Interactions between effecters linked to serotonin receptors

Annals of the New York Academy of Sciences

Volumn 861, Issue , 1998, Pages 111-120

  Berg, K A ^a   Maayani, S ^b   Clarke, W P ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; ARACHIDONIC ACID; BETA 2 ADRENERGIC RECEPTOR; CYTOCHROME P450; KETANSERIN; PHOSPHOLIPASE C; PURINE RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; PHOSPHOLIPASE A; SEROTONIN AGONIST;

CONFERENCE PAPER; DRUG EFFICACY; DRUG SPECIFICITY; DRUG TARGETING; NONHUMAN; RECEPTOR DOWN REGULATION; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; HUMANS; PHOSPHOLIPASE C; PHOSPHOLIPASES A; RECEPTOR CROSS-TALK; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SIGNAL TRANSDUCTION;

EID: 0032534297     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10181.x     Document Type: Conference Paper

References (24)

1. 1. CONN, P. J. & E. SANDERS-BUSH. 1985. Serotonin-stimulated phosphoinositide turnover: Mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions. J. Pharmacol. Exp. Ther. 234: 195-203.
2. 2. CONN, P. J., E. SANDERS-BUSH, B. J. HOFFMAN & P. R. HARTIG. 1986. A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc. Natl. Acad. Sci. USA 83: 4086-4088.
3. 3. BERG, K. A., W. P. CLARKE, Y. CHEN, B. J. EBERSOLE, R. D. G. MCKAY & S. MAAYANI. 1994. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Mol. Pharmacol. 45: 826-836.
4. 1B-like receptor function via arachidonic acid metabolism. Mol. Pharmacol. 50: 1017-1023.
5. 2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. Proc. Natl. Acad. Sci. USA 87: 2187-2191.
6. 1C receptor. In The Neuropharmacology of Serotonin. P. M. Whitaker-Azimitia & S. J. Peroutka, Eds. Ann. N.Y Acad. Sci. 600: 149-166. New York.
7. 2C receptor stimulates cyclic GMP formation in choroid plexus. J. Neurochem. 64: 199-205.
8. 8. SHIMIZU, T. & L. S. WOLFE. 1990. Arachidonic acid cascade and signal transduction. J. Neurochem. 55: 1-15.
9. 9. BERG, K. A., W. P. CLARKE, C. SAILSTAD, A. SALTZMAN & S. MAAYANI. 1994. Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Mol. Pharmacol. 46: 477-484.
10. 2 receptors. Mol. Pharmacol. 42: 328-335.
11. 2-arachidonic acid pathway. Soc. for Neurosci. 23: 133. abstract.
12. 2C receptor systems. Soc. for Neurosci. 22: 1777. abstract.
13. 1C receptor density and mRNA levels in choroid plexus epithelial cells after treatment with mianserin and n(-)-1-(4-bromo-2,5-dimehtosyphenyl)-2-aminopropane. Mol. Pharmacol. 44: 725-730.
14. 14. MILLIGAN, G., R. A. BOND & M. LEE. 1995. Inverse agonism: Pharmacological curiosity or potential therapeutic strategy? Trends Pharmacol. Sci. 16: 10-13.
15. 15. MACEWAN, D. J. & G. MILLIGAN. 1996. Up-regulation of a constitutively active form of the β2-adrenoceptor by sustained treatment with inverse agonists but not antagonists. FEBS lett. 399: 108-112.
16. 2-adrenoceptor in transfected neuroblastoma x glioma hybrid cells. Mol. Pharmacol. 50: 1479-1486.
17. 2B receptor antagonist with anxiolytic-like properties. Br. J. Pharmacol. 117: 427-434.
18. 18. LEFF, P., C. SCARAMELLINI, C. LAW & K. MCKECHNIE. 1997. A three state model of agonist action. Trends Pharmacol. Sci. 18: 355-362.
19. 1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br. J. Pharmacol. 117: 1119-1126.
20. 20. FITZPATRICK, F. A. & R. C. MURPHY. 1989. Cytochrome P-450 metabolism of arachidonic acid: Formation and biological actions "epoxygenase"-derived eicosanoids. Pharmacol. Rev. 40: 229-241.
21. 21. HOYER, D., D. E. CLARKE, J. R. FOZARD, P. R. HARTIG, G. R. MARTIN, E. J. MYLECHARANE, P. R. SAXENA & P. P. HMPHREY. 1994. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46: 157-203.
22. 22. BLIER, P., C. DE MONTIGNY & Y. CHAPUT. 1990. A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. J. Clin. Psychiatry. 51: 14-20.
23. 23. BOLSHAKOV, V. Y. & S. A. SIEGELBAUM. 1995. Hippocampal long-term depression: Arachidonic acid as a potential retrograde messenger. Neuropharmacology 34: 1581-1587.
24. 24. BERG, K. A., S. MAAYANI, J. GOLDFARB, C. SCARAMELLINI, P. LEFF & W. P. CLARKE. 1998. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors. Evidence for agonist-directed trafficking of receptor stimulus. Mol. Pharmacol. 54: 94-104.