-
1
-
-
0025992146
-
A leucine zipper-like motif may mediate HIV reverse transcriptase subunit binding
-
Baillon JG, Nashed NT, Kumar A, Wilson SH, Jerina DM. 1991. A leucine zipper-like motif may mediate HIV reverse transcriptase subunit binding. New Biol 3:1015-1019.
-
(1991)
New Biol
, vol.3
, pp. 1015-1019
-
-
Baillon, J.G.1
Nashed, N.T.2
Kumar, A.3
Wilson, S.H.4
Jerina, D.M.5
-
2
-
-
0025044785
-
Characterization of the human immunodeficiency virus type 1 reverse transcriptase produced in yeast
-
Bathurst IC, Moen LK, Lujan MA, Gibson HL, Feucht PH, Pichuantes S, Craik CS, Santi DV, Barr PJ. 1990. Characterization of the human immunodeficiency virus type 1 reverse transcriptase produced in yeast. Biochem Biophys Res Commun 171:589-595.
-
(1990)
Biochem Biophys Res Commun
, vol.171
, pp. 589-595
-
-
Bathurst, I.C.1
Moen, L.K.2
Lujan, M.A.3
Gibson, H.L.4
Feucht, P.H.5
Pichuantes, S.6
Craik, C.S.7
Santi, D.V.8
Barr, P.J.9
-
3
-
-
0026355738
-
Protein-protein interactions of HIV-1 reverse transcriptase: Implications of central and C-terminal regions in subunit binding. (Lewis MS. Appendix: Ultracentrifuge analysis of a mixed association.)
-
Becerra SP, Kumar A, Lewis MS, Wide SG, Abbotts J, Karawya EM, Hughes SH, Shiloach J, Wilson SH. 1991. Protein-protein interactions of HIV-1 reverse transcriptase: Implications of central and C-terminal regions in subunit binding. (Lewis MS. Appendix: Ultracentrifuge analysis of a mixed association.) Biochemistry 30:11707-11719.
-
(1991)
Biochemistry
, vol.30
, pp. 11707-11719
-
-
Becerra, S.P.1
Kumar, A.2
Lewis, M.S.3
Wide, S.G.4
Abbotts, J.5
Karawya, E.M.6
Hughes, S.H.7
Shiloach, J.8
Wilson, S.H.9
-
4
-
-
0026751771
-
Purification, characterization and crystallization of recombinant HIV-1 reverse transcriptase
-
Bhikhabhai R, Jackson T, Unge T, Strandberg B, Carlsson T, Lövgren S. 1992. Purification, characterization and crystallization of recombinant HIV-1 reverse transcriptase. J Chromatogr 604:157-170.
-
(1992)
J Chromatogr
, vol.604
, pp. 157-170
-
-
Bhikhabhai, R.1
Jackson, T.2
Unge, T.3
Strandberg, B.4
Carlsson, T.5
Lövgren, S.6
-
5
-
-
0022475490
-
Biochemical heterogeneity of reverse transcriptase purified from the AIDS virus
-
Chandra A, Gerber T, Kaul S, Wolf C, Demirhan I, Chandra P. 1986. Biochemical heterogeneity of reverse transcriptase purified from the AIDS virus. FEBS Lett 200:321-323.
-
(1986)
FEBS Lett
, vol.200
, pp. 321-323
-
-
Chandra, A.1
Gerber, T.2
Kaul, S.3
Wolf, C.4
Demirhan, I.5
Chandra, P.6
-
6
-
-
0027500534
-
A model for reverse transcription by a dimeric enzyme
-
Cook PR. 1993. A model for reverse transcription by a dimeric enzyme. J Gen Virol 74:691-697.
-
(1993)
J Gen Virol
, vol.74
, pp. 691-697
-
-
Cook, P.R.1
-
7
-
-
0014817347
-
Use of dimethylsuberimidate, a crosslinking reagent, in studying the subunit structure of oligomeric proteins
-
Davies GE, Stark GR. 1970. Use of dimethylsuberimidate, a crosslinking reagent, in studying the subunit structure of oligomeric proteins. Proc Natl Acad Sci USA 66:651-656.
-
(1970)
Proc Natl Acad Sci USA
, vol.66
, pp. 651-656
-
-
Davies, G.E.1
Stark, G.R.2
-
8
-
-
13344286154
-
Studies on HIV-1 reverse transcriptase and reverse transcriptase inhibitors
-
Viral DNA synthesis. Leuven University Press
-
Debyser Z. 1994. Studies on HIV-1 reverse transcriptase and reverse transcriptase inhibitors. In: Viral DNA synthesis. Leuven University Press. Acta Biomedica Lovaniensia 77:43-46.
-
(1994)
Acta Biomedica Lovaniensia
, vol.77
, pp. 43-46
-
-
Debyser, Z.1
-
9
-
-
0026503005
-
Allosteric inhibition of HIV-1 reverse transcriptase by TIBO compounds
-
Debyser Z, Pauwels R, Andries K, Desmyter J, Engelborghs Y, Janssen PAJ, De Clercq E. 1992. Allosteric inhibition of HIV-1 reverse transcriptase by TIBO compounds. Mol Pharmacol 41:203-208.
-
(1992)
Mol Pharmacol
, vol.41
, pp. 203-208
-
-
Debyser, Z.1
Pauwels, R.2
Andries, K.3
Desmyter, J.4
Engelborghs, Y.5
Janssen, P.A.J.6
De Clercq, E.7
-
10
-
-
0025962924
-
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo[4,5,1-jk] [1,4]benzodiazepin-2(1H)one and -thione derivatives
-
Debyser Z, Pauwels R, Andries K, Desmyter J, Kukla M, Janssen PAJ, De Clercq E. 1991. An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo[4,5,1-jk] [1,4]benzodiazepin-2(1H)one and -thione derivatives. Proc Natl Acad Sci USA 88:1451-1455.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 1451-1455
-
-
Debyser, Z.1
Pauwels, R.2
Andries, K.3
Desmyter, J.4
Kukla, M.5
Janssen, P.A.J.6
De Clercq, E.7
-
11
-
-
0026523623
-
HIV inhibitors targeted at the reverse transcriptase
-
De Clercq E. 1992. HIV inhibitors targeted at the reverse transcriptase. AIDS Res Human Retrovir 8:119-134.
-
(1992)
AIDS Res Human Retrovir
, vol.8
, pp. 119-134
-
-
De Clercq, E.1
-
12
-
-
0022498061
-
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV
-
Di Marzo-Véronese F, Copeland TD, DeVico AL, Rahman R, Oroszlan S, Gallo RC, Sarngadharan MG. 1986. Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science 231:1289-1291.
-
(1986)
Science
, vol.231
, pp. 1289-1291
-
-
Di Marzo-Véronese, F.1
Copeland, T.D.2
DeVico, A.L.3
Rahman, R.4
Oroszlan, S.5
Gallo, R.C.6
Sarngadharan, M.G.7
-
13
-
-
0028447435
-
Buried surface analysis of HIV-1 reverse transcriptase p66/p51 heterodimer and its interaction with dsDNA template/primer
-
Ding J, Jacobo-Molina A, Tantillo C, Lu X, Nanni RG, Arnold E. 1994. Buried surface analysis of HIV-1 reverse transcriptase p66/p51 heterodimer and its interaction with dsDNA template/primer. J Mol Recognition 7:157-161.
-
(1994)
J Mol Recognition
, vol.7
, pp. 157-161
-
-
Ding, J.1
Jacobo-Molina, A.2
Tantillo, C.3
Lu, X.4
Nanni, R.G.5
Arnold, E.6
-
14
-
-
0027240045
-
Kinetics of interaction of HIV reverse transcriptase with primer/template
-
Divita G, Müller B, Immendörfer U, Gautel M, Rittinger K, Restle T, Goody RS. 1993. Kinetics of interaction of HIV reverse transcriptase with primer/template. Biochemistry 32:7966-7971.
-
(1993)
Biochemistry
, vol.32
, pp. 7966-7971
-
-
Divita, G.1
Müller, B.2
Immendörfer, U.3
Gautel, M.4
Rittinger, K.5
Restle, T.6
Goody, R.S.7
-
15
-
-
0028308202
-
Inhibition of human immunodeficiency virus type 1 reverse transcriptase using synthetic peptides derived from the connection domain
-
Divita G, Restle T, Goody RS, Chermann JC, Baillon JG. 1994. Inhibition of human immunodeficiency virus type 1 reverse transcriptase using synthetic peptides derived from the connection domain. J Biol Chem 269: 13080-13083.
-
(1994)
J Biol Chem
, vol.269
, pp. 13080-13083
-
-
Divita, G.1
Restle, T.2
Goody, R.S.3
Chermann, J.C.4
Baillon, J.G.5
-
16
-
-
0027769772
-
Structure/function studies of HIV-1 reverse transcriptase: Dimerization-defective mutant L289K
-
Goel R, Beard WA, Kumar A, Casas-Finet JR, Strub MP, Stahl SJ, Lewis MS, Bebenek K, Becerra SP, Kunkel TA, Wilson SH. 1993. Structure/function studies of HIV-1 reverse transcriptase: Dimerization-defective mutant L289K. Biochemistry 32:13012-13018.
-
(1993)
Biochemistry
, vol.32
, pp. 13012-13018
-
-
Goel, R.1
Beard, W.A.2
Kumar, A.3
Casas-Finet, J.R.4
Strub, M.P.5
Stahl, S.J.6
Lewis, M.S.7
Bebenek, K.8
Becerra, S.P.9
Kunkel, T.A.10
Wilson, S.H.11
-
17
-
-
0024999452
-
Retroviral reverse transcriptase: Synthesis, structure and function
-
Goff SP. 1990. Retroviral reverse transcriptase: Synthesis, structure and function. J AIDS 3:817-831.
-
(1990)
J AIDS
, vol.3
, pp. 817-831
-
-
Goff, S.P.1
-
18
-
-
0023673620
-
Identification and characterization of HIV-specific RNase H by monoclonal antibody
-
Hansen J, Schultze T, Mellert W, Moelling K. 1988. Identification and characterization of HIV-specific RNase H by monoclonal antibody. EMBO J 7:239-243.
-
(1988)
EMBO J
, vol.7
, pp. 239-243
-
-
Hansen, J.1
Schultze, T.2
Mellert, W.3
Moelling, K.4
-
19
-
-
0028874048
-
Rapid turnover of plasma virions and CD4 lymphocyte in HIV-1 infection
-
Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. 1995. Rapid turnover of plasma virions and CD4 lymphocyte in HIV-1 infection. Nature 373:123-126.
-
(1995)
Nature
, vol.373
, pp. 123-126
-
-
Ho, D.D.1
Neumann, A.U.2
Perelson, A.S.3
Chen, W.4
Leonard, J.M.5
Markowitz, M.6
-
20
-
-
0022344161
-
Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions
-
Hoffman AD, Banapour B, Levy JA. 1985. Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions. Virology 147:326-335.
-
(1985)
Virology
, vol.147
, pp. 326-335
-
-
Hoffman, A.D.1
Banapour, B.2
Levy, J.A.3
-
21
-
-
0025775810
-
HIV reverse transcriptase structurefunction relationships
-
Jacobo-Molina A, Arnold E. 1991. HIV reverse transcriptase structurefunction relationships. Biochemistry 30:6351-6361.
-
(1991)
Biochemistry
, vol.30
, pp. 6351-6361
-
-
Jacobo-Molina, A.1
Arnold, E.2
-
22
-
-
0027318776
-
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Ȧ resolution shows bent DNA
-
Jacobo-Molina A, Ding J, Nanni R, Clark AD, Lu X, Tantillo C, Williams R, Kamer G, Ferris AL, Clark P, Hizi A, Hughes S, Arnold E. 1993. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Ȧ resolution shows bent DNA. Proc Natl Acad Sci USA 90:6320-6324.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 6320-6324
-
-
Jacobo-Molina, A.1
Ding, J.2
Nanni, R.3
Clark, A.D.4
Lu, X.5
Tantillo, C.6
Williams, R.7
Kamer, G.8
Ferris, A.L.9
Clark, P.10
Hizi, A.11
Hughes, S.12
Arnold, E.13
-
23
-
-
2642604727
-
Computer analysis of retroviral pol genes: Assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes
-
Johnson MA, McClure MA, Feng DF, Gray J, Doolittle RF. 1986. Computer analysis of retroviral pol genes: Assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes. Proc Natl Acad Sci USA 83:7648-7452.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 7648-17452
-
-
Johnson, M.A.1
McClure, M.A.2
Feng, D.F.3
Gray, J.4
Doolittle, R.F.5
-
24
-
-
0028099251
-
138→Lys on the p51 subunit
-
138→Lys on the p51 subunit. J Biol Chem 269:25255-25258.
-
(1994)
J Biol Chem
, vol.269
, pp. 25255-25258
-
-
Jonckheere, H.1
Taymans, J.M.2
Balzarini, J.3
Velazquez, S.4
Camarasa, M.J.5
Desmyter, J.6
De Clercq, E.7
Anné, J.8
-
25
-
-
0026693137
-
Crystal structure at 3.5 Ȧ resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. 1992. Crystal structure at 3.5 Ȧ resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 255:1783-1790.
-
(1992)
Science
, vol.255
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
26
-
-
0000456849
-
Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance
-
Skalka AM, Goff SP, eds. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
-
Larder BA. 1993. Inhibitors of HIV reverse transcriptase as antiviral agents and drug resistance. In: Skalka AM, Goff SP, eds. Reverse transcriptase. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. pp 205-222.
-
(1993)
Reverse Transcriptase
, pp. 205-222
-
-
Larder, B.A.1
-
27
-
-
0028138893
-
Human immunodeficiency virus-1 reverse transcriptase heterodimer stability
-
Lebowitz J, Kar S, Braswell E, McPherson S, Richard DL. 1994. Human immunodeficiency virus-1 reverse transcriptase heterodimer stability. Protein Sci 3:1374-1382.
-
(1994)
Protein Sci
, vol.3
, pp. 1374-1382
-
-
Lebowitz, J.1
Kar, S.2
Braswell, E.3
McPherson, S.4
Richard, D.L.5
-
28
-
-
0000650563
-
Human immunodeficiency virus reverse transcriptase
-
Skalka AM, Goff SP, eds. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
-
Le Grice SFJ. 1993. Human immunodeficiency virus reverse transcriptase. In: Skalka AM, Goff SP, eds. Reverse transcriptase. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. pp 163-191.
-
(1993)
Reverse Transcriptase
, pp. 163-191
-
-
Le Grice, S.F.J.1
-
29
-
-
0023019732
-
Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus
-
Lightfoote NN, Coligon JE, Folks TM, Fauci AS, Martin MA, Venkatesan S. 1986. Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus. J Virol 60:771-775.
-
(1986)
J Virol
, vol.60
, pp. 771-775
-
-
Lightfoote, N.N.1
Coligon, J.E.2
Folks, T.M.3
Fauci, A.S.4
Martin, M.A.5
Venkatesan, S.6
-
30
-
-
0025679303
-
Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
-
Merluzzi VJ, Hargrave KD, Labadia M, Grozinger K, Skoog M, Wu JC, Shih CK, Eckner E, Hattox S, Adams J, Rosenthal AS, Faanes R, Eckner RJ, Koup RA, Sullivan JL. 1990. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science 250:1411-1413.
-
(1990)
Science
, vol.250
, pp. 1411-1413
-
-
Merluzzi, V.J.1
Hargrave, K.D.2
Labadia, M.3
Grozinger, K.4
Skoog, M.5
Wu, J.C.6
Shih, C.K.7
Eckner, E.8
Hattox, S.9
Adams, J.10
Rosenthal, A.S.11
Faanes, R.12
Eckner, R.J.13
Koup, R.A.14
Sullivan, J.L.15
-
31
-
-
0027538456
-
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
-
Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362:355-358.
-
(1993)
Nature
, vol.362
, pp. 355-358
-
-
Pantaleo, G.1
Graziosi, C.2
Demarest, J.F.3
Butini, L.4
Montroni, M.5
Fox, C.H.6
Orenstein, J.M.7
Kotler, D.P.8
Fauci, A.S.9
-
32
-
-
0027195850
-
Oligomeric structure of bacteriophage T7 DNA primase/helicase proteins
-
Patel SS, Hingorani MM. 1993. Oligomeric structure of bacteriophage T7 DNA primase/helicase proteins. J Biol Chem 268:10668-10675.
-
(1993)
J Biol Chem
, vol.268
, pp. 10668-10675
-
-
Patel, S.S.1
Hingorani, M.M.2
-
33
-
-
0025014499
-
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
-
Pauwels R, Andries K, Desmyter J, Schols D, Kukla MJ, Breslin HJ, Raeymaeckers A, Van Gelder J, Woestenborghs R, Heykants J, Schellekens K, Janssen MAC, De Clercq E, Janssen PAJ. 1990. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives. Nature 343:470-474.
-
(1990)
Nature
, vol.343
, pp. 470-474
-
-
Pauwels, R.1
Andries, K.2
Desmyter, J.3
Schols, D.4
Kukla, M.J.5
Breslin, H.J.6
Raeymaeckers, A.7
Van Gelder, J.8
Woestenborghs, R.9
Heykants, J.10
Schellekens, K.11
Janssen, M.A.C.12
De Clercq, E.13
Janssen, P.A.J.14
-
34
-
-
0017338248
-
Chemical crosslinking: Reagents and problems in studies of membrane structure
-
Peters K, Richards FM. 1977. Chemical crosslinking: Reagents and problems in studies of membrane structure. Annu Rev Biochem 46:523-551.
-
(1977)
Annu Rev Biochem
, vol.46
, pp. 523-551
-
-
Peters, K.1
Richards, F.M.2
-
35
-
-
0025297454
-
Dimerization of human immunodeficiency virus type 1 reverse transcriptase
-
Restle T, Muller B, Goody RS. 1990. Dimerization of human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem 265:8986-8988.
-
(1990)
J Biol Chem
, vol.265
, pp. 8986-8988
-
-
Restle, T.1
Muller, B.2
Goody, R.S.3
-
36
-
-
0025224522
-
Expression, purification, and crystallization of the HIV-1 reverse transcriptase (RT)
-
Unge T, Ahola H, Bhikhabhai R, Backbro K, Lövgren S, Fenyö EM, Honigman A, Panet A, Gronowitz JS, Strandberg B. 1990. Expression, purification, and crystallization of the HIV-1 reverse transcriptase (RT). AIDS Res Human Retrovir 6:1297-1303.
-
(1990)
AIDS Res Human Retrovir
, vol.6
, pp. 1297-1303
-
-
Unge, T.1
Ahola, H.2
Bhikhabhai, R.3
Backbro, K.4
Lövgren, S.5
Fenyö, E.M.6
Honigman, A.7
Panet, A.8
Gronowitz, J.S.9
Strandberg, B.10
-
37
-
-
0025398721
-
A molecular modeling and drug design program
-
Vriend G. 1990. A molecular modeling and drug design program. J Mol Graph 8:52-56.
-
(1990)
J Mol Graph
, vol.8
, pp. 52-56
-
-
Vriend, G.1
-
38
-
-
0028811974
-
Viral dynamics in human immunodeficiency virus type 1 infection
-
Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-122.
-
(1995)
Nature
, vol.373
, pp. 117-122
-
-
Wei, X.1
Ghosh, S.K.2
Taylor, M.E.3
Johnson, V.A.4
Emini, E.A.5
Deutsch, P.6
Lifson, J.D.7
Bonhoeffer, S.8
Nowak, M.A.9
Hahn, B.H.10
Saag, M.S.11
Shaw, G.M.12
|