Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: Cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 3, 1996, Pages 1719-1725

  Sestili, Piero ^a   Brandi, Giorgio ^b   Brambilla, Liliana ^a   Cattabeni, Flaminio ^a   Cantoni, Orazio ^a,b  

^a Istituto di Farmacologia e Farmacognosia   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; ASCORBIC ACID; CATALASE; DNA FRAGMENT; HYDROGEN PEROXIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CELL DENSITY; CELL KILLING; CELL PROTECTION; CULTURE MEDIUM; CYTOTOXICITY; DRUG ANTAGONISM; ERYTHROCYTE; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL CULTURE;

ASCORBIC ACID; CATALASE; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; LEUKEMIA, MYELOCYTIC, ACUTE; TUMOR CELLS, CULTURED;

EID: 0030434542     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. AEBI, H.: Catalase in vitro. Methods Enzymol. 105: 121-126, 1984.
2. ARAKAWA, N., NEMOTO, S., SUZUKI, E. AND OTSUKA, M.: Role of hydrogen peroxide in the inhibitory effect of ascorbate on cell growth. J. Nutr. Sci. Vitaminol. 40: 219-227, 1994.
3. BAADER, S. L., BRUCHELT, G., CARMINE, T. C., LODE, H. N., RIETH, A. G. AND NIETHAMMER, D.: Ascorbic-acid-mediated iron release from cellular ferritin and its relation to the formation of DNA strand breaks in neuroblastoma cells. J. Cancer Res. Clin. Oncol. 120: 415-421, 1994.
4. BASU, S., SOM, S., MUKHERJEE, D. AND CHATTERJEE, J. B.: Estimation of dehydroascorbic acid in blood of diabetic patients. Biochem. Biophys. Res. Commun. 90: 1335-1340, 1979.
5. BICKNELL, G. M. AND COHEN, G. R.: Cleavage of DNA to large kilobase pair fragments occurs in some forms of necrosis as well as apoptosis. Biochem. Biophys. Res. Commun. 207: 40-47, 1995.
6. BIGLEY, R. H. AND STANKOVA, H.: Uptake and reduction of oxidized and reduced ascorbate by human leukocytes. J. Exp. Med. 139: 1089-1092, 1974.
7. BIGLEY, R. H., WIRTH, M., LAYMAN, D., RIDDLE, M. AND STANKOVA, H.: Interactions between glucose and dehydroascorbate transport in human neutrophils and fibroblasts. Diabetes 32: 545-548, 1983.
8. BLANCHARD, J., CONRAD, K. A. AND WATSON, R. R.: Comparison of plasma, mononuclear and polymorphonuclear leukocyte vitamin C levels in young and elderly women during depletion and supplementation. Eur. J. Clin. Nutr. 43: 97-106, 1989.
9. BLOCHER, D., EINSPENNER, M. AND ZAJACKOWSKI, J.: CHEF electrophoresis, a sensitive technique for the determination of DNA double strand breaks. Int. J. Radiat. Biol. 56: 446-448, 1989.
10. BLOCK, G.: Vitamin C, cancer and aging. Age 16: 55-58, 1993.
11. BRAM, S., FROUSSARD, P., GUICHARD, M., JASMIN, C., AUGERY, Y., SINOUSSI-BARRE, F. AND WRAY, W.: Vitamin C preferential toxicity for malignant melanoma cells. Nature (Lond.) 284: 629-631, 1980.
12. 2 on iron dependent DNA strand breaks and related processes in the neuroblastoma cell line SK-N-SH. Cancer Res. 51: 6066-6072, 1991.
13. CANTONI, O., MURRAY, D. AND MEYN R. E.: Effect of 3-aminobenzamide on DNA strand-break rejoining and cytotoxicity in CHO cells treated with hydrogen peroxide. Biochim. Biophys. Acta 867: 135-143, 1986.
14. CHAVANCE, M., HERVETH, B. AND FOURNIER, C.: Vitamin status, immunity and infections in an elderly population. Eur. J. Clin. Nutr. 43: 827-835, 1989.
15. CORCORAN, G. B., FIX, L., JONES, D. P., TREINEN MOSLEN, T., NICOTERA, P., OBERHAMMER, F. A. AND BUTTYAN, N.: Apoptosis: Molecular control point in toxicity. Toxicol. Appl. Pharmacol. 128: 169-181, 1994.
16. HUNT, C., CHAKRAVORTY, N. K., ANNAN, G., HABIBZADEH, N. AND SCHORAH, C. J.: The clinical effects of Vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. Int. J. Vitaminol. Nutr. Res. 64: 212-219, 1994.
17. IYANAGI, T., YAMAZAKI, I. AND ANAN, K. F.: One-electron oxidation-reduction properties of ascorbic acid. Biochim. Biophys. Acta 806: 255-261, 1985.
18. JAMPEL, H. D.: Ascorbic acid is cytotoxic to dividing human tenon's capsule fibroblasts. Arch. Ophthalmol. 108: 1323-1325, 1990.
19. KING, G., BEINS, M., LARKIN, J., SUMMERS, B. AND ORDMAN, A. B.: Rate of excretion of Vitamin C in human urine. Age 17: 87-92, 1994.
20. LODE, H. N., BRUCHELT, G., RIEPH, A. G. AND NIETHAMMER, D.: Release of iron from ferritin by 6-hydroxydopamine under aerobic and anaerobic conditions. Free Radiat. Res. Commun. 11: 153-185, 1990.
21. MEDINA, M. A., GARCIA DE VEAS, R. AND SCHEIGERER, L.: Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro. Biochem. Mol. Biol. Int. 34: 871-874, 1994.
22. NIKI, E., SAITO, T., KAWANAMI, A. AND KAMIYA Y.: Inhibition of oxidation of methyl-linoleate in solution by vitamin E and vitamin C. J. Biol. Chem. 259: 4177-1182, 1984.
23. NOSSERI, C., COPPOLA, S. AND GHIBELLI, L.: Possible involvement of poly(ADP-ribosyl)polymerase in triggering stress-induced apoptosis. Exp. Cell Res. 212: 367-373, 1994.
24. PARK, C. H., AMARE, M., SAVIN, M. A. AND HOOGSTRATEN, B.: Growth suppression of leukemic cells in vitro by L-ascorbic acid. Cancer Res. 40: 1062-1065, 1980.
25. PETERKOFSKY, B. AND PRATHER, W.: Cytotoxicity of ascorbate and other reducing agents towards cultured fibroblasts as a result of hydrogen peroxide formation. J. Cell. Physiol. 90: 61-70, 1977.
26. REYNOLDS, C. P., REYNOLDS, D. A., FRENKEL, E. P. AND SMITH, R. G.: Selective toxicity of 6-hydroxydopamine and ascorbate for human neuroblastoma in vitro: A model for clearing marrow prior to autologous transplant. Cancer Res. 42: 1331-1336, 1982.
27. SCHWEINZER, E. AND GOLDENBERG, H.: Ascorbate-mediated transmembrane electron transport and ascorbate uptake in leukemic cell lines are two different processes. Eur. J. Biochem. 206: 807-812, 1992.
28. SESTILI, P., CATTABENI, F. AND CANTONI, O.: Simultaneous determination of DNA double strand breaks and DNA fragment size in cultured mammalian cells exposed to hydrogen peroxide/histidine or etoposide with CHEF electrophoresis. Carcinogenesis 16: 703-706, 1995.
29. TAPPEI, A. L.: Vitamin E as the biological lipid antioxidant. Vit. Horm. 20: 493-510, 1962.
30. VALLANCE, S.: Platelets, leukocytes and buffy layer vitamin C after surgery. Hum. Nutr. 40c: 35-41, 1986.
31. VOJDANI, A. AND GHONEUM, M.: In vivo effect of ascorbic acid enhancement of human natural killer cell activity. Nutr. Res. 13: 753-762, 1993.
32. WEBSTER, D. A.: The formation of hydrogen peroxide during the oxidation of reduced nicotinamide adenine dinucleotide by cytochrome o from Vitreoscilla. J. Biol. Chem. 250: 4955-4958, 1975.
33. YUE, B. Y., NIEDRA, J. T. AND BAUM, J. L.: Effects of ascorbic acid on cultured rabbit endothelial cells. Invest. Ophthalmol. Vis. Sci. 19: 1471-1476, 1980.