Assignment of voltage-gated potassium channel blocking activity to κ-KTx1.3, a non-toxic homologue of κ-hefutoxin-1, from Heterometrus spinifer venom

Biochemical Pharmacology

Volumn 69, Issue 4, 2005, Pages 669-678

  Nirthanan, Selvanayagam ^a   Pil, Joost ^b   Abdel Mottaleb, Yousra ^b   Sugahara, Yuko ^c   Gopalakrishnakone, Ponnampalam ^d   Joseph, Jeremiah S ^e   Sato, Kazuki ^c   Tytgat, Jan ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c FUKUOKA WOMEN'S UNIVERSITY   (Japan)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Hefutoxin 1; KTx1.3; Functional dyad; Heterometrus spinifer; Scorpion toxin; Voltage gated potassium channel

Indexed keywords

KAFFA HEFUTOXIN 2; KAPPA HEFUTOXIN 1; KAPPA HEFUTOXIN 3; LYSINE; POTASSIUM CHANNEL BLOCKING AGENT; RECEPTOR SUBTYPE; SCORPION VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA FLANKING REGION; DRUG ACTIVITY; DRUG INHIBITION; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTRICITY; FILTER; GENE FUNCTION; HYPOTHESIS; IC 50; MUTANT; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SEQUENCE HOMOLOGY; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; DISULFIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; SCORPION VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; TOXINS, BIOLOGICAL;

EID: 12744252922     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.10.018     Document Type: Article

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