Hypothalamic Y2 receptors: Central coordination of energy homeostasis and bone mass regulation

Drug News and Perspectives

Volumn 15, Issue 8, 2002, Pages 506-510

  Herzog, Herbert ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; PANCREAS POLYPEPTIDE; PEPTIDE YY;

ARCUATE NUCLEUS; BLOOD PRESSURE REGULATION; BONE DEVELOPMENT; BONE MASS; CARDIOVASCULAR DISEASE; CIRCADIAN RHYTHM; DISEASE MODEL; ENERGY METABOLISM; FOOD INTAKE; HOMEOSTASIS; HORMONE RELEASE; HUMAN; KNOCKOUT MOUSE; MEMORY CONSOLIDATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OSSIFICATION; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SATIETY; SIGNAL TRANSDUCTION; TRANQUILIZING ACTIVITY;

EID: 0036826537     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2002.15.8.740226     Document Type: Review

References (45)

1. Seidell, J.C. Obesity: A growing problem. Acta Paediatr Suppl 1999, 88: 46-50.
2. Ikeda, J.P., Hayes, D., Satter, E., Parham, E.S., Kratina, K., Woolsey, M., Lowey, M. and Tribole, E. A commentary on the new obesity guidelines from NIH. J Am Diet Assoc 1999, 99: 918-9.
3. Bakris, G.L., Weir, M.R. and Sowers, J.R. Therapeutic challenges in the obese diabetic patient with hypertension. Am J Med 1996, 101: 33-46S.
4. Cooper, C. and Melton, L.J., III. Magnitude and impact of osteoporosis and fractures. In: Osteoporosis. R. Marcus, D. Feldman and J. Kelsey (Eds). Academic Press: San Diego, 1996, pp. 419-34.
5. Baron, R., Ravesloot, J.-H., Neff, L., Chakraborty, M., Chatterjee, D., Lombri, A. and Home, W. Cellular and molecular biology of the osteoclast. In: Cellular and Molecular Biology of Bone. M. Noda (Ed.). San Diego: Academic Press, 1993, pp. 445-95.
6. Felix, R., Hofsletter, W. and Cecchini, M.G. Recent developments in the understanding of the pathophysiology of osteoporosis. Eur J Endocrinol 1996, 134: 143-56.
7. Kaita, S.P., Dube, M.G., Pu, S., Xu, B., Horvath, T.L. and Kalra, P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 1999, 20: 68-100.
8. Sainsbury, A., Cusin, I., Doyle, P., Rohner-Jeanrenaud, F. and Jeanrenaud, B. Intracerebroventricular administration of neuropeptide Y to normal rats increases obese gene expression in white adipose tissue. Diabetologia 1996, 39: 353-6.
9. Sainsbury, A. and Herzog, H. Inhibitory effects of central neuropeptide Y on the somatotrupic and gonadotropic axes in male rats are independent of adrenal hormones. Peptides 2001, 22: 467-71.
10. Blomqvist, A.G. and Herzog, H. Y-receptor subtypes - How many more? Trends Neurosci 1997, 20: 294-8.
11. Inui, A. Feeding and body-weight regulation by hypothalamic neuropeptides - Mediation of the actions of leptin. Trends Neurosci 1999, 22: 62-7.
12. Friedman, J.M. and Halaas, J.L. Leptin and the regulation of the body weight in mammals. Nature 1998, 395: 763-70.
13. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devo, R., Richards, G.J., Campfield, A., Clark, F.T., Deeds, J., Muir, C., Sanker, S., Mariarty, A., Moore, K.K., Smutko, J.S., Mays, G.G., Woolf, E.A., Monroe, C.A. and Tepper, R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995, 83: 1263-71.
14. Stephens, T.W., Basinski, M., Bristow, P.K. et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995, 377: 530-2.
15. Coleman, D.L. Classical diabetes models: Past lessons and potential new therapies. In: Frontiers in Diabetes Research. Lessons from Animal Diabetes 11. E. Shafrir, and A.E. Renold, (Eds.). John Libbey & Co Ltd.: London. 1988, pp. 253-6.
16. Erickson, J.C., Hollopeter, G. and Palmiter, R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996, 274: 1704-7.
17. Parker, R.M. and Herzog, H. Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci 1999, 11: 1431-48.
18. Naveilhan, P., Neveu, I., Arenas, E. and Ernfors, P. Complementary and overlapping expression of Y1, Y2 and Y5 receptors in the developing and adult mouse nervous system. Neuroscience 1998, 87: 289-302.
19. Baskin, D.G., Breininger, J.F. and Schwartz, M.W. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 1999, 48: 828-33.
20. Broberger, C., Landry, M., Wang, H., Walsh, J.N. and Hokfelt, T. Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 1997, 66: 393-408.
21. King, P.J., Williams, G., Doods, H. and Widdowson, P.S. Effect of a selective neuropeptide Y Y(2) receptor antagonist. BHE0246 on neuropeptide Y release. Eur J Pharmacol 2000, 396: R1-3.
22. Gehlert, D.R., Beavers, L.S., Johnson, D., Gackenheimer, S.L., Schober, D.A. and Gadski, R.A. Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol 1996, 49: 224-8.
23. Cunningham, S.M., Mihara, S. and Lees, G.M. Y2-receptor-mediated selective inhibition of slow, inhibitory postsynaptic potential in submacous neurones of guinea-pig caecum. British J Pharmacol 1994, 113: 883-8.
24. Chen, G. and van den Pol, A.N. Multiple NPY receptors coexist in pre- and postsynaptic sites: Inhibition of GABA release in isolated self-innervating SCN neurons. J Neurosci 1996, 16: 7711-24.
25. Kalra, S.P., Dube, M.G., Sahu, A., Phelps, C.P. and Kaita, P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA 1991, 88: 10931-5.
26. O'Shea, D., Morgan, D.G., Meeran, K., Edwards, C.M., Turton, M.D., Choi, S.J., Heath, M.M., Gunn, I., Taylor, G.M., Howard, J.K., Bloom, C.I., Small, C.J., Haddo, O., Ma, J.J., Callinan, W., Smith, D.M., Ghatei, M.A. and Bloom, S.R. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology 1997, 138: 196-202.
27. Leibowitz, S.F. and Alexander, J.T. Analysis off neuropeptide Y-induced feeding: Dissociation off Y1 and Y2 receptor effects on natural meal patterns. Peptides 1991, 12: 1251-60.
28. Batterham, R., Cowley, M., Small, C., Herzog, H., Cohen, M., Dakin, C., Wren, A., Brynes, A., Low, M., Ghatei, M., Cone, R. and Bloom, S. The gut hormone, PYY3-36 physiological inhibits food intake. Nature 2002, 418: 650-3.
29. Tremollieres, F.A., Pouilles, J.M. and Ribot, C. Vertebral post-menopausal bone loss is reduced in overweight women: A longitudinal study in 155 early postmenopausal women. J Clin Endocrinol Metab 1993, 77: 683-6.
30. Riggs, B., Khosla, S. and Melton, M.J. A unitary model for involutional osteoporosis. Estragen deficiency causes both Type I and Type II osteoporosis in postmenopaasal women and contributes to bone loss its aging men. J Bone Miner Res 1998, 13: 763-73.
31. Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A.F., Beil, F.T., Shen, J., Vinson, C., Rueger, J.M. and Karsenty, G. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell 2000, 100: 197-207.
32. Broadwell, R.D and Brightman, M.W. Entry of peroxidase into neurons of the central and peripheral nervous system from extracerebral and cerebral blood. J Comp Neurol 1976, 166: 257-83.
33. Erickson, J.C., Hollopeter, G. and Palmiter, R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996, 274: 1704-7.
34. Erickson, J.C., Clegg, K.E. and Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996, 381: 415-8.
35. Pedrazzini, T., Seydoux, J., Kunstner, P., Aubert, J.F., Grouzmann, E., Beermann, F. and Brunner, H.R. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor: Nat Med 1998, 4: 722-6.
36. Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Fürtinger, S., Jenkins, A., Cox, H.M., Sperk, G., Hökfelt, T. and Herzog, H. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci USA 2002, 99: 8938-43.
37. Sainsbury, A., Schwarzer, C. Couzens, M., Jenkins, A., Oakes, S.R., Ormandy, C.J. and Herzog, H. Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 2002, 16: 1077-88.
38. Marsh, D.J., Hollopeter, G., Kafer, K.E. and Palmiter, R.D. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med 1998, 4: 718-21.
39. Baldock, P., Sainsbury, A., Couzens, M., Enriquez, R.F. Gardiner, E.M. and Herzog, H. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 2002, 109: 915-21.
40. Piper, K., Boyde, A. and Jones, S.J. Volumes of chick and rat osteoclasts cultured on glass. Calcif Tissue Int 1995, 56: 382-9.
41. Piper, K., Boyde, A. and Jones, S.J. The relationship between the number of nuclei of an osteoclast and its resorptive capability in vitro. Anat Embryol 1992, 186: 291-9.
42. Saper, C.B., Loewy, A.D., Swanson, L.W. and Cowan, W.M. Direct hypothalamo-autonomic connections. Brain Res 1976, 117: 305-12.
43. Bray, G.A. The MONA LISA hypothesis. Most obesities known are low in sympathetic activity. In: Progress in Obesity Research. Y. Oomura, S. Tarui, S. Inoue and T. Shimazu (Eds.). John Libbey and Company Ltd.: London, 1990, pp. 61-6.
44. Sisask, G., Bjurholm, A., Ahmed, M. and Kreicbergs, A. The development of autonomic innervation in bone and joints of the rat. J Autonom Nerv Syst 1996, 59: 27-33.
45. Pralong, F.P., Gonzales, C., Voirol, M.J., Palmiter, R.D., Brunner, H.R., Galliard, R.C., Seydoux, J. and Pedrazzini, T. The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J 2002, 16: 712-4.