Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties

Tetrahedron

Volumn 60, Issue 10, 2004, Pages 2235-2246

  Fader, Lee D ^a   Myers, Eddie L ^a   Tsantrizos, Youla S ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

Novel aromatic peptide nucleic acid monomers; PNA APNA triplexes with DNA and RNA

Indexed keywords

2 (TERT BUTOXYCARBONYLAMINOBENZYLAMINO)ACETIC ACID BENZYL ESTER; 2 AMINO 3 [[TERT BUTOXYCARBONYLMETHYL[2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL]AMINO]METHYL]BENZOIC ACID METHYL ESTER; 3 (2 TERT BUTOXYCARBONYLAMINOPHENYLAMINO)PROPIONIC ACID METHYL ESTER; 3 BROMOMETHYL 2 NITROBENZOIC ACID METHYL ESTER; 3 METHYL 2 NITROBENZOIC ACID METHYL ESTER; 3 [(2 TERT BUTOXYCARBONYLAMINOPHENYL)[2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL]AMINO]PROPIONIC ACID METHYL ESTER; 3 [(TERT BUTOXYCARBONYLMETHYLAMINO)METHYL] 2 NITROBENZOIC ACID METHYL ESTER; 3 [[(TERT BUTOXYCARBONYLMETHYL[2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL]AMINO]METHYL] 2 NITROBENZOIC ACID METHYL ESTER; AROMATIC PEPTIDE NUCLEIC ACID; DNA; PEPTIDE NUCLEIC ACID; RNA; UNCLASSIFIED DRUG; [(2 TERT BUTOXYCARBONYLAMINOBENZYL)[2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL]AMINO]ACETIC ACID BENZYL ESTER; [2 [(2,3 DIHYDROXYPROPYL)[2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL]AMINO]BENZYL]CARBAMIC ACID TERT BUTYL ESTER; [2 [[2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL](2 OXOETHYL)AMINO]BENZYL]CARBAMIC ACID TERT BUTYL ESTER; [2 [[2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL]AMINO]BENZYL]CARBAMIC ACID TERT BUTYL ESTER; [[2 TERT BUTOXYCARBONYLAMINOMETHYL)PHENYL][2 (5 METHYL 2,4 DIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETYL]AMINO]ACETIC ACID;

AQUEOUS SOLUTION; ARTICLE; DNA STRUCTURE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYBRIDIZATION; MOLECULAR RECOGNITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 1242351225     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2004.01.026     Document Type: Article

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