Enzyme association with PPARγ: Evidence of a new role for 15-lipoxygenase type 2

Chemico-Biological Interactions

Volumn 151, Issue 2, 2005, Pages 121-132

  Flores, Anthony M ^a   Li, Lu ^a   McHugh, Nora G ^a   Aneskievich, Brian J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Arachidonic acid; Keratinocyte; Lipoxygenase; Nuclear receptors; PPAR; Protein:protein interaction

Indexed keywords

15 LIPOXYGENASE 2; CELL NUCLEUS RECEPTOR; ENZYME; HYDROXYICOSATETRAENOIC ACID; LIGAND; LIPOXYGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; UNCLASSIFIED DRUG; ARACHIDONATE 15 LIPOXYGENASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; EPIDERMIS CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; KERATINOCYTE; MOLECULE; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; AMINO ACID SEQUENCE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; REPORTER GENE; TUMOR CELL LINE; TWO HYBRID SYSTEM;

AMINO ACID SEQUENCE; ARACHIDONATE 15-LIPOXYGENASE; BASE SEQUENCE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; KERATINOCYTES; MOLECULAR SEQUENCE DATA; PPAR GAMMA; PROTEIN BINDING; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 13444282360     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2004.11.001     Document Type: Article

References (48)

1. V. Laudet, J. Auwerx, J.-A. Gustafsson, and W. Wahli A unified nomenclature system for the nuclear receptor superfamily Cell 97 1999 161 163
2. O. Nosjean, and J.A. Boutin Natural ligands of PPARgamma Cell Signal. 14 2002 573 583
3. L. Iversen, and K. Kragballe Arachidonic acid metabolism in skin health and disease Prostag. Other Lipid Mediat. 63 2000 25 42
4. S.B. Shappell, R.A. Gupta, S. Manning, R. Whitehead, W.E. Boeglin, C. Schneider, T. Case, J. Price, G.S. Jack, T.M. Wheeler, R.J. Matusik, A.R. Brash, and R.N. Dubois 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor g and inhibits proliferation in PC3 prostate carcinoma cells Cancer Res. 61 2001 497 503
5. A.R. Brash, W.E. Boeglin, and M.S. Chang Discovery of a second 15S-lipoxygenase in humans Proc. Natl. Acad. Sci. U.S.A. 94 1997 6148 6152
6. S.B. Shappell, D.S. Keeney, J. Zhang, R. Page, S.J. Olson, and A.R. Brash 15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa J. Invest. Dermatol. 117 2001 36 43
7. A.R. Brash, M. Jisaka, W.E. Boeglin, M.S. Chang, D.S. Keeney, L.B. Nanney, S. Kasper, R.J. Matusik, S.J. Olson, and S.B. Shappell Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues Adv. Exp. Med. Biol. 469 1999 83 89
8. G. Krey, O. Braissant, F. Lhorset, E. Kalkhoven, M. Perroud, M.G. Parker, and W. Wahli Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay Mol. Endocrinol. 11 1997 779 791
9. N.Y. Schürer, W. Stremmel, J.U. Grundmann, V. Schliep, H. Kleinert, N.M. Bass, and M.L. Williams Evidence for a novel keratinocyte fatty acid uptake mechanism with preference for linoleic acid: comparison of oleic and linoleic acid uptake by cultured human keratinocytes, fibroblasts and a human hepatoma cell line Biochim. Biophys. Acta 1211 1994 51 60
10. C. Fuchs, and B.J. Aneskievich Nuclear receptor regulation by peroxisome proliferators in epidermal keratinocytes J. Invest. Dermatol. 108 1997 578
11. K. Hanley, Y. Jiang, S.S. He, M. Friedman, P.M. Elias, D.D. Bikle, M.L. Williams, and K.R. Feingold Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha J. Invest. Dermatol. 110 1998 368 375
12. M. Rivier, I. Safonova, P. Lebrun, C.E. Griffiths, G. Ailhaud, and S. Michel Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes J. Invest. Dermatol. 111 1998 1116 1121
13. A. Aranda, and A. Pascual Nuclear hormone receptors and gene expression Physiol. Rev. 81 2001 1269 1304
14. M.G. Rosenfeld, and C.K. Glass Coregulator codes of transcriptional regulation by nuclear receptors J. Biol. Chem. 276 2001 36865 36868
15. Y. Kodera, K. Takeyama, A. Murayama, M. Suzawa, Y. Masuhiro, and S. Kato Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators J. Biol. Chem. 275 2000 33201 33204
16. Y. Zhu, C. Qi, S. Jain, M.S. Rao, and J.K. Reddy Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor J. Biol. Chem. 272 1997 25500 25506
17. P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, and B.M. Spiegelman A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell. 92 1998 829 839
18. H. Kawabata, K. Kawahara, T. Kanekura, N. Araya, H. Daitoku, M. Hatta, N. Miura, A. Fukamizu, T. Kanzaki, I. Maruyama, and T. Nakajima Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium induced keratinocyte differentiation J. Biol. Chem. 10 2001 8099 8105
19. A.M. Flores, L. Li, B.J. Aneskievich, Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator, J. Invest. Dermatol. 123 (2004) 1092-1101.
20. B.J. Aneskievich, J.I. Lee, and L.B. Taichman Analysis of adenovirus early and late gene expression in cultured epidermal keratinocytes J. Invest. Dermatol. 94 1990 183 186
21. B.J. Aneskievich, and E. Fuchs The A/B domain of truncated retinoic acid receptors can block differentiation and promote features of malignancy J. Cell Sci. 108 1995 195 205
22. B.J. Aneskievich Deletion of RAR carboxyl terminus reveals promoter- and receptor-specific AF-1 effects Biochem. Biophys. Res. Commun. 289 2001 950 956
23. P. Alen, F. Claessens, E. Schoenmakers, J.V. Swinnen, G. Verhoeven, W. Rombauts, and B. Peeters Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform Mol. Endocrinol. 13 1999 117 128
24. O.C. Meijer, P.J. Steenbergen, and E.R. De Kloet Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary Endocrinology 141 2000 2192 2199
25. B. Bhatia, C.J. Maldonado, S. Tang, D. Chandra, R.D. Klein, D. Chopra, S.B. Shappell, P. Yang, R.A. Newman, and D.G. Tang Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants J. Biol. Chem. 278 2003 25091 25100
26. S. Tang, B. Bhatia, C.J. Maldonado, P. Yang, R.A. Newman, J. Liu, D. Chandra, J. Traag, R.D. Klein, S.M. Fischer, D. Chopra, J. Shen, H. Zhau, L.W. Chung, and D.G. Tang Evidence that arachidonate 15-lipoxygenase 2 is a negative cell-cycle regulator in normal prostate epithelial cells J. Biol. Chem. 277 2002 16189 16201
27. M.B. Frungieri, S. Weidinger, V. Meineke, F.M. Kohn, and A. Mayerhofer Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma: possible relevance to human fibrotic disorders Proc. Natl. Acad. Sci. U.S.A. 99 2002 15072 15077
28. J.D. Ciarlo, A.M. Flores, N.G. McHugh, and B.J. Aneskievich FHL2 expression in keratinocytes and transcriptional effect on PPARα/RXRα J. Dermatol. Sci. 35 2004 61 63
29. B.M. Forman, J. Chen, and R.M. Evans Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta Proc. Natl. Acad. Sci. U.S.A. 94 1997 4312 4317
30. S.A. Kliewer, S.S. Sundseth, S.A. Jones, P.J. Brown, G.B. Wisely, C.S. Koble, P. Devchand, W. Wahli, T.M. Willson, J.M. Lenhard, and J.M. Lehmann Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma Proc. Natl. Acad. Sci. U.S.A. 94 1997 4318 4323
31. J.T. Huang, J.S. Welch, M. Ricote, C.J. Binder, T.M. Willson, C. Kelly, J.L. Witztum, C.D. Funk, D. Conrad, and C.K. Glass Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase Nature 400 1999 378 382
32. K. Djabali, V.M. Aita, and A.M. Christiano Hairless is translocated to the nucleus via a novel bipartite nuclear localization signal and is associated with the nuclear matrix J. Cell Sci. 114 2001 367 376
33. G.B. Potter, G.M. Beaudoin, C.L. DeRenzo, J.M. Zarach, S.H. Chen, and C.C. Thompson The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor Genes Dev. 15 2001 2687 2701
34. Y. Barak, M.C. Nelson, E.S. Ong, Y.Z. Jones, P. Ruiz-Lozano, K.R. Chien, A. Koder, and R.M. Evans PPAR gamma is required for placental, cardiac, and adipose tissue development Mol. Cell 4 1999 585 595
35. S.C. Hasmall, N.H. James, N. Macdonald, A.R. Soames, and R.A. Roberts Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression Arch. Toxicol. 74 2000 85 91
36. N.H. James, and R.A. Roberts Species differences in the clonal expansion of hepatocytes in response to the co-action of epidermal growth factor and nafenopin, a rodent hepatocarcinogenic peroxisome proliferator Fund. Appl. Toxicol. 26 1995 143 149
37. K.E. Rys-Sikora, A.P. Pentland, and R.L. Konger Pertussis toxin-sensitive secretory phospholipase A2 expression and motility in activated primary human keratinocytes J. Invest. Dermatol. 120 2003 86 95
38. S. Kippenberger, S.M. Loitsch, M. Grundmann-Kollmann, S. Simon, T.A. Dang, K. Hardt-Weinelt, R. Kaufmann, and A. Bernd Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light- induced inflammation J. Invest. Dermatol. 117 2001 1430 1436
39. K. Henry, M.L. O'Brien, W. Clevenger, L. Jow, and D.J. Noonan Peroxisome proliferator-activated receptor response specificities as defined in yeast and mammalian cell transcription assays Toxicol. Appl. Pharmacol. 132 1995 317 324
40. S.L. Marcus, K.S. Miyata, R.A. Rachubinski, and J.P. Capone Transactivation by PPAR/RXR heterodimers in yeast is potentiated by exogenous fatty acid via a pathway requiring intact peroxisomes Gene Expr. 4 1995 227 329
41. Y. Zhu, L. Kan, C. Qi, Y.S. Kanwar, A.V. Yeldandi, M.S. Rao, and J.K. Reddy Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR J. Biol. Chem. 275 2000 13510 13516
42. T. Shiraki, N. Sakai, E. Kanaya, and H. Jingami Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha J. Biol. Chem. 278 2003 11344 11350
43. L. Amazit, Y. Alj, R.K. Tyagi, A. Chauchereau, H. Loosfelt, C. Pichon, J. Pantel, E. Foulon-Guinchard, P. Leclerc, E. Milgrom, and A. Guiochon-Mantel Subcellular localization and mechanisms of nucleocytoplasmic trafficking of steroid receptor coactivator-1 J. Biol. Chem. 278 2003 32195 32203
44. C.L. Smith, and B.W. O'Malley Coregulator function: a key to understanding tissue specificity of selective receptor modulators Endocrinol. Rev. 25 2004 45 71
45. L. Delva, J.N. Bastie, C. Rochette-Egly, R. Kraiba, N. Balitrand, G. Despouy, P. Chambon, and C. Chomienne Physical and functional interactions between cellular retinoic acid binding protein II and the retinoic acid-dependent nuclear complex Mol. Cell Biol. 19 1999 7158 7167
46. A.S. Budhu, and N. Noy Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest Mol. Cell Biol. 22 2002 2632 2641
47. N.S. Tan, N.S. Shaw, N. Vinckenbosch, P. Liu, R. Yasmin, B. Desvergne, W. Wahli, and N. Noy Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription Mol. Cell Biol. 22 2002 5114 5127
48. T. Helledie, M. Antonius, R.V. Sorensen, A.V. Hertzel, D.A. Bernlohr, S. Kolvraa, K. Kristiansen, and S. Mandrup Lipid-binding proteins modulate ligand-dependent trans-activation by peroxisome proliferator-activated receptors and localize to the nucleus as well as the cytoplasm J. Lipid Res. 41 2000 1740 1751