Characterization of the active site and insight into the binding mode of the anti-angiogenesis agent fumagillin to the manganese(II)-loaded methionyl aminopeptidase from Escherichia coli

Journal of Biological Inorganic Chemistry

Volumn 10, Issue 1, 2005, Pages 41-50

  D'Souza, Ventris M ^a   Brown, Robert S ^a   Bennett, Brian ^b   Holz, Richard C ^a  

^a UTAH STATE UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cobalt; Fumagillin; Manganese; Methionyl aminopeptidase; Peptide hydrolysis

Indexed keywords

FUMAGILLIN; HELIUM; METHIONYL AMINOPEPTIDASE; NITROGEN; OXYGEN;

ANGIOGENESIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; ELECTRON SPIN RESONANCE; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAGNETISM; MICROFILTRATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TEMPERATURE MEASUREMENT; X RAY CRYSTALLOGRAPHY;

AMINOPEPTIDASES; ANGIOGENESIS INHIBITORS; BINDING SITES; CYCLOHEXANES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; FATTY ACIDS, UNSATURATED; MANGANESE; MOLECULAR CONFORMATION; SESQUITERPENES;

ESCHERICHIA COLI;

EID: 13144279326     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-004-0611-7     Document Type: Article

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