TNFα reduces tachykinin, PGE 2-dependent, relaxation of the cultured mouse trachea by increasing the activity of COX-2

British Journal of Pharmacology

Volumn 144, Issue 2, 2005, Pages 220-230

  Bachar, Ofir ^a   Rose, Andrew C ^b,c   Adner, Mikael ^a   Wang, Xudong ^b   Prendergast, Clodagh E ^b   Kempf, Ashley ^b   Shankley, Nigel P ^b   Cardell, Lars Olaf ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c MerseyBIO   (United Kingdom)

Author keywords

Airways; Asthma; Chronic inflammation; Cyclooxygenase; Microarray; Murine; Prostaglandin E 2; Tachykinin; Tumour necrosis factor

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ A; NEUROKININ B; NOLPITANTIUM; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; PROSTAGLANDIN SYNTHASE; SAREDUTANT; SUBSTANCE P; TACHYKININ; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; ASTHMA; CHRONIC INFLAMMATION; CONTROLLED STUDY; DNA MICROARRAY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

ANIMALS; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MUSCLE RELAXATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, NEUROKININ-1; TACHYKININS; TRACHEA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 13444303910     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706067     Document Type: Article

References (37)

1. 2A-mediated contraction. Br. J. Pharmacol., 137, 971-982.
2. AMRANI, Y., AMMIT, A.J. & PANETTIERI JR, R.A. (2001). Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases. Mol. Pharmacol., 60, 646-655.
3. AMRANI, Y., CHEN, H. & PANETTIERI JR, R.A. (2000). Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? Respir. Res., 1, 49-53.
4. BELVISI, M.G., SAUNDERS, M.A., HADDAD EL, B., HIRST, S.J., YACOUB, M.H., BARNES, P.J. & MITCHELL, J.A. (1997). Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. Br. J. Pharmacol., 120, 910-916.
5. BROIDE, D.H., LOTZ, M., CUOMO, A.J., COBURN, D.A., FEDERMAN, E.C. & WASSERMAN, S.I. (1992). Cytokines in symptomatic asthma airways. J. Allergy Clin. Immunol., 89, 958-967.
6. CHEN, C.C., SUN, Y.T., CHEN, J.J. & CHIU, K.T. (2000). TNF-α-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway. J. Immunol., 165, 2719-2728.
7. EMONDS-ALT, X., DOUTREMEPUICH, J.D., HEAULME, M., NELIAT, G., SANTUCCI, V., STEINBERG, R., VILAIN, P., BICHON, D., DUCOUX, J.P. & PROIETTO, V. (1993). In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. Eur. J. Pharmacol., 250, 403-413.
8. EMONDS-ALT, X., VILAIN, P., GOULAOUIC, P., PROIETTO, V., VAN BROECK, D., ADVENIER, C., NALINE, E., NELIAT, G., LE FUR, G. & BRELIERE, J.C. (1992). A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life Sci., 50, PL101-PL106.
9. FORTNER, C.N., BREYER, R.M. & PAUL, R.J. (2001). EP2 receptors mediate airway relaxation to substance P, ATP, and PGE2. Am. J. Physiol. Lung Cell. Mol. Physiol., 281, L469-L474.
10. FROLICH, J.C. (1997). A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol. Sci., 18, 30-34.
11. HALASZ, A., CSERHATI, E., KOSA, L. & CSEH, K. (2003). Relationship between the tumor necrosis factor system and the serum interleukin-4, interleukin-5, interleukin-8, eosinophil cationic protein, and immunoglobulin E levels in the bronchial hyperreactivity of adults and their children. Allergy Asthma Proc., 24, 111-118.
12. HLA, T. & NEILSON, K. (1992). Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. U.S.A., 89, 7384-7388.
13. IKEGAMI, R., SUGIMOTO, Y., SEGI, E., KATSUYAMA, M., KARAHASHI, H., AMANO, F., MARUYAMA, T., YAMANE, H., TSUCHIYA, S. & ICHIKAWA, A. (2001). The expression of prostaglandin E receptors EP2 and EP4 and their different regulation by lipopolysaccharide in C3H/HeN peritoneal macrophages. J. Immunol., 166, 4689-4696.
14. JAKOBSSON, P.J., THOREN, S., MORGENSTERN, R. & SAMUELSSON, B. (1999). Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U.S.A., 96, 7220-7225.
15. JONES, D.A., CARLTON, D.P., MCINTYRE, T.M., ZIMMERMAN, G.A. & PRESCOTT, S.M. (1993). Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem., 268, 9049-9054.
16. JOOS, G.F., GERMONPRE, P.R. & PAUWELS, R.A. (2000). Neural mechanisms in asthma. Clin. Exp. Allergy, 30 (Suppl 1), 60-65.
17. KAO, J., FORTNER, C.N., LIU, L.H., SHULL, G.E. & PAUL, R.J. (1999). Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle. Am. J. Physiol., 277, L264-L270.
18. KARGMAN, S., WONG, E., GREIG, G.M., FALGUEYRET, J.P., CROMLISH, W., ETHIER, D., YERGEY, J.A., RIENDEAU, D., EVANS, J.F., KENNEDY, B., TAGARI, P., FRANCIS, D.A. & O'NEILL, G.P. (1996). Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. Biochem. Pharmacol., 52, 1113-1125.
19. KIPS, J.C., TAVERNIER, J. & PAUWELS, R.A. (1992). Tumor necrosis factor causes bronchial hyperresponsiveness in rats. Am. Rev. Respir. Dis., 145, 332-336.
20. KIRIYAMA, M., USHIKUBI, F., KOBAYASHI, T., HIRATA, M., SUGIMOTO, Y. & NARUMIYA, S. (1997). Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br. J. Pharmacol., 122, 217-224.
21. LAN, R.S., KNIGHT, D.A., STEWART, G.A. & HENRY, P.J. (2001). Role of PGE(2) in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea. Br. J. Pharmacol., 132, 93-100.
22. NISHIGAKI, N., NEGISHI, M. & ICHIKAWA, A. (1996). Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol. Pharmacol., 50, 1031-1037.
23. PASCUAL, K.M., BILLINGTON, C.K., HALL, I.P., PANETTIERI JR, R.A., FISH, I.E., PETERS, S.P. & PENN, R.B. (2001). Mechanisms of cytokine effects on G protein-coupled receptor-mediated signaling in airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol., 281, L1425-L1435.
24. PAVORD, I.D., WISNIEWSKI, A., MATHUR, R., WAHEDNA, I., KNOX, A.J. & TATTERSFIELD, A.E. (1991). Effect of inhaled prostaglandin E2 on bronchial reactivity to sodium metabisulphite and methacholine in patients with asthma. Thorax, 46, 633-637.
25. PAVORD, I.D., WONG, C.S., WILLIAMS, J. & TATTERSFIELD, A.E. (1993). Effect of inhaled prostaglandin E2 on allergen-induced asthma. Am. Rev. Respir. Dis., 148, 87-90.
26. ROSE, A.C., GODDARD, C.A., COLLEDGE, W.H., CHENG, S.H., GILL, D.R. & HYDE, S.C. (2002). Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways. Gene Ther., 9, 1312-1320.
27. RYTILA, P., METSO, T., HEIKKINEN, K., SAARELAINEN, P., HELENIUS, I.J. & HAAHTELA, T. (2000). Airway inflammation in patients with symptoms suggesting asthma but with normal lung function. Eur. Respir. J., 16, 824-830.
28. STICHTENOTH, D.O., THOREN, S., BIAN, H., PETERS-GOLDEN, M., JAKOBSSON, P.J. & CROFFORD, L.J. (2001). Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J. Immunol., 167, 469-474.
29. SZAREK, J.L., SPURLOCK, B., GRUETTER, C.A. & LEMKE, S. (1998). Substance P and capsaicin release prostaglandin E2 from rat intrapulmonary bronchi. Am. J. Physiol., 275, L1006-L1012.
30. SZELENYI, I. (2000). Animal models of bronchial asthma. Inflamm. Res., 49, 639-654.
31. TONNEL, A.B., GOSSET, P. & TILLIE-LEBLOND, I. (2001). Characteristics of the inflammatory response in bronchial lavage fluids from patients with status asthmaticus. Int. Arch. Allergy Immunol., 124, 267-271.
32. TOURNOY, K.G., DE SWERT, K.O., LECLERE, P.G., LEFEBVRE, R.A., PAUWELS, R.A. & JOOS, G.F. (2003). Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea. Eur. Respir. J., 21, 3-10.
33. TUSHER, V.G., TIBSHIRANI, R. & CHU, G. (2001). Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U.S.A., 98, 5116-5121.
34. VADAS, P., STEFANSKI, E., WLOCH, M., GROUIX, B., VAN DEN BOSCH, H. & KENNEDY, B. (1996). Secretory non-pancreatic phospholipase A2 and cyclooxygenase-2 expression by tracheobronchial smooth muscle cells. Eur. J. Biochem., 235, 557-563.
35. VAN GELDER, R.N., VON ZASTROW, M.E., YOOL, A., DEMENT, W.C., BARCHAS, J.D. & EBERWINE, J.H. (1990). Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proc. Natl. Acad. Sci. U.S.A., 87, 1663-1667.
36. WARDLAW, A.J., BRIGHTLING, C.E., GREEN, R., WOLTMANN, G., BRADDING, P. & PAVORD, I.D. (2002). New insights into the relationship between airway inflammation and asthma. Clin. Sci. (Lond.), 103, 201-211.
37. WILLS-KARP, M., UCHIDA, Y., LEE, J.Y., JINOT, J., HIRATA, A. & HIRATA, F. (1993). Organ culture with proinflammatory cytokines reproduces impairment of the beta-adrenoceptor-mediated relaxation in tracheas of a guinea pig antigen model. Am. J. Respir. Cell. Mol. Biol., 8, 153-159.