Absence of N-acetylaspartate in the human brain: Impact on neurospectroscopy?

Annals of Neurology

Volumn 49, Issue 4, 2001, Pages 518-521

  Martin, Ernst ^a   Capone, Andrea ^a   Schneider, Jacques ^b   Hennig, Juergen ^b   Thiel, Thorsten ^c  

^a Department of Diagnostic Imaging ^*  (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CHOLINE; CREATINE; GLUTAMIC ACID; GLUTAMINE; INOSITOL; LACTIC ACID; N ACETYLASPARTIC ACID;

ARTICLE; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CLINICAL FEATURE; DEVELOPMENTAL DISORDER; DISEASE COURSE; ELECTROENCEPHALOGRAM; HUMAN; KARYOTYPE; MALE; METABOLIC DISORDER; MYELINATION; NEWBORN SCREENING; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL DETECTION; SPECTROSCOPY;

ASPARTIC ACID; BRAIN; CHILD, PRESCHOOL; DIPEPTIDES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NERVOUS SYSTEM DISEASES;

EID: 0035072775     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.102     Document Type: Article

References (20)

1. Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy
2. Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS
3. Proton NMR spectroscopy of cerebral metabolic alterations in infantile peroxisomal disorders
4. Creatine deficiency in the brain: A new, treatable inborn error of metabolism
5. Clinical proton MR spectroscopy of neurodegenerative disease in childhood
6. Leukoencephalopathy associated with a disturbance in the metabolism of polyols
7. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
8. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro
9. In vitro expression of N-acetylaspartate by oligodendrocytes: Implications for proton magnetic resonance spectroscopy signal in vivo
10. N-acetylaspartate as an in vivo marker of neuronal viability in kainate-induced status epilepticus: H-1 magnetic resonance spectroscopic imaging
11. N-acetyl-L-aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain
12. Investigation into the role of N-acetylaspartate in cerebral osmoregulation
13. Differential distribution of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat forebrain
14. Estimation of metabolite concentrations from localized in vivo NMR spectra
15. N-acetylaspartate: A marker for neuronal loss or mitochondrial dysfunction
16. Biochemical markers of intelligence: A proton MR spectroscopy study of normal human brain
17. Reduced N-acetylaspartate in the brain observed on in vivo proton magnetic resonance spectroscopy in patients with mental retardation
18. In vivo proton magnetic resonance spectroscopy of the brain in a patient with L-2-hydroxyglutaric acidemia
19. Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human-immunodeficiency-virus-seropositive individuals: In vivo H-1 magnetic resonance spectroscopic imaging
20. Cerebral lactate and N-acetyl-aspartate/choline ratios in asphyxiated full-term neonates demonstrated in vivo using proton magnetic resonance spectroscopy