Mol Biol Cell , vol.12 , pp. 2629-2645
    • Qiao, L.1    Studer, E.2    Leach, K.3    McKinstry, R.4    Gupta, S.5    Decker, R.6
  • 28
    • 0041322990 scopus 로고    scopus 로고
    • Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
    • R. Reinehr, D. Graf, and D. Haussinger Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation Gastroenterology 125 2003 839 853
    • (2003) Gastroenterology , vol.125 , pp. 839-853
    • Reinehr, R.1    Graf, D.2    Haussinger, D.3
  • 29
    • 0347361545 scopus 로고    scopus 로고
    • Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95
    • R. Reinehr, and D. Haussinger Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95 Gastroenterology 126 2004 249 262
    • (2004) Gastroenterology , vol.126 , pp. 249-262
    • Reinehr, R.1    Haussinger, D.2
  • 30
    • 0035914341 scopus 로고    scopus 로고
    • The bile acid glycochenodeoxycholate induces TRAIL-receptor 2/DR5 expression and apoptosis
    • H. Higuchi, S.F. Bronk, Y. Takikawa, N. Werneburg, R. Takimoto, and W. El-Deiry The bile acid glycochenodeoxycholate induces TRAIL-receptor 2/DR5 expression and apoptosis J Biol Chem 276 2001 38610 38618
    • (2001) J Biol Chem , vol.276 , pp. 38610-38618
    • Higuchi, H.1    Bronk, S.F.2    Takikawa, Y.3    Werneburg, N.4    Takimoto, R.5    El-Deiry, W.6
  • 31
    • 0028816461 scopus 로고
    • Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
    • R. Botla, J.R. Spivey, H. Aguilar, S.F. Bronk, and G.J. Gores Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection J Pharmacol Exp Ther 272 1995 930 938
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 930-938
    • Botla, R.1    Spivey, J.R.2    Aguilar, H.3    Bronk, S.F.4    Gores, G.J.5
  • 32
    • 0034899577 scopus 로고    scopus 로고
    • Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria
    • A.P. Rolo, P.J. Oliveira, A.J. Moreno, and C.M. Palmeira Chenodeoxycholate is a potent inducer of the permeability transition pore in rat liver mitochondria Biosci Rep 21 2001 73 80
    • (2001) Biosci Rep , vol.21 , pp. 73-80
    • Rolo, A.P.1    Oliveira, P.J.2    Moreno, A.J.3    Palmeira, C.M.4
  • 33
    • 13844278938 scopus 로고    scopus 로고
    • Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor
    • F.P. Wachs, R.C. Krieg, C.M. Rodrigues, H. Messmann, F. Kullmann, and R. Knuchel-Clarke Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor Int J Colorectal Dis 2004
    • (2004) Int J Colorectal Dis
    • Wachs, F.P.1    Krieg, R.C.2    Rodrigues, C.M.3    Messmann, H.4    Kullmann, F.5    Knuchel-Clarke, R.6
  • 34
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • C.M. Rodrigues, G. Fan, X. Ma, B.T. Kren, and C.J. Steer A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation J Clin Invest 101 1998 2790 2799
    • (1998) J Clin Invest , vol.101 , pp. 2790-2799
    • Rodrigues, C.M.1    Fan, G.2    Ma, X.3    Kren, B.T.4    Steer, C.J.5
  • 35
    • 4644238904 scopus 로고    scopus 로고
    • Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation
    • J.S. Gujral, J. Liu, A. Farhood, and H. Jaeschke Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation Hepatology 40 2004 998 1007
    • (2004) Hepatology , vol.40 , pp. 998-1007
    • Gujral, J.S.1    Liu, J.2    Farhood, A.3    Jaeschke, H.4
  • 37
    • 0036788277 scopus 로고    scopus 로고
    • Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
    • A. Canbay, H. Higuchi, S.F. Bronk, M. Taniai, T.J. Sebo, and G.J. Gores Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis Gastroenterology 123 2002 1323 1330
    • (2002) Gastroenterology , vol.123 , pp. 1323-1330
    • Canbay, A.1    Higuchi, H.2    Bronk, S.F.3    Taniai, M.4    Sebo, T.J.5    Gores, G.J.6
  • 39
    • 1342329725 scopus 로고    scopus 로고
    • The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse
    • A. Canbay, A. Feldstein, E. Baskin-Bey, S.F. Bronk, and G.J. Gores The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse J Pharmacol Exp Ther 308 2004 1191 1196
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1191-1196
    • Canbay, A.1    Feldstein, A.2    Baskin-Bey, E.3    Bronk, S.F.4    Gores, G.J.5
  • 40
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • L. Yu, A. Alva, H. Su, P. Dutt, E. Freundt, and S. Welsh Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8 Science 304 2004 1500 1502
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6
  • 41
    • 0041666539 scopus 로고    scopus 로고
    • Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties
    • T.M. Caserta, A.N. Smith, A.D. Gultice, M.A. Reedy, and T.L. Brown Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties Apoptosis 8 2003 345 352
    • (2003) Apoptosis , vol.8 , pp. 345-352
    • Caserta, T.M.1    Smith, A.N.2    Gultice, A.D.3    Reedy, M.A.4    Brown, T.L.5
  • 42
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • F. Martinon, K. Burns, and J. Tschopp The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta Mol Cell 10 2002 417 426
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 43
    • 4344616982 scopus 로고    scopus 로고
    • Targeting apoptosis via chemical design: Inhibition of Bid-induced cell death by small organic molecules
    • B. Becattini, S. Sareth, D. Zhai, K.J. Crowell, M. Leone, and J.C. Reed Targeting apoptosis via chemical design: inhibition of Bid-induced cell death by small organic molecules Chem Biol 11 2004 1107 1117
    • (2004) Chem Biol , vol.11 , pp. 1107-1117
    • Becattini, B.1    Sareth, S.2    Zhai, D.3    Crowell, K.J.4    Leone, M.5    Reed, J.C.6
  • 44
    • 0141996262 scopus 로고    scopus 로고
    • First clinical trial of a novel caspase inhibitor: Anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes
    • K.L. Valentino, M. Gutierrez, R. Sanchez, M.J. Winship, and D.A. Shapiro First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes Int J Clin Pharmacol Ther 41 2003 441 449
    • (2003) Int J Clin Pharmacol Ther , vol.41 , pp. 441-449
    • Valentino, K.L.1    Gutierrez, M.2    Sanchez, R.3    Winship, M.J.4    Shapiro, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.