Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl) -N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]-acrylamide (JNJ-5207787), a Small Molecule Antagonist of the Neuropeptide Y Y2 Receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 1130-1137

  Bonaventure, Pascal ^a   Nepomuceno, Diane ^a   Mazur, Curt ^a   Lord, Brian ^a   Rudolph, Dale A ^a   Jablonowski, Jill A ^a   Carruthers, Nicholas I ^a   Lovenberg, Timothy W ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE 5' O (3 THIOTRIPHOSPHATE); L 152804; N (1 ACETYL 2,3 DIHYDRO 1H INDOL 6 YL) 3 (3 CYANOPHENYL) N [1 (2 CYCLOPENTYLETHYL) 4 PIPERIDINYL]ACRYLAMIDE; N (1 ACETYL 2,3 DIHYDRO 1H INDOL 6 YL) 3 (3 CYANOPHENYL) N [1 (2 CYCLOPENTYLETHYL)PIPERIDINE 4 YL]ACRYLAMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y [3-36]; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y4 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; PEPTIDE YY; PEPTIDE YY [3-36]; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN CORTEX; BRAIN REGION; BRAIN TISSUE; CEREBELLUM; CONTROLLED STUDY; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; EMBRYO; EX VIVO STUDY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN CELL; HYPOTHALAMUS; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOASSAY; RAT; RECEPTOR BINDING; SEPTUM PELLUCIDUM; SUBSTANTIA NIGRA; THALAMUS;

ACRYLAMIDES; ANIMALS; AUTORADIOGRAPHY; BINDING, COMPETITIVE; BLOOD-BRAIN BARRIER; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROPEPTIDE Y;

EID: 1342265788     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.060459     Document Type: Article

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