Airway wall remodelling: The influence of corticosteroids

Current Opinion in Allergy and Clinical Immunology

Volumn 5, Issue 1, 2005, Pages 43-48

  Ward, Chris ^a,c   Walters, Haydn ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF TASMANIA   (Australia)

^c FREEMAN HOSPITAL   (United Kingdom)

Author keywords

Airway remodelling; Inhaled corticosteroids

Indexed keywords

BECLOMETASONE DIPROPIONATE; CORTICOSTEROID; FLUTICASONE PROPIONATE;

AIRWAY; ASTHMA; BIOPSY; CHRONIC INFLAMMATION; CLINICAL FEATURE; DOSE RESPONSE; HUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; REVIEW;

EID: 12944255788     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/00130832-200502000-00009     Document Type: Review

References (53)

1. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001; 164(10 Pt 2):S28-S38.
2. Hogg JC, Chu F, Utokaparch S, Woods R, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350:2645-2653. This detailed study of airway remodelling in chronic obstructive pulmonary disease indicated inter-relationships with disease severity.
3. Stewart S. In: Explant pathology in lung transplantation. Cambridge: Cambridge University Press; 2004. pp. 96-110.
4. Davies DE, Wicks J, Powell RM, et al. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 2003; 111:215-225; quiz 226.
5. Lange P, Parner J, Vestbo J, et al. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339:1194-1200.
6. Fish JE, Peters SP. Airway remodeling and persistent airway obstruction in asthma. J Allergy Clin Immunol 1999; 104(3 Pt 1);509-516.
7. Elias JA. Airway remodeling in asthma. Unanswered questions. Am J Respir Crit Care Med 2000; 161(3 Pt 2):S168-S171.
8. Pedersen S. Why does airway inflammation persist? Is it failure to treat early? Am J Respir Crit Care Med 2000; 161(3 Pt 2):S182-S185.
9. Huber H, Koessler K. The pathology of bronchial asthma. Arch Intern Med 1922; 30:689-760.
10. Houston JC, De Navasquez S, Trounce JR. A clinical and pathological study of fatal cases of status asthmaticus. Thorax 1953; 8:207-213.
11. Beckett PA, Howarth PH. Pharmacotherapy and airway remodelling in asthma? Thorax 2003; 58(2):163-174.
12. Fahy JV. Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med 2001; 164(10 Pt 2):S46-S51.
13. Busse WW, Banks-Schlegel S, Wenzel SE. Pathophysiology of severe asthma. J Allergy Clin Immunol 2000; 106:1033-1042.
14. Kelly C, Ward C, Stenton CS, et al. Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway responsiveness. Thorax 1988; 43:684-692.
15. Ward C, Pais M, Bish R, et al. Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 2002; 57:309-316.
16. Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002; 418:426-430.
17. Tschumperlin DJ, Shively JD, Kikuchi T, Drazen JM. Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. Am J Respir Cell Mol Biol 2003; 28:142-149.
18. Tschumperlin DJ, Dai G, Maly IV, et al. Mechanotransduction through growth-factor shedding into the extracellular space. Nature 2004; 429:83-86. Recent evidence has shown that mechanical stress may directly lead to remodelling. Here mechanical stresses modelled to occur in asthmatics in vivo were shown to shrink the lateral intercellular space surrounding epithelial cells. This triggered cellular signalling via autocrine binding of epidermal growth factor family ligands to the epidermal growth factor receptor.
19. Wilson JW, Li X. The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway. Clin Exp Allergy 1997; 27:363-371.
20. Chakir J, Shannon J, Molet S, et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 2003; 111:1293-1298.
21. Chu HW, Halliday JL, Martin RJ, et al. Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am J Respir Crit Care Med 1998; 158:1936-1944.
22. Ward C, Reid D, Pais M, et al. PD20 tomethacholine is predicted by airway inflammation and remodelling: a systematic longitudinal steroid intervention study of airway biopsy (Ebb) and BAL parameters. Thorax 2002; 57 (Suppl 3):89.
23. Payne DN, Rogers AV, Adelroth E, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003; 167:78-82. This study showed that reticular basement membrane thickening is already present in children with difficult asthma and to a similar extent to that seen in adults. In addition, there was no association with age, symptom duration, lung function, or eosinophilic airway inflammation. Airway remodelling may be a very early finding in asthma.
24. Barbato A, Turato G, Baraldo S, et al. Airway inflammation in childhood asthma. Am J Respir Crit Care Med 2003; 168:798-803.
25. Orsida BE, Li X, Hickey B, et al. Vascularity in asthmatic airways: relation to inhaled steroid dose. Thorax 1999; 54:289-295.
26. Orsida BE, Ward C, Li X, et al. Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthma. Am J Respir Crit Care Med 2001; 164:117-121.
27. Wignarajah D, Zheng L, Reid D, et al. Fluticasone propionate affects airway vascularity after 3 months of treatment. Am J Respir Crit Care Med 2004; 169:A451.
28. Wignarajah D, Zheng L, Harding R, et al. Inhaled corticosteroids and VEGF concentrations in asthmatic bronchoalveolar lavage fluid. Thorax 2003; 58(Suppl 3):15.
29. Wignarajah D, Zheng L, Pais M, et al. Inhaled corticosteroids and airway wall angiogenesis in asthma. Am J Respir Crit Care Med 2003; 167:A454.
30. Chetta A, Zanini A, Foresi A, et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am J Respir Crit Care Med 2003; 167:751-757.
31. Black JL Asthma: more muscle cells or more muscular cells? Am J Respir Crit Care Med 2004; 169:980-981.
32. Woodruff PG, Dolganov GM, Ferrando RE, et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 2004; 169:1001-1006. Using a combination of cell counting with state of the art laser microdissection and the polymerase chain reaction this study supported the hypothesis that an increased smooth muscle cell number, rather than increased size accounts for increased smooth muscle in asthma.
33. Burgess JK, Johnson PR, Ge Q, et al. Expression of connective tissue growth factor in asthmatic airway smooth muscle cells. Am J Respir Crit Care Med 2003; 167:71-77.
34. Gizycki MJ, Adelroth E, Rogers AV, et al. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 1997; 16:664-673.
35. Carroll NG, Mutavdzic S, James AL. Increased mast cells and neutrophils in submucosal mucus glands and mucus plugging in patients with asthma. Thorax 2004; 57:677-682.
36. Klapper LN, Kirschbaum MH, Sela M, Yarden Y. Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. Adv Cancer Res 2000; 77:25-79.
37. Davies DE, Chamberlin SG. Targeting the epidermal growth factor receptor for therapy of carcinomas. Biochem Pharmacol 1996; 51:1101-1110.
38. Yarden Y. The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37(Suppl 4): S3-S8.
39. Puddicombe SM, Polosa R, Richter A, et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. Faseb J 2000; 14:1362-1374.
40. Polosa R, Puddicombe SM, Krishna MT, et al. Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects. J Allergy Clin Immunol 2002; 109:75-81.
41. Puddicombe SM, Torres-Lozano C, Richter A, et al. Increased expression of p21 (waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium. Am J Respir Cell Mol Biol 2003; 28(1):61-68.
42. Dorscheid DR, Wojcik KR, Sun S, et al. Apoptosis of airway epithelial cells induced by corticosteroids. Am J Respir Crit Care Med 2001; 164(10 Pt 1):1939-1947.
43. Pelaia G, Cuda G, Vatrella A, et al. Effects of transforming growth factor-β and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells. Am J Respir Cell Mol Biol 2003; 29:12-18.
44. Goncharova EA, Billington CK, Irani C, et al. Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration. Am J Respir Cell Mol Biol 2003; 29:19-27.
45. Zheng L, Ward C, Snell GI, et al. Scar collagen deposition in the airways of allografts of lung transplant recipients. Am J Respir Crit Care Med 1997; 52:551-556.
46. Zheng L, Orsida BE, Ward C, et al. Airway vascular changes in lung allograft recipients. J Heart Lung Transplantation 1999; 18:231-238.
47. Ward C. A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients. J Heart Lung Trans (in press).
48. Ward C. Airway reticular basement membrane thickening in lung transplant recipients is not affected by inhaled corticosteroids. Clin Exp Allergy (in press).
49. Whitford H, Walters EH, Lewey B, et al. Addition of inhaled corticosteroids to systemic immunosuppression after lung transplantation: a double-blind, placebo-controlled trial. Transplantation 2002; 73:1793-1799.
50. Zheng L, Walters EH, Wang N, et al. Effect of inhaled futicasone on BAL TGF-beta 1 and bFGF concentrations in clinically stable lung transplant recipients. J Heart Lung Transplant 2004; 23:446-455.
51. Ward C, Forrest IA, Robertson H, et al. Epithelial mesenchymal transition in lung allografts [abstract]. Eur Respir J 2004;(Suppl 481):80S.
52. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112:1776-1784.
53. Gerhardt SG, McDyer JF, Girgis RE, et al. Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study. Am J Respir Crit Care Med 2003; 168:121-125. This study showed that a non-bactericidal dose of a macrolide antibiotic gave an unprecedented reversal of airflow limitation in chronic lung allograft rejection. The mechanisms are unknown but this may indicate that airway remodelling is reversible.