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Volumn 46, Issue 3, 2005, Pages 435-442

Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia

Author keywords

AG490; Apoptosis; B CLL; Fludarabine; STAT1; WHI P131

Indexed keywords

4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; BENEFLUR; FLUDARABINE; JANUS KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHOTRANSFERASE INHIBITOR; STAT1 PROTEIN; TYRPHOSTIN A42;

EID: 13544249962     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190400018398     Document Type: Article
Times cited : (30)

References (33)
  • 1
    • 0034306290 scopus 로고    scopus 로고
    • STAT proteins and transcriptional responses to extracellular signals
    • Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 2000;25:496-502.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 496-502
    • Horvath, C.M.1
  • 3
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli M, Baer MR, Baumann H, Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood 2003;101:2940-2954.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3    Wetzler, M.4
  • 4
    • 0034658153 scopus 로고    scopus 로고
    • STAT signaling in the pathogenesis and treatment of leukemias
    • Lin TS, Mahajan S, Frank DA. STAT signaling in the pathogenesis and treatment of leukemias. Oncogene 2000;19:2496-2504.
    • (2000) Oncogene , vol.19 , pp. 2496-2504
    • Lin, T.S.1    Mahajan, S.2    Frank, D.A.3
  • 5
    • 0033976059 scopus 로고    scopus 로고
    • The Jak-Stat pathway in normal and perturbed hematopoiesis
    • Ward AC, Touw I, Yoshimura A. The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood 2000;95:19-29.
    • (2000) Blood , vol.95 , pp. 19-29
    • Ward, A.C.1    Touw, I.2    Yoshimura, A.3
  • 6
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer-new molecular targets come of age
    • Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004;4:97-105.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 7
    • 0032530972 scopus 로고    scopus 로고
    • Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
    • Schwaller J, Frantsve J, Aster J, Williams IR, Tomasson MH, Ross TS, Peeters P, Van Rompaey L, Van Etten RA, Ilaria R, Jr, et al. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J 1998;17:5321-5333.
    • (1998) EMBO J. , vol.17 , pp. 5321-5333
    • Schwaller, J.1    Frantsve, J.2    Aster, J.3    Williams, I.R.4    Tomasson, M.H.5    Ross, T.S.6    Peeters, P.7    Van Rompaey, L.8    Van Etten, R.A.9    Ilaria Jr., R.10
  • 9
    • 0031815977 scopus 로고    scopus 로고
    • Molecular biology of chronic lymphocytic leukemia: Implications for therapy
    • Reed JC. Molecular biology of chronic lymphocytic leukemia: implications for therapy. Semin Hematol 1998;35:3-13.
    • (1998) Semin. Hematol. , vol.35 , pp. 3-13
    • Reed, J.C.1
  • 10
    • 0031890032 scopus 로고    scopus 로고
    • Molecular biology of chronic lymphocytic leukemia
    • Reed JC. Molecular biology of chronic lymphocytic leukemia. Semin Oncol 1998;25:11-18.
    • (1998) Semin. Oncol. , vol.25 , pp. 11-18
    • Reed, J.C.1
  • 11
    • 0042971643 scopus 로고    scopus 로고
    • B cell chronic lymphocytic leukemia: Lessons learned from studies of the B cell antigen receptor
    • Chiorazzi N, Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol 2003;21:841-894.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 841-894
    • Chiorazzi, N.1    Ferrarini, M.2
  • 12
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest 1997;100:3140-3148.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 13
    • 0032950743 scopus 로고    scopus 로고
    • Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling
    • Frank DA, Mahajan S, Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med 1999;5:444-447.
    • (1999) Nat. Med. , vol.5 , pp. 444-447
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 15
    • 0344466789 scopus 로고    scopus 로고
    • In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 ′4-(4′hydroxyphenyl)-amino-6,7- dimethoxyquinazoline
    • Uckun FM, Ek O, Liu XP, Chen CL. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 ′4-(4′hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res 1999;5:2954-2962.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2954-2962
    • Uckun, F.M.1    Ek, O.2    Liu, X.P.3    Chen, C.L.4
  • 16
    • 0033053383 scopus 로고    scopus 로고
    • Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
    • Sudbeck EA, Liu XP, Narla RK, Mahajan S, Ghosh S, Mao C, Uckun FM. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res 1999;5:1569-1582.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1569-1582
    • Sudbeck, E.A.1    Liu, X.P.2    Narla, R.K.3    Mahajan, S.4    Ghosh, S.5    Mao, C.6    Uckun, F.M.7
  • 17
    • 0025833550 scopus 로고
    • Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
    • Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C, Levitzki A. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem 199 1;34:1896-1907.
    • (1991) J. Med. Chem. , vol.34 , pp. 1896-1907
    • Gazit, A.1    Osherov, N.2    Posner, I.3    Yaish, P.4    Poradosu, E.5    Gilon, C.6    Levitzki, A.7
  • 18
    • 0001123864 scopus 로고    scopus 로고
    • JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response
    • Wang LH, Kirken RA, Erwin RA, Yu CR, Farrar WL. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J Immunol 1999;62:3897-3904.
    • (1999) J. Immunol. , vol.62 , pp. 3897-3904
    • Wang, L.H.1    Kirken, R.A.2    Erwin, R.A.3    Yu, C.R.4    Farrar, W.L.5
  • 19
    • 0032504249 scopus 로고    scopus 로고
    • Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells
    • Goodman PA, Niehoff LB, Uckun FM. Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells. J Biol Chem 1998;273:17742-17748.
    • (1998) J. Biol. Chem. , vol.273 , pp. 17742-17748
    • Goodman, P.A.1    Niehoff, L.B.2    Uckun, F.M.3
  • 20
    • 0027989808 scopus 로고
    • Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
    • Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994;84:1415-1420.
    • (1994) Blood , vol.84 , pp. 1415-1420
    • Koopman, G.1    Reutelingsperger, C.P.2    Kuijten, G.A.3    Keehnen, R.M.4    Pals, S.T.5    van Oers, M.H.6
  • 21
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
    • Schreiber E, Matthias P, Muller MM, Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 1989;17:6419.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 22
    • 0027159217 scopus 로고
    • The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds
    • Kanno Y, Kozak CA, Schindler C, Driggers PH, Ennist DL, Gleason SL, Darnell JE, Jr, Ozato K. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Mol Cell Biol 1993;13:3951-3963.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 3951-3963
    • Kanno, Y.1    Kozak, C.A.2    Schindler, C.3    Driggers, P.H.4    Ennist, D.L.5    Gleason, S.L.6    Darnell Jr., J.E.7    Ozato, K.8
  • 25
    • 0027505303 scopus 로고
    • Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine
    • Robertson LE, Chubb S, Meyn RE, Story M, Ford R, Hittelman WN, Plunkett W. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine. Blood 1993;81:143-150.
    • (1993) Blood , vol.81 , pp. 143-150
    • Robertson, L.E.1    Chubb, S.2    Meyn, R.E.3    Story, M.4    Ford, R.5    Hittelman, W.N.6    Plunkett, W.7
  • 27
    • 0025160266 scopus 로고
    • Tyrphostins-potential antiproliferative agents and novel molecular tools
    • Levitzki A. Tyrphostins-potential antiproliferative agents and novel molecular tools. Biochem Pharmacol 1990;40: 913-918.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 913-918
    • Levitzki, A.1
  • 29
    • 0028175969 scopus 로고
    • Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor
    • Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Larner AC, Finbloom DS. Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J Biol Chem 1994;269: 14333-14336.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14333-14336
    • Igarashi, K.1    Garotta, G.2    Ozmen, L.3    Ziemiecki, A.4    Wilks, A.F.5    Harpur, A.G.6    Larner, A.C.7    Finbloom, D.S.8
  • 31
    • 0026754538 scopus 로고
    • Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression
    • Dancescu M, Rubio-Trujillo M, Biron G, Bron D, Delespesse G, Sarfati M. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J Exp Med 1992;176:1319-1326.
    • (1992) J. Exp. Med. , vol.176 , pp. 1319-1326
    • Dancescu, M.1    Rubio-Trujillo, M.2    Biron, G.3    Bron, D.4    Delespesse, G.5    Sarfati, M.6
  • 32
    • 0029930173 scopus 로고    scopus 로고
    • Interleukin-8 induces the accumulation of B-cell chronic lymphocytic leukemia cells by prolonging survival in an autocrine fashion
    • Francia di Celle P, Mariani S, Riera L, Stacchini A, Reato G, Foa R. Interleukin-8 induces the accumulation of B-cell chronic lymphocytic leukemia cells by prolonging survival in an autocrine fashion. Blood 1996;87:4382-4389.
    • (1996) Blood , vol.87 , pp. 4382-4389
    • Francia di Celle, P.1    Mariani, S.2    Riera, L.3    Stacchini, A.4    Reato, G.5    Foa, R.6
  • 33
    • 0027479470 scopus 로고
    • Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia
    • Frishman J. Long B, Knospe W, Gregory S, Plate J. Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia. J Exp Med 1993;177:955-964.
    • (1993) J. Exp. Med. , vol.177 , pp. 955-964
    • Frishman, J.1    Long, B.2    Knospe, W.3    Gregory, S.4    Plate, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.