Effect of ascorbate oxidase on radical intensity and cytotoxic activity of ascorbate

Anticancer Research

Volumn 17, Issue 2 A, 1997, Pages 1163-1166

  Sakagami, Hiroshi ^a   Satoh, Kazue ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Ascorbate oxidase; Cytotoxicity; Degradation; Radical

Indexed keywords

ASCORBATE OXIDASE; ASCORBIC ACID; FREE RADICAL;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

ANTINEOPLASTIC AGENTS; ASCORBATE OXIDASE; ASCORBIC ACID; FREE RADICALS; HUMANS;

EID: 0030939469     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, Kuribayashi N, Sakagami T, Momose K and Takeda M: Relationship between ascorbyl radical intensity and apoptosis-inducing activity. Anticancer Res 16: 2635-2644, 1996.
2. Satoh K, Sakagami H and Nakamura K: Enhancement of radical intensity and cytotoxic activity of ascorbate by PSK and lignins. Anticancer Res 16: 2981-2986, 1996.
3. Satoh K and Sakagami H: Ascorbyl radical scavenging activity of polyphenols. Anticancer Res 16: 2885-2890, 1996.
4. Sakagami H and Satoh K: Prooxidant action of two antioxidants: Ascorbic acid and gallic acid. Anticancer Res 17: in press, 1997.
5. Satoh K, Sakagami H and Nakamura K: Enhancement of radical intensity and cytotoxic activity of ascorbate by hyperthermia. Anticancer Res 16: 2987-1992, 1996.
6. Sakagami H, Satoh K, Sugaya K, Iida M, Hirota N, Matsumoto K, Kimura S, Gomi K, Taguchi S, Kato S and Takeda M: Effect of the type of serum in the medium on sodium ascorbate-induced cytotoxicity. Anticancer Res 16: 1937-1942, 1996.
7. Sakagami H, Satoh K, Taguchi S and Takeda M: Inhibition of cytotoxic activity of ascorbate by human cancer patient sera. Anticancer Res. 17: in press, 1997.
8. Satoh K and Sakagami H: Effect of metal ions on radical intensity and cytotoxic activity of ascorbate. Anticancer Res. 17: in press, 1997.
9. L-Ascorbate oxidase, Enzyme Handbook, Springer-Verlag Berlin Heidelberg 1994
10. Iyanagi T, Yamazaki I and Anan KF: One-electron oxidation- reduction properties of ascorbic acid. Biochim Biophys Acta 806: 255-261, 1985.
11. Bielski BHJ: Chemistry of ascorbic acid radicals. In: Ascorbic acid, chemistry, metabolism, and uses. Sieb PA, Tolbert BM, eds. (Advances in chemistry series 200), pp81-100, 1982
12. Sakagami H, Kuribayashi N, Iida M, Hagiwara T, Takahashi H, Yoshida H, Shiota F, Ohata H, Momose K and Takeda M: The requirement for and mobilization of calcium during induction by sodium ascorbate and by hydrogen peroxide of cell death. Life Sciences 58: 1131-1138, 1996.