Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 8, 1998, Pages 1163-1169

  Turk, Benjamin E ^a   Su, Zhuang ^a   Liu, Jun O ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Angiogenesis; Immunosuppression; MetAP2; Ovalicin; TNP 470

Indexed keywords

AMINOPEPTIDASE; ANGIOGENESIS INHIBITOR; FUMAGILLOL CHLOROACETYLCARBAMATE; IMMUNOSUPPRESSIVE AGENT; OVALICIN; OVALICIN DERIVATIVE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; DRUG SYNTHESIS; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CATTLE; CELL DIVISION; CELLS, CULTURED; CYCLOHEXANES; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; SESQUITERPENES;

BOVINAE;

EID: 0031661585     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00078-9     Document Type: Article

References (23)

1. Folkman, J. N. Engl. J. Med. 1971, 285, 1182.
2. Hanahan, D.; Folkman, J. Cell 1996, 86, 353.
3. Ingber, D.; Fujita, T.; Kishimoto, S.; Sudo, K.; Kanamaru, T.; Brem, H.; Folkman, J. Nature 1990, 348, 555.
4. Castronovo, V.; Belotti, D. Eur. J. Cancer 1996, 32A, 2520.
5. Yanase, T.; Tamura, M.; Fujita, K.; Kodama, S.; Tanaka, K. Cancer Res. 1993, 53, 2566.
6. Corey, E. J.; Guzman-Perez, A.; Noe, M. C. J. Am. Chem. Soc. 1994, 116, 12109.
7. Lazary, S.; Stähelin, H. Experentia 1968, 24, 1171.
8. Lazary, S.; Stähelin, H. Antibiot. Chemother. 1969, 15, 177.
9. Hartmann, G. R.; Richter, H.; Weiner, E. M.; Zimmermann, W. Planta Med. 1978, 34, 231.
10. Zimmermann, W. A.; Hartmann, G. R. Eur. J. Biochem. 1981, 118, 143.
11. Antoine, N.; Bours, V.; Heinen, E.; Simar, L. J.; Castronovo, V. J. Natl. Cancer Inst. 1995, 87, 136.
12. Antoine, N.; Daukandt, M.; Heinen, E.; Simar, L. J.; Castronovo, V. Am. J. Pathol. 1996, 148, 393.
13. Griffith, E. C.; Su, Z.; Turk, B. E.; Chen, S.; Chang, Y.-W.; Wu, Z.; Biemann, K.; Liu, J. O. Chem. Biol. 1997, 4, 461.
14. Sin, N.; Meng, L.; Wang, M. Q. W.; Wen, J.; Bornmann, W. G.; Crews, C. M. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 6099.
15. Marui, S.; Itoh, F.; Kozai, Y.; Sudo, K.; Kishimoto, S. Chem. Pharm. Bull. 1992, 40, 96.
16. Marui, S.; Yamamoto, T.; Sudo, K.; Akimoto, H.; Kishimoto, S. Chem. Pharm. Bull. 1995, 43, 588.
17. Kishimoto, S.; Fujita, T. U.S. Patent 5 204 345, 1993.
18. Hatanaka, H.; Kino, T.; Hashimoto, M.; Tsurui, Y.; Kuroda, A.; Tanaka, H.; Goto, T.; Okuhara, M. J. Antibiotics 1988, 8, 999.
19. Berger, A. E.; Dortch, K. A.; Staite, N. D.; Mitchell, M. A.; Evans, B. R.; Holm, M. S. Agents Actions 1993, 39, C86.
20. Kusaka, M.; Sudo, K.; Matsutani, E.; Kozai, Y.; Marui, S.; Fujita, T.; Ingber, D; Folkman, J. Br. J. Cancer 1994, 69, 212.
21. Abe, J.; Zhou, W.; Takuwa, N.; Taguchi, J.; Kurokawa, K.; Kumada, M.; Takuwa, Y. Cancer Res. 1994, 54, 3407.
22. Hori, A.; Ikeyama, S.; Sudo, K. Biochem. Biophys. Res. Comm. 1994, 204, 1067.
23. Figg, W. D.; Pluda, J. M.; Lush, R. M.; Saville, M. W.; Wyvill, K.; Reed, E.; Yarchoan, R. Pharmacotherapy 1997, 17, 91.