Effects of transforming growth factor-β and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 29, Issue 1, 2003, Pages 12-18

  Pelaia, Girolamo ^a   Cuda, Giovanni ^b   Vatrella, Alessandro ^b   Fratto, Donatella ^b   Grembiale, Rosa D ^b   Tagliaferri, Pierosandro ^b   Maselli, Rosario ^b   Costanzo, Francesco S ^b   Marsico, Serafino A ^b  

^a Policlinico Mater Domini   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CASPASE 3; GLUCOCORTICOID; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCLONAL ANTIBODY; PROPIDIUM IODIDE; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; INFLAMMATION; LUNG INJURY; RESPIRATORY EPITHELIUM; WESTERN BLOTTING;

ADMINISTRATION, TOPICAL; ANTHRACENES; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BRONCHI; BUDESONIDE; CASPASE 3; CASPASES; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; FLAVONOIDS; GLUCOCORTICOIDS; HUMANS; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0038374999     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2002-0074OC     Document Type: Article

References (48)

1. Redington, A. E., J. Madden, A. J. Frew, R. Djukanovic, W. R. Roche, S. T. Holgate, and P. H. Howarth. 1997. Transforming growth factor-β1 in asthma: measurement in bronchoalveolar lavage. Am. J. Respir. Crit. Care Med. 156:642-647.
2. Hastie, A. T., W. K. Kraft, K. B. Nyce, J. G. Zangrilli, A. I. Musani, J. E. Fish, and S. P. Peters. 2002. Asthmatic epithelial cell proliferation and stimulation of collagen production. Am. J. Respir. Crit. Care Med. 165:266-272.
3. Trautmann, A., P. Schmid-Grendelmeier, K. Kruger, R. Crameri, M. Akdis, A. Akkaya, E.-B. Brocker, K. Blaser, and C. A. Akdis. 2002. T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma. J. Allergy Clin. Immunol. 109:329-337.
4. Knight, D. 2001. Epithelium-fibroblast interactions in response to airway inflammation. Immunol. Cell Biol. 79:160-164.
5. Vignola, A. M., P. Chanez, G. Chiappara, A. Merendino, E. Pace, A. Rizzo, A. M. la Rocca, V. Bellia, G. Bonsignore, and J. Bousquet. 1997. Transforming growth factor-β expression in mucosal biopsies in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 156:591-599.
6. Holgate, S. T., D. E. Davies, P. M. Lackie, S. J. Wilson, S. M. Puddicombe, and J. L. Lordan. 2000. Epithelial-mesenchimal interactions in the pathogenesis of asthma. J. Allergy Clin. Immunol. 105:193-204.
7. Vignola, A. M., R. Gagliardo, A. Siena, G. Chiappara, M. R. Bonsignore, J. Bousquet, and G. Bonsignore. 2001. Airway remodeling in the pathogenesis of asthma. Curr. Allergy Asthma Rep. 1:108-115.
8. Nakao, A. 2001. Is TGF-β1 the key suppressor of human asthma? Trends Immunol. 22:115-118.
9. Whitman, M. 1998. Smads and early developmental signaling by the TGFβ superfamily. Genes Dev. 12:2445-2462.
10. Attisano, L., and J. L. Wrana. 2000. Smads as transcriptional co-modulators. Curr. Opin. Cell Biol. 12:235-243.
11. Ip, Y. T., and R. J. Davis. 1998. Signal transduction by the c-Jun N-terminal kinase (JNK): from inflammation to development. Curr. Opin. Cell Biol. 10:205-219.
12. Widmann, C., S. Gibson, M. B. Jarpe, and G. L. Johnson. 1999. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79:143-180.
13. Chang, L., and M. Karin. 2001. Mammalian MAP kinase signalling cascades. Nature 410:37-40.
14. Hanafusa, H., J. Ninomiya-Tsuji, N. Masuyama, M. Nishita, J. Fujisawa, H. Shibuya, K. Matsumoto, and E. Nishida. 1999. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression. J. Biol. Chem. 274:27161-27167.
15. Atfi, A., S. Djelloul, E. Chastre, R. Davis, and C. Gespach. 1997. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor TGF-β-mediated signalling. J. Biol. Chem. 272:1429-1432.
16. Pelaia, G., G. Cuda, A. Vatrella, R. D. Grembiale, G. B. De Sarro, R. Maselli, F. S. Costanzo, V. E. Avvedimento, D. Rotiroti, and S. A. Marsico. 2001. Effects of glucocorticoids on activation of c-Jun N-terminal, extracellular signal-regulated, and p38 MAP kinases in human pulmonary endothelial cells. Biochem. Pharmacol. 62:1719-1724.
17. Caelles, C., J. M. Gonzalez-Sancho, and A. Munoz. 1997. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev. 11:3351-3364.
18. Gonzalez, M. V., J. M. Gonzalez-Sancho, C. Caelles, A. Munoz, and B. Jimenez. 1999. Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells. FEBS Lett. 459:272-276.
19. Ventura, J.-J., C. Roncero, I. Fabregat, and M. Benito. 1999. Glucocorticoid receptor down-regulates c-Jun amino terminal kinases induced by tumor necrosis factor α in fetal rat hepatocyte primary cultures. Hepatology 29:849-857.
20. Hansson, A., K. Hehenberger, and M. Thoren. 1996. Long-term treatment of Swiss 3T3 fibroblasts with dexamethasone attenuates MAP kinase activation induced by insulin-like growth factor-I (IGF-I). Cell Biochem. Funct. 14:121-129.
21. Lasa, M., M. Brook, J. Saklatvala, and A. R. Clark. 2001. Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol. Cell. Biol. 31:771-780.
22. Barnes, P. J., S. Pedersen, and W. W. Busse. 1998. Efficacy and safety of inhaled corticosteroids: new developments. Am. J. Respir. Crit. Care Med. 157:S1-S53.
23. Gruenert, D. C., C. B. Basbaum, and J. H. Widdicombe. 1990. Long-term culture of normal and cystic fibrosis epithelial cells grown under serum-free conditions. In Vitro Cell. Dev. Biol. 26:411-418.
24. Kelsen, S. G., I. A. Mardini, S. Zhou, J. L. Benovic, and N. C. Higgins. 1992. A technique to harvest viable tracheobronchial epithelial cells from living human donors. Am. J. Respir. Cell Mol. Biol. 7:66-72.
25. Holgate, S. T. 2000. Epithelial damage and response. Clin. Exp. Allergy 30:37-41.
26. Holgate, S. T., P. M. Lackie, P. H. Howarth, W. R. Roche, S. M. Puddicombe, A. Richter, S. J. Wilson, J. W. Holloway, and D. E. Davies. 2001. Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma. Int. Arch. Allergy Immunol. 124:253-258.
27. Zhang, S., H. Smartt, S. T. Holgate, and W. R. Roche. 1999. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation. Lab. Invest. 79:395-405.
28. Linnala, A., V. Kinnula, L. A. Laitinen, V.-P. Lehto, and I. Virtanen. 1995. Transforming growth factor-β regulates the expression of fibronectin and tenascin in BEAS 2B human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 13:578-585.
29. Pulleyn, L. J., R. Newton, I. M. Adcock, and P. J. Barnes. 2001. TGFβ1 allele association with asthma severity. Hum. Genet. 109:623-627.
30. van den Bosch, J. M. M., C. Westermann, J. Aumann, S. Edsbacker, M. Ton-nesson, and O. Selroos. 1993. Relationship between lung tissue and blood concentrations of inhaled budesonide. Biopharm. Drug Dispos. 14:455-459.
31. Wen, L.-P., K. Madani, J. A. Fahrni, S. R. Duncan, and G. D. Rosen. 1997. Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-γ and Fas. Am. J. Physiol. 273:L921-L929.
32. Dorscheid, D. R., K. R. Wojcik, S. Sun, B. Marroquin, and S. R. White. 2001. Apoptosis of airway epithelial cells induced by corticosteroids. Am. J. Respir. Crit. Care Med. 164:1939-1947.
33. Guo, C., L. M. Luttrell, and D. T. Price. 2000. Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines. J. Urol. 163:1027-1032.
34. Olivieri, D., A. Chetta, M. Del Donno, G. Bertorelli, A. Canalini, A. Pesci, R. Testi, and A. Foresi. 1997. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study. Am. J. Respir. Crit. Care Med. 155:1864-1871.
35. Trigg, C. J., N. D. Manolitsas, J. Wang, M. A. Calderon, A. McAulay, S. E. Jordan, M. J. Herdman, N. Jhalli, J. M. Duddle, S. A. Hamilton, J. L. Devalia, and R. J. Davies. 1994. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am. J. Respir. Crit. Care Med. 150:17-22.
36. Lange, P., J. Parner, J. Vestbo, P. Schnohr, and G. Jensen. 1998. A 15-year follow-up study of ventilatory function in adults with asthma. N. Engl. J. Med. 339:1194-1200.
37. Song, C.-Z., X. Tian, and T. D. Gelehrter. 1999. Glucocorticoid receptor inhibits transforming growth factor-β signaling by directly targeting the transcriptional activation function of Smad3. Proc. Natl. Acad. Sci. USA 96:11776-11781.
38. Holgate, S. T., P. Lackie, S. Wilson, W. Roche, and D. Davies. 2000. Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma. Am. J. Respir. Crit. Care Med. 162:S113-S117.
39. Fujii, T., S. Hayashi, J. C. Hogg, R. Vincent, and S. F. Van Eeden. 2001. Particulate matter induces cytokine expression in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 25:265-271.
40. Hashimoto, S., Y. Gon, I. Takeshita, K. Matsumoto, I. Jibiki, H. Takizawa, S. Kudoh, and T. Horie. 2000. Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation. Am. J. Respir. Crit. Care Med. 161:280-285.
41. Kujime, K., S. Hashimoto, Y. Gon, K. Shimizu, and T. Horie. 2000. p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells. J. Immunol. 164:3222-3228.
42. Horiba, K., and Y. Fukuda. 1994. Synchronous appearance of fibronectin, integrin α5β1, vinculin and actin in epithelial cells and fibroblasts during rat tracheal wound healing. Virchows Arch. 425:425-434.
43. Singhal, P. C., M. Bhaskaran, J. Patel, K. Patel, B. S. Kasinath, F. N. Duraisamy, K. Reddy, and A. A. Kapasi. 2002. Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis. J. Immunol. 168:4025-4033.
44. Schrantz, N., M. F. Bourgeade, S. Mouhamad, G. Leca, S. Sharma, and A. Vazqu. 2001. p38-mediated regulation of an Fas-associated death domain protein-independent pathway leading to caspase-8 activation during TGFβ-induced apoptosis in human Burkitt lymphoma B cells BL41. Mol. Biol. Cell 12:3139-3151.
45. Liao, J. H., J. S. Chen, M. Q. Chai, S. Zhao, and J. G. Song. 2001. The involvement of p38 MAPK in transforming growth factorβ1-induced apoptosis in murine hepatocytes. Cell Res. 11:89-94.
46. Birrell, M., D. Hele, K. McCluskie, S. Webber, M. Foster, and M. G. Belvisi. 2000. Effect of the p38 kinase inhibitor. SB 203580, on sephadex induced airway inflammation in the rat. Eur. Respir. J. 16:947-950.
47. Haddad, E. B., M. Birrell, K. McCluskie, A. Ling, S. E. Webber, M. L. Foster, and M. G. Belvisi. 2001. Role of p38 MAP kinase in LPS-induced airway inflammation in the rat. Br. J. Pharmacol. 132:1715-1724.
48. Barnes, P. J. 2002. Cytokine modulators as novel therapies for asthma. Annu. Rev. Pharmacol. Toxicol. 42:81-98.