Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors

Toxicology

Volumn 196, Issue 1-2, 2004, Pages 127-136

  Tao, Lianhui ^a,b   Li, Yingzhe ^a   Kramer, Paula M ^a   Wang, Wei ^a   Pereira, Michael A ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Dichloroacetic acid; DNA hypomethylation; Insulin like growth factor II gene; Mouse liver tumors; MRNA expression; Trichloroacetic acid

Indexed keywords

DICHLOROACETIC ACID; DNA; SOMATOMEDIN B; TRICHLOROACETIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; DOT HYBRIDIZATION; LIVER; LIVER CARCINOMA; METHYLATION; MOLECULAR PROBE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 1242338859     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2003.11.011     Document Type: Article

References (38)

1. Baylin S.B., Esteller M., Rountree M.R., Bachman K.E., Schuebel K., Herman J.G. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol. Genet. 10:2001;687-692.
2. Boorman G.A. Drinking water disinfection byproducts: review and approach to toxicity evaluation. Environ. Health Perspect. 107(Suppl. 1):1999;207-217.
3. Bull R.J., Sanchez I.M., Nelson M.A., Larson J.L., Lansing A.J. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology. 63:1990;341-359.
4. Chen W.J., Weisel C.P. Concentration changes of halogenated disinfection by-products in a drinking water distribution system. J. Am. Water Works Assoc. 90:1998;151-163.
5. Coffin J.C., Ge R., Yang S., Kramer P.M., Tao L., Pereira M.A. Effect of trihalomethanes on cell proliferation and DNA methylation in female B6C3F1 mouse liver. Toxicol. Sci. 58:2000;243-252.
6. Counts J.L., Goodman J.I. Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion. Toxicol. Lett. 82/83:1995;663-672.
7. Counts J.L., Sarmiento J.I., Harbison M.L., Downing J.C., McClain R.M., Goodman J.L. Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration. Carcinogenesis. 17:1996;1251-1257.
8. EPA, US, 2003a. Dichloroacetic acid (CASRN 79-43-6). US Environmental Protection Agency at website, http://www.epa.gov/iriswebp/iris/subst/0654.htm.
9. EPA, US, 2003b. Trichloroacetic acid (CASRN 76-03-9). US Environmental Protection Agency at website, http://www.epa.gov/iris/subst/0655.htm.
10. Furstenberger G., Senn H.J. Insulin-like growth factors and cancer. Lancet Oncol. 3:2002;298-302.
11. Ge R., Tao L., Kramer P.M., Cunningham M.L., Pereira M.A. Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liver. J. Biochem. Mol. Toxicol. 16:2002;41-47.
12. Ge R., Wang W., Kramer P.M., Yang S., Tao L., Pereira M.A. Wy-14,643-induced hypomethylation of the c-myc gene in mouse liver. Toxicol. Sci. 62:2001a;28-35.
13. Ge R., Yang S., Kramer P.M., Tao L., Pereira M.A. The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice. J. Biochem. Mol. Toxicol. 15:2001b;100-106.
14. Goodman J.I., Watson R.E. Altered DNA methylation: a secondary mechanism involved in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 42:2002;501-525.
15. Grigg G.W. Sequencing 5-methylcytosine residues by the bisulphite method. DNA Seq. 6:1996;189-198.
16. Henning S.M., Swendseid M.E. The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets. Adv. Exp. Med. Biol. 399:1996;143-155.
17. Herren-Freund S.L., Pereira M.A., Khoury M.D., Olson G. The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 90:1987;183-189.
18. IARC, 1995. Trichloroethylene. In: IARC Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Human. IARC, Lyon, France, pp. 75-158.
19. Khandwala H.M., McCutcheon I.E., Flyvbjerg A., Friend K.E. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocrin. Rev. 21:2000;215-244.
20. Li S., Hursting S.D., Davis B.J., McLachlan J.A., Barrett J.C. Environmental exposure, DNA methylation, and gene regulation: lessons from diethylstilbesterol-induced cancers. Ann. N.Y. Acad. Sci. 983:2003;161-169.
21. Miller J.H., Minard K., Wind R.A., Orner G.A., Sasser L.B., Bull R.J. In vivo MRI measurements of tumor growth induced by dichloroacetate: implications for mode of action. Toxicology. 145:2000;115-125.
22. Olek A., Oswald J., Walter J. A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res. 24:1996;5064-5066.
23. Pereira M.A. Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice. Fund. Appl. Toxicol. 31:1996;192-199.
24. Pereira M.A., Li K., Kramer P.M. Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice. Cancer Lett. 115:1997;15-23.
25. Pereira M.A., Phelps J.B. Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice. Cancer Lett. 102:1996;133-141.
26. Robertson K.D., Jones P.A. DNA methylation: past, present and future directions. Carcinogenesis. 21:2000;461-467.
27. Scharf J.G., Dombrowski F., Ramadori G. The IGF axis and hepatocarcinogenesis. Mol. Pathol. 54:2001;138-144.
28. Snyder R.D., Pullman J., Carter J.H., Carter H.W., DeAngelo A.B. In vivo administration of dichloroacetic acid suppresses spontaneous apoptosis in murine hepatocytes. Cancer Res. 55:1995;3702-3705.
29. Stauber A.J., Bull R.J. Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA). Toxicol. Appl. Pharmacol. 144:1997;235-246.
30. Tao L., Ge R., Xie M., Kramer P.M., Pereira M.A. Effect of trichloroethylene on DNA methylation and expression of early-intermediate protooncogenes in the liver of B6C3F1 mice. J. Biochem. Mol. Toxicol. 13:1999;231-237.
31. Tao L., Kramer P.M., Ge R., Pereira M.A. Effect of dichloroacetic acid and trichloroacetic acid on DNA methylation in liver and tumors of female B6C3F1 mice. Toxicol. Sci. 43:1998;139-144.
32. Tao L., Li Y., Wang W., Kramer P.M., Gunning W.T., Lubet R.A., Steele V.E., Pereira M.A. Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors. Mol. Carcinogen. 35:2002;93-102.
33. Tao L., Yang S., Xie M., Kramer P.M., Pereira M.A. Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-jun and c-myc protooncogenes in mouse liver: prevention by methionine. Toxicol. Sci. 54:2000a;399-407.
34. Tao L., Yang S., Xie M., Kramer P.M., Pereira M.A. Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Cancer Lett. 158:2000b;185-193.
35. Uden P.C., Miller J.W. Chlorinated acids and chloral in drinking water. J. Am. Water Works Assoc. 75:1983;524-527.
36. Wainfan E., Poirier L.A. Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res. 52:1992;2071s-2077s.
37. Ware G.W. Tetrachloroethylene. Rev. Environ. Contam. Toxicol. 106:1988;175-188.
38. Werner H., Le Roith D. New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell. Mol. Life Sci. 57:2000;932-942.