Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model

Brain Research

Volumn 871, Issue 1, 2000, Pages 98-103

  Lyu, Yeoung Su ^a   Park, Soon Kwon ^a   Chung, Kyungsoon ^a,b   Chung, Jin Mo ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Allodynia; Dorsal root ganglion; Ectopic discharge; Local anesthetic; Sodium channel; Tetrodotoxin

Indexed keywords

SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; ALLODYNIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; NERVE POTENTIAL; NEURALGIA; NONHUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

ACTION POTENTIALS; ANIMALS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; GANGLIA, SPINAL; HINDLIMB; MALE; NEURONS; PAIN; PAIN THRESHOLD; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SKIN; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN;

EID: 0034648050     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02451-3     Document Type: Article

References (35)

1. S. Abdi, D.H. Lee, J.M. Chung, The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain, Anesth. Analg. 87 (1998) 1360-1366.
2. A.N. Akoplan, L. Sivilotti, J.N. Wood, A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons, Nature 379 (1996) 257-262.
3. F.W. Bach, T.S. Jensen, J. Kastrup, B. Stigsby, A. Dejgård, The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy, Pain 40 (1990) 29-34.
4. R.A. Boas, B.G. Covino, A. Shahnarian, Analgesic responses to i.v. lidocaine, Brit. J. Anaesth. 54 (1982) 501-505.
5. J.M. Caffrey, D.L. Eng, J.A. Black, S.G. Waxman, J.D. Kocsis, Three types of sodium channels in adult rat dorsal root ganglion neurons, Brain Res. 592 (1992) 283-297.
6. C. Chabal, L. Jacobson, L. Russell, K.J. Burchiel, Pain response to perineuromal injection of normal saline, epinephrine, and lidocaine in humans, Pain 49 (1992) 9-12.
7. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, T.L. Yaksh, Quantitative assessment of tactile allodynia in the rat paw, J. Neurosci. Meth. 53 (1994) 55-63.
8. S.R. Chaplan, F.W. Bach, S.L. Shafer, T.L. Yaksh, Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats, Anesthesiology 83 (1995) 775-785.
9. Y. Choi, Y.W. Yoon, H.S. Na, S.H. Kim, J.M. Chung, Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain, Pain 59 (1994) 369-376.
10. + channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation, J. Neurosci. 13 (1993) 1976-1992.
11. M. Devor, P.D. Wall, N. Catalan, Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction, Pain 48 (1992) 261-268.
12. W.J. Dixon, Efficient analysis of experimental observations, Ann. Rev. Phar. Tox. 20 (1980) 441-462.
13. A.A. Elliott, J.R. Elliott, Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia, J. Physiol. 463 (1993) 39-56.
14. R.H. Gracely, S.A. Lynch, G.J. Bennett, Painful neuropathy: altered central processing maintained dynamically by peripheral input, Pain 51 (1992) 175-194.
15. J.C. Hunter, D. Loughhead, Voltage-gated sodium channel blockers for the treatment of chronic pain, Curr. Opin. CPNS Invest. Drugs 1 (1999) 72-81.
16. K.C. Kajander, G.J. Bennett, Onset of a painful peripheral neuropathy in rat: A partial and differential deafferentation and spontaneous discharge in Ab and Ad primary afferent neurons, J. Neurophysiol. 68 (1992) 734-744.
17. S.H. Kim, J.M. Chung, Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat, Neurosci. Lett. 134 (1991) 131-134.
18. S.H. Kim, J.M. Chung, An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain 50 (1992) 355-363.
19. S.H. Kim, H.S. Na, K. Sheen, J.M. Chung, Effects of sympathectomy on a rat model of peripheral neuropathy, Pain 55 (1993) 85-92.
20. E. Kinnman, J.D. Levine, Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat, Neuroscience 64 (1995) 751-767.
21. P.G. Kostyuk, N.S. Veselovsky, A.Y. Tsyndrenko, Ionic currents in the somatic membrane of rat dorsal root ganglion neurons-I. Sodium currents, Neuroscience 6 (1981) 2423-2430.
22. J. Lai, J.C. Hunter, M.H. Ossipov, F. Porreca, Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons, Meth. Enzymol. 314 (2000) 201-213.
23. D.H. Lee, K. Chung, J.M. Chung, Strain differences in adrenergic sensitivity of neuropathic pain behaviors in an experimental rat model, NeuroReport 8 (1997) 3453-3456.
24. X. Liu, K. Chung, J.M. Chung, Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury, Brain Res. 849 (1999) 244-247.
25. + conductance and the threshold for repetitive neuronal firing, Brain Res. 597 (1992) 92-98.
26. + channels, J. Neurophysiol. 72 (1994) 349-359.
27. H.S. Na, Y.W. Yoon, J.M. Chung, Both motor and sensory abnormalities contribute to changes in foot posture in an experimental rat neuropathic model, Pain 67 (1996) 173-178.
28. I. Omana-Zapata, M.A. Khabbaz, J.C. Hunter, K.R. Bley, QX-314 inhibits ectopic nerve activity associated with neuropathic pain, Brain Res. 771 (1997) 228-237.
29. I. Omana-Zapata, M.A. Khabbaz, J.C. Hunter, D.E. Clarke, K.R. Bley, Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons, Pain 72 (1997) 41-49.
30. A.M. Rush, M.E. Bräu, A.A. Elliott, J.R. Elliott, Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia, J. Physiol. 511 (3) (1998) 771-789.
31. L. Sangameswaran, S.G. Delgado, L.M. Fish, B.D. Koch, G.R. Stewart, P. Sze, J.C. Hunter, R.M. Eglen, R.C. Herman, Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons, J. Biol. Chem. 271 (1996) 5953-5956.
32. J.W. Scadding, Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons, Exp. Neurol. 73 (1981) 345-364.
33. K. Sheen, J.M. Chung, Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model, Brain Res. 610 (1993) 62-68.
34. E. Tzoumaka, S.D. Novakovic, M. Haraguchi, L. Sangameswaran, K. Wong, K.R. Gogas, J.C. Hunter, PN3 sodium channel distribution in the dorsal root ganglia of normal and neuropathic rats, Proc. West. Pharmacol. Soc. 40 (1997) 69-72.
35. P.D. Wall, M. Devor, Sensory afferent impulses originate from dorsal root ganglion as well as from the periphery in normal and nerve injured rats, Pain 17 (1983) 321-329.