Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy

International Immunology

Volumn 17, Issue 2, 2005, Pages 123-132

  Smyth, Christine M ^a   Logan, Grant ^a   Boadle, Ross ^b   Rowe, Peter B ^a   Smythe, Jason A ^c   Alexander, Ian E ^a  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

^c NONE

Author keywords

Cytoplasmic CD86

Indexed keywords

CD86 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ARTICLE; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL POPULATION; CELL STRUCTURE; CELL TYPE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DENDRITIC CELL; ENDOCYTOSIS; FLOW CYTOMETRY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOELECTRON MICROSCOPY; IMMUNOPHENOTYPING; IN VITRO STUDY; MACROPHAGE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TRANSMISSION ELECTRON MICROSCOPY;

ANTIGENS, CD; ANTIGENS, CD86; CYCLOHEXIMIDE; CYTOPLASMIC VESICLES; DENDRITIC CELLS; GOLGI APPARATUS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICROSCOPY, IMMUNOELECTRON; MONOCYTES; PROTEIN BIOSYNTHESIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 13844271265     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh193     Document Type: Article

References (36)

1. Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P. and Hodes, R. J. 1994. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180:631.
2. Guinan, E. C., Gribben, J. G., Boussiotis, V. A., Freeman, G. J. and Nadler, L. M. 1994. Pivotal role of the BTCD28 pathway in transplantation tolerance and tumor immunity. Blood 84:3261.
3. Linsley, P. S., Greene, J. L., Brady, W., Bajorath, J., Ledbetter, J. A. and Peach, R. 1994. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
4. Linsley, P. S. and Ledbetter, J. A. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
5. Zhou, L. J. and Tedder, T. F. 1996. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc. Natl Acad. Sci. USA 93:2588.
6. Smyth, C., Logan, G., Weinberger, R. P., Rowe, P. B., Alexander, I. E. and Smythe, J. A. 1998. Identification of a dynamic intracellular reservoir of CD86 protein in peripheral blood monocytes that is not associated with the Golgi complex. J. Immunol. 160:5390.
7. Randolph, G. J., Beaulieu, S., Lebecque, S., Steinman, R. M. and Muller, W. A. 1998. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282:480.
8. Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B. and Palucka, K. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:767.
9. Banchereau, J. and Steinman, R. M. 1998. Dendritic cells and the control of immunity. Nature 392:245.
10. Hathcock, K. S., Laszlo, G., Dickler, H. B., Bradshaw, J., Linsley, P. and Hodes, R. J. 1993. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 262:905.
11. Freeman, G. J. et al. 1993. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262:907.
12. Lohr, J., Knoechel, B., Jiang, S., Sharpe, A. H. and Abbas, A. K. 2003. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat. Immunol. 4:664.
13. Van Voorhis, W. C., Steinman, R. M., Hair, L. S., Luban, J., Witmer, M. D., Koide, S. and Cohn, Z. A. 1983. Specific antimononuclear phagocyte monoclonal antibodies. Application to the purification of dendritic cells and the tissue localization of macrophages. J. Exp. Med. 158:126.
14. Bender, A., Sapp, M., Schuler, G., Steinman, R. M. and Bhardwaj, N. 1996. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods 196:121.
15. Sallusto, F. and Lanzavecchia, A. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp. Med. 179:1109.
16. Diao, J., Smythe, J. A., Smyth, C., Rowe, P. B. and Alexander, I. E. 1999. Human PBMC-derived dendritic cells transduced with an adenovirus vector induce cytotoxic T lymphocyte responses against a vector-encoded antigen in vitro. Gene Ther. 6:845.
17. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
18. Tokuyasu, K. T. 1989. Use of poly(vinylpyrrolidone) and poly(vinyl alcohol) for cryo-ultramicrotomy. Histochem. J. 21:163.
19. Turley, S. J., Inaba, K., Garrett, W. S., Ebersold, M., Unternaehrer, J., Steinman, R. M. and Mellman, I. 2000. Transport of peptide-MHC class II complexes in developing dendritic cells. Science 288:522.
20. Pierre, P., Turley, S. J., Gatti, E., Hull, M., Meltzer, J., Mirza, A., Inaba, K., Steinman, R. M. and Mellman, I. 1997. Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 388:787.
21. Arkema, J. M., Schadee-Eestermans, I. L., Broekhuis-Fluitsma, D. M. and Hoefsmit, E. C. 1991. Localization of class II molecules in storage vesicles, endosomes and lysosomes in human dendritic cells. Immunobiology 183:396.
22. Azuma, M., Ito, D., Yagita, H., Okumura, K., Phillips, J. H., Lanier, L. L. and Somoza, C. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76.
23. Ziegler-Heitbrock, H. W. 2000. Definition of human blood monocytes. J. Leukoc. Biol. 67:603.
24. Inaba, K., Turley, S., Iyoda, T., Yamaide, F., Shimoyama, S., Reis, E., Germain, R. N., Mellman, I. and Steinman, R. M. 2000. The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J. Exp. Med. 191:927.
25. Kleijmeer, M. J., Morkowski, S., Griffith, J. M., Rudensky, A. Y. and Geuze, H. J. 1997. Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments. J. Cell Biol. 139:639.
26. Engering, A. J., Cella, M., Fluitsma, D., Brockhaus, M., Hoefsmit, E. C., Lanzavecchia, A. and Pieters, J. 1997. The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. Eur. J. Immunol. 27:2417.
27. Boes, M., Cerny, J., Massol, R., Op, D. B., Kirchhausen, T., Chen, J. and Ploegh, H. L. 2002. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418:983.
28. Chow, A., Toomre, D., Garrett, W. and Mellman, I. 2002. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 418:988.
29. Duperrier, K., Eljaafari, A., Dezutter-Dambuyant, C., Bardin, C., Jacquet, C., Yoneda, K., Schmitt, D., Gebuhrer, L. and Rigal, D. 2000. Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplements. J. Immunol. Methods 238:119.
30. Grassi, F. et al. 1998. Monocyte-derived dendritic cells have a phenotype comparable to that of dermal dendritic cells and display ultrastructural granules distinct from Birbeck granules. J. Leukoc. Biol. 64:484.
31. Mellman, I. and Steinman, R. M. 2001. Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255.
32. Van Voorhis, W. C., Valinsky, J., Hoffman, E., Luban, J., Hair, L. S. and Steinman, R. M. 1983. Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J. Exp. Med. 158:174.
33. Grage-Griebenow, E., Flad, H. D. and Ernst, M. 2001. Heterogeneity of human peripheral blood monocyte subsets. J. Leukoc. Biol. 69:11.
34. MacDonald, K. P., Munster, D. J., Clark, G. J., Dzionek, A., Schmitz, J. and Hart, D. N. 2002. Characterization of human blood dendritic cell subsets. Blood 100:4512.
35. Nestle, F. O., Banchereau, J. and Hart, D. 2001. Dendritic cells: on the move from bench to bedside. Nat. Med. 7:761.
36. Osugi, Y., Vuckovic, S. and Hart, D. N. 2002. Myeloid blood CD11c(+) dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes. Blood 100:2858.