Characteristic features of optic nerve ganglion cells and approaches for neuroprotection. From intracellular to capillary processes and therapeutic considerations;Besonderheiten der optikusganglienzellen und ansätze zur neuroprotektion: Von intrazellulären vorgängen zur kapillare bis zu therapeutischen überlegungen

Ophthalmologe

Volumn 101, Issue 11, 2004, Pages 1062-1070

  Funk, R H W ^a,c   Schmidt, K G ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Advanced glycation end products; Calcium channel blocker; Ganglion cell death; NMDA receptor; Optic nerve ganglion cells; Primary chronic open angle glaucoma

Indexed keywords

ANTIGLAUCOMA AGENT; ANTIOXIDANT; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DIZOCILPINE; FLUNARIZINE; GLYOXAL; IONOTROPIC RECEPTOR; METHYLGLYOXAL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; NIFEDIPINE; NIMODIPINE; PHENCYCLIDINE;

APOPTOSIS; CALCIUM TRANSPORT; CAPILLARY; CELL DAMAGE; CELL DEATH; CELL DESTRUCTION; DISEASE COURSE; GLYCATION; HUMAN; HYPERGLYCEMIA; HYPOXIA; NERVE CELL; NEUROPROTECTION; OPEN ANGLE GLAUCOMA; OPTIC NERVE; OXIDATIVE STRESS; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; RETINA GANGLION CELL; REVIEW; SIDE EFFECT; STRESS; VISUAL FIELD DEFECT;

GLAUCOMA, OPEN-ANGLE; HUMANS; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; OPTIC NERVE DISEASES; RETINAL DEGENERATION; RETINAL GANGLION CELLS;

EID: 12444330396     PISSN: 0941293X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00347-004-1116-z     Document Type: Review

References (90)

1. Anderson DR (1996) Glaucoma, capillaries and pericytes. 1. Blood flow regulation. Ophthalmologica 210:257-262
2. Anderson DR, Davis EB (1996) Glaucoma, capillaries and pericytes. 5. Preliminary evidence that carbon dioxide relaxes pericyte contractile tone. Ophthalmologica 210:280-284
3. Anderson DR, Davis EB (1996) Glaucoma, capillaries and pericytes. 2. Identification and characterization of retinal pericytes in culture. Ophthalmologica 210:263-268
4. Brown SM, Jampol LM (1996) New concepts of regulation of retinal vessel tone. Arch Ophthalmol 114:199-204
5. Chakravarthy U, Gardiner TA, Anderson P, Archer DB, Trimble ER (1992) The effect of endothelin 1 on the retinal microvascular pericyte. Microvasc Res 43:241-254
6. 2 on intracellular pH and contraction of retinal capillary pericytes. Invest Ophthalmol Vis Sci 38:643-651
7. Chidlow G, Schmidt KG, Wood JPM, Osborne NN (2002) Lipoic acid protects the retina against ischaemia/reperfusion. Neuropharmacology 43:15-25
8. Crosson CE, Willis JA, Potter DE (1990) Effect of the calcium antagonist, nifedipine, on ischemic retinal dysfunction. J Ocul Pharmacol 6:293-299
9. Crosson CE, DeBenedetto R, Gidday JM (1994) Functional evidence for retinal adenosine receptors. J Ocul Pharmacol 10:499-507
10. Danser AH, Derkx FH, Admiraal PJ, Deinum J, de Jong PT, Schalekamp MA (1994) Angiotensin levels in the eye. Invest Ophthalmol Vis Sci 35:1008-1018
11. Dawson TM, Dawson VL (1996) Nitric oxide synthase: role as a transmitter/mediator in the brain and endocrine system. Annu Rev Med 47:219-227
12. Dodge AB, Hechtman HB, Shepro D (1991) Microvascular endothelial-derived autacoids regulate pericyte contractility. Cell Motil Cytoskeleton 8:18880-18915
13. Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA (1996) Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 114:299-305
14. Funk R (1986) Studies on the functional morphology of rat ocular vessels with scanning electron microscopy. Acta Anat 125:252-257
15. Funk RH (1997) Blood supply of the retina. Ophthalmic Res 29:320-325
16. Funk R, Rohen JW (1985) Comparative morphological studies on blood vessels in eyes of normotensive and spontaneously hypertensive rats. Exp Eye Res 40:191-203
17. Funk RH, Nagel F, Wonka F, Krinke HE, Golfert F, Hofer A (1999) Effects of heat shock on the functional morphology of cell organelles observed by video-enhanced microscopy. Anat Rec 255:458-464
18. Gasser P, Flammer J (1990) Short- and long-term effect of nifedipine on the visual field in patients with presumed vasospasm. J Int Med Res 18:334-339
19. Giusti P, Franceschini D, Petrone M, Manev H, Floreani M (1996) In vitro and in vivo protection against kainate-induced excitotoxicity by melatonin. J Pineal Res 20:226-231
20. Gupta LY, Marmor MF (1993) Mannitol, dextromethorphan, and catalase minimize ischemic damage to retinal pigment epithelium and retina. Arch Ophthalmol 111:384-388
21. Haefliger IO, Meyer P, Flammer J, Luscher TF (1994) The vascular endothelium as a regulator of the ocular circulation: A new concept in ophthalmology? Surv Ophthalmol 39:123-132
22. Haefliger IO, Anderson DR (1997) Oxygen modulation of guanylatecyclase-mediated retinal pericyte relaxations with 3-morpholino- sydnonimine and atrial natriuretic peptide. Invest Ophthalmol Vis Sci 38:1563-1568
23. Haefliger IO, Chen Q, Anderson DR (1997) Effect of oxygen on relaxation of retinal pericytes by sodium nitroprusside. Graefes Arch Clin Exp Ophthalmol 235:388-392
24. 2+ concentration and pHi during metabolic inhibition. Am J Physiol 262:628-634
25. Hernandez MR, Pena JD, Selvidge JA, Salvador-Silva M, Yang P (2000) Hydrostatic pressure stimulates synthesis of elastin in cultured optic nerve head astrocytes. Glia 32:122-136
26. Hessemer V, Schmidt KG (1997) Influence of the vasodilator drug isosorbide dinitrate on ocular circulation. Arch Ophthalmol 115:324-327
27. Hofer A, Nagel F, Wonka F, Krinke H, Gölfert F, Funk R (1999) A new perfusable microchamber system for determination of cellular stress effects using video-enhanced microscopy during and after heat shock. Med Biol Eng Comput 37:667-669
28. Jacobson MD (1996) Reactive oxygen species and programmed cell death.Trends Biochem Sci 21:83-86
29. 2(+)- antagonist on visual field in low-tension glaucoma. Graefes Arch Clin Exp Ophthalmol 227:408-412
30. Klingmüller V, Schmidt KG, v Rückmann A, Gumbrecht S, Stein A, Koch B (2000) Farb- und Spektral-Doppler-sonographische Perfusionsmessungen in den kurzen hinteren Ziliararterien bei gesunden Probanden. In: Schmidt KG, Pillunat LE (Hrsg) Fortbildung Glaukom, Bd 3. Enke, Stuttgart, S 29-38
31. Koch T, Funk RH (2001) Cellular dysfunction in the pathogenesis of organ failure. New insights from molecular and cell biology. Anaesthesist 50:742-749
32. Kornhuber J, Weller M (1997) Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy. Biol Psychiatry 41:135-144
33. Kumagai N, Yuda K, Kadota T, Goris RC, Kishida R (1988) Substance P-like immunoreactivity in the central retinal artery of the rabbit. Exp Eye Res 46:591-596
34. Lam TT, Siew E, Chu R, Tso MO (1997) Ameliorative effect of MK-801 on retinal ischemia. J Ocul Pharmacol Ther 13:129-137
35. Levin LA, Clark JA, Johns LK (1996) Effect of lipid peroxidation inhibition on retinal ganglion cell death. Invest Ophthalmol Vis Sci 37:2744-2749
36. Lieberman MF, Maumenee AE, Green WR (1976) Histologic studies of the vasculature of the anterior optic nerve. Am J Ophthalmol 82:405-423
37. Luksch A, Polak K, Beier C et al. (2000) Effects of systemic NO synthase inhibition on choroidal and optic nerve head blood flow in healthy subjects. Invest Ophthalmol Vis Sci 41:3080-3084
38. Manev H, Uz T, Kharlamov A, Joo JY (1996) Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats. FASEB J 10:1546-1551
39. Matsugi T, Chen Q, Anderson DR (1997) Adenosine-induced relaxation of cultured bovine retinal pericytes. Invest Ophthalmol Vis Sci 38:2695-2701
40. Menke T, Gille G, Reber F, Janetzky B, Andler W, Funk RH, Reichmann H (2003) Coenzyme Q10 reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential. Biofactors 18:65-72
41. Mori H, Mishina M (1995) Structure and function of the NMDA receptor channel. Neuropharmacology 34:1219-1237
42. Morrison JC, Johnson EC, Cepurna WO, Funk RH (1999) Microvasculature of the rat optic nerve head. Invest Ophthalmol Vis Sci 40:1702-1709
43. Müller A, Pietri S, Villain M, Frejaville C, Bonne C, Culcas M (1997) Free radicals in rabbit retina under ocular hyperpressure and functional consequences. Exp Eye Res 64:637-643
44. Müller M, Albrecht S, Gölfert F et al. (1999) Localization of tissue factor in actin-filament-rich membrane areas of epithelial cells. Exp Cell Res 248:136-147
45. Neufeld AH, Liu B (2003) Glaucomatous optic neuropathy: when glia misbehave. Neuroscientist 9:485-495
46. Ophir A, Berenshtein E, Kitrossky N, Averbukh E (1994) Protection of the transiently ischemic cat retina by zinc-desferrioxamine. Invest Ophthalmol Vis Sci 35:1212-1222
47. Osborne NN (1999) Memantine reduces alterations to the mammalian retina, in situ, induced by ischaemia. Vis Neurosci 16:45-52
48. Osborne NN, DeSantis L, Bae JH et al. (1999) Topically applied betaxolol attenuates NMDA-induced toxicity to ganglion cells and the effects of ischaemia to the retina. Exp Eye Res 69:331-342
49. Osborne NN, Ugarte M, Chao M et al. (1999) Neuroprotection in relation to retinal ischaemia and relevance to glaucoma. Surv Ophthalmol 43 [suppl]: S102-S129
50. Osborne NN, Wood JPM, Chidlow G et al. (1999) Ganglion cell death in glaucoma: what do we really know? Brit J Ophthalmol 83:980-986
51. Osborne NN, Chidlow G, Wood JPM, Schmidt KG, Casson R, Melena J (2001) Expectations in the treatment of retinal diseases: neuroprotection. Curr Eye Res 22:321-232
52. Parsons CG, Gruner R, Rozental J, Millar J, Lodge D (1993) Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology 32:1337-1350
53. Pillunat LE, Stodtmeister R, Willmanns I (1987) Pressure compliance of the optic nerve head in low tension glaucoma. Brit J Ophthalmol 71:181-187
54. Pillunat LE, Stodtmeister R, Marquardt R, Mattern A (1989) Ocular perfusion pressures in different types of glaucoma. Int Ophthalmol 13:37-42
55. Pillunat LE, Anderson DR, Knighton RW, Joos KM, Feuer WJ (1997) Autoregulation of human optic nerve head circulation in response to increased intraocular pressure. Exp Eye Res 64:737-744
56. Quigley HA, Sanchez RM, Dunkelberger GR, Baginski TA (1987) Chronic glaucoma selectively damages large optic nerve fibers. Invest Ophthalmol Vis Sci 28:913-920
57. Quigley HA, Nickells RW, Kerigan LA et al. (1995) Retinal cell ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci 36:774-786
58. Reber F, Kasper M, Siegner A, Kniep E, Seigel G, Funk RH (2002) Alteration of the intracellular pH and apoptosis induction in a retinal cell line by the AGE-inducing agent glyoxal. Graefes Arch Clin Exp Ophthalmol 240:1022-1032
59. Reber F, Geffarth R, Kasper M, Reichenbach A, Schleicher ED, Siegner A, Funk RH (2003) Graded sensitiveness of the various retinal neuron populations on the glyoxal-mediated formation of advanced glycation end products and ways of protection. Graefes Arch Clin Exp Ophthalmol 241:213-225
60. Reber F, Gersch U, Funk RW (2003) Blockers of carbonic anhydrase can cause increase of retinal capillary diameter, decrease of extracellular and increase of intracellular pH in rat retinal organ culture. Graefes Arch Clin Exp Ophthalmol 241:140-148
61. Reber F, Reber U, Funk RH (2003) Intracellular changes in astrocytes and NG 108-15 neuroblastoma X glioma cells induced by advanced glycation end prod ucts. J Neural Transm 110:1103-1118
62. Reiter RJ (1997) Antioxidant actions of melatonin. Adv Pharmacol 38:103-117
63. Reiter RJ, Melchiorri D, Sewerynek E et al. (1995) A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 18:1-11
64. Sakagami K, Wu DM, Puro DG (1999) Physiology of rat retinal pericytes: modulation of ion channel activity by serum-derived molecules. J Physiol 521:637-650
65. Schmidt KG (1999) Antiglaukomatosa und choroidale Perfusion bei primärem und experimentell induziertem Offenwinkelglaukom. In: Schmidt KG, Pillunat LE (Hrsg) Fortbildung Glaukom, Bd 1, Perfusion und Pharmakologie. Enke, Stuttgart, S 39-50
66. Schmidt KG (1999) Einfluß antiglaukomatöser Substanzen auf die okuläre Perfusion. In: Pillunat LE, Böhm A, Schmidt KG (Hrsg) Fortbildung Glaukom, Bd 2. Enke, Stuttgart, S 79-99
67. Schmidt KG, Stegmann DY, Serie JB, Garrett DT, Camras CB, Mittag TW, Podos SM (1991) Ocular pulse amplitude (OPA) in primary open angle glaucoma, low tension glaucoma, and in ocular hypertensive patients before and after topical drug treatment. Invest Ophthalmol Vis Sci 32:943
68. Schmidt KG, Mittag TW, Pavlovic S, Hessemer V (1996) Influence of physical exercise and nifedipine on ocular pulse amplitude. Graefes Arch Clin Exp Ophthalmol 234:527-532
69. Schmidt KG, v Rückmann A, Geyer O, Mittag TW (1997) Einfluß des Nifedipins auf die okuläre Pulsamplitude bei Normaldruckglaukom. Klin Monatsbl Augenheilkd 210:355-359
70. Schmidt KG, v Rückmann A, Mittag TW, Hessemer V, Pillunat LE (1997) Reduced ocular pulse amplitude in low-tension glaucoma is independent of vasospasm. Eye 11:485-488
71. Schmidt KG, v Rückmann A, Pillunat LE (1998) Dorzolamide increases ocular pulse amplitude in high tension primary open angle glaucoma. Br J Ophthalmol 82:758-762
72. Schmidt KG, Klingmüller V, v Rückmann A, Koch B (2000) Retrobulbäre und chorioidale Hämodynamik bei Hochdruck- und Normaldruckglaukom. In: Schmidt KG, Pillunat LE (Hrsg) Fortbildung Glaukom, Bd 3. Enke, Stuttgart, S 103-114
73. Schmidt KG, Klingmüller V, Gouveia SM, Osborne NN, Pillunat LE (2003) Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients. Am J Ophthalmol 136:1038-1048
74. Schmidt KG, Geyer O, Mittag TW (2004) Adenylyl and guanylyl cyclase activity in the choroid. Exp Eye Res 78:901-907
75. Schönfelder U, Hofer A, Paul M, Funk RH (1998) In situ observation of living pericytes in rat retinal capillaries. Microvasc Res 56:22-29
76. Sims DE (1991) Recent advances in pericyte biology - implications for health and disease. Can J Cardiol 7:431-443
77. Stitt AW, Li YM, Gardiner TA, Bucala R, Archer DB, Vlassara H (1997) Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats. Am J Pathol 150:523-531
78. 2+ shifts in rat retina: effects of two free radical scavengers, SOD and EGB 761. Exp Eye Res 55:39-15
79. 2+) by free radical scavengers in the rat retina. Ophthalmic Res 25:1-9
80. Takahashi K, Lam TT, Edward DP, Buchi ER, Tso MO (1992) Protective effects of flunarizine on ischemic injury in the rat retina. Arch Ophthalmol 110:862-870
81. Toda N, Kitamura Y, Okamura T (1995) Functional role of nerve-derived nitric oxide in isolated dog ophthalmic arteries. Invest Ophthalmol Vis Sci 36:563-570
82. 2+ entry and quantal dopamine secretion in carotid body glomus cells. Proc Natl Acad Sci U S A 91:10208-10211
83. Uz T, Giusti P, Franceschini D, Kharlamov A, Manev H (1996) Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats. Neuroscience 73:631-636
84. Veriac S, Tissie G, Bonne C (1993) Oxygen free radicals adversely affect the regulation of vascular tone by nitric oxide in the rabbit retina under high intraocular pressure. Exp Eye Res 56:85-88
85. Wang L, Dong J, Cull G, Fortune B, Cioffi GA (2003) Varicosities of intraretinal ganglion cell axons in human and nonhuman primates. Invest Ophthalmol Vis Sci 44:2-9
86. Winter M, Eberhardt W, Scholz C, Reichenbach A (2000) Failure of potassium siphoning by Müller cells: a new hypothesis of perfluorocarbon liquid-induced retinopathy. Invest Ophthalmol Vis Sci 41:256-261
87. Wood JPM, Schmidt KG, Melena J, Chidlow G, Allmeier H, Osborne NN (2003) The β-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol. Exp Eye Res 76:505-516
88. Yamamoto T, Kitazawa Y (1998) Vascular pathogenesis of normal-tension glaucoma: a possible pathogenic factor, other than intraocular pressure, of glaucomatous optic neuropathy. Prog Ret Eye Res 17:127-143
89. Ye XD, Laties AM, Stone RA (1990) Peptidergic innervation of the retinal vasculature and optic nerve head. Invest Ophthalmol Vis Sci 31:1731-1737
90. Yoon YH, Marmor MF (1989) Dextromethorphan protects retina against ischemic injury in vivo. Arch Ophthalmol 107:409-411