Developmental increase of aspartoacylase in oligodendrocytes parallels CNS myelination

Developmental Brain Research

Volumn 140, Issue 1, 2003, Pages 105-115

  Kirmani, Batool F ^a   Jacobowitz, David M ^a,b   Namboodiri, M A A ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Acetate deficiency hypothesis; Acetate supplementation therapy; Canavan disease; In situ hybridization; N Acetylaspartate; Oligodendroglia

Indexed keywords

ACETIC ACID; ASPARTOACYLASE;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN REGION; CANAVAN DISEASE; CONTROLLED STUDY; IN SITU HYBRIDIZATION; MALE; MYELINATION; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RNA PROBE; SCHWANN CELL; SUPPLEMENTATION; WHITE MATTER;

AGING; AMIDOHYDROLASES; ANIMALS; ANIMALS, NEWBORN; BRAIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IN SITU HYBRIDIZATION; MALE; MYELIN SHEATH; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ANIMALIA; MURINAE;

EID: 0037434071     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(02)00592-8     Document Type: Article

References (27)

1. Baslow M.H., Sucknow R.F., Sapirstein V., Hungund B.L. Expression of aspartoacylase in cultured rat macroglial cells is limited to oligodendrocytes. J. Mol. Neurosci. 13:1999;47-53.
2. Bhakoo K.K., Williams I.T., Williams S.R., Guardian D.G., Noble M.D. Proton nuclear magnetic resonance spectroscopy of primary cells derived from nervous tissue. J. Neurochem. 66:1996;1254-1263.
3. Bhakoo K.K., J Craig T., Styles P. Developmental and regional distribution of aspartoacylase in rat brain tissues. J. Neurochem. 79:2001;211-220.
4. Burri B., Steffen C., Herschkowitz N. N-Acetylaspartate is a major source of acetyl groups for lipid synthesis during rat brain development. Dev. Neurosci. 13:1991;403-411.
5. Chakraborty G., Mekala P., Yahya D., Wu G., Ledeen R.W. Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J. Neurochem. 78:2001;736-745.
6. D'Adamo A.F. Jr., Yatsu F.M. Acetate metabolism in the nervous system: N-acetylaspartic acid and the biosynthesis of brain lipids. J. Neurochem. 13:1966;961-965.
7. D'Adamo A.F. Jr., Gidez L.I., Yatsu F.M. Acetyl transport mechanisms: involvement of N-acetyl aspartate in de novo fatty acid biosynthesis in the developing brain. Exp. Brain Res. 5:1968;267-273.
8. D'Adamo A.F. Jr., Smith J., Woiler C. The occurrence of N-acetylaspartate amidohydrolase (aminoacylase 11) in the developing rat brain. J. Neurochem. 20:1972;1275-1278.
9. Dhopeshwarker G.A., Mead J.F. Uptake and transport of fatty acids into the brain and the role of the blood-brain barrier system. Adv. Lipid Res. 11:1973;109-142.
10. Goldstein F.B. Amidohydrolases of brain; enzymatic hydrolysis of N-acetylaspartate and other N-acyl-amino acids. J. Neurochem. 26:1976;45-49.
11. Hegenfeldt L., Bollgren I., Venizelos N.J. N-Acetylaspartic aciduria due to aspartoacylase deficiency - a new etiology of childhood leukodystrophy. J. Inherit. Metab. Dis. 10:1987;135-141.
12. Holz A., Schwab M.E. Developmental expression of the myelin gene MOBP in the rat nervous system. J. Neurocytol. 26:1997;467-477.
13. Janson C., McPhee S., Bilaniuk L., Haselgrove J., Testaiuti M., Freese A., Wang D., Shera D., Hurh P., Rupin J., Saslow E., Goldfarb O., Goldberg M., Larijani G., Sharrar W., Liouterman L., Camp A., Kolodny E., Samulski J., Leone P. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain. Hum. Gene Ther. 13:2002;1391-1412.
14. Kaul R., Casanova J., Johnson A.B., Tang P., Matalon R. Purification, characterization, and localization of aspartoacylase from bovine brain. J. Neurochem. 56:1991;129-135.
15. B.F. Kirmani, D.M. Jacobowitz, A. Kallarakal, M.A.A. Namboodiri, Aspartocylase is restricted primarily to myelin synthesizing cells in the CNS: Therapeutic implications for Canavan disease, Mol. Brain Res. (in press).
16. Kristensson K., Zeller N.K., Dubois-Dalcq M.E., Lazzarini R.A. Expression of myelin basic protein gene as revealed by in situ hybridization. J. Histochem. Cytochem. 34:1986;467-473.
17. Leone P., Janson C.G., McPhee S.J., During M.J. Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease. Curr. Opin. Mol. Ther. 1:1999;487-492.
18. Madhavarao C.N., Hammer J.A., Quarles R.H., Namboodiri M.A.A. A radiometric assay for aspartoacylase activity in cultured oligodendrocytes. Anal. Biochem. 308:2002;314-319.
19. Matalon R., Michals K., Kaul R. Canavan disease: from spongy degeneration to molecular analysis. J. Pediatr. 127:1995;511-517.
20. Matalon R., Rady P.L., Platt K.A., Skinner H.B., Quast M.J., Campbell G.A., Matalon K., Ceci J.D., Tyring S.K., Nehls M., Surendren S., Wei J., Ezell E.L., Szucs S. Knock-out model for Canavan disease: a model for gene transfer to the central nervous system. J. Gene Med. 2:2000;165-175.
21. Mehta V., Namboodiri M.A.A. N-Acetylaspartate as an acetyl source in the nervous system. Mol. Brain Res. 31:1995;151-157.
22. Namboodiri M.A.A., Corigliano-Murphy A., Jiang G., Rollag M., Provencio I. Murine aspartoacylase: cloning, expression, and comparison with the human enzyme. Mol. Brain Res. 77:2000;285-289.
23. Ramon-Cueto A., Avila J. Olfactory ensheathing glia: properties and function. Brain Res. Bull. 46:1989;175-187.
24. Shioto C., Miura M., Mikoshiba K. Developmental profile and differential localization of mRNAs of myelin proteins (MBP and PLP) in oligodendrocytes in the brain and in culture. Dev. Brain Res. 45:1989;83-84.
25. Terasaki T., Takakuwa S., Moritani S., Tsuji A. Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells. J. Pharmacol. Exp. Ther. 258:1991;932-937.
26. Tsai G., Coyle J.T. N-Acetylaspartate in neuropsychiatric disorders. Prog. Neurobiol. 46:1995;531-540.
27. Waniewski R.A., Martin D.L. Preferential utilization of acetate by astrocytes is attributable to transport. J. Neurosci. 18:1998;5225-5233.