Orally administrated risedronate can commit VγV2δ2 T cells to IFN-γ secreting effectors in patients with osteoporosis

Biomedical Research

Volumn 25, Issue 1, 2004, Pages 1-8

  Saito, Tadashi ^a   Tada, Kinji ^a   Shimizu, Masumi ^a   Nakamura, Tetsuo ^b   Ito, Hiromoto ^a   Takahashi, Hidemi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b University of Tokyo   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD8ALPHA ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; RISEDRONIC ACID; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; OSTEOPOROSIS; T LYMPHOCYTE;

EID: 13444289950     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.25.1     Document Type: Article

References (22)

1. Berenson JR, Lichtenstein A, Porter L, Dimopoulos MA, Bordoni R, George S, Lipton A, Keller A, Ballester O, Kovacs MJ, Blacklock HA, Bell R, Simeone J, Reitsma DJ, Heffernan M, Seaman J and Knight RD (1996) Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 334, 488-493.
2. Brenner MB, Strominger JL and Krangel MS (1988) The gamma delta T cell receptor. Adv Immunol 43, 133-192.
3. Bukowski JF, Morita CT and Brenner MB (1999) Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 11, 57-65.
4. Das H, Wang L, Kamath A and Bukowski JF (2001) Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates. Blood 98, 1616-1618.
5. Dieli F, Gebbia N, Poccia F, Caccamo N, Montesano C, Fulfaro F, Arcara C, Valerio MR, Meraviglia S, Di Sano C, Sireci G and Salerno A (2003) Induction of gamma delta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo. Blood 102, 2310-2311.
6. Gioia C, Agrati C, Casetti R, Cairo C, Borsellino G, Battistini L, Mancino G, Goletti D, Colizzi V, Pucillo LP and Poccia F (2002) Lack of CD27-CD45RA-V gamma 9V delta 2 T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis. J Immunol 168, 1484-1489.
7. Gober HJ, Kistowska M, Angman L, Jeno P, Mori L and De Libero G (2003) Human T cell receptor gamma delta cells recognize endogenous mevalonate metabolites in tumor cells. J Exp Med 197, 163-168.
8. Janeway CA, Jr. and Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20, 197-216.
9. Kabelitz D, Glatzel A and Wesch D (2000) Antigen recognition by human gamma delta T lymphocytes. Int Arch Allergy Immunol 122, 1-7.
10. Kamath AB, Wang L, Das H, Li L, Reinhold VN and Bukowski JF (2003) Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proc Natl Acad Sci USA 100, 6009-6014.
11. Kunzmann V, Bauer E and Wilhelm M (1999) Gamma/delta T-cell stimulation by pamidronate. N Engl J Med 340, 737-738.
12. Kunzmann V, Bauer E, Feurle J, Weissinger F, Tony HP and Wilhelm M (2000) Stimulation of gamma delta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 96, 384-392.
13. McCloskey EV, MacLennan IC, Drayson MT, Chapman C, Dunn J and Kanis JA. (1998) A randomized trial of the effect of clodronate on skeletal morbidity in multiple myeloma. MRC Working Party on Leukaemia in Adults. Br J Haematol 100, 317-325.
14. Medzhitov R and Janeway C, Jr. (2000) Innate immune recognition: mechanisms and pathways. Immunol Rev 173, 89-97.
15. Miyagawa F, Tanaka Y, Yamashita S and Minato N (2001) Essential requirement of antigen presentation by monocyte lineage cells for the activation of primary human gamma delta T cells by aminobisphosphonate antigen. J Immunol 166, 5508-5514.
16. Openshaw P, Murphy EE, Hosken NA, Maino V, Davis K, Murphy K and O'Garra A (1995) Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 182, 1357-1367.
17. Rodan GA and Fleisch HA (1996) Bisphosphonates: mechanisms of action. J Clin Invest 97, 2692-2696.
18. Rodan GA (1998) Mechanisms of action of bisphosphonates. Annu Rev Pharmacol Toxicol 38, 375-388.
19. Takahashi H (2003) Antigen presentation in vaccine development. Comp Immunol Microbiol Infect Dis 26, 309-328.
20. Takahashi M, Osono E, Nakagawa Y, Wang J, Berzofsky JA, Margulies DH and Takahashi H (2002) Rapid induction of apoptosis in CD8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide. J Immunol 169, 6588-9653.
21. Takeuchi J, Watari E, Shinya E, Norose Y, Matsumoto M, Seya T, Sugita M, Kawana S and Takahashi H (2003) Downregulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells. Biochem Biophys Res Commun 306, 674-679.
22. Wilhelm M, Kunzmann V, Eckstein S, Reimer P, Weissinger F, Ruediger T and Tony HP (2003) Gamma delta T cells for immune therapy of patients with lymphoid malignancies. Blood 102, 200-206.